Glutamate is the primary excitatory neurotransmitter in the CNS and
disturbances in glutamate transport contribute to a number of
neurological and neurodegenerative disorders. Appropriate levels of
cholesterol are very important for the proper functioning of
glutamate transport while unbalanced levels of cholesterol have
been implicated in the pathogenesis of disorders such as stroke,
ischemia, traumatic brain injury, and neurotoxicity. In the
proposed book, the author presents data from the literature and
from her own lab to address the extent to and way in which membrane
cholesterol modulates presynaptic glutamate transport and whether
lowering the level of cholesterol available can offer some
neuroprotective benefits.
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