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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Myasthenia Gravis - Disease Mechanism and Immunointervention (Paperback, Softcover reprint of the original 1st ed. 2000)
Loot Price: R2,854
Discovery Miles 28 540
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Myasthenia Gravis - Disease Mechanism and Immunointervention (Paperback, Softcover reprint of the original 1st ed. 2000)
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Autoimmune myasthenia gravis (MG) is a classical autoimmune
disease, for which the target antigen, nicotinic acetylcholine
receptor, has been cloned, sequenced and biochemically
characterized. Antibodies to acetylcholine receptors destroy
acetylcholine receptor at the neuromuscular junction, thus leading
to defective neuromuscular transmission, muscle fatigue, and
weakness. In the last few years, rapid advances have been made in
unraveling the cellular and molecular mechanisms involved in the
pathogenesis of MG, both in the animal model, experimental
autoimmune MG (EAMG), and in human MG. Significant advances are
being made in characterizing the cells and molecules involved in
the autoimmune response to the acetylcholine receptor (AChR). These
advances are leading to the development of specific methods of
immunointervention in EAMG. Further understanding of the intricate
involvement of the major histocompatibility complex (MHC) and
non-MHC genes, T cell receptors (TCR), costimulator molecules, and
specific cytokines in the afferent and efferent autoimmune response
of AChR should pave the way to future antigen/clone-specific
therapy of MG. This book is the outcome of the MG workshop
proceedings in Mysore, India, 1998. The majority of the chapters in
this book are contributed by world-renowned authors and their
students. The book not only contains a timely review of specific
topics, but also up-to-date findings. Immunologists and
neurologists will find, in this volume, the latest in MG/EAMG
cutting-edge research. Clinicians will be interested in the
applications of the various immunointervention strategies into
clinical trials in MG patients. Finally, students will not only be
interested in reading the latest in EAMG/MG research, but will also
find information to help them develop a future strategy to unravel
the precise mechanism of disease. To summarize, in this book, the
readers should find up-to-date information related to immunological
mechanisms involved in MG pathogenesis and various modalities for
possible approaches to immunointervention to treat MG.
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