This book provides an overview of the application of statistical methods to problems in metrology, with emphasis on modelling measurement processes and quantifying their associated uncertainties. It covers everything from fundamentals to more advanced special topics, each illustrated with case studies from the authors' work in the Nuclear Security Enterprise (NSE). The material provides readers with a solid understanding of how to apply the techniques to metrology studies in a wide variety of contexts. The volume offers particular attention to uncertainty in decision making, design of experiments (DOEx) and curve fitting, along with special topics such as statistical process control (SPC), assessment of binary measurement systems, and new results on sample size selection in metrology studies. The methodologies presented are supported with R script when appropriate, and the code has been made available for readers to use in their own applications. Designed to promote collaboration between statistics and metrology, this book will be of use to practitioners of metrology as well as students and researchers in statistics and engineering disciplines.

This volume provides a brief but important summary of the essential tests that need to be performed on all new compounds--whether they are new drugs, pesticides or food additives--before they can be registered for use in the United Kingdom. These basic tests for mutagenicity, originally drawn up by the United Kingdom Environmental Mutagen Society in 1983 have now been fully revised under the auspices of expert working groups from academia and industry and in collaboration with the UK Department of Health. This volume therefore provides the latest official guidelines and recommendations for all scientists involved in the testing and registration of new compounds not only in the UK, but in wider international context. The four main test procedures for measuring mutagenicity described in this volume are bacterial mutation assays, metaphase chromosome aberration assays in vitro, gene mutation assays in cultured mammalian cells, and in vivo cytogenetics assays. Each of these tests is fully explained and described in practical and procedural detail, with additional information on the presentation and data processing of results.

The book highlights recent developments in the field of biomedical systems covering a wide range of technological aspects, methods, systems and instrumentation techniques for diagnosis, monitoring, treatment, and assistance. Biomedical systems are becoming increasingly important in medicine and in special areas of application such as supporting people with disabilities and under pandemic conditions. They provide a solid basis for supporting people and improving their health care. As such, the book offers a key reference guide about novel medical systems for students, engineers, designers, and technicians.

< p=""> This book focuses both on the basics and more complex topics in mechanical measurements such as measurement errors & statistical analysis of data, regression analysis, heat flux, measurement of pressure, and radiation properties of surfaces. End of chapter problems, solved illustrations, and exercise problems are presented throughout the book to augment learning. It is a useful reference for students in both undergraduate and postgraduate programs. ^

This book describes the active vibration control techniques which have been developed to suppress excessive vibrations of structures. It covers the fundamental principles of active control methods and their applications and shows how active vibration control techniques have replaced traditional passive vibration control. The book includes coverage of dynamic modeling, control design, sensing methodology, actuator mechanism and electronic circuit design, and the implementation of control algorithms via digital controllers. An in-depth approach has been taken to describe the modeling of structures for control design, the development of control algorithms suitable for structural control, and the implementation of control algorithms by means of Simulink block diagrams or C language. Details of currently available actuators and sensors and electronic circuits for signal conditioning and filtering have been provided based on the most recent advances in the field. The book is used as a textbook for students and a reference for researchers who are interested in studying cutting-edge technology. It will be a valuable resource for academic and industrial researchers and professionals involved in the design and manufacture of active vibration controllers for structures in a wide variety of fields and industries including the automotive, rail, aerospace, and civil engineering sectors.

Since the turn of the century, the increasing availability of photoelectron imaging experiments, along with the increasing sophistication of experimental techniques, and the availability of computational resources for analysis and numerics, has allowed for significant developments in such photoelectron metrology. Quantum Metrology with Photoelectrons, Volume 2: Applications and Advances discusses the fundamental concepts along with recent and emerging applications. Volume 2 explores the applications and development of quantum metrology schemes based on photoelectron measurements. The author begins with a brief historical background on ""complete"" photoionization experiments, followed by the details of state reconstruction methodologies from experimental measurements. Three specific applications of quantum metrology schemes are discussed in detail. In addition, the book provides advances, future directions, and an outlook including (ongoing) work to generalise these schemes and extend them to dynamical many-body systems. Volume 2 will be of interest to readers wishing to see the (sometimes messy) details of state reconstruction from photoelectron measurements as well as explore the future prospects for this class of metrology.

This book describes hydration structures of proteins by combining experimental results with theoretical considerations. It is designed to introduce graduate students and researchers to microscopic views of the interactions between water and biological macromolecules and to provide them with an overview of the field. Topics on protein hydration from the past 25 years are examined, most of which involve crystallography, fluorescence measurements, and molecular dynamics simulations. In X-ray crystallography and molecular dynamics simulations, recent advances have accelerated the study of hydration structures over the entire surface of proteins. Experimentally, crystal structure analysis at cryogenic temperatures is advantageous in terms of visualizing the positions of hydration water molecules on the surfaces of proteins in their frozen-hydrated crystals. A set of massive data regarding hydration sites on protein surfaces provides an appropriate basis, enabling us to identify statistically significant trends in geometrical characteristics. Trajectories obtained from molecular dynamics simulations illustrate the motion of water molecules in the vicinity of protein surfaces at sufficiently high spatial and temporal resolution to study the influences of hydration on protein motion. Together with the results and implications of these studies, the physical principles of the measurement and simulation of protein hydration are briefly summarized at an undergraduate level. Further, the author presents recent results from statistical approaches to characterizing hydrogen-bond geometry in local hydration structures of proteins. The book equips readers to better understand the structures and modes of interaction at the interface between water and proteins. Referred to as "hydration structures", they are the subject of much discussion, as they may help to answer the question of why water is indispensable for life at the molecular and atomic level.

This volume surveys recent research on autonomous sensor networks from the perspective of enabling technologies that support medical, environmental and military applications.

State of the art, as well as emerging concepts in wireless sensor networks, body area networks and ambient assisted living introduce the reader to the field, while subsequent chapters deal in depth with established and related technologies, which render their implementation possible. These range from smart textiles and printed electronic devices to implanted devices and specialized packaging, including the most relevant technological features.

The last four chapters are devoted to customization, implementation difficulties and outlook for these technologies in specific applications.

Authored by two highly respected experts in this specialist area, The Fundamentals of Radiation Thermometers is an essential resource for anyone intending to measure the temperature of an object using the radiated energy from that object. This readable, user-friendly book gives important background knowledge for anyone working in the field of non-contact thermometry. The book begins with an accessible account of how temperature scales are set up and defined, and explores the historic development of temperature scales and Planck's radiation law. Through explaining the reliability of both emissivity values and extrapolation to different wavelengths and temperatures, the book provides a foundation for understanding when a valid measurement with realistic uncertainties has been made, or if an inappropriate emissivity value has been used with consequent unknown errors. The book also presents the hardware of radiation thermometers, allowing the reader to specify an appropriate design for a particular measurement problem. It explores multi-wavelength radiation thermometry and its associated pitfalls, and a final chapter suggests strategies to minimise the uncertainties from unreliable emissivity data.

This book discusses the development of Fano-based techniques and reveals the characteristic properties of various wave processes by studying interference phenomena. It explains that the interaction of discrete (localized) states with a continuum of propagation modes leads to Fano interference effects in transmission, and explores novel coherent effects such as bound states in the continuum accompanied by collapse of Fano resonance. Originating in atomic physics, Fano resonances have become one of the most appealing phenomena of wave scattering in optics, microwaves, and terahertz techniques. The generation of extremely strong and confined fields at a deep subwavelength scale, far beyond the diffraction limit, plays a central role in modern plasmonics, magnonics, and in photonic and metamaterial structures. Fano resonance effects take advantage of the coupling of these bound states with a continuum of radiative electromagnetic waves. With their unique physical properties and unusual combination of classical and quantum structures, Fano resonances have an application potential in a wide range of fields, from telecommunication to ultrasensitive biosensing, medical instrumentation and data storage. Including contributions by international experts and covering the essential aspects of Fano-resonance effects, including theory, modeling and design, proven and potential applications in practical devices, fabrication, characterization and measurement, this book enables readers to acquire the multifaceted understanding required for these multidisciplinary challenges.

Accuracy in the laboratory setting is key to maintaining the integrity of scientific research. Inaccurate measurements create false and non-reproducible results, rendering an experiment or series of experiments invalid and wasting both time and money. This handy guide to solid, fluid, and thermal measurement helps minimize this pitfall through careful detailing of measurement techniques. Concise yet thorough, Mechanical Variables Measurement-Solid, Fluid, and Thermal describes the use of instruments and methods for practical measurements required in engineering, physics, chemistry, and the life sciences. Organized according to measurement problem, the entries are easy to access. The articles provide equations to assist engineers and scientists who seek to discover applications and solve problems that arise in areas outside of their specialty. Sections include references to more specialized publications for advanced techniques, as well. It offers instruction for a range of measuring techniques, basic through advanced, that apply to a broad base of disciplines. As an engineer, scientist, designer, manager, researcher, or student, you encounter the problem of measurement often and realize that doing it correctly is pivotal to the success of an experiment. This is the first place to turn when deciding on, performing, and troubleshooting the measurement process. Mechanical Variables Measurement-Solid, Fluid, and Thermal leads the reader, step-by-step, through the straits of experimentation to triumph.

Since the turn of the century, the increasing availability of photoelectron imaging experiments, along with the increasing sophistication of experimental techniques, and the availability of computational resources for analysis and numerics, has allowed for significant developments in such photoelectron metrology. Quantum Metrology with Photoelectrons, Volume 1: Foundations discusses the fundamental concepts along with recent and emerging applications. The core physics is that of photoionization, and Volume 1 addresses this topic. The foundational material is presented in part as a tutorial with extensive numerical examples and also in part as a collected reference to the relevant theoretical treatments from the literature for a range of cases. Topics are discussed with an eye to developing general quantum metrology schemes, in which full quantum state reconstruction of the photoelectron wavefunction is the goal. In many cases, code and/or additional resources are available online. Consequently, it is hoped that readers at all levels will find something of interest and that the material provides something rather different from existing textbooks.

This volume contains original, refereed contributions by researchers from institutions and laboratories across the world that are involved in metrology and testing. They were adapted from presentations made at the eleventh edition of the Advanced Mathematical and Computational Tools in Metrology and Testing conference held at the University of Strathclyde, Glasgow, in September 2017, organized by IMEKO Technical Committee 21, the National Physical Laboratory, UK, and the University of Strathclyde. The papers present new modeling approaches, algorithms and computational methods for analyzing data from metrology systems and for evaluation of the measurement uncertainty, and describe their applications in a wide range of measurement areas.This volume is useful to all researchers, engineers and practitioners who need to characterize the capabilities of measurement systems and evaluate measurement data. Through the papers written by experts working in leading institutions, it covers the latest computational approaches and describes applications to current measurement challenges in engineering, environment and life sciences.

Systems of units still fail to attract the philosophical attention they deserve, but this could change with the current reform of the International System of Units (SI). Most of the SI base units will henceforth be based on certain laws of nature and a choice of fundamental constants whose values will be frozen. The theoretical, experimental and institutional work required to implement the reform highlights the entanglement of scientific, technological and social features in scientific enterprise, while it also invites a philosophical inquiry that promises to overcome the tensions that have long obstructed science studies.

This second open access volume of the handbook series deals with detectors, large experimental facilities and data handling, both for accelerator and non-accelerator based experiments. It also covers applications in medicine and life sciences. A joint CERN-Springer initiative, the "Particle Physics Reference Library" provides revised and updated contributions based on previously published material in the well-known Landolt-Boernstein series on particle physics, accelerators and detectors (volumes 21A,B1,B2,C), which took stock of the field approximately one decade ago. Central to this new initiative is publication under full open access.

This thesis focuses on a cutting-edge area of research, which is aligned with CERN's mainstream research, the "AWAKE" project, dedicated to proving the capability of accelerating particles to the energy frontier by the high energy proton beam. The author participated in this project and has advanced the plasma wakefield theory and modelling significantly, especially concerning future plasma acceleration based collider design. The thesis addresses electron beam acceleration to high energy whilst preserving its high quality driven by a single short proton bunch in hollow plasma. It also demonstrates stable deceleration of multiple proton bunches in a nonlinear regime with strong resonant wakefield excitation in hollow plasma, and generation of high energy and high quality electron or positron bunches. Further work includes the assessment of transverse instabilities induced by misaligned beams in hollow plasma and enhancement of the wakefield amplitude driven by a self-modulated long proton bunch with a tapered plasma. This work has major potential to impact the next generation of linear colliders and also in the long-term may help develop compact accelerators for use in industrial and medical facilities.

This book on astronomical measurement takes a fresh approach to teaching the subject. After discussing some general principles, it follows the chain of measurement through atmosphere, imaging, detection, spectroscopy, timing, and hypothesis testing. The various wavelength regimes are covered in each section, emphasising what is the same, and what is different. The author concentrates on the physics of detection and the principles of measurement, aiming to make this logically coherent.
The book is based on a short self contained lecture course for advanced undergraduate students developed and taught by the author over several years.

This book presents a systematic and comprehensive exposition of the theory of measurement accuracy and provides solutions that fill significant and long-standing gaps in the classical theory. It eliminates the shortcomings of the classical theory by including methods for estimating accuracy of single measurements, the most common type of measurement. The book also develops methods of reduction and enumeration for indirect measurements, which do not require Taylor series and produce a precise solution to this problem. It produces grounded methods and recommendations for summation of errors. The monograph also analyzes and critiques two foundation metrological documents, the International Vocabulary of Metrology (VIM) and the Guide to the Expression of Uncertainty in Measurement (GUM), and discusses directions for their revision. This new edition adds a step-by-step guide on how to evaluate measurement accuracy and recommendations on how to calculate systematic error of multiple measurements. There is also an extended section on the method of reduction, which provides an alternative to the least-square method and the method of enumeration. Many sections are also rewritten to improve the structure and usability of the material. The 3rd edition reflects the latest developments in metrology and offers new results, and it is designed to be accessible to readers at various levels and positions, including scientists, engineers, and undergraduate and graduate students. By presenting material from a practical perspective and offering solutions and recommendations for problems that arise in conducting real-life measurements, author Semyon Rabinovich offers an invaluable resource for scientists in any field.

This book is a continuous learning tool for experienced technical staff facing laser vibrometry technology for the first time. The book covers both theoretical aspects and practical applications of laser Doppler vibrometry, and is accompanied by a multimedia presentation that allows the audience to browse the content and come as close as possible to performing real experiments. After a brief introduction, Chapter 2 presents supporting theory, providing general information on light sources, light scattering and interference for a better understanding of the rest of the book. Chapter 3 examines the theory of laser vibrometers, explaining interferometers from an optical perspective and in terms of the related electronics. It also addresses options like tracking filters and different signal demodulation strategies, since these have a significant impact on the practical use of vibrometers. Chapter 4 explores the configurations that are encountered in today's instrumentation, with a focus on providing practical suggestions on the use of laser vibrometers. Lastly, Chapter 5 investigates metrology for vibration and shock measurements using laser interferometry, and analyses the uncertainty of laser vibrometers in depth.

In this book on Fundamentals of Mass Determination, the definition and dissemination of units of mass is explained, starting with an introduction to metrology and mass determination. Establishing a mass scale requires corresponding mass standards and mass comparators. The metrological requirements for weighing instruments, weight pieces, and measuring conditions are explained and discussed based on international directives and applicable legal regulations. International directives and institutions are striving towards the worldwide uniform implementation of these requirements. Processes used to determine density and volume are described to the extent that they apply to mass determination. Calculating measurement uncertainty entails taking into consideration the effect of influence variables on mass determination. An overview of this topic is provided to make it easier to determine and specify measurement uncertainty in practice, while additional information in the form of tables, illustrations, and literature references allow the reader to study mass metrology further.

The search for neutrinoless double beta decay is one of the highest priority areas in particle physics today; it could provide insights to the nature of neutrino masses (currently not explained by the Standard Model) as well as how the universe survived its early stages. One promising experimental approach involves the use of large volumes of isotope-loaded liquid scintillator, but new techniques for background identification and suppression must be developed in order to reach the required sensitivity levels and clearly distinguish the signal. The results from this thesis constitute a significant advance in this area, laying the groundwork for several highly effective and novel approaches based on a detailed evaluation of state-of-the-art detector characteristics. This well written thesis includes a particularly clear and comprehensive description of the theoretical motivations as well as impressively demonstrating the effective use of diverse statistical techniques. The professionally constructed signal extraction framework contains clever algorithmic solutions to efficient error propagation in multi-dimensional space. In general, the techniques developed in this work will have a notable impact on the field.

This book focuses on the issues of integrating large-scale renewable power generation into existing grids. The issues covered in this book include different types of renewable power generation along with their transmission and distribution, storage and protection. It also contains the development of medium voltage converters for step-up-transformer-less direct grid integration of renewable generation units, grid codes and resiliency analysis for large-scale renewable power generation, active power and frequency control and HVDC transmission. The emerging SMES technology for controlling and integrating large-scale renewable power systems is also discussed.Since the protection issues with large-scale distributed renewable power systems are different compared to the existing protection system for one way power flow, this book includes a new protection technique for renewable generators along with the inclusion of current status of smart grid. This book is a good reference for the researchers who are working the area of renewable power generation and smart grids."