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Books > Medicine > Other branches of medicine > Pathology > Medical microbiology & virology
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Immunological Memory (Paperback, Softcover reprint of the original 1st ed. 1990)
Loot Price: R2,834
Discovery Miles 28 340
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Immunological Memory (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: Current Topics in Microbiology and Immunology, 159
Expected to ship within 10 - 15 working days
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Although immunologists know rather a lot about the manif estation
of immunological memory, an understanding of the mechanism of
memory at cellular and biochemical levels eludes us. Indeed, as we
shall see, it is not even clear which of the several models used to
explain the working of memory approximates to the truth. It is in
order to report on approaches to this problem and on recent
experimental advances in the field of memory cells that this volume
has been put together. In the past 4-5 years cell surface molecules
that may enable us to define memory Band T cells have been
identified. It may now be possible to ask how memory cells are
generated and to define what signals are required during or after
antigenic encounter for a cell to enter the memory cell pool rather
than to terminally differentiate into an effector cell. The
transition from virgin cell to memory cell is clearly accompanied
by several biochemical changes. For B cells, isotype switching and
somatic mutations (leading to affinity maturation) are well-defined
phenomena, although the molecular mechanisms remain mys terious.
Both have received attention in many excellent reviews of late and
so are not considered in detail in this book. Neither switching nor
somatic mutation is a feature of peripheral T-cell maturation;
biochemical differences between virgin and mem ory T cells may only
relate to differing activation requirements and possibly changes in
the expression of accessory molecules.
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