Dynamic-clamp is a fascinating electrophysiology technique that
consists of merging living neurons with computational models. The
dynamic-clamp (also called "conductance injection") allows
experimentalists and theoreticians to challenge neurons (or any
other type of cell) with complex conductance stimuli generated by a
computer.
The technique can be implemented from neural simulation
environments and a variety of custom-made or commercial systems.
The real-time interaction between the computer and cell also
enables the design of recording paradigms with unprecedented
accuracy via a computational model of the electrode. Dynamic-Clamp:
From Principles to Applications contains contributions from leading
researchers in the field, who investigate these paradigms at the
cellular or network level, in vivo and in vitro, and in different
brain regions and cardiac cells. Topics discussed include the
addition of artificially-generated synaptic activity to neurons;
adding, amplifying or neutralizing voltage-dependent conductances;
creating hybrid networks with real and artificial cells; attaching
simulated dendritic tree structures to the living cell; and
connecting different neurons.
This book will be of interest to experimental biophysicists,
neurophysiologists, and cardiac physiologists, as well as
theoreticians, engineers, and computational neuroscientists.
Graduate and undergraduate students will also find up-to-date
coverage of physiological problems and how they are
investigated.
About the Editors:
Dr. Alain Destexhe and Dr.Thierry Bal are Research Directors at
the Centre National de la Recherche Scientifique (CNRS), a
governmental research institution in France. Their laboratories are
located in the CNRS campus of Gif-sur-Yvette in the research unit
(Unite de Neurosciences Integratives et Computationnelles, UNIC).
Gif-sur-Yvette is solely devoted to research and provides an ideal
environment for close interaction between theory and experiments,
as exemplified by the numerous publications on dynamic-clamp
experiments co-authored by Dr. Bal and Dr. Destexhe. Each editor
holds Ph.D.s in biophysics and neurobiology, respectively. Dr.
Destexhe is also Chief Editor of the Journal of Computational
Neuroscience. "
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