Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells (Paperback, Softcover reprint of the original 1st ed. 1990)

This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s assigned Cl- a ther modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and the extracellular fluid. Second, work on Cl- transport in red blood cells confirmed that the Cl- transmembrane distribution was thermodynamically passive and, in addition, showed that Cl- crossed the mem brane extremely rapidly. This latter finding [for a long time interpreted as being the result of a high passive chloride electrical permeability(? CI)] made it quite likely that Cl- would remain at thermodynamic equilibrium. These two observations were gener alized and virtually all cells were thought to have a very high P Cl and a ther modynamically passive Cl- transmembrane distribution. These concepts can still be found in some physiology and neuroscience textbooks.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Release date:	April 2013
First published:	1990
Editors:	F.J.Alvarez- Leefmans • John M Russell
Dimensions:	254 x 178 x 23mm (L x W x T)
Format:	Paperback
Pages:	426
Edition:	Softcover reprint of the original 1st ed. 1990
ISBN-13:	978-1-4757-9687-2
Categories:	Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal physiology Promotions
LSN:	1-4757-9687-0
Barcode:	9781475796872

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