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Protein Folding, Misfolding and Aggregation - Classical Themes and Novel Approaches (Hardcover)
Loot Price: R4,633
Discovery Miles 46 330
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Protein Folding, Misfolding and Aggregation - Classical Themes and Novel Approaches (Hardcover)
Series: RSC Biomolecular Sciences, Volume 13
Expected to ship within 10 - 15 working days
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Protein folding and aggregation is the process by which newly
synthesized proteins fold into the specific three-dimensional
structures defining their biologically active states. It has always
been a major focus of research in biochemistry and has often been
seen as the unsolved second part of the genetic code. In the last
10 years we have witnessed a quantum leap in the research in this
exciting area. Computational methods have improved to the extent of
making possible to simulate the complete folding process of small
proteins and the early stages of protein aggregation. Experimental
methods have evolved to permit resolving fast processes of folding
reactions and visualizing single molecules during folding. The
findings from these novel experiments and detailed computer
simulations have confirmed the main predictions of analytical
theory of protein folding. In summary, protein folding research has
finally acquired the status of a truly quantitative science, paving
the way for more exciting developments in the near future. This
unique book covers all the modern approaches and the many advances
experienced in the field during the last 10 years. There is also
much emphasis on computational methods and studies of protein
aggregation which have really flourished in the last decade. It
includes chapters in the areas that have witnessed major
developments and are written by top experts including:computer
simulations of folding, fast folding, single molecule spectroscopy,
protein design, aggregation studies (both computational and
experimental). Readers will obtain a unique perspective of the
problems faced in the biophysical study of protein conformational
behaviour in aqueous solution and how these problems are being
solved with a multidisciplinary approach that combines theory,
experiment and computer simulations. Protein Folding, Misfolding
and Aggregation Classical Themes and Novel Approaches is essential
reading for graduate students actively involved in protein folding
research, other scientists interested in the recent progress of the
field and instructors revamping the protein folding section of
their biochemistry and biophysics courses.
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