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Hydrogels - Biological Properties and Applications (Paperback, 2009 ed.)
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Hydrogels - Biological Properties and Applications (Paperback, 2009 ed.)
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Hydrogels are a particular class of compounds of which the major
constituent is wa- ter. In fact, water is present in the hydrogel
up to 90% and is contained in a scaffold which is generally
polymeric and obviously hydrophilic. As a result, hydrogels re-
semble each other even though obtained from different polymers.
Nevertheless, the polymeric matrix gives particular characteristics
to the hydrogel leading to applica- tions in different fields.
Water is the main element of the human body, thus hydrogels are
excellent struc- tures to favourably shelter proteins, cells etc. ,
without altering their characteristics and properties. This is why
hydrogels are mainly designed and synthesized for their usein
thebiologicalfield;hence the name biohydrogels. Their
propertiespoint totheir use as scaffolds for stem cells which has
turned out to be a very promising technique for tissue and organ
regeneration. For this reason their investigation falls within the
Biomaterials Science. Paradoxically, the conceptual simplicity of
hydrogelsupto nowhas led to a super- ficialstudy of their
chemistry, chemical physics and mechanics preventing their wider
application in the human body due to a lack of knowledge of
biological component interactions. For example, it is not clear,
yet, how to store hydrogels without alter- ing their
characteristics. In fact, hydrogels re-hydrated after
lyophylization or oven drying, generally show corrupted properties
once swollen in water, in comparison with their native
counterparts.
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