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Morphogenesis and Maturation of Retroviruses (Paperback, Softcover reprint of the original 1st ed. 1996)
Loot Price: R2,977
Discovery Miles 29 770
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Morphogenesis and Maturation of Retroviruses (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Current Topics in Microbiology and Immunology, 214
Expected to ship within 10 - 15 working days
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Retroviruses arguably belong to the most fascinating of all viruses
because of their unusual and highly efficient mode of replication
involving reverse transcription and integration of the viral genome
and a complex system of transcriptional and post transcriptional
regulatory mechanisms. The importance of ret roviruses as human and
animal pathogens has also enhanced scientific and medical interest
in this diverse group of viruses and has spurred an intensive
search for novel and improved antiviral agents. More recently,
analysis of retroviral replication and in particular understanding
the formation and composition of the virus particle has received
additional attention because of the promise of retroviral vectors
as vehicles for human somatic gene therapy. Many recent advances
have been made in our understanding of the molecular mechanisms
governing as sembly and release of infectious retrovirus particles.
This book attempts to summarize these recent developments and to
provide an overview of our current knowledge on retrovirus particle
formation. The individual chapters of the book deal with specific
steps in the pathway of retroviral morphogenesis and maturation,
starting at the time when the components of the virus have been
synthesized within the infected cell and ending once the infectious
virion has been released from the cell. An introductory chapter
provides a comparative description of the structure and morphology
of various retroviruses."
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