A great deal is now known about the cellular changes which take place in neural circuits and, over the past twenty years, the chick has proved to be an invaluable model for work on memory formation. The prior experience of the chick is controllable in a way that is impossible to match in any other vertebrate, and the pharmacology and phases of memory formation are better established. In addition, the anatomy of the chick brain is now well established, allowing valuable comparisons with animal models. This book reviews all the main aspects of work on learning and plasticity in behaviour and neural mechanisms in the chick, together with related topics such as the development of behaviour and lateralization of function. It is an authoritative reference for researchers who wish to use the chick or to draw on the relevant literature. The aim is to introduce a wider audience to the chick as an experimental model and to describe the way in which it has been used in the investigation of learning and plasticity at every level, from the behavioural to the molecular. The authors are all experts in their field, from laboratories throughout the world. The book will be useful to all researchers in the field and of interest to psychologists, neurophysiologists, and those studying animal behaviour.

This book provides current information for a judicious use of conventional and molecular ICC markers performed in cytologic samples to help in the cost-effective diagnosis of superficial and deep-seated masses. By providing both an eminently practical information for appropriate technical preparation of cytologic samples and a systematic exposure of the immunophenotypic and biomolecular characteristics of normal and pathological cells, the reported morphological-molecular findings highlight the characteristics of different lesions that are useful for the practical solution of a particular differential diagnosis. Chapters include description of the cytomorphology followed by a practical ICC staining pattern for each entity. Cytologic materials include serous effusions, exfoliative cytology, fine needle aspiration cytology of superficial and deep-seated masses, and squash preparation from central nervous system masses. Practical Immunocytochemistry in Diagnostic Cytology serves as a valuable resource towards understanding critical differences between tests performed on tissue samples and those carried out on cytologic samples.

Written in a clear, reader-friendly style, Speech Science Primer serves as an introduction to speech science and covers basic information on acoustics, the acoustic analysis of speech, speech anatomy and physiology, and speech perception. It also includes topics such as research methodology, speech motor control, and history/evolution of speech science. With its reader-friendly content and valuable online resources, Speech Science Primer: Physiology, Acoustics, and Perception of Speech, Sixth Edition is an ideal text for beginning speech pathology and audiology students and faculty.

This book is about doing research, not about the results obtained. Those engaged on their first research may have had plenty of preparation about the techniques and results of prior research related to their proposed study, but may have limited knowledge of the actual strategies employed or pitfalls encountered by others who have conducted successful field and survey studies. In this book, a number of researchers with experience of working on problems including environmental stresses, population genetics, parasitic vectors and vital records describe obstacles encountered and successful strategies used in their own studies and in those of others. One learns to do research by trial and error, but accounts by experienced investigators can supplement what one learns from mentors and fellow students.

Cranial nerves are involved in head and neck function, and processes such as eating, speech and facial expression. This clinically oriented survey of cranial nerve anatomy and function was written for students of medicine, dentistry and speech therapy, but will also be useful for postgraduate physicians and GPs, and specialists in head and neck healthcare (surgeons, dentists, speech therapists etc.). After an introductory section surveying cranial nerve organisation and tricky basics such as ganglia, nuclei and brain stem pathways, the nerves are considered in functional groups: (1) for chewing and facial sensation; (2) for pharynx and larynx, swallowing and phonation; (3) autonomic components, taste and smell; (4) vision and eye movements; and (5) hearing and balance. In each chapter, the main anatomical features of each nerve are followed by clinical aspects and details of clinical testing. Simple line diagrams accompany the text. Detailed anatomy is not given.

Hundreds of questions you'd only ask your doctor after your third martini! You know how it is... you're at a party, you've had a drink or two, and then someone introduces you to a friend. He's a doctor. And it seems like the perfect time to ask all those strange questions you've always wondered about, but never had the courage to ask: Can poppy seeds make you test positive for heroin? What are goosebumps? Why does asparagus make your wee smell? Why do old people get hairy ears? Is it possible to lose your contact lenses inside your head forever? Why do some people have an "outie" belly button and some people an "innie"? Does warm milk really help you sleep? Is it actually possible to get scared to death? This book gives the answer to these and many more questions - pretty much everything you've ever wanted to know - but never had enough Dutch courage to ask!

This book seeks to present, through a combination of morphological data and physiological and neurological studies, a comprehensive survey of our knowledge of the human brain. The major emphasis is upon structural organisation, based upon the evolution of this most complex of organs. However, functional aspects, including experimental research and clinical findings, have also been incorporated, broadening the interest for students of neurobiology and clinical medicine.

Archaeological discoveries of teeth provide remarkable information on humans, animals and the health, hygiene and diet of ancient communities. In this fully revised and updated 2005 edition of his seminal text, Simon Hillson draws together a mass of material from archaeology, anthropology and related disciplines to provide a comprehensive manual on the study of teeth. The range of mammals examined has been extended to include descriptions and line drawings for 325 mammal genera from Europe, North Africa, western, central and northeastern Asia, and North America. The book also introduces dental anatomy and the microscopic structure of dental tissues, explores how the age or season of death is estimated and looks at variations in tooth size and shape. With its detailed descriptions of the techniques and equipment used and its provision of tables and charts, this book is essential reading for students of archaeology, zoology and dental science.

With strong correlations between gross anatomy and the microanatomy of structures, Netter's Essential Histology, 3rd Edition, is the perfect text for today's evolving medical education. Concise and easy to use, it integrates gross anatomy and embryology with classic histology slides and state-of-the-art scanning electron microscopy, offering a clear, visual understanding of this complex subject. Additional histopathology images, more clinical boxes, and new histopathology content ensure that this textbook-atlas clearly presents the most indispensable histologic concepts and their clinical relevance. Helps you recognize both normal and diseased structures at the microscopic level with the aid of succinct explanatory text as well as numerous clinical boxes. Features more histopathology content and additional clinical boxes to increase your knowledge of pathophysiology and clinical relevance. Includes high-quality light and electron micrographs, including enhanced and colorized electron micrographs that show ultra-structures in 3D, side by side with classic Netter illustrations that link your knowledge of anatomy and cell biology to what is seen in the micrographs. Provides online access to author-narrated video overviews of each chapter, plus Zoomify images and Virtual Slides that include histopathology and can be viewed at different magnifications. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Featuring more than 85 vibrant, fully annotated charts-19 new to this edition-this updated fourth edition of Diseases and Disorders: The World's Best Anatomical Charts is a perfect quick reference for medical and nursing students and an ideal visual aid for patient education. Printed on oversized, cardstock pages and compiled in a convenient, 10" x 12" spiral-bound volume with a laminated cover, these full-color charts created by some of the world's best medical illustrators illustrate and explain common diseases and disorders of the brain; heart; GI tract; eye and ear; endocrine, muscular, skeletal, reproductive, and respiratory systems; dental diseases; infectious diseases; healthy lifestyle issues; and cancer. Nineteen new charts cover Schizophrenia, Ovarian Cancer, Multiple Myeloma, Liver Cancer, Pancreatic Cancer, Prostate Cancer, Heart Failure, Peripheral Artery Disease, UC/Crohn's Disease, Irritable Bowel Syndrome, Age-Related Macular Degeneration, and more. All charts have been reviewed and updated. Medical terminology and easy-to-understand supporting text are printed directly on each chart. Every chart depicts an aspect of human anatomy, physiology, and disease presented in a clear, visual presentation. The book is ideal as a review resource or quick reference for studying human anatomy or for patient consultation and education.

In Functional Anatomy of the Pelvis and the Sacroiliac Joint author and respected bodywork specialist John Gibbons looks at one of the most important areas of the body: the pelvis and the sacroiliac joint. He takes readers on a fascinating journey of enlightenment, teaching us to recognize pain and dysfunctional patterns that arise from the pelvic girdle. Gibbons addresses key issues such as: * The walking/gait cycle and its relationship to the pelvis * Leg length discrepancy and its relationship to the kinetic chain and the pelvis * The laws of spinal mechanics * The relationship of the hip joint, gluteal muscles, lumbar spine to the pelvis * Sacroiliac joint screening In addition, he provides step-by-step techniques to identify and correct a number of impaired patterns as well as functional exercises for the pelvis that promote recovery.

This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

Remarkable atlas provides exceptionally detailed, clinically relevant anatomic knowledge! Praise for the prior edition: "The second edition of The THIEME Atlas of Anatomy: Volume 3 Head, Neck and Neuroanatomy is an exceptional book that combines very detailed and accurate illustrations of the region with relevant applied and clinical anatomy. As the authors mention in their preface, this book does really combine the very best of a clinically oriented text and an atlas."-Journal of Anatomy Thieme Atlas of Anatomy: Head, Neck, and Neuroanatomy, Third Edition by renowned educators Michael Schuenke, Erik Schulte, and Udo Schumacher, along with consulting editor Cristian Stefan, expands on prior editions with hundreds of new images and significant updates to the neuroanatomy content. Head and neck sections encompass the bones, ligaments, joints, muscles, lymphatic system, organs, related neurovascular structures, and topographical and sectional anatomy. The neuroanatomy section covers the histology of nerve and glial cells and autonomic nervous system, then delineates different areas of the brain and spinal cord, followed by sectional anatomy and functional systems. The final section features a glossary and expanded CNS synopses, featuring six new topics, from neurovascular structures of the nose to the pharynx. Key Features Nearly 1,800 images including extraordinarily realistic illustrations by Markus Voll and Karl Wesker, photographs, diagrams, tables, and succinct clinical applications make this the perfect study and teaching resource Expanded clinical references include illustrated summary tables and synopses of motor and sensory pathways Neuroanatomy additions include an in-depth overview and content focused on functional circuitry and pathways Online images with "labels-on and labels-off" capability are ideal for review and self-testing This visually stunning atlas is an essential companion for medical students or residents interested in pursuing head and neck subspecialties or furthering their knowledge of neuroanatomy. It will also benefit dental and physical therapy students, as well as physicians and physical therapists seeking an image-rich clinical resource to consult in practice. The THIEME Atlas of Anatomy series also includes two additional volumes, General Anatomy and Musculoskeletal System and Internal Organs. All volumes of the THIEME Atlas of Anatomy series are available in softcover English/International Nomenclature and in hardcover with Latin nomenclature. This book includes complimentary access to a digital copy on https://medone.thieme.com.

The past few years have witnessed rapid progress in the characterization of mechanisms that underlie the generation and processing of inter- and intracellular signals. While there have been significant corollary advances in the area of signaling in disease processes, there is as yet no single resource that connects these advances with an understanding of disease processes and applications for novel therapeutics. Collecting chapters from the leading experts in their respective fields, editors Toren Finkel and Silvio Gutkind deliver a much-needed introduction to signaling and a fruitful discussion of promising directions for future research.

Signal Transduction and Human Disease capitalizes on the current emphasis on translational research and biological relevance in biotechnology and, conversely, the importance of molecular approaches for clinical research. Each chapter conveys the sense of a disease process, what it affects, how it presents, how common it is, and what the treatments are. Clinical descriptions are not exhaustive but rather serve as an outline regarding the disease’s manifestations and current treatment options. Following this introduction, the authors present an in-depth discussion of one or two signal transduction pathways or biological processes relevant to the disease. The editors divide their study into five sections:

• Cardio-Pulmonary Disease
• Oncology
• Endocrinology
• Infectious Disease
• Allergy/Rheumatology
• Neurology/Psychiatry

Biochemists, molecular and cell biologists, immunologists, pharmacologists, and clinical researchers, as well as graduate students in a variety of scientific disciplines, will find Signal Transduction and Human Disease to be an invaluable addition to the literature.

Written by experienced and well-respected physicians and professors, this new all-color volume presents the ultrasonic topographical and pathotopographical anatomy of the body, including the head, neck, chest, anterolateral abdominal wall, abdominal organs, retroperitoneal space, male and female pelvises, and lower extremities. Specific and non-specific ultrasonic symptoms are suggested for normal and abnormal developmental variants, diffuse and local pathotopographical anatomy. This color atlas contains comparative topographical and pathotopographical data and is the first manual of its kind for students and medical specialists in different areas, including those specializing in medical sonography. The original technology was tested at clinics in patients subjected to ultrasonic monitoring. Because of early detection there were no false-positive or false-negative results. The therapy was effective, and, in some cases, the use of the original method of "seagalography" (optometry and pulsemotorgraphy) has made it possible to develop new methods of treatment and/or to determine the optimal doses of drugs, as well as to develop effective drug complexes for treatment of a given pathology. This important new volume will be valuable to physicians, junior physicians, medical residents, lecturers in medicine, and medical students alike, either as a textbook or as a reference. It is a must-have for any physician's library.

Color Atlas of Human Anatomy, Volume 3: Nervous System and Sensory Organs For over 45 years, the three-volume Color Atlas of Human Anatomy has provided readers with a compact review of the human body and its structures. It is ideal for studying, preparing for exams, and as a reference. The new, 8th edition of Volume 3: Nervous System and Sensory Organs builds on a robust foundation of scientific knowledge, summarizing in its compactness the structure and functions of the nervous system and sensory organs. Key highlights: Updated to include the latest findings in neuroanatomy Proven concept of concise texts paired with 190 color plates of outstanding anatomical illustrations The structure and topography of the various components of the nervous system and their complex, functional interactions are explained Important neuroanatomical research techniques and the use of imaging methods (CT, MRI, PET, and SPECT) are discussed Volume 3: Nervous System and Sensory Organs is accompanied by Volume 1: Locomotor System (ISBN 978-3-13-242443-3) and Volume 2: Internal Organs (ISBN 978-3-13-242448-7).

This revision aid is of great practical benefit to all radiology trainees studying for their professional examinations. The carefully structured questions and answers enable trainees to undertake a systematic assessment of their knowledge; they also highlight areas where additional study is required. It is developed to complement its highly illustrated parent text, Applied Radiological Anatomy (Cambridge, 1999); but both books can be used together or independently of one another. The questions posed within are relevant and useful for radiology trainees worldwide.

A knowledge of anatomy has always played a vital role in medicine, and is especially important in the everyday practice of anaesthesia. This 2002 text presents the core anatomical knowledge required for the Primary and Final FRCA examinations in a simple and straightforward manner. Adopting the philosophy of the examination itself, where candidates are often required to reproduce simple line drawings to illustrate the depth of their knowledge, the many illustrations in the book are clear and easy to understand at a glance. The illustrations are accompanied by explanatory text throughout and for each anatomical region, sample examination questions are included which follow the format of those asked in the examinations. This book will interest anaesthesia Primary and Final candidates, as well as providing a valuable quick reference for busy anaesthetists at all levels of experience.

Now in its eighth edition, this highly respected core textbook is essential reading for all healthcare students learning about the bones and joints of the body. The information is logically ordered and easy to read; comprehensive enough for students and health professionals alike, but not so dense as to be overwhelming. It covers the normal structure of bones and joints and goes on to provide an introduction to common fractures and pathology and how they appear on imaging. Bones and Joints is the perfect initial textbook, as well as a revision and refresher guide that will suit students of radiography, physiotherapy, osteology, sports medicine and nursing. Clear and concise introduction to the bones and joints and associated pathology Logically ordered - easy to follow and understand Provides a good introduction to image interpretation Clear identification of important or commonly misunderstood concepts Extensive glossary to help explain and develop terminology Online quizzes/tests to gauge learning and for revision Colour coded illustrations to aid understanding and learning Extensive clear line diagrams and fully updated radiographic/radiological images to reflect the role of current imaging modalities Revised fracture and pathology sections to include the most common and significant conditions that a student will face 'Insights' highlighting important concepts for the reader to understand New images identifying the ossification centres of the bones

The Understanding the Foot & Ankle chart presents an in-depth look at the structure of the ankle joints and the foot. The main image shows the left and right feet and ankles with musculature and ligaments. Several smaller views illustrate the bones and ligaments. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

The Understanding the Stomach chart presents an overview of a major component of the digestive system. The internal structure of the stomach and stomach lining are covered, as well as common disorders. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

The Understanding the Hand & Wrist chart presents an in-depth look at the structure of the wrist and hand. The main image shows the left and right hands and wrists with musculature and ligaments. Smaller views illustrate the bones and ligaments. Heavy cover stock with protective varnish for durability.

Humans possess the most expressive faces in the animal kingdom. Adam Wilkins presents evidence ranging from the fossil record to recent findings of genetics, molecular biology, and developmental biology to reconstruct the fascinating story of how the human face evolved. Beginning with the first vertebrate faces half a billion years ago and continuing to dramatic changes among our recent human ancestors, Making Faces illuminates how the unusual characteristics of the human face came about-both the physical shape of facial features and the critical role facial expression plays in human society. Offering more than an account of morphological changes over time and space, which rely on findings from paleontology and anthropology, Wilkins also draws on comparative studies of living nonhuman species. He examines the genetic foundations of the remarkable diversity in human faces, and also shows how the evolution of the face was intimately connected to the evolution of the brain. Brain structures capable of recognizing different individuals as well as "reading" and reacting to their facial expressions led to complex social exchanges. Furthermore, the neural and muscular mechanisms that created facial expressions also allowed the development of speech, which is unique to humans. In demonstrating how the physical evolution of the human face has been inextricably intertwined with our species' growing social complexity, Wilkins argues that it was both the product and enabler of human sociality.

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism.