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Base Excision Repair Pathway, The: Molecular Mechanisms And Role In Disease Development And Therapeutic Design (Hardcover)
Loot Price: R7,837
Discovery Miles 78 370
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Base Excision Repair Pathway, The: Molecular Mechanisms And Role In Disease Development And Therapeutic Design (Hardcover)
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This book will serve as the preeminent text book on the topic of
'base excision repair', a key DNA repair pathway that protects
cells from most spontaneous forms of DNA damage, including
oxidative lesions that arise both in the nuclear and mitochondrial
genomes. The book, which includes contributions from many of the
world leaders in the field, provides a detailed description of the
molecular mechanisms of base excision repair, as well as its
emerging relationship to epigenetic regulation, the aging process
and human disease, such as cancer susceptibility, immunological
defects and neurological disorders. The book will also cover the
state-of-the-art technologies being developed to assess base
excision repair capacity among individuals in the population, in
addition to the strategies being employed to target base excision
repair as part of therapeutic paradigms to eradicate disease,
namely cancer.This book represents one of the most extensive
efforts to date to cover the topic of 'base excision repair'. It
includes chapters by many of the most established investigators in
the field, from all over the world.
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