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Diversity of Selenium Functions in Health and Disease (Hardcover)
Loot Price: R5,205
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Diversity of Selenium Functions in Health and Disease (Hardcover)
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Named after Selene, Greek goddess of the moon, selenium (Se) has
moved has moved from being thought of as a toxicant to being
considered an essential nutrient with the potential to reduce
cancer risk in the span of seven decades. Diversity of Selenium
Functions in Health and Disease focuses on current knowledge of
aspects of Se research relevant to its medical use, and
particularly to chemoprevention of cancer. It covers how Se is
integrated into selenoproteins, selenium compounds with individual
functions and dual functions, and unexpected links to Se such as
with diabetes. The text ends with a discussion of polymorphisms and
mutations in genes of selenoproteins. The chapters elucidate why
studies undertaken to prevent diseases with selenium ended with
disappointing outcomes and often with the opposite result, i.e.
disease promotion. They show that benefit, failure, or side effects
depend on: The chemical form and dose of selenium The selenium
status of the individual ingesting selenium The capacity of
selenium form to serve as a source for selenoprotein biosynthesis
The function of selenoproteins reacting to a change in the selenium
status The stage of the disease (mainly cancer) at the time point
of intervention The genetic background of individuals to be treated
Bringing together the accumulated evidence regarding selenium
biochemistry, the book covers aspects not found in available
general monographs. The narrow focus on medical uses of Se helps
resolve the present confusion about potential benefits and hazards
of selenium in human health. The book gives you a solid scientific
basis for optimum use of selenium in preventing or treating human
diseases and answering the questions: Why is selenium essential?
How much is required? What are the health consequences of low
selenium and can selenium reduce cancer risk?
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