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Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
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Airway Smooth Muscle in Health and Disease (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R1,416
Discovery Miles 14 160
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Airway Smooth Muscle in Health and Disease (Paperback, Softcover reprint of the original 1st ed. 1989)
Expected to ship within 18 - 22 working days
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I organized this book because there is a need to put together in
book form recent advances in our knowledge of how airway smooth
muscle: works in health and in disease. After a period when it
seemed that progress was very slow, there has been in the past few
years an incredibly rapid gathering of knowledge in this area. In
particular, our understanding has improved regarding the cascades
of events that follow the initial binding of agonist to plasma
membrane receptors and that lead to the cross-bridge movements that
determine contraction. This advance in our knowledge was stimulated
by use of single-and whole-cell channel recordings of plasma
membrane currents and by description of the l3-receptor-GTP-binding
protein-adenylate cyclase-cAMP coupling system, which serves as a
model for other coupling mechanisms. The discovery of the
receptor-activated inositol phospholipid transduction system has
greatly stimulated research and led to advances in our
understanding of mechanisms involved in smooth muscle con traction.
Major advances were also triggered by the development of indicators
for measuring free cytosolic calcium concentration and starting the
unraveling of 2 the events involved in Ca + -dependent activation
of contractile proteins. Al though most of the studies that led to
our current understanding of these areas were performed on
nonairway smooth muscle, these studies usually add to our
understanding of airway smooth muscle, and there is an enlarging
body of data that have been obtained on airway smooth muscle."
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