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Molecular Basis of Viral and Microbial Pathogenesis - April 9-11, 1987 (Paperback, Softcover reprint of the original 1st ed. 1988)
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Molecular Basis of Viral and Microbial Pathogenesis - April 9-11, 1987 (Paperback, Softcover reprint of the original 1st ed. 1988)
Series: Colloquium der Gesellschaft fur Biologische Chemie in Mosbach Baden, 38
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Elucidation of the mechanisms of pathogenesis underlying the
diseases caused by viruses and bacteria has fascinated scientists
for many years in two ways. Firstly, these pathogenic agents
represent relatively sim ple biological systems for the study of
basic biological processes such as replication, gene regulation,
genetic variability and host-pathogen interactions. Secondly,
process in this field is valuable in a practi cal sence, since it
can help in the control of these diseases. The avail ability of new
genetic and immunological techniques, especially recom binant DNA
methods and monoclonal antibody technology, has provided powerful
tools for unravelling the genetic, biochemical and immunologi cal
basis of viral and microbial pathogenesis. Molecular cloning has
allowed the isolation of single genes or groups of genes related to
phenotypes which appear to be immunologically important for
pathogene sis. The specific elimination of such genes from the
complex genomes of the pathogens can now be achieved with similar
genetic techniques. These genetic studies have provided additional
information on the role played by specific phenotypic traits in
pathogenesis, especially when combined with relevant animal model
systems. Furthermore, the struc tural analysis of important
virulence factors and surface antigens may allow the prediction of
antigenic domains suitable for the development of new vaccines. The
38th Mosbacher Colloquium focuses on the molecular basis of viral
and microbial pathogenesis. The virology part begins with the well
studied plant viroids. The unusual structure of their genome, as
well as knowledge about their replication and pathogenicity, are
presented.
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