The new edition of this book incorporates the recent remarkable changes in electric power generation, transmission and distribution. The consequences of the latest development to High Voltage (HV) test and measuring techniques result in new chapters on Partial Discharge measurements, Measurements of Dielectric Properties, and some new thoughts on the Shannon Theorem and Impuls current measurements. This standard reference of the international high-voltage community combines high voltage engineering with HV testing techniques and HV measuring methods. Based on long-term experience gained by the authors the book reflects the state of the art as well as the future trends in testing and diagnostics of HV equipment. It ensures a reliable generation, transmission and distribution of electrical energy. The book is intended not only for experts but also for students in electrical engineering and high-voltage engineering.

This is an open access book. This course-tested text is an ideal starting point for engineers and physicists entering the field of particle accelerators. The fundamentals are comprehensively introduced, derivations of essential results are provided and a consistent notation style used throughout the book allows readers to quickly familiarize themselves with the field, providing a solid theoretical basis for further studies. Emphasis is placed on the essential features of the longitudinal motion of charged particle beams, together with the corresponding RF generation and power amplification devices for synchrotron and storage ring systems. In particular, electrical engineering aspects such as closed-loop control of system components are discussed. The book also offers a valuable resource for graduate students in physics, electronics engineering, or mathematics looking for an introductory and self-contained text on accelerator physics.

"Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics" is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics.
Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceuticalContains the most pertinent international regulatory guidance documents for nonclinical evaluationCovers early de-risking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines, as well as follow-on biologics or "biosimilars"A multi-authored book with chapters written by qualified experts in their respective fields

This thesis describes the first detection of a nuclear transition that had been sought for 40 years, and marks the essential first step toward developing nuclear clocks. Atomic clocks are currently the most reliable timekeepers. Still, they could potentially be outperformed by nuclear clocks, based on a nuclear transition instead of the atomic transitions employed to date. An elusive, extraordinary state in thorium-229 seems to be the only nuclear transition suitable for this purpose and feasible using currently available technology. Despite repeated efforts over the past 40 years, until recently we had not yet successfully detected the decay of this elusive state. Addressing this gap, the thesis lays the foundation for the development of a new, better frequency standard, which will likely have numerous applications in satellite navigation and rapid data transfer. Further, it makes it possible to improve the constraints for time variations of fundamental constants and opens up the field of nuclear coherent control.

This book is exceptional in offering a thorough but accessible introduction to calorimetry that will meet the needs of both students and researchers in the field of particle physics. It is designed to provide the sound knowledge of the basics of calorimetry and of calorimetric techniques and instrumentation that is mandatory for any physicist involved in the design and construction of large experiments or in data analysis. An important feature is the correction of a number of persistent common misconceptions. Among the topics covered are the physics and development of electromagnetic showers, electromagnetic calorimetry, the physics and development of hadron showers, hadron calorimetry, and calibration of a calorimeter. Two chapters are devoted to more promising calorimetric techniques for the next collider. Calorimetry for Collider Physics, an introduction will be of value for all who are seeking a reliable guide to calorimetry that occupies the middle ground between the brief chapter in a generic book on particle detection and the highly complex and lengthy reference book.

This book presents developments of techniques for detection and analysis of two electrons resulting from the interaction of a single incident electron with a solid surface. Spin dependence in scattering of spin-polarized electrons from magnetic and non-magnetic surfaces is governed by exchange and spin-orbit effects. The effects of spin and angular electron momentum are shown through symmetry of experimental geometries: (i) normal and off normal electron incidence on a crystal surface, (ii) spin polarization directions within mirror planes of the surface, and (iii) rotation and interchange of detectors with respect to the surface normal. Symmetry considerations establish relationships between the spin asymmetry of two-electron distributions and the spin asymmetry of Spectral Density Function of the sample, hence providing information on the spin-dependent sample electronic structure. Detailed energy and angular distributions of electron pairs carry information on the electron-electron interaction and electron correlation inside the solid. The "exchange - correlation hole" associated with Coulomb and exchange electron correlation in solids can be visualized using spin-polarized two-electron spectroscopy. Also spin entanglement of electron pairs can be probed. A description of correlated electron pairs generation from surfaces using other types of incident particles, such as photons, ions, positrons is also presented.

This book highlights the latest research advances in the planning and management of electric distribution networks. It addresses various aspects of distribution network management including planning, operation, customer engagement, and technology accommodation. Given the importance of electric distribution networks in power delivery systems, effectively planning and managing them are vital to satisfying technical, economic, and customer requirements. A new planning and management philosophy, techniques, and methods are essential to handling uncertainties associated with the integration of renewable-based distributed generation, demand forecast, and customer needs. This book covers topics on managing the capacity of distribution networks, while also addressing the future needs of electric systems. The efficient and economical operation of distribution networks is an essential aspect of ensuring the effective use of resources. Accordingly, this book addresses operation and control approaches and techniques suitable for future distribution networks.

Before any kind of new physics discovery could be made at the LHC, a precise understanding and measurement of the Standard Model of particle physics' processes was necessary. The book provides an introduction to top quark production in the context of the Standard Model and presents two such precise measurements of the production of top quark pairs in proton-proton collisions at a center-of-mass energy of 7 TeV that were observed with the ATLAS Experiment at the LHC. The presented measurements focus on events with one charged lepton, missing transverse energy and jets. Using novel and advanced analysis techniques as well as a good understanding of the detector, they constitute the most precise measurements of the quantity at that time.

These proceedings present the latest information on software reliability, industrial safety, cyber security, physical protection, testing and verification for nuclear power plants. The papers were selected from more than 80 submissions and presented at the First International Symposium on Software Reliability, Industrial Safety, Cyber Security and Physical Protection for Nuclear Power Plants, held in Yinchuan, China on May 30 - June 1, 2016. The primary aim of this symposium was to provide a platform to facilitate the discussion for comprehension, application and management of digital instrumentation, control systems and technologies in nuclear power plants. The book reflects not only the state of the art and latest trends in nuclear instrumentation and control system technologies, but also China's increasing influence in this area. It is a valuable resource for both practitioners and academics working in the field of nuclear instrumentation, control systems and other safety-critical systems, as well as nuclear power plant managers, public officials and regulatory authorities.

This book describes the design, development, characterisation and application of two novel fluorescence imaging instruments based on spectrally resolved detector arrays (SRDAs). The simplest SRDA is the standard colour camera, which integrates a Bayer filter array of red, green and blue colour filters to replicate the colour sensing capability of the human eye. The SRDAs used in this book contain many more colours, ranging from 16 to over 100 colour channels. Using these compact, robust and low-cost detectors for biomedical applications opens new avenues of exploration that were not possible before, in particular, the use of spectral imaging in endoscopy. The work presented shows for the first time that not only can this new type of camera be used for fluorescence imaging, but also that it is able to resolve signals from up to 7 different dyes - a level of multiplexing not previously achieved in tissue with such compact and robust equipment. Furthermore, it reports the application of a bimodal endoscope performing both reflectance and fluorescence imaging using these cameras in an ex vivo pig oesophagus model.

The main goal of the book is to provide a systematic and didactic approach to the physics and technology of free-electron lasers. Numerous figures are used for illustrating the underlying ideas and concepts and links to other fields of physics are provided. After an introduction to undulator radiation and the low-gain FEL, the one-dimensional theory of the high-gain FEL is developed in a systematic way. Particular emphasis is put on explaining and justifying the various assumptions and approximations that are needed to obtain the differential and integral equations governing the FEL dynamics. Analytical and numerical solutions are presented and important FEL parameters are defined, such as gain length, FEL bandwidth and saturation power. One of the most important features of a high-gain FEL, the formation of microbunches, is studied at length. The increase of gain length due to beam energy spread, space charge forces, and three-dimensional effects such as betatron oscillations and optical diffraction is analyzed. The mechanism of Self-Amplified Spontaneous Emission is described theoretically and illustrated with numerous experimental results. Various methods of FEL seeding by coherent external radiation are introduced, together with experimental results. The world s first soft X-ray FEL, the user facility FLASH at DESY, is described in some detail to give an impression of the complexity of such an accelerator-based light source. The last chapter is devoted to the new hard X-ray FELs which generate extremely intense radiation in the Angstrom regime. The appendices contain supplementary material and more involved calculations."

Chemical reactions and growth processes on surfaces depend on the diffusion and re-orientation of the adsorbate molecules. A fundamental understanding of the forces guiding surface motion is thus of utmost importance for the advancement of many fields of science and technology. To date, our understanding of the principles underlying surface dynamics remains extremely limited, due to the difficulties involved in measuring these processes experimentally. The helium-3 spin-echo (HeSE) technique is uniquely capable of probing such surface dynamical phenomena. The present thesis extends the field of application of HeSE from atomic and small molecular systems to more complex systems. Improvements to the supersonic helium beam source, a key component of the spectrometer, as well as a detailed investigation of a range of five-membered aromatic adsorbate species are presented. The thesis provides a comprehensive description of many aspects of the HeSE method - instrumentation, measurement and data analysis - and as such offers a valuable introduction for newcomers to the field.

Scientific communication depends primarily on publishing in journals. The most important indicator to determine the influence of a journal is the Impact Factor. Since this factor only measures the average number of citations per article in a certain time window, it can be argued that it does not reflect the actual value of a periodical. This book defines five dimensions, which build a framework for a multidimensional method of journal evaluation. The author is winner of the Eugene Garfield Doctoral Dissertation Scholarship 2011.

This book explains digital signal processing topics in detail, with a particular focus on ease of understanding. Accordingly, it includes a wealth of examples to aid in comprehension, and stresses simplicity. The book is divided into four chapters, which respectively address the topics sampling of continuous time signals; multirate signal processing; the discrete Fourier transform; and filter design concepts. It provides original practical techniques to draw the spectrum of aliased signals, together with well-designed numerical examples to illustrate the operation of the fast transforms, filter algorithms, and circuit designs. Readers of this book should already have some basic understanding of signals and transforms. They will learn fundamental concepts for signals and systems, as the focus is more on digital signal processing concepts rather than continuous time signal processing topics.

The scienti c method is based on the measurement of di erent physical qu- tities and the search for relations between their values. All measured values of physical quantities are, however, a ected by uncertainty. Understanding the origin of uncertainty, evaluating its extent, and suitably taking it into account in data analysis, are fundamental steps for assessing the global accuracy of physical laws and the degree of reliability of their technological applications. The introduction to uncertainty evaluation and data analysis procedures is generally made in laboratory courses for freshmen. During my long-lasting teaching experience, I had the feeling of some sort of gap between the ava- able tutorial textbooks, and the specialized monographs. The present work aims at lling this gap, and has been tested and modi ed through a feedback interaction with my students for several years. I have tried to maintain as much as possible a tutorial approach, that, starting from a phenomenolo- cal introduction, progressively leads to an accurate de nition of uncertainty and to some of the most common procedures of data analysis, facilitating the access to advanced monographs. This book is mainly addressed to - dergraduate students, but can be a useful reference for researchers and for secondary school teachers. The book is divided into three parts and a series of appendices. Part I is devoted to a phenomenological introduction to measurement and uncertainty. In Chap.

This book reflects the results of the 2nd and 3rd International Workshops on Turbulent Spray Combustion. The focus is on progress in experiments and numerical simulations for two-phase flows, with emphasis on spray combustion. Knowledge of the dominant phenomena and their interactions allows development of predictive models and their use in combustor and gas turbine design. Experts and young researchers present the state-of-the-art results, report on the latest developments and exchange ideas in the areas of experiments, modelling and simulation of reactive multiphase flows.

The first chapter reflects on flame structure, auto-ignition and atomization with reference to well-characterized burners, to be implemented by modellers with relative ease. The second chapter presents an overview of first simulation results on target test cases, developed at the occasion of the 1st International Workshop on Turbulent Spray Combustion. In the third chapter, evaporation rate modelling aspects are covered, while the fourth chapter deals with evaporation effects in the context of flamelet models. In chapter five, LES simulation results are discussed for variable fuel and mass loading. The final chapter discusses PDF modelling of turbulent spray combustion.

In short, the contributions in this book are highly valuable for the research community in this field, providing in-depth insight into some of the many aspects of dilute turbulent spray combustion.

The International Linear Collider (ILC) is a mega-scale, technically complex project, requiring large financial resources and cooperation of thousands of scientists and engineers from all over the world. Such a big and expensive project has to be discussed publicly, and the planned goals have to be clearly formulated. This book advocates for the demand for the project, motivated by the current situation in particle physics. The natural and most powerful way of obtaining new knowledge in particle physics is to build a new collider with a larger energy. In this approach, the Large Hadron Collider (LHC) was created and is now operating at the world record center of-mass energy of 13 TeV. Although the design of colliders with a larger energy of 50-100 TeV has been discussed, the practical realization of such a project is not possible for another 20-30 years. Of course, many new results are expected from LHC over the next decade. However, we must also think about other opportunities, and in particular, about the construction of more dedicated experiments. There are many potentially promising projects, however, the most obvious possibility to achieve significant progress in particle physics in the near future is the construction of a linear e+e- collider with energies in the range (250-1000) GeV. Such a project, the ILC, is proposed to be built in Kitakami, Japan. This book will discuss why this project is important and which new discoveries can be expected with this collider.

This monograph collects and critically reviews the main results obtained by the scientific community in gyroscope technologies research field. It describes architectures, design techniques and fabrication technology of angular rate sensors proposed in literature. MEMS, MOEMS, optical and mechanical technologies are discussed together with achievable performance. The book also consideres future research trends aimed to cover special applications. The book is intended for researchers and Ph.D. students interested in modelling, design and fabrication of gyros. The book may be a useful education support in some university courses focused on gyro technologies.

Neutrinos continue to be the most mysterious and, arguably, the most fascinating particles of the Standard Model as their intrinsic properties such as absolute mass scale and CP properties are unknown. The open question of the absolute neutrino mass scale will be addressed with unprecedented accuracy by the Karlsruhe Tritium Neutrino (KATRIN) experiment, currently under construction. This thesis focusses on the spectrometer part of KATRIN and background processes therein. Various background sources such as small Penning traps, as well as nuclear decays from single radon atoms are fully characterized here for the first time. Most importantly, however, it was possible to reduce the background in the spectrometer by more than five orders of magnitude by eliminating Penning traps and by developing a completely new background reduction method by stochastically heating trapped electrons using electron cyclotron resonance (ECR). The work beautifully demonstrates that the obstacles and challenges in measuring the absolute mass scale of neutrinos can be met successfully if novel experimental tools (ECR) and novel computing methods (KASSIOPEIA) are combined to allow almost background-free tritium ss-spectroscopy.

This 2nd edition volume of Modern Gas-Based Temperature and Pressure Measurements follows the first publication in 1992. It collects a much larger set of information, reference data, and bibliography in temperature and pressure metrology of gaseous substances, including the physical-chemical issues related to gaseous substances. The book provides solutions to practical applications where gases are used in different thermodynamic conditions. Modern Gas-Based Temperature and Pressure Measurements, 2nd edition is the only comprehensive survey of methods for pressure measurement in gaseous media used in the medium-to-low pressure range closely connected with thermometry. It assembles current information on thermometry and manometry that involve the use of gaseous substances which are likely to be valid methods for the future. As such, it is an important resource for the researcher. This edition is updated through the very latest scientific and technical developments of gas-based temperature and pressure measurements using thermometry and manometry, and brings all of the techniques together under one cover. This book fills the gap in international literature, as no other recently published book provides a comprehensive survey for gaseous media closely connected with thermometry. Updates in this new edition include revised appendices and new chapters on Mutual Recognition Agreement of the Comite International des Poids et Mesures and its main applications, and developments in the European Metrology Society.

This dissertation focuses on the study of novel high-gain free-electron laser (FEL) operation schemes with external seed lasers. The technique of manipulating the phase space of the electron beam, which is widely used in novel seeded FEL schemes, is systematically studied. Several novel FEL schemes are proposed for the generation of intense coherent FEL pulses with short wavelength, sub-femtosecond pulse length or multiple carrier frequency properties, which meet the needs of FEL users. Results of experiments are described for the recently proposed FEL schemes such as echo-enabled harmonic generation and cascaded high-gain harmonic generation. New photon/electron beam diagnostic methods are also developed for these experiments and future high-gain FEL facilities.

Measuring Technology and Mechatronics Automation in Electrical Engineering includes select presentations on measuring technology and mechatronics automation related to electrical engineering, originally presented during the International Conference on Measuring Technology and Mechanatronics Automation (ICMTMA2012). This Fourth ICMTMA, held at Sanya, China, offered a prestigious, international forum for scientists, engineers, and educators to present the state of the art of measuring technology and mechatronics automation research.

This book presents experimental and theoretical results on extremely powerful plasma generators. It addresses pulsed electrical mega-ampere arcs and the mechanisms of energy transfer from the arc into hydrogen, helium and air under pressures up to 250 MPa and currents up to 2 MA. Extreme plasma parameters and increased energy density in the arc were achieved. It was found experimentally that increasing the initial gas pressure to hundreds of MPa leads to improved arc stability, high efficiency of energy transfer from arc to gas, and plasma enthalpy growth. The data obtained data provides the basis for the development of electrophysical devices with high energy density, e.g. high intensity sources for visible, UV and X-ray irradiation for laser pumping, generators of high enthalpy plasma jets, and plasma chemical reactors.

Nuclear and radioactive agents are considerable concerns especially after the early 1990s and more attention has been focused on the radiation detection technologies. This book comprises the selected presentations of NATO Advanced Training Course held 26-30 May 2008 in Mugla, Turkey. The contributions represent a wide range of documents related to control, monitoring and measurement methods of nuclear / radioactive isotopes and agents for both fundamental and applied works dealing with their use for different purposes. This book presents environmental data from many locations of different countries and also contains the contributions in the detection/monitoring programs of some authors from CIS countries.

The basic goal of this book is to deal with recent developments and applications of environmental monitoring and measurement techniques of environmental radionuclides and nuclear agents as well as the auxiliary techniques. The many recent examples contributed by authors will be useful in monitoring/ measurement studies of radioactive/nuclear agents in the present environment, and can help, not only in carrying out outdoor and laboratory experiments, but also in protection of possible sources of radionuclides and nuclear agents. Especially the contributions of experts and specialists involved in this book assured the highest level of knowledge in the field of techniques for the detection of radioactive and nuclear agents.