Pharmaceutical Biocatalysis - Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients (Hardcover)

This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.

General

Imprint:	Pan Stanford Publishing Pte Ltd
Country of origin:	Singapore
Release date:	December 2019
First published:	2020
Editors:	Peter Grunwald
Dimensions:	229 x 152mm (L x W)
Format:	Hardcover
Pages:	838
ISBN-13:	978-981-4800-80-8
Categories:	Books > Medicine > General issues > General Books > Professional & Technical > Environmental engineering & technology > General Books > Medicine > Other branches of medicine > Pharmacology > General Books > Medicine > Nursing & ancillary services > Biomedical engineering > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > Toxicology (non-medical) Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
LSN:	981-4800-80-5
Barcode:	9789814800808

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