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Books > Medicine > Nursing & ancillary services > Biomedical engineering
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Novel (Trans)dermal Drug Delivery Strategies - Micro- and Nano-scale Assessments (Hardcover, 1st ed. 2016)
Loot Price: R3,552
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Novel (Trans)dermal Drug Delivery Strategies - Micro- and Nano-scale Assessments (Hardcover, 1st ed. 2016)
Series: Springer Theses
Expected to ship within 10 - 15 working days
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This work represents an inventive attempt to apply recent advances
in nanotechnology to identify and characterise novel polymer
systems for drug delivery through the skin. Atomic force microscopy
(AFM) measurements of the nanoscale mechanical properties of
topical, drug-containing polymeric films enabled the author to
identify optimal compositions, in terms of flexibility and
substantivity, for application to the skin. To elucidate the
enhanced drug release from polyacrylate films incorporating medium
chain triglycerides, the author combined AFM studies with the
complementary technique of Raman micro-spectroscopy. This
experimental strategy revealed that the significant increase in the
drug released from these films is the result of a nanoscale
two-phase structure. Finally, in experiments examining the
microporation of skin using femtosecond laser ablation, the author
demonstrated that the threshold at which the skin's barrier
function is undermined can be dramatically reduced by the
pre-application of ink. The approach allows thermal damage at the
pore edge to be minimised, suggesting a very real potential for
substantially increasing drug delivery in a minimally invasive
fashion.
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