Tremor represents one of the most common movement disorders
worldwide. It affects both sexes and may occur at any age. In most
cases, tremor is disabling and causes social difficulties,
resulting in poorer quality of life. Tremor is now recognized as a
public health issue given the aging of the population. Tremor is a
complex phenomenon that has attracted the attention of scientists
from various disciplines. Tremor results from dynamic interactions
between multiple synaptically coupled neuronal systems and the
biomechanical, physical, and electrical properties of the external
effectors. There have been major advances in our understanding of
tremor pathogenesis these last three decades, thanks to new imaging
techniques and genetic discoveries. Moreover, significant progress
in computer technologies, developments of reliable and unobtrusive
wearable sensors, improvements in miniaturization, and advances in
signal processing have opened new perspectives for the accurate
characterization and daily monitoring of tremor. New therapies are
emerging. In this book, we provide an overview of tremor from
pathogenesis to therapeutic aspects. We review the definitions, the
classification of the varieties of tremor, and the contribution of
central versus peripheral mechanisms. Neuroanatomical,
neurophysiological, neurochemical, and pharmacological topics
related to tremor are pointed out. Our goals are to explain the
fundamental basis of tremor generation, to show the recent
technological developments, especially in instrumentation, which
are reshaping research and clinical practice, and to provide
up-to-date information related to emerging therapies. The
integrative transdisciplinary approach has been used, combining
engineering and physiological principles to diagnose, monitor, and
treat tremor. Guidelines for evaluation of tremor are explained.
This book has been written for biomedical engineering students,
engineers, researchers, medical students, biologists, neurologists,
and biomedical professionals of any discipline looking for an
updated and multidisciplinary overview of tremor. It can be used
for biomedical courses. Table of Contents: Introduction /
Anatomical Overview of the Central and Peripheral Nervous System /
Physiology of the Nervous System / Characterization of Tremor /
Prinipal Disorders Associated with Tremor / Quantification of
Tremor / Mechanisms of Tremor / Treatments
General
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