Immune Metabolism in Health and Tumor (Hardcover, 1st ed. 2017)

This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.

General

Imprint:	Springer
Country of origin:	Netherlands
Series:	Advances in Experimental Medicine and Biology, 1011
Release date:	September 2017
First published:	2017
Editors:	Bin Li • Fan Pan
Dimensions:	235 x 155mm (L x W)
Format:	Hardcover
Pages:	223
Edition:	1st ed. 2017
ISBN-13:	978-9402411683
Categories:	Books > Medicine > Other branches of medicine > Pathology > Medical microbiology & virology Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
LSN:	9402411682
Barcode:	9789402411683

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