Since 1982, Ras proteins have been the subject of intense
research investigation by the biomedical research community. The
wide interest in Ras has been stimulated for three key reasons.
First, their frequent mutational activation in human cancers
establishes Ras proteins as important mediators of oncogenesis and
targets for anti-cancer drug discovery. Second, Ras proteins act as
signalling nodes activated by diverse extracellular stimuli, and
activated Ras in turn regulates a diversity of cytoplasmic
signalling networks. Third, Ras proteins are founding members of a
large superfamily of Ras-related small GTPases. Over 150
Ras-related small GTPases are found in the human genome, with
orthologs found in all vertebrate species and invertebrates.
This book features chapters by leading investigators in the
field that highlight the current state-of-the art in Ras
biochemistry, structure and biology. This book is an excellent
reference for students in the biomedical sciences and for
investigators in the field.
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