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Complex Systems in Biomedicine (Paperback, Softcover reprint of hardcover 1st ed. 2006)
Loot Price: R3,216
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Complex Systems in Biomedicine (Paperback, Softcover reprint of hardcover 1st ed. 2006)
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Mathematicalmodelingofhumanphysiopathologyisatremendouslyambitioustask.
It encompasses the modeling of most diverse compartments such as
the cardiovas- lar, respiratory, skeletalandnervoussystems,
aswellasthemechanicalandbioch- ical interaction between blood ?ow
and arterial walls, and electrocardiac processes and electric
conduction in biological tissues. Mathematical models can be set up
to simulate both vasculogenesis (the aggregation and organization
of endothelial cells dispersed in a given environment) and
angiogenesis (the formation of new vessels sprouting from an
existing vessel) that are relevant to the formation of vascular
networks, and in particular to the description of tumor growth. The
integration of models aimed at simulating the cooperation and
interrelation of different systems is an even more dif?cult task.
It calls for the setting up of, for instance, interaction models
for the integrated cardio-vascular system and the interplay between
the central circulation and peripheral compartments, models for the
mid-to-long range cardiovascular adjustments to pathological
conditions (e.g., to account for surgical interventions, congenital
malformations, or tumor growth), models for integration among
circulation, tissue perfusion, biochemical and thermal regulation,
models for parameter identi?cation and sensitivity analysis to
parameter changes or data uncertainty - and many othe
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