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Inflammation in the Pathogenesis of Chronic Diseases - The COX-2 Controversy (Paperback, Softcover reprint of hardcover 1st ed. 2007) Loot Price: R5,591
Discovery Miles 55 910
Inflammation in the Pathogenesis of Chronic Diseases - The COX-2 Controversy (Paperback, Softcover reprint of hardcover 1st ed....

Inflammation in the Pathogenesis of Chronic Diseases - The COX-2 Controversy (Paperback, Softcover reprint of hardcover 1st ed. 2007)

Randall E Harris

Series: Subcellular Biochemistry, 42

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Loot Price R5,591 Discovery Miles 55 910 | Repayment Terms: R524 pm x 12*

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In "Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy," a worldwide panel of leading experts discusses the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is intended for scientists in medicine, epidemiology, pharmacology, molecular biology, and related fields. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specfic chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the "COX-2 controversy" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Recent findings suggest that cardiovascular risk associated with some COX-2 inhibitors may not be due to a class effect, but rather depends upon the molecular structure of specific compounds. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents. "

General

Imprint: Springer
Country of origin: Netherlands
Series: Subcellular Biochemistry, 42
Release date: November 2010
First published: 2007
Editors: Randall E Harris
Dimensions: 235 x 155 x 18mm (L x W x T)
Format: Paperback
Pages: 324
Edition: Softcover reprint of hardcover 1st ed. 2007
ISBN-13: 978-90-481-7429-4
Categories: Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology
Books > Medicine > Other branches of medicine > Pathology > Gross pathology
Books > Medicine > Other branches of medicine > Pharmacology > General
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
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LSN: 90-481-7429-5
Barcode: 9789048174294

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