Allegations of fraud, conflict of interest, and other ethical dilemmas have troubled the scientific community. With increasing frequency, graduate programs in the biomedical sciences are offering formalized training in the principles of responsible scientific conduct. Scientific Integrity, Fourth Edition covers essential topics related to the conduct of scientific investigation, such as guidelines, policies, standards, and codes and contains highly relevant interactive case studies. This textbook covers broad areas of scientific integrity and meets the needs of students and scientists working in the biomedical sciences. Newly updated case studies that parallel the material presented in the chapters are included to illustrate the diversity of issues that have been identified under the umbrella of scientific integrity. All chapters have been thoroughly updated, especially with regard to the new technologies in data discovery and sharing, and the latest NIH and international best practices guidelines. This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.

This book lays out a new, general theory of light propagation and imaging through Earth's turbulent atmosphere. Current theory is based on the - now widely doubted - assumption of Kolmogorov turbulence. The new theory is based on a generalized atmosphere, the turbulence characteristics of which can be established, as needed, from readily measurable properties of point-object, or star, images. The pessimistic resolution predictions of Kolmogorov theory led to lax optical tolerance prescriptions for large ground-based astronomical telescopes which were widely adhered to in the 1970s and 1980s. Around 1990, however, it became clear that much better resolution was actually possible, and Kolmogorov tolerance prescriptions were promptly abandoned. Most large telescopes built before 1990 have had their optics upgraded (e.g., the UKIRT instrument) and now achieve, without adaptive optics (AO), almost an order of magnitude better resolution than before. As well as providing a more comprehensive and precise understanding of imaging through the atmosphere with large telescopes (both with and without AO), the new general theory also finds applications in the areas of laser communications and high-energy laser beam propagation.

This book presents the theory of quantum effects used in metrology and results of the author’s own research in the field of quantum electronics. The book provides also quantum measurement standards used in many branches of metrology for electrical quantities, mass, length, time and frequency. This book represents the first comprehensive survey of quantum metrology problems. As a scientific survey, it propagates a new approach to metrology with more emphasis on its connection with physics. This is of importance for the constantly developing technologies and nanotechnologies in particular. Providing a presentation of practical applications of the effects used in quantum metrology for the construction of quantum standards and sensitive electronic components, the book is useful for a wide audience of physicists and metrologists in the broad sense of both terms. In 2014 a new system of units, the so called Quantum SI, is introduced. This book helps to understand and approve the new system to both technology and academic community.

Chemical reactions and growth processes on surfaces depend on the diffusion and re-orientation of the adsorbate molecules. A fundamental understanding of the forces guiding surface motion is thus of utmost importance for the advancement of many fields of science and technology. To date, our understanding of the principles underlying surface dynamics remains extremely limited, due to the difficulties involved in measuring these processes experimentally. The helium-3 spin-echo (HeSE) technique is uniquely capable of probing such surface dynamical phenomena. The present thesis extends the field of application of HeSE from atomic and small molecular systems to more complex systems. Improvements to the supersonic helium beam source, a key component of the spectrometer, as well as a detailed investigation of a range of five-membered aromatic adsorbate species are presented. The thesis provides a comprehensive description of many aspects of the HeSE method - instrumentation, measurement and data analysis - and as such offers a valuable introduction for newcomers to the field.

This book is devoted to the analysis of measurement signals which requires specific mathematical operations like Convolution, Deconvolution, Laplace, Fourier, Hilbert, Wavelet or Z transform which are all presented in the present book. The different problems refer to the modulation of signals, filtration of disturbance as well as to the orthogonal signals and their use in digital form for the measurement of current, voltage, power and frequency are also widely discussed. All the topics covered in this book are presented in detail and illustrated by means of examples in MathCad and LabVIEW. This book provides a useful source for researchers, scientists and engineers who in their daily work are required to deal with problems of measurement and signal processing and can also be helpful to undergraduate students of electrical engineering.

This book focuses on the state of the art in worldwide research on applying optimization approaches to intelligently control charging and discharging of batteries of Plug-in Electric Vehicles (PEVs) in smart grids. Network constraints, cost considerations, the number and penetration level of PEVs, utilization of PEVs by their owners, ancillary services, load forecasting, risk analysis, etc. are all different criteria considered by the researchers in developing mathematical based equations which represent the presence of PEVs in electric networks. Different objective functions can be defined and different optimization methods can be utilized to coordinate the performance of PEVs in smart grids. This book will be an excellent resource for anyone interested in grasping the current state of applying different optimization techniques and approaches that can manage the presence of PEVs in smart grids.

In this book the applicability and the utility of two statistical approaches for understanding dark energy and dark matter with gravitational lensing measurement are introduced. For cosmological constraints on the nature of dark energy, morphological statistics called Minkowski functionals (MFs) to extract the non-Gaussian information of gravitational lensing are studied. Measuring lensing MFs from the Canada-France-Hawaii Telescope Lensing survey (CFHTLenS), the author clearly shows that MFs can be powerful statistics beyond the conventional approach with the two-point correlation function. Combined with the two-point correlation function, MFs can constrain the equation of state of dark energy with a precision level of approximately 3-4 % in upcoming surveys with sky coverage of 20,000 square degrees. On the topic of dark matter, the author studied the cross-correlation of gravitational lensing and the extragalactic gamma-ray background (EGB). Dark matter annihilation is among the potential contributors to the EGB. The cross-correlation is a powerful probe of signatures of dark matter annihilation, because both cosmic shear and gamma-ray emission originate directly from the same dark matter distribution in the universe. The first measurement of the cross-correlation using a real data set obtained from CFHTLenS and the Fermi Large Area Telescope was performed. Comparing the result with theoretical predictions, an independent constraint was placed on dark matter annihilation. Future lensing surveys will be useful to constrain on the canonical value of annihilation cross section for a wide range of mass of dark matter annihilation. Future lensing surveys will be useful to constrain on the canonical value of annihilation cross section for a wide range of mass of dark matter.

This book is based on the author's work in the T2K long-baseline neutrino oscillation experiment, in which neutrinos are generated by a proton beam and are detected by near and far neutrino detectors. In order to achieve the precise measurement of the neutrino oscillation, an accurate understanding of the neutrino beam and the neutrino interaction is essential. Thus, the author measured the neutrino beam properties and the neutrino interaction cross sections using a near neutrino detector called INGRID and promoted a better understanding of them. Then, the author performed a neutrino oscillation analysis using the neutrino beam and neutrino interaction models verified by the INGRID measurements. As a result, some values of the neutrino CP phase are disfavored at the 90% confidence level. If the measurement precision is further improved, we may be able to discover the finite CP phase which involves the CP violation. Thus, this result is an important step towards the discovery of CP violation in the lepton sector, which may be the key to understanding the origin of the matter-antimatter asymmetry in the universe.

Housed by a 4 m diameter tunnel of 27 km circumference, with huge underground labs and numerous surface facilities, and set up with a precision of 0.1 mm per kilometer, the Large Electron-Positron Collider (LEP) was not only the largest but also one of the most sophisticated scientific research instruments ever created by Man. Located at CERN, near Geneva, LEP was built during the years 1983 - 1989, was operational until 2000, and corroborated the standard model of particle physics through continuous high precision measurements. The Author, director-general of CERN during the crucial period of the construction of LEP, recounts vividly the convoluted decision-making and technical implementation processes - the tunnel alone being a highly challenging geo- and civil engineering project - and the subsequent extremely fruitful period of scientific research. Finally he describes the difficult decision to close down LEP, at a time when the discovery of the Higgs boson seemed within reach. LEP was eventually dismantled in 2000, enabling the tunnel to be reused for building the next generation machine, the much more powerful Large Hadron Collider (LHC), an upgrade then called LEP3 and foreseen from the beginning. It became operational just as this account was being completed. Written by the main protagonist responsible for making LEP a reality, this is the definitive inside story of a remarkable machine and the many thousands of scientists and engineers from around the world, whose efforts contributed to the new knowledge it produced.

The book offers a thorough introduction to machine vision. It is organized in two parts. The first part covers the image acquisition, which is the crucial component of most automated visual inspection systems. All important methods are described in great detail and are presented with a reasoned structure. The second part deals with the modeling and processing of image signals and pays particular regard to methods, which are relevant for automated visual inspection.