In "Inflammation in the Pathogenesis of Chronic Diseases: The
COX-2 Controversy," a worldwide panel of leading experts discusses
the role of inflammation in the pathogenesis of major chronic
diseases and the current controversy regarding risk versus benefit
of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is
intended for scientists in medicine, epidemiology, pharmacology,
molecular biology, and related fields. The authors provide exciting
and enlightening perspectives on COX-2 and related molecular
targets in the future of medicine, including historical
perspectives on the discovery and development of aspirin,
ibuprofen, and compounds that selectively inhibit COX-2, and the
potential for development of new compounds with better efficacy and
safety in the 21st century. Specfic chapters illuminate the role of
inflammatory mechanisms in the pathogenesis of arthritis,
cardiovascular disease, cancer, neurodegenerative disease, diabetes
mellitus, obesity, and other life-threatening and debilitating
conditions. Experts in cardiovascular medicine explore the "COX-2
controversy" regarding adverse effects of some (not all) selective
COX-2 inhibitors on the cardiovasculature. Recent findings suggest
that cardiovascular risk associated with some COX-2 inhibitors may
not be due to a class effect, but rather depends upon the molecular
structure of specific compounds. Important findings are documented
in cancer research showing that selective COX-2 inhibitors have
powerful antineoplastic effects against major forms of cancer. A
special section explores the current evidence supporting the role
of COX-2 and inflammation in the development of Alzheimer s disease
and other neurodegenerative conditions and the potential benefit of
compounds that modulate COX-2 and other inflammatory cytokines. The
final section addresses nutritional modulation of inflammation and
the chemopreventive value of anti-inflammatory nutraceutical
agents. "
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