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Omega-3 Fatty Acids and the DHA Principle (Paperback)
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Omega-3 Fatty Acids and the DHA Principle (Paperback)
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The physical-chemical properties of the omega-3 fatty acid DHA
(docosahexaenoic acid) enable it to facilitate rapid biochemical
processes in the membrane. This effect has numerous benefits,
including those involved in the growth of bacteria, rapid energy
generation, human vision, brain impulse, and photosynthesis, to
name a few. Yet DHA also carries risks that can lead to cellular
death and disease. Omega-3 Fatty Acids and the DHA Principle
explores the roles of omega-3 fatty acids in cellular membranes
ranging from human neurons and swimming sperm to deep sea bacteria,
and develops a principle by which to assess their benefits and
risks. The DHA Principle states that the blending of lipids to form
cellular membranes is evolutionarily-honed to maximize benefit
while minimizing risk, and that a complex blending code involving
conformational dynamics, energy stress, energy yield, and chemical
stability underlies all cellular membranes. This book lays the
groundwork to understanding this code. It examines the evolution of
DHA and the membrane and explores the general properties of
omega-3s and other membrane lipids. It then focuses on cellular
biology before shifting to a practical discussion on applications.
The authors discuss the DHA Principle as applied to petroleum
degradation, winemaking, global warming, molecular farming, aging,
neurodegenerative diseases, and the prevention of colon cancer.
Reflecting the increased public interest that has emerged over the
years, this volume uses an integrative approach to explain the
complex roles of omega-3s in the membrane. Incorporating principles
from chemistry, cellular biology, evolution, and ecology, this work
gives researchers in a variety of fields the building blocks to
stimulate further study.
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