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Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane (Paperback, 2012 ed.) Loot Price: R1,463
Discovery Miles 14 630
Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane (Paperback, 2012 ed.): Ksenia Guseva

Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane (Paperback, 2012 ed.)

Ksenia Guseva

Series: Springer Theses

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Loot Price R1,463 Discovery Miles 14 630 | Repayment Terms: R137 pm x 12*

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With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.

General

Imprint: Springer-Verlag
Country of origin: Germany
Series: Springer Theses
Release date: November 2013
First published: 2012
Authors: Ksenia Guseva
Dimensions: 235 x 155 x 5mm (L x W x T)
Format: Paperback
Pages: 80
Edition: 2012 ed.
ISBN-13: 978-3-642-26994-3
Categories: Books > Science & Mathematics > Physics > Thermodynamics & statistical physics > Statistical physics
Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
Books > Science & Mathematics > Chemistry > Organic chemistry > Polymer chemistry
Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
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LSN: 3-642-26994-X
Barcode: 9783642269943

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