In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway's involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker H2AX: from bench science to clinical trials What's the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children's exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children's Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.

This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers. CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding cancer metastasis has been steadily growing, and CTCs provide effective biomarkers that can be examined in peripheral blood through a minimally invasive "liquid biopsy" procedure. CTCs offer several exciting applications, not only as markers of disease progression but also as biomarkers of monitoring response to therapy and companion diagnostics for novel anticancer drug development. In recent years there has been rapid growth and worldwide developments on CTCs, which span both the basic sciences and biomedical engineering fields.

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The "synthetic lethality" of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.

'An enthralling read' - Dr Rachel Clarke, bestselling author of Dear Life A Royal Society Science Prize shortlisted author 'A remarkable book' - Sunday Times __________ What is phantom limb pain? Can words actually hurt? Why do we experience pain, even after we've healed? We know pain when we feel it. We fear it and try to avoid it. But do we know what it really is? We're currently experiencing a Renaissance in pain science. In recent years our understanding of pain has altered so radically it's fair to say that everything we thought we knew about pain is wrong. As Dr Monty Lyman reveals, we misunderstand pain - with harmful consequences. Exploring cutting-edge research that encompasses everything from phantom aches to persistent pain, as well as interviews with survivors of torture and those who have never felt pain, Dr Lyman not only provides hope for reducing and managing pain but takes us to a deeper understanding of what it means to be human. This is the untold story of pain - our most elusive feeling. 'Accessible and well-written... Dr Lyman takes us into the world of pain' Mail on Sunday __________ Praise for Monty Lyman and The Remarkable Life of the Skin - 'Seriously entertaining' The Times - 'A talented new writer' Sunday Times - 'Beautifully written, revealing and surprising' Daily Mail - 'Imaginatively told' The Spectator - 'An absorbing, fact-packed study' Nature - 'What a read it is' Vogue - 'Fascinating' Daily Express

A visually-rich and clinically relevant anatomy resource for dental students Anatomy for Dental Medicine, Third Edition strikes an optimal balance between systemic and regional approaches to complex head and neck anatomy. Award-winning full-color illustrations, succinct text, summary tables, and questions put anatomical structures and knowledge into a practical context. Key Features NEW! Additional radiologic images and landmark features throughout NEW! Reorganized brain/nerve sections NEW! Expanded clinical question appendix including patient box questions in the style of the INBDE NEW! Factual question appendix places greater emphasis on areas including the skull, larynx, cross sectional anatomy, body below the neck, and local anesthesia Also included in this new edition: 1,200 clear and detailed full-color illustrations 150 tables for rapid access to key information Expanded captions detail key information and clinical correlations Appendix covering anatomy for local anesthesia Online images with "labels-on and labels-off" capability are ideal for review and self-testing This is an essential resource for dental students and residents that also provides a robust review for the boards or dissection courses. What users say about the Atlas of Anatomy: "…I am impressed with the 2nd edition of the atlas because it provides multiple, complimentary paths to learning head and neck anatomy." "…organization is in an effective sequence that walks the learner through the anatomy in a layered, step-wise manner." This book includes complimentary access to a digital copy on https://medone.thieme.com.

This beautiful trigger point educational tool includes two charts: Trigger Points: Torso and Trigger Points: Extremities. Each chart illustrates and labels the muscles affected by trigger points, and shows trigger point locations with primary and secondary pain sensitive zones. Each chart includes a legend that explains how to identify particular trigger points and their pain zones.

This edition has updated images and improved content organization to maximize visual impact. The torso chart shows trigger points of the upper torso and shoulder, posterior deep and anterior-posterior pain referral guide. The extremities chart shows upper extremity, lower extremity, and head and neck trigger points.

This image-rich book explores the practice as well as the theory of visual representation and presents us with the importance of designing appropriate images for communication to specific target audiences. This includes the appropriate choice of high-tech digital or low-tech analogue technologies in image-making for communication within the medical education, biological research and community health contexts. We hear from medical students about the value of using clay modelling in their understanding of anatomy, from educators and curriculum designers about visual affordances in medical education and from a community-driven project in South Africa about their innovative use of locally designed images and culture-specific narratives for communicating important health information to marginalised communities. A chapter explores the evolution of scientific visualisation and representation of big data to a variety of audiences, and another presents the innovative 3D construction of internal cellular structures from microscopic 2D slices. As we embrace blended learning in anatomy education, a timely chapter prompts us to think further about and contribute to the ongoing discourse around important ethical considerations in the use and sharing of digital images of body donors. This book will appeal to educators, medical illustrators, curriculum designers, post-graduate students, community health practitioners and biomedical researchers.

The Ross & Wilson Pocket Reference Guide to Anatomy and Physiology is an exciting new resource which offers over 250 anatomical entries carefully selected for their biological importance and/or clinical relevance. Each piece of carefully crafted artwork is accompanied by helpful summary notes describing key aspects of the relevant anatomy, physiology and clinical application to aid readers with their understanding of the human body. The volume also comes with a helpful online self-assessment program which presents a range of interactive exercises designed to stimulate critical thinking and information recall. Perfect for learning and consolidating knowledge while 'on the go', Ross & Wilson Pocket Reference Guide to Anatomy and Physiology will be ideal for students of nursing and allied health professions, paramedical science, operating department practice, complementary therapy and massage therapy, as well as trainee Health Care Assistants and those studying A' level or BTEC (or equivalent) human biology. Summarizes essential facts from the world's favourite human biology textbook! Presents over 250 key anatomical structures together with 'quick reference' revision notes regarding their structure, function and clinical relevance Straightforward language and user-friendly approach provides a useful, up-to-date aide-memoire in a helpful, easy-to-carry format Helpful website provides a range of self-assessment exercises on anatomy and physiology to help consolidate learning

Neil Shubin's Your Inner Fish is the unexpected story of how one creature's journey out of the water made the human body what it is today - and one man's voyage of discovery in search of our origins. Have you ever wondered why our bodies look and work and fail the way they do? One of the world's leading experts in evolutionary history, Neil Shubin reveals the secrets of our biology: why if we want to understand our limbs we should take a close look at Tiktaalik, the first fish capable of doing a push-up; why if we want to know why we hiccup, the answer is in the way fish breathe; and why it is that fish teeth are surprisingly similar to human breasts. 'This would be Darwin's book of the year' Sunday Telegraph 'An intelligent, exhilarating, and compelling scientific adventure story' Oliver Sacks, author of The Man Who Mistook His Wife for a Hat 'Delightful ... his enthusiasm is infectious' Steven D. Levitt, author of Freakonomics 'Profoundly fascinating ... a magisterial work ... expressed so clearly and with such good humour' Financial Times 'Will make you think about your organs in ways you have never considered before' Sunday Times Neil Shubin is a palaeontologist in the great tradition of his mentors, Ernst Mayr and Stephen Jay Gould. He has discovered fossils around the world that have changed the way we think about many of the key transitions in evolution and has pioneered a new synthesis of expeditionary palaeontology, developmental genetics and genomics. He trained at Columbia, Harvard and Berkeley and is currently Chairman of the Department of Anatomy at the University of Chicago.

This text describes a system of reporting breast fine needle aspiration biopsy that uses five clearly defined categories, each described by a specific term and each with a specific risk of malignancy. The five categories are insufficient/inadequate, benign, atypical, suspicious of malignancy and malignant. Each category has a risk of malignancy and is linked to management recommendations, which include several options because it is recognized that diagnostic infrastructure, such as the availability of core needle biopsy and ultrasound guidance, vary between developed and low and middle income countries. This text includes key diagnostic cytological criteria for each of the many lesions and tumors found in the breast. The cytopathology of specific lesions is illustrated with high quality photomicrographs with clear figure descriptions. Chapters also discuss current and potential future ancillary tests, liquid based cytology, nipple cytology and management. An additional chapter provides an overview of an approach to the diagnosis of direct smears of breast fine needle aspiration biopsies. The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology provides a clear logical approach to the diagnosis and categorization of breast lesions by FNAB cytology, and aims to facilitate communication with breast clinicians, further research into breast cytopathology and related molecular pathology, and improve patient care.

Clinically focused, consistently and clearly illustrated, and logically organized, Gray's Atlas of Anatomy, the companion resource to the popular Gray's Anatomy for Students, presents a vivid, visual depiction of anatomical structures. Stunning illustrations demonstrate the correlation of structures with clinical images and surface anatomy - essential for proper identification in the dissection lab and successful preparation for course exams. Build on your existing anatomy knowledge with structures presented from a superficial to deep orientation, representing a logical progression through the body. Identify the various anatomical structures of the body and better understand their relationships to each other with the visual guidance of nearly 1,000 exquisitely illustrated anatomical figures. Visualize the clinical correlation between anatomical structures and surface landmarks with surface anatomy photographs overlaid with anatomical drawings. Recognize anatomical structures as they present in practice through more than 270 clinical images - including laparoscopic, radiologic, surgical, ophthalmoscopic, otoscopic, and other clinical views - placed adjacent to anatomic artwork for side-by-side comparison. Gain a more complete understanding of the inguinal region in women through a brand-new, large-format illustration, as well as new imaging figures that reflect anatomy as viewed in the modern clinical setting. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices - as well as dissection videos and self-assessment questions and answers.

This book covers the basics of evoked spinal cord potentials (SCPs) with reference to studies in animals. Many illustrations help the reader grasp the neurophysiological and neuropharmacological background of spinal cord functions. Case studies offer insight into monitoring and diagnosing spinal cord dysfunctions and spinal cord diseases. The book is intended for students in clinical neurophysiology, neurosurgery, neurology, orthopedics and neuroanesthesia.

Bicycles have been a common device to enhance physical fitness level in gyms and training centers along with solid use in competitive sport. For that reason, biomechanics of cycling has grown as a research field with many publications addressing different perspective of the interaction between the cyclist and his bicycle. The most common end point of research on biomechanics of cycling is optimization of performance and reduction of injury risk. One goal of this book is to meet the growing need for a comprehensive presentation of contemporary knowledge on biomechanics of cycling which will positively influence the activity of cycling in a global fashion. In order to accomplish this purpose, ten chapters are presented with focus on varying methods for biomechanical analysis of cycling motion. The introduction section provides an overview of the main methods for assessment of cycling motion, including motion analysis, pedal force measurements, muscle activation, anthropometry and joint kinetics. These methods are discussed in depth in individual chapters followed by chapters on characteristics of bicycles and potential perspectives to improve their configuration in order to improve performance of cyclists and reduce their overuse injury risk. Moreover, a preliminary method to train technique in cyclists is shown. A final chapter provides authors perspective on the upcoming technology that should be effective in helping training of cyclists.