Cytokines and Joint Injury (Paperback, Softcover reprint of the original 1st ed. 2004)

The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology.

General

Imprint:	Birkhauser Verlag AG
Country of origin:	Switzerland
Series:	Progress in Inflammation Research
Release date:	October 2012
First published:	2004
Editors:	Wim B.Van Den Berg • Pierre Miossec
Dimensions:	235 x 155 x 17mm (L x W x T)
Format:	Paperback
Pages:	296
Edition:	Softcover reprint of the original 1st ed. 2004
ISBN-13:	978-3-03-489609-2
Categories:	Books > Medicine > Clinical & internal medicine > Rheumatology Books > Medicine > Surgery > Orthopaedics & fractures Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
LSN:	3-03-489609-3
Barcode:	9783034896092

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