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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Frontiers in Cerebral Vascular Biology - Transport and Its Regulation (Paperback, Softcover reprint of the original 1st ed. 1993)
Loot Price: R1,585
Discovery Miles 15 850
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Frontiers in Cerebral Vascular Biology - Transport and Its Regulation (Paperback, Softcover reprint of the original 1st ed. 1993)
Series: Advances in Experimental Medicine and Biology, 331
Expected to ship within 10 - 15 working days
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During the past three decades, the cerebral vasculature and its
role in blood-brain transport has been an increasingly active area
of investigation and learning, particularly from an anatomical and
physiological point of view. However, much less is known at the
molecular and cellular level about the blood-brain barrier
especially regarding the macromolecules responsible for transport,
the roles played by vascular wall components (endothelial cell,
pericyte, smooth muscle, basement membrane), and the mechanisms
regulating brain vascular-specific protein expression and their
molecular alterations during development and disease. Fundamental
questions still unanswered include: What are the molecular
constituents of brain endothelial cell tight junctions? What are
the membrane proteins responsible for transport of specific
substrates? What are the molecular signals that cause glucose
transporter gene expression to be 20 to 100 times greater in brain
endothelial cells in vivo than in vitro? What roles do pericytes,
smooth muscle cells and basement membrane have in establishing or
maintaining blood-brain transport characteristics? Are brain
vascular transport systems responsible for edema following injury?
Are transporter systems regulated via receptor-mediated events? Do
hormones or neuromodulators regulate transporter expression? What
is the molecular mechanism by which plasma proteins enter the
extravascular space? Are transporters asymmetrically distributed
between the luminal and abluminal endothelial cell membranes? Can
prodrugs or pharmacologic agents be designed as substrate analogs
and be delivered to the central nervous system via existing
transporters or receptors? Can new and beneficial transporters be
introduced into the brain vasculature?
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