Soon to be a feature film, "The Late Bloomer" is the revealing, harrowing and often funny memoir of a celebrity journalist and former hotshot hockey player who discovers that he has been biochemically infused with a female hormone. On the surface, Ken Baker seemed a model man. He was a nationally ranked hockey goalie; a Hollywood correspondent for" People;" a guest-lister at celebrity parties; and girls came on to him. Inside, though, he didn't feel like the man he was supposed to be. Although attracted to women, Ken had little sex drive and thus even less of a sex life. To his anguish, he repeatedly found himself unable to perform sexually. And, regardless of strenuous workouts, his body struggled to build muscle, earning him the nickname "Pear" from his macho teammates. Physically, matters turned bizarre when he discovered that he was lactating. The testosterone-driven culture in which Ken grew up made it agonizingly difficult for him to seek help. But in time he discovered something that lifted years of pain, frustration, and confusion: a brain tumor was causing his body to be flooded with massive amounts of a female hormone, which was disabling his masculinity. Five hours of surgery accomplished what years of therapy, rumination, and denial could not -- and allowed Ken Baker to finally feel -- and function -- like a man. Now Ken's story comes to the screen in the feature film, T"he Late Bloomer," starring Academy Award-winner J.K. Simmons and Jane Lynch.

Clinics in Developmental Medicine No. 170

Elimination disorders (nocturnal enuresis, urinary incontinence and encopresis) are among the most common disorders of childhood. Some disorders are primarily genetically determined, in others environmental factors predominate. Also, the rate of comorbid behavioural disturbances differs greatly from one syndrome to another. Because of this variety and heterogeneity, each disorder requires specific approaches in assessment and treatment. This book provides an evidence-based overview of functional elimination disorders. It draws on the standardisation and terminology suggested by the International Children's Continence Society. Short case vignettes, photos and line drawings, as well as questionnaires and charts are provided. To enable a quick orientation for clinical purposes, each chapter is followed by summaries, guidelines and diagrams. It will be of interest to all professionals working in the field.

Prostate cancer is the commonest cancer in men. Current treatments include surgery to remove the whole prostate or radiotherapy of the whole prostate. These radical treatments can treat the cancer effectively but often cause unwanted side effects. Meanwhile widespread screening with prostate-specific antigen has led to an increased diagnosis of localised prostate cancer; at the same time, widespread use of abdominal imaging has led to increased detection of renal masses. In response to demand for improved outcomes with reduced side effects, focal therapy has emerged as an important procedure in managing both prostate and renal cancers. It targets individual areas of cancer, reducing unwanted side effects and the amount of damage to collateral tissue. This new method of treatment has major advantages: it involves less radiation, the removal of less tissue and less time spent in hospital. Handbook of Focal Therapy for Prostate and Renal Cancer provides a comprehensive, timely review of targeted ablation methods to treat prostate and renal cancers. It describes the most effective techniques in current practice, with discussion of the selection criteria, ablation technologies and their limitations, and advice on the management of common side effects. The book opens with a summary of the principles of prostate and renal cancer treatment and the mechanisms of focal therapy. Separate sections on prostate and kidney follow, covering the role of focal therapy, side effects and their treatment and follow-up after targeted ablation. Written in a practical, clinically-oriented style, Handbook of Focal Therapy for Prostate and Renal Cancer is the ideal reference for urologists, radiologists and radiation oncologists wishing to employ the latest focal therapy techniques in the care of their patients.

Overactive Bladder Syndrome (OAB) is a clinical entity characterised by urgency, with or without increased urinary frequency and/or urgency incontinence. It is a chronic condition with a high prevalence that increases with age, thus being a growing health problem especially in developed countries due to increased life expectancy. Patients with this disorder are often reluctant to seek advice due to embarassment, fear of social exclusion or the belief that symptoms are an expected consequence of ageing. Costs associated with treatments, use of pads/diapers and general economic burden are expected to increase in the future. OAB has a negative impact on quality of life (QoL) in varying degrees, depending upon the severity of symptoms and the presence of urgency incontinence. It has been linked to increased risk of fractures, institutionalisation and depression in older populations particularly prone to the development of OAB. This books discusses the prevalence, risk factors and management options available for OAB.

This book is written by a high-skilled specialist with huge experience in diagnosis, therapy and surgery for urogenital tuberculosis UGTB is the second most common form of TB in countries with a severe epidemic situation and the third most common form in regions with low incidence of TB. With patients living in the region of a high TB incidence rate or patients who had contact with TB or suffer from recurrent course of the disease, all urogenital tract infections should be tested for UGTB. Patients with tuberculosis, including UGTB need long multi-drug chemotherapy, and compliance depends on the drug tolerance. Anti-TB therapy for kidney TB was complicated by adverse effects in 41.0%. This book discovers ways of minimizing side effects and presents optimal regimens and surgical techniques for UGTB patients.

Since the 1990s China has seen a dramatic increase in the number of men seeking treatment for impotence. Everett Yuehong Zhang argues in The Impotence Epidemic that this trend represents changing public attitudes about sexuality in an increasingly globalized China. In this ethnography he shifts discussions of impotence as a purely neurovascular phenomenon to a social one. Zhang contextualizes impotence within the social changes brought by recent economic reform and through the production of various desires in post-Maoist China. Based on interviews with 350 men and their partners from Beijing and Chengdu, and concerned with de-mystifying and de-stigmatizing impotence, Zhang suggests that the impotence epidemic represents not just trauma and suffering, but also a contagion of individualized desire and an affirmation for living a full life. For Zhang, studying male impotence in China is one way to comprehend the unique experience of Chinese modernity.

Since the 1990s China has seen a dramatic increase in the number of men seeking treatment for impotence. Everett Yuehong Zhang argues in The Impotence Epidemic that this trend represents changing public attitudes about sexuality in an increasingly globalized China. In this ethnography he shifts discussions of impotence as a purely neurovascular phenomenon to a social one. Zhang contextualizes impotence within the social changes brought by recent economic reform and through the production of various desires in post-Maoist China. Based on interviews with 350 men and their partners from Beijing and Chengdu, and concerned with de-mystifying and de-stigmatizing impotence, Zhang suggests that the impotence epidemic represents not just trauma and suffering, but also a contagion of individualized desire and an affirmation for living a full life. For Zhang, studying male impotence in China is one way to comprehend the unique experience of Chinese modernity.

The clinical management of urolithiasis is now in a new era of ureteroscopic lithotripsy. Ureteroscopic lithotripsy has become an effective and safe treatment for both renal and ureteral stones, and its indications have been expanding. The advantages of ureteroscopy over shock-wave lithotripsy are its ability to directly access stones throughout the entire urinary collecting system either unilaterally or bilaterally, and to actively remove stone fragments. For large renal stones, percutaneous nephrolithotomy is now a standard treatment, but its major complication rates are not negligible. Ureteroscopic lithotripsy is a type of endoscopic surgery that is performed through the natural orifice, which thus avoids the onset of any renal parenchymal damage. New surgical techniques which combine percutaneous and transurethral approaches have been developed. Ureteroscopes and their working devices have rapidly improved, and further improvements will lead to even better outcomes in the next decade. This book presents the latest knowledge and the skills used for ureteroscopic surgery for urolithiasis. It consists of four sections (Indications, Instrumentations, Techniques and Evaluations). This book provides essential information for urologists who want to learn the techniques of this type of endourological surgery.

Acute kidney injury (AKI), defined as an abrupt decrease in renal function over a period of hours to days, is a common complication among hospitalised patients with different acute diseases. Its incidence has been increasing in recent years and is reported to be very high especially in the acute settings. Since clinical signs and symptoms of acute renal damage are not specific, it is difficult to promptly distinguish AKI at the time of patient presentation. Currently the diagnosis of AKI requires serial assessment of laboratory tests over a period of several days, and is based mainly on the evaluation of serum creatinine (sCr) and decrease in urine output as supported by Risk, Injury, Failure, Loss, and End-Stage Kidney Disease (RIFLE) criteria, Acute Kidney Injury Network (AKIN) criteria, and the recent Kidney Disease: Improving Global Outcomes (KDIGO) practice guidelines for AKI. Such a need for repeated sCr evaluations and monitoring of urinary output for too long time after admission could therefore result in a diagnostic delay. With delays in diagnosis, clinicians miss opportunities to start appropriate treatment to minimise damage, and patients incur more severe AKI with subsequent greater risk of developing progression of renal damage leading to chronic kidney disease (CKD), dialysis and increased risk of severe cardiovascular diseases and death.