The natural killer NK] cell plays a critical role in regulating the innate and adaptive immune response to pathogens, injury and stress. It has emerged as a cell capable of helper function, expansion, contraction, and accelerated memory responses - features similar to other adaptive immune cells. It is a professional accelerator of immunity, mediating dendritic cell maturation and its precursors critical for the origin and development of secondary lymph node structures. These characteristics place the NK cell in a unique position, with a major role in sculpting the host response to damage and injury. This volume is the first complete and authoritative reference to explore these emergent, exciting aspects of the NK cell, placing it at the center of damage/danger recognition and the response to stress. "Natural Killer Cells" details NK cell biology, the role of NK cells in regulating immunity through interactions with other cells and tissues, the participation of NK cells in disease and special topics in NK biology.

- Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners - Includes figures, histologic sections, and illustrations of the ontogeny of NK cells - Companion website includes full-color image database

Designed specifically to meet the unique needs of students studying to become rehabilitation professionals - including physical therapists, occupational therapists, and chiropractors - this full-color dissection guide helps you connect discoveries in the dissection lab with function and pathology. With the necessary technical information you need - including content on applied anatomy, embryology, and structural histology - in 25 laboratory exploration chapters, this unique guide uses case studies and critical thinking exercises to encourage you to explore human anatomy, synthesize your findings, and apply your knowledge to clinical practice. Extensive coverage of the musculoskeletal and nervous system emphasizes the information on muscles, vertebral column, and the upper and lower extremities that you need as a rehabilitation health professional. Clinical cases, thought-provoking questions, clinical notes, and review exercises encourage you to explore through dissection and apply what you've learned to real-life practice. Sections on embryology and histology provide important insights into the origin and nature of adult anatomy and follow the national guidelines for physical therapy anatomy curricula. References to the most popular human anatomy atlases - Netter's, Gray's, Grant's, and Clemente's - allow for flexibility of use in any program. Emphasis on variations in anatomy reinforces the real-life diversity among patients. Over 200 full-color illustrations clearly demonstrate anatomy and dissection processes.

Providing the ocular anatomy and physiology content needed for a thorough comprehension of this complex field, Clinical Anatomy and Physiology of the Visual System, 4th Edition, offers a solid foundation for recognizing and understanding specific clinical situations and how they relate to anatomic structure. This concise, well-referenced resource covers the clinical anatomy of the eye, its adnexa and visual pathways, and histologic information-the information you need for success in coursework, certification exams, and clinical practice. Features vivid, full-color illustrations that help you visualize the clinical anatomy of the eye along with the cellular physiology behind diseases and disorders of the visual system. Emphasizes clinical application throughout, helping you better understand the processes that occur in disease and dysfunction. Clinical Comment sections offer a unique focus on clinical situations, conditions, diseases, and treatments. Contains new OCT, OCTA, MRI, and CT images that demonstrate clinical views of ocular anatomy. OCT technology is incorporated to describe the retinal layers, newly described anatomical components of the vitreous, corneal and anterior chamber angle anatomy, and the choroidal and retinal vasculature. Covers current topics such as genes essential in eye development, scleral and choroidal changes occurring with myopia progression, limbal stem cells, age-related macular degeneration and VEGF therapies, and microinvasive glaucoma surgical procedures. Includes updated concepts and terminology: Edinger Westfall preganglionic cells, sensory innervation to the cornea, knees of Wilbrand, intrinsically photosensitive retinal ganglion cells, and more. Provides expert coverage by a practicing optometrist, giving you a practical framework for recognizing and understanding clinical situations, problems, and treatments. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The new edition of this well-known hybrid anatomy core text and atlas superbly depicts and describes the human body, so you can identify anatomical structures with confidence and have a clear understanding of the core anatomy you need. Now fully revised and updated, it is the only textbook and atlas of gross anatomy that illustrates all structures using high-quality dissection photographs AND clearly labelled line drawings for each photograph. This is combined with concise yet thorough text to support and explain all key human anatomy and clearly relate it to clinical practice. The complete, downloadable eBook (via Student Consult), enhanced with interactive self-assessment material, completes this superb, comprehensive resource. It will be particularly relevant to medical and dental students, as well as candidates preparing for higher surgical specialties and radiology. It will also be an invaluable, accessible guide for students in other professions where anatomy is an important component of the course. New highlighting of expanded clinically relevant portions of the text and the Clinical Case Skills pages help readers quickly understand how to apply gross anatomical knowledge to clinical settings High quality, colored dissection photographs show structures most likely to be seen and tested in the lab - helps students recognize and interpret gross specimens accurately Interpretive line drawings next to every photograph clearly identify structures described in the adjacent text and consistent use of color-coding helps differentiate muscle, ligament, peritoneum etc. New photographs with the latest imaging techniques employed in current practice reveal anatomical structures clearly This book comes with the complete, downloadable eBook via STUDENT CONSULT - enhanced with new interactive self-assessment material to check understanding and aid exam preparation High quality, richly coloured dissection photographs show structures most likely to be seen and tested in the lab - helps you recognize and interpret gross specimens accurately Interpretive line drawings next to every photograph, with consistent colour-coding - helps you clearly identify structures and differentiate fat, muscle, ligament, etc. 'Clinical Skills' pages and new highlighting of the most clinically relevant text helps readers quickly understand how to apply knowledge of gross anatomy to the clinical setting New photographs reflect the latest imaging techniques as seen in current practice This book comes with the complete, downloadable eBook via STUDENT CONSULT- enhanced with new interactive self-assessment material to check understanding and aid exam preparation High quality, richly coloured dissection photographs show structures most likely to be seen and tested in the lab - helps you recognize and interpret gross specimens accurately Interpretive line drawings next to every photograph, with consistent colour-coding - helps you clearly identify structures and differentiate fat, muscle, ligament, etc. 'Clinical Skills' pages and new highlighting of the most clinically relevant text helps readers quickly understand how to apply knowledge of gross anatomy to the clinical setting New photographs reflect the latest imaging techniques as seen in current practice This book comes with the complete, downloadable eBook via STUDENT CONSULT - enhanced with new interactive self-assessment material to check understanding and aid exam preparation

This Third Edition of Medical Cell Biology focuses on the scientific aspects of cell biology important to medical students, dental students, veterinary students, and prehealth undergraduates. Maintaining a primary focus on eukaryotic cell biology, the text explains general cell biology principles in the context of organ systems and human and animal disease.
* 60% New Material
* New Topics include:
Apoptosis and cell dealth from a neural perspective
Signal transduction as it relates to normal and abnormal heart function
Cell cycle and cell division related to cancer biology
* All new clinical cases
* Serves as a prep guide to the National Medical Board Exam with a CD-ROM of 200 sample board-style questions (using Exam Master(R) technology): www.exammaster.com
* Focuses on eukaryotic cell biology as it related to human disease, thus making the subject more accessible to pre-med and pre-health students

Meik Kunz erforscht die Interaktion zwischen den Wachstumshormonen Cytokinin und Auxin und untersucht deren Zusammenspiel im Hinblick auf die pflanzliche Immunabwehr. Der Autor zeigt zudem mittels einer eigens entwickelten Methode die Moeglichkeit auf, wie in einer Transkriptom-Interaktom-Analyse zentrale funktionelle Netzwerkknoten (sogenannte Hubproteine) einer Cytokinin-vermittelten Immunabwehr identifiziert werden koennen. Begleitend wurde eine fur den Forschungsalltag zugeschnittene Datenbank zur Analyse von Protein-Interaktionen erstellt.

This series of 7 large format wall charts (560x710mm) explores the basic organs of the human body. Each chart graphically illustrates the general anatomy and function of a specific organ. Ideal for students or the informed consumer, the series is suitable for the home, school or physician's office. A perfect companion to the Body System Wall Chart Set. Set Includes: The Brian; The Ear; The Eye; The Heart; The Kidney; The Liver; The Skin.

This series of 7 large format wall charts (560x710mm) explores the basic organs of the human body. Each chart graphically illustrates the general anatomy and function of a specific organ. Ideal for students or the informed consumer, the series is suitable for the home, school or physician's office. A perfect companion to the Body System Wall Chart Set. Set Includes: The Brian; The Ear; The Eye; The Heart; The Kidney; The Liver; The Skin.

The vertebrate skeleton is one of nature's most amazing feats. Composed of cartilage and bone, it forms the supportive structure for all the remaining aspects of our anatomy. Stripped of skin, we can see the body's fascinating underlying architecture. In this one-of-a-kind book, biologist and skeletal reconstructionist Steve Huskey lays bare the vertebrate skeleton, providing a guided tour of the nuanced differences among the many featured vertebrate species. Using skeletal preparations he has spent decades assembling, Huskey helps us understand why animals live the way they do. He shows us the jaw and fang structures that allow venomous snakes to both kill and consume their prey whole. We see that the eastern mole is built like a weightlifter, allowing it to "swim through soil." Startling images demonstrate that the odd-looking trumpetfish is built not for music but for suction, with a skull that expands to vacuum in its prey. The pages of The Skeleton Revealed illuminate not only the elegance of each skeleton, but also the natural history story each skeleton tells. Come along-let's take a voyage through the boneyard.

The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.

In Skeleton Keys: An Introduction to Human Skeletal Morphology, Development, and Analysis, Second Edition, Jeffrey H. Schwartz presents a detailed yet highly accessible introduction to the study of the human skeleton. This unique volume examines the skeleton from its developmental basis to the expression of individual variation. It reviews a variety of different approaches used to determine an individual's sex, age, and pathological history and challenges readers to think critically about how to analyze a human skeleton rather than learning formulas for quick results. An ideal text for courses in human osteology, skeletal analysis, and bioarchaeology, this book is also a helpful reference for professionals.
Thoroughly revised and updated, the second edition of Skeleton Keys features:
* A unique CD-ROM containing hundreds of color images of skeletons and skeletal elements--demonstrating morphology, pathology, and nonmetric variation--that can be used as classroom projections or for individual study
* Coverage of the most recent developments in the field, including the molecular regulation of bone and tooth formation
* Expanded studies in each area of analysis: sex, age, nonmetric variation, pathology, biodistance and bioarchaeology, and stable isotope analysis
* Additional photographic images, especially in the pathology and sexing chapters
* Two separate and extensively illustrated chapters on the skull, one dealing with articulated elements and one with isolated bones (these topics were covered in one chapter in the first edition)
* Integration of material--such as anthropometric landmarks--from appendices in the previous edition into relevant chapters astables
* More accessible language throughout and an extensive glossary

Dieses Buch fuhrt in grundlegende Methoden der Mathematik ein, die in den Biowissenschaften angewendet werden. Die Themenbereiche wurden in der dritten Auflage erheblich erweitert. Sie umfassen u.a. Verfahren zur Auswertung von Beobachtungsdaten, die fur das Fachgebiet wichtigen Funktionen, die Anpassung von Funktionen an Daten, Modellbildung mit Differentialgleichungen, Vektoren und Matrizen sowie Schatz- und Testverfahren. Die Darstellung der Inhalte baut auf der Schulmathematik auf. Das Buch enthalt ein umfangreiches UEbungsmaterial, mit dem eine Sicherheit in der Anwendung der Methoden und der numerischen Problemloesung mit R erreicht werden kann.

Abrahams' and McMinn's Clinical Atlas of Human Anatomy, 8th Edition delivers the straightforward visual guidance you need to perform confidently in all examinations and understand spatial relationships required during your medical training, while also acquiring the practical anatomical knowledge needed for your future clinical career. Respected authority Prof. Peter Abrahams and his team of leading international anatomists and radiologists link a vast collection of clinical images to help you master all the essential correlations between the basic science of anatomy and its clinical practice. See what to look for and how to proceed thanks to an unsurpassed collection of labelled dissection photographs, supported by clear, explanatory diagrams and modern imaging Correlate anatomy to clinical practice with a wealth of MR, CT, DSA, radiographic, endoscopic, and operative images that demonstrate how structures are viewed today in the clinical setting Thoroughly revised and updated throughout, including: brand new dissections, to further improve clarity and consistency throughout the book in every region all new colour overlays added to selected dissections making it even easier to identify key nerves, arteries, veins and especially lymphatics fully revised neuroanatomy content reflects the latest understanding of functional neuroanatomy as seen with modern 3D and functional imaging updated and coloured and a unique lymphatics section Includes access to the complete, enhanced eBook - unlocking a huge, carefully-selected collection of BONUS CLINICAL material, integrated throughout on almost every page to enhance your study and help make those essential clinical / anatomical connections. This sets Abrahams' and McMinn's apart from any other atlases of human anatomy! 200+ 3D scans,- allowing you to view the body in a more dynamic way to aid your understanding of dynamic anatomy. Master the 500 clinical conditions every physician should know by reviewing the associated clinical topics - featuring over 2000 additional clinical photos, radiological images, and case presentations not found in the printed book. Learn from the culmination of over 45 years international clinical experience of Prof. Abrahams and over 100 of his colleagues worldwide who have contributed to this unique collection of clinical anatomy images.

Schritt fur Schritt zu den Konzepten Die Autoren fuhren den Leser von den mathematischen Grundlagen zu den konkreten Methoden der Bioinformatik. Das Buch wendet sich damit an alle, die bioinformatische Methoden und Softwarepakete verwenden wollen, sie aber nicht als Black Boxes akzeptieren moechten. Ein besonderes Highlight ist die schrittweise Implementierung wichtiger Algorithmen der Bioinformatik im Computeralgebra-Programm Mathematica, um die Konzepte auch auf der informatischen Ebene zu verstehen. Das Themenspektrum reicht von bioinformatischen Alltagsfragen bis in die Systembiologie. Die zweite, stark erweiterte Auflage geht auch auf eine Reihe sehr aktueller Themen der Bioinformatik ein, etwa Next-Generation Sequencing (NGS), GWAS-Daten und Protein-Interaktions-Netzwerke. Der Inhalt ist spannend und leicht verstandlich.

From the author of the groundbreaking New York Times bestseller The Female Brain, here is the eagerly awaited follow-up book that demystifies the puzzling male brain.

Dr. Louann Brizendine, the founder of the first clinic in the country to study gender differences in brain, behavior, and hormones, turns her attention to the male brain, showing how, through every phase of life, the "male reality" is fundamentally different from the female one. Exploring the latest breakthroughs in male psychology and neurology with her trademark accessibility and candor, she reveals that the male brain:

• is a lean, mean, problem-solving machine. Faced with a personal problem, a man will use his analytical brain structures, not his emotional ones, to find a solution.
• thrives under competition, instinctively plays rough and is obsessed with rank and hierarchy.
• has an area for sexual pursuit that is 2.5 times larger than the female brain, consuming him with sexual fantasies about female body parts.
• experiences such a massive increase in testosterone at puberty that he perceive others' faces to be more aggressive.

The Male Brain finally overturns the stereotypes. Impeccably researched and at the cutting edge of scientific knowledge, this is a book that every man, and especially every woman bedeviled by a man, will need to own.

Bernd Herrmann erlautert die Grundlagen der Prahistorischen Anthropologie. Grundsatzliches Thema dieses Forschungsgebietes ist die Untersuchung koerperlicher UEberreste von Menschen historischer Zeitraume mit dem Ziel der Aufdeckung ihrer Lebensumstande. Damit werden Kenntnisse uber Menschen vor allem der Nacheiszeit gewonnen, die Rekonstruktion von Einflussen auf ihr Leben wird ermoeglicht.

Now available in paperback.

Many neurological conditions are caused by damage to neurons and glial cells. For most of these diseases there are at present no effective treatments to minimise the extent of neuronal and glial loss, and no effective way of replacing what has been lost.

This picture is rapidly changing. Developments in basic neuroscience have produced various potential therapies that can protect neurons and glia followiing traumatic, anoxic, infectious and immunological damage. The old doctrine that axons cannot be made to regenerate, and dead neurons cannot be replaced is no longer tenable, and a wide variety of reconstructive techniques for the nervous system are under development. These and other basic science discoveries will progress into clinical practice, and lead to a revolution in neurology and neurosurgery. This book describes the various conditions that lead to damage to the nervous system, and the ways in which they may be ameliorated. It covers the burgeoning science of reconstruction of the nervous system, through neuronal, glial and stem cell transplantation, axon regeneration, remyelination, plasticity and pharmacological interventions. The clinical conditions to which these treatments will be applied and their assessment are described.

This is the first book to cover this enormous and expanding field of neuroscience and neurology. It will be useful to students and scientists working in the field of nervous system damage and reconstruction, and also to clinicians who wish to look forward to the developments which will shape the future of their practice.

Multidisciplinary Anatomy & Physiology textbook for Health Professionals! This title will enable the reader to take an informed interest in the patient's or client's condition, and in the planning of total patient care or complementary therapy treatments. It is relevant to students studying anatomy and physiology at a basic level - nursing, complementary therapies, sport therapy, physiotherapy and occupational therapy. A systems approach is presented in an accessible way accompanied by clear illustrations. It is written in an easy to read style explaining otherwise complicated topics.

Emilia Schax beschreibt die Herstellung von Hitzeschockproteinen und die Entwicklung eines direkt-kompetitiven Inhibitor-Screenings fur Hitzeschockproteine im Microarray-Format. Dieser Assay liefert in kurzester Zeit mit geringem Materialverbrauch Informationen zu den Bindeeigenschaften potenzieller Inhibitoren, die dann als moegliche Therapeutika dienen koennten. Der Assay basiert auf der Kompetition von fluoreszenzmarkierten ATP mit den potentiellen Inhibitoren um die ATP-Bindetasche der Proteine. Wahrend der Masterarbeit wurden zehn potentielle Inhibitoren, die Geldanamycin- oder Reblastatin-Derivate sind, getestet. Ihre IC50-Werte lagen im Bereich zwischen 0,5 nM und 4 M.

La TC spirale Multidetettore (TCMD) rappresenta oggi una delle più diffuse metodiche diagnostiche in campo radiologico. Le apparecchiature con 64 file di detettori consentono di ottenere studi di ampi volumi corporei in pochi secondi che, in associazione all’ elaborazione di immagini multiplanari, forniscono una valutazione anatomica topografica di facile approccio. Il presente volume descrive l’anatomia TCMD sul piano assiale, coronale e sagittale dei vari organi, strutture e compartimenti del torace, dell’addome e della pelvi attraverso molteplici illustrazioni. Le indicazioni a lato delle figure e la didascalia a fondo pagina rendono particolarmente facile la consultazione, costituendo una preziosa guida per l’elaborazione dei differenti protocolli di studio con TCMD del settore body.

Das Buch umfasst die ganze Bandbreite der neurobiologischen Ansatze bei verschiedenen psychiatrischen Erkrankungen, sowohl hinsichtlich der AEtiopathogenese als auch der Therapie. In Form von UEbersichtsarbeiten und Originalpublikationen von Ergebnissen einzelner Studien wird ein sehr aktuelles und sehr weit gefachertes Spektrum der biologisch-psychiatrischen Forschung geliefert. Neben einer Vielzahl anderer Themen stehen dabei dementielle Erkrankungen, angesichts der medizinischen und gesundheitspolitischen Bedeutung und der derzeitigen Intensitat von Forschungsaktivitaten, ganz besonders im Mittelpunkt.