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Books > Medicine > Nursing & ancillary services > Biomedical engineering
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MRI Contrast Agents - From Molecules to Particles (Paperback, 1st ed. 2017)
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MRI Contrast Agents - From Molecules to Particles (Paperback, 1st ed. 2017)
Series: Nanotheranostics
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This book describes the multiple aspects of (i) preparation of the
magnetic core, (ii) the stabilization with different coatings,
(iii) the physico-chemical characterization and (iv) the
vectorization to obtain specific nanosystems. Several
bio-applications are also presented in this book. In the early days
of Magnetic Resonance Imaging (MRI), paramagnetic ions were
proposed as contrast agents to enhance the diagnostic quality of MR
images. Since then, academic and industrial efforts have been
devoted to the development of new and more efficient molecular,
supramolecular and nanoparticular systems. Old concepts and
theories, like paramagnetic relaxation, were revisited and
exploited, leading to new scientific tracks. With their high
relaxivity payload, the superparamagnetic nanoparticles are very
appealing in the context of molecular imaging but challenges are
still numerous: absence of toxicity, specificity, ability to cross
the biological barriers, etc.
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