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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)
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Bacterial Capsules (Paperback, Softcover reprint of the original 1st ed. 1990)
Loot Price: R2,846
Discovery Miles 28 460
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Bacterial Capsules (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: Current Topics in Microbiology and Immunology, 150
Expected to ship within 10 - 15 working days
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Many bacteria, such as certain Neisseria and Haemophilus or
Escherichia coli, are able to withstand the bactericidal activity
of complement and phagocytes. This bacterial self protection is
brought about by encapsulation. Bacterial capsules thus enable the
pathogenic bacteria to survive in the host by counter action or
evasion of the nonspecific host defense in the early pre immune
phase of an infection. It is only in the late immune phase of the
infection, when specific anticapsular antibodies are formed and
enforce the host's defense system, that this protective action is
overcome. Encapsulated bacteria are then killed and eliminated.
Interestingly, some capsules can not or only inefficiently be
handled by the immune system. The ensuing lack of antibody
formation results in a prolonged susceptibility of the host to the
pathogenic bacteria exhibiting such capsules. It was found that
bacterial capsules consist of acidic poly saccharides. From this it
followed that the role of the capsules in the interaction of
encapsulated bacteria with the host may be due to the chemistry of
the capsular polysaccharides. This led to intensive studies of
capsular polysaccharides in many laboratories. Our increasing
knowledge of the structural features of capsular polysaccharides
prompted not only immuno chemical studies analyzing the
interactions of these poly saccharide antigens and characterizing
the epitopes, but also investigations into their biosynthesis.
These studies were complemented and supported by genetic analyses.
Today many interdisciplinary investigations of capsular
polysaccharides are in progress.
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