This book provides the basis for understanding the elastic
properties of nucleic acids (DNA, RNA), the methods used to
manipulate them (e.g. optical, magnetic and acoustic tweezers and
traps), and how to observe their interactions with proteins (e.g.
fluorescence microscopy, FCS, FRET, etc.). It then exemplifies the
use of these various methods in the study of three families of DNA
enzymes: polymerases, helicases and topoisomerases. The book aims
not to be exhaustive, but rather to stimulate the imagination of
readers in the application of these single molecule approaches to
the study of DNA/RNA and their interactions.
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