1. 1 Brief History The diversity of cells constituting the central nervous system did not deceive last century neurohistologists in recognizing that this organ contained essentially two cell types: the nerve cells, or as termed according to the emerging concept of neural contiguity, the neurons, and the neuroglial cells. Neurons were clearly shown to be the means of excitability, impulse generation, impulse transmission, and connectivity in the neural tissue. The neuroglia, as indicated by its name (YAloc=cement or glue) given by Virchow (1860), was thought to be the cement ing material ensuring the coherence of the nervous tissue, filling in the spaces of the neuropil, and isolating neuronal cell bodies. While this supposedly passive role did not attract multidisciplinary research on the neuroglia, successful efforts were made to extend our knowledge of the physiology, morphology, and bio chemistry of neurons. As a result of this, the investigation of the neuroglia carried out in the first half of this century was mainly confined to morphology, often as a by-product of comprehensive analyses of neuronal systems. At any rate, the histological classification of the neuroglia was accomplished, laying a framework which has been used to the present day. Accordingly, the glia was divided into two major groups: the macro- and microglia. The former comprises two further subclasses, the astroglia and oligodendroglia."

Of all cytoarchitectonic structures in the brain of mammals, the hippocampus is perhaps the most conspicuous because of its unusual macroscopic and micro- scopic appearance. During phylogeny, the hippocampus has developed from a single cortical plate in amphibia into a complicated, three-dimensional convo- luted structure in mammals. Because of its clear lamination into axonal, perikaryal, and dendritic layers, the hippocampus has often been considered a simple cortex model. Indeed, this trilaminated construction resembles perhaps the least complicated type of neuronal cortex. There is a large literature describing hippocampal morphology in many species with respect to cytoarchitectonics, fiberarchitectonics, angioar- chitectonics, chemoarchitectonics, synaptology, and fine structure. On the other hand, up to the present day there has been no generally accepted concept on the main functions of the hippocampus, although many studies dealing with its physiological and biochemical properties and its possible influences on behav- ior have provided some valuable indications. Early investigators described the hippocampus as being a part of the "rhinen- cephalon" (e. g. Zuckerkandl 1887), together with other allocortical structures, such as the olfactory bulb, olfactory tubercle, and piriform lobe. Thus, the hippocampus was assigned to the olfactory system, and it was not until improved degeneration techniques were applied that this error could be corrected. It be- came clear that only part of the allocortical areas receive direct olfactory inputs, namely the retrobulbar region (anterior olfactory nucleus), precommissural hip- pocampus, olfactory tubercle, prepiriform region, periamygdalar region, and part of the entorhinal region.

In the operation of reasoning, the mind does nothing but run over its objects, as they are supposed to stand in reality, without adding any thing to them or diminishing any thing from them. If I examine the Ptolomaic and Copernican systems, I endeavour only, by my inquiries, to know the real situation of the planets; that is, in other words, I endeavour to give them, in my conception, the same relation that they bear towards each other in the heavens. To this operation of the mind, therefore, there seems to be always a real, though often unknown standard, in the nature of things; nor is truth or falsehood variable by the various apprehensions of mankind. D. Hume, The sceptic. In: Essays. Moral Political and Literary. Oxford University Press, Oxford, 1963, p. 166. Contents 1 Introduction 1 2 Materials and Methods 2 3 Observations . . . . 4 3. 1 Topography of the Medial Geniculate Body 4 3. 2 Cytoarchitectonic Subdivisions of the Medial Geniculate Body 4 3. 3 Neuronal Architecture of the Ventral Division 7 3. 4 Structure ofAxons in the Ventral Division 21 3. 5 Cortical Connections of the Ventral Division 27 3. 6 Neuronal Architecture of the Dorsal Division 27 3. 7 Structure of Axons in the Dorsal Nuclei 39 3. 8 Neuronal and Axonal Architecture of the Suprageniculate Nucleus and the Posterior Limitans Nucleus . . . . . . 43 3. 9 Cortical Connections of the Dorsal Division . . . . . . 49 3. 10 Neuronal and Axonal Architecture of the Medial Division 56 4 Discussion . . . . . . . . . . . . . . . . . . .

Ever since the behavioral work of Lissrnann (1958), who showed that the weak electric discharges of some families of fish (hitherto considered useless for prey capture or for scaring away enemies) are part of a strange sensory system, these fish have attracted attention from biologists. The subsequent discovery of the electroreceptors in the skin of gymnotids and mormyrids (Bullock et al. 1961; Fessard and Szabo 1961) and the evidence that the ampullae of Lorenzini of nonelectric sharks and rays are also electro- receptors (Digkgraaf and Kalmijn 1962) was a start for a lively branch of physiological, anatomical, and behavioral research. Many fmdings of general importance for these fields have made the case to which extremes the performance of the central and peri- pheral nervous systems can be driven. Among those fmdings is the temporal accuracy of the pacemaker of some high-frequency fish which controls the electric organ, pro- bably the most accurate biological clock (coefficient of variation < 0. 0 1 %, Bullock 1982). The functional analysis of the pacemaker cells and their axons has established most of our knowledge on electrotonic synapses, the alternative to chemical synapses (Bennett et al. 1967), and of the implications of axonal delay lines for achieving extreme synchrony of parallel inputs to postsynaptic elements (Bennett 1972; Bruns 1971).

This monograph has attempted to bring together morphological and physiological studies of reptilian lungs, to analyze the nature of the resulting correlations, and to risk some speculations regarding the evolution of reptilian lung structure. Central to this work is the morphometric evaluation of the lungs in two species of lizard: "the teju (Tupinambis nigropunctatus Spix) and the savanna monitor (Varanus exanthema- ticus [Bosc]) which is presented here for the first time. These two species are similar in body form, and both are diurnally active predators, but their lungs are of basic- ally different structural types. The teju possesses relatively small, single-chambered (unicameral) lungs in which the homeycomb-like (faveolar) parenchyma is more or less evenly distributed along their length. In the monitor the lungs are large and many-chambered (multicameral), the individual chambers connecting to an unbranched, intrapulmonary bronchus. The parenchyma is in the form of shallow cubicles (ediculae), which are elaborated on the intercameral septa. The parenchyma is heterogeneously distributed within the lungs, tending to be most concentrated near the intrapulmonary bronchus and the middle third of the lung length. The ventral and caudal portions of these lungs are thin-walled and highly flexible. In both species those portions of the lungs which are most exposed to air convection possess dense capillary nets which almost completely cover both sides of the parenchymal partitions. In more distal regions of the parenchy- ma or of the lung, the intercapillary spaces become larger, creating a pseudo-single capillary net.

The study of the development of the spinal cord has a relatively long history. The spinal cord was singled out as a favorable site when cytological techniques were first applied to the study of the embryonic development of the nervous system. Bidder and Kupffer (1857), using the new procedure of hardening nerve tissue with chromic acid (Hannover 1844), made an investigation of spinal cord development in fetal sheep. They reported that the cellular central mass of the spinal cord develops before its fibrous envelope, deducing from this that the fibers of the white matter of the embryonic spinal cord were outgrowths of cells in the gray matter. Bidder and Kupffer also noted that in the spinal ganglia fibers grew out from cells in both directions, peripherally and centrally. Their report was one of the earliest ontogenetic lines of evidence in support of the later-formulated neuron doctrine (Waldeyer 1891). The spinal cord re mained a favorite topic of morphogenetic studies of the nervous system through out the last quarter of the nineteenth century, with seminal contributions made by His (1886, 1889), von Lenhossek (1889), Retzius (1898), and Ramon y Cajal (1960). Indeed, the preoccupation with the spinal cord in the early investigations of neural development had a lasting, and to some extent regrettable, influence on ideas about the ontogeny of the brain and on the terminology adopted by anatomists."

Primary cortical areas receive a defmed input which makes them especially appropria- te for investigating cortical functions. The striate area is the only isocortical field which can be delineated unequivocally in the human brain. Nevertheless, there have been only a few morphological studies of this particular area (cytoarchitectonic studies: Bailey and Von Bonin 1951, Beck 1934, Von Economo and Koskinas 1925, Filimo- noff 1932; myeloarchitectonic studies: Sanides and Vitzthum 1965, Vogt and Vogt 1919; pigmentoarchitectonic studies: Braak H 1976, 1977). For Golgi impregnations, Ramon y Cajal (1900, 1909-1911), Conel (1939-1967), and Shkol'nik-Yarros (1971) preferred the incompletely myelinated material taken from brains of young childre- a fact that somewhat restricts their descriptions of the human striate area. Pigment preparations (Braak H 1978) provide a detailed view of the lamination of cortical areas. Furthermore, many types of cortical nerve cells reveal a typicallipofus- cin-pigment pattern (Braak H 1974a). Thus, a correlation can be drawn between the type of neuron as classified in Golgi preparations and the characteristic number and distribution of lipofuscin granules found in the cell body. Neurolipofuscin granules can therefore be considered the internal markers. In this study several cell types of the striate area have been identified under light and electron microscopes by means of their characteristic pigmentation.

In many aspects hematopoiesis in newborn rodents, especially in rats, resembles hema- topoiesis in the human fetus in the 6th-7th month of gestation. In man the transition from the stage of liver to bone marrow erythropoiesis takes place at this time (Bessis, 1973). In rodents, however, the liver is almost the only place where hematopoiesis occurs until birth. Thereafter it is replaced to a growing extent by the bone marrow, which so far consists mainly of immature mesenchymal cells (Maximow, 1910; Cuda, 1970). Thus hematopoietic precursor cells appear in the sternum only around 30 h after birth. Just as in premature human infants, a macrocytic anemia can be demonstrat- ed in normal neonatal rats (Lucarelli et aI., 1964, 1968). Beside liver (fetal) and bone marrow, the spleen is involved in hematopoiesis. In rodents like rats and mice, splenic hematopoiesis persists more or less markedly until adulthood; in man, however, it ceases after birth and reappears only under certain pathological conditions (Fischer et aI., 1970; Hennekeuser et aI., 1967; Fresen, 1960).

The octapeptide angiotensin II (ANG II, Fig. 1) is the key effector substance of the renin-angiotensin system (RAS) (Werning 1972, Page and Bumpus 1974, Hierholzer 1977, Vecsei et al. 1978, Johnson and Anderson 1980 lit. ). ANG II is formed in two enzymatic steps. Renin acts on renin substrate, a glycoprotein, to produce angiotensin I (ANG I, a decapeptide), which in turn is acted upon by converting enzyme to form ANG II (Skeggs et al. 1968, Fig. 1). Renin substrate (angiotensinogen) is produced mainly in the liver (Page et al. 1941) and is a constituent of the ~-globulin fraction in the circulating plasma (Plentl et al. 1943). The two enzymes involved in the formation of ANG II from renin substra- te are formed at various sites in the body. Renin (E. C. 3. 4. 99. 19) is produced mainly in the granular epithelioid cells of the kidney (Cook 1971, Taugner et al. 1979, Davi- doff and Schiebler 1981), and converting enzyme (CE, E. C. 3. 4. 15. 1) occurs chiefly in the lung (Ng and Vane 1967, Bakhle 1974 lit. ) as well as in numerous other tissues, such as the juxtaglomerular apparatus of the kidney (Granger et al. 1969, 1972) and the brush border of the renal proximal tubule (Ward et al. 1975, 1976; Ward und Erdos 1977). The biological effects of ANG II are numerous.

The aim of this investigation is threefold: (a) to determine the time of origin of neurons of the rat cranial nerve ganglia; (b) to reexamine the embryonic development of the cranial nerve ganglia in the light ofthese dating results; and (c) to attempt to relate the chronology of these peripheral events to developmental events in those nuclei of the medulla that are intimately associated with the cranial nerve ganglia. Although thymidine-radiography has been used for over 2 decades to investigate the time of origin of neurons, most of these studies dealt with central nervous struc tures. There are relatively few studies available concerning the birth dates of neurons in the peripheral nervous system. In fact, to our knowledge, there is only a single thymidine-radiographic report available dealing with the time of origin of neurons of a cranial nerve ganglion in a mammal; this is the recent study by Forbes and Welt (1981) of neurogenesis in the trigeminal ganglion of the rat. In the present study we determined the birth dates of neurons of the trigeminal, facial, vestibular, "glosso pharyngeal, and vagal ganglia of the rat. We utilized the progressively delayed com prehensive labeling procedure, a method which, in contrast to the single-pulse labeling procedure, allows the exact quantification of the proportion of neurons formed on a particular day."

In 1949, the Dutch anatomist Jan Boeke was able to write: "The socalled interstitial cells . . . which lie at the end of the sympathetic endformation as a connecting link between the nervous endformation and the effector cells, are . . . shown to be of pri mary importance for the transferring and the remoulding of the nervous stimulus . . . . " And: " . . . the problem of the interstitial cells and of the synapse is the most impor tant problem of neurohistology of the future. " When Boeke wrote this, he advocated the generalized concept, holding that inter stitial cells were intercalated between autonomic nerves and effector cells. A frank illus tration of this is presented by Tinel (l937), who places interstitial cells of Cajal (ICC) as terminal neurons of all autonomic nerves (his Fig. 1). While there have been over 100 light microscopic investigations (Table 1) of ICC in tissues and organs other than intestine, none of these have been followed up by electron microscopic studies. It is important to bear in mind that when the term ICC is used today, the only reference tissue for which sufficient information (i. e., including an ultrastructural identification) on the ICC is at hand is the intestine, or rather the muscularis externa of small inte stine (in Table 1, those contributions which relate to intestinal ICC are underlined)."

Of all the classes in the animal kingdom, birds represent the best known. There are in total about 8600 living species, and the systematic study of this class is more or less complete. Extensive observations - to a large extent by amateur ornithologists - with respect to geographical distribution, life cycles, demands on and adaptations to the environment, breeding habits, migration, and so forth have contributed towards basic and more widely relevant knowledge, e. g., in the areas of ethology, ecology, and evo lution and also in social biology (Hilprecht 1970; Farner and King 1971). Together, all these aspects are affected by the reproductive biology of birds, and studies have therefore been carried out for many years with special emphasis on this subject. How ever, until now this emphasis in avian reproductive biology has been physiological and in particular endocrinological (Murton and Westwood 1977; Roosen-Runge 1977). The morphology of the gonads has been treated in far less detail, and has been confined to a comparatively small number of species, compared with other classes of vertebrates. Reproduction is the section in the life cycle of an animal which is most dependent upon environmental conditions. Reproduction therefore usually takes place at a par ticular time, when stress for the adult animals is at its lowest and the chances of sur vival for the newborn are at their highest, i. e."

Over the past few decades an exceedingly large number of experimental and clinical investigations have been performed in an attempt to analyze the way in which the kidney functions. The basis for all this work was established during the nineteenth and the early twentieth century by morphologists (Bowman 1842; Hyrtl1863, 1872; Heidenhain 1874; Peter 1909; von Mollendorf 1930). All these investigators clearly outlined the extremely heterogeneous assembly of renal tissue and also defined the nephron as the smallest morphological unit. It was further the merit of these anato- mists and histologists to preclude quite a number of nephron functions based merely on their careful observations. Contemporary histologists have been able to add little to these observations. Unfortunately with the introduction of physiologic in vivo et situ studies on kidneys the interest in heterogeneity waned. This lack of attention was aggravated by the introduction of the clearance techniques which cannot account for regional differences in the function of the smallest unit, the nephron. That ana- tomic heterogeneity has a functional correlate was strongly suggested by Trueta et al. (1947) and vigorously stimulated a number of studies. The development of physiologic microtechniques, like micropuncture and microperfusion of single nephrons, or the perfusion of isolated nephron portions and electrophysiologic studies, enormously expanded our knowledge concerning details regarding nephron and total renal func- tion.

The present monograph is an imaginative and courageous attempt to provide a synthesis of knowledge concerning the af- ferent connections of the medial basal hypothalamus. Only somebody who has lived through most of the explosive develop- ment - over the last 25 years or so - in the neuroscience in general, and in hypothalamic functional neuroanatomy in parti- cular, can fully appreciate the remarkably consistent picture emerging from this study. The writer of this foreword was (alas!) an active participant in the very early and premature, and also largely naive, attempts to penetrate the "jungle" of hypothalamic connections with degeneration methods when they first became available in the late 1930s. (I have told a part of this rather pathetic story is an autobiographical sketch in Pioneers in Neuroendocrinology [Meites et aI. , (eds) (1975), Vol I. Plenum] because I was sufficiently self-critical not to publish my early results. ) Even with the suppressive Nauta-type silver stains, introduced in the mid-1950s, studies of hypothala- mic connections had only marginal results, which the reader will certainly appreciate if he compares the relevant figures in the first edition of Hypothalamic Control of the Anterior Pituitary [Szentagothai et al. (1962) Akademiai Kiad6, Budapest], with Dr. Zaborszky's concluding diagrams. The approach used by Dr. Zaborszky of combining the more advanced Fink-Heimer type degeneration techniques, and some of their most recent modifications by Gallyas et al.

The mature vertebrate retina is a highly complicated array of several kinds of cells, capable of receiving light impulses, transforming them into neuronal membrane currents, and transmitting these in a meaningful way to central processing. Before it starts to develop, it is a small sheet of unconspicuous cells, which do not differ from other cells of the central nervous system. The chain of events which lead to the trans formation from this stage into that of highly specialized cells ready to fulfll a specific task, is usually called "differentiation. " Originally, this word indicated firstly the proc ess of divergence from other cells which were previously alike, and secondly, the change from an earlier stage of the same cello lt has become widespread practice to imply by the word "differentiation" also the acquisition of specific properties and capacities which are characteristic of a mature, Le. , specifically active, cello Every cell is active at any stage of development, but certain activities are shared by most cells (e. g. , the activities of preparing and accomplishing proliferation, that of initiating development, that of maintaining a certain level of metabolism), while there are others which are shared by only a small number of - originally relate- cells. In most cases these latter activities are acquired by the fmal steps of cellular development, the terminal "differentiation. " In the context of the present paper, the word "function" will refer to this latter type of specific activity.

History of Anatomy: An International Perspective is unique in its global approach to studying the development of human anatomy. Though it references widely known anatomists, such as Aristotle, Galen, and Bell, the book also pay homage to less famous contributors to the field and explains their findings. This comprehensive history of the morphology of humans serves as a useful guide to anatomists, anthropologists, physicians, surgeons, and anyone interested in the early history of medicine and surgery.

Biopsy pathology of the lymphoreticular system has been written primarily for diagnostic histopathologists although we hope that other workers in the field of lymphoreticular disease will find it of interest and value. With our primary readership in mind we have generously illustrated most sections of the book. Allillustrationsare of haematoxylin and eosin stained sections unless otherwise specified. Conceptual understanding of the histogenesis and interrelationship of non-Hodgkin's Iymphomas has been in a state of turmoil for over a decade. In more recent years immunological and immunocytochemical studies have clarified some problems although in other areas such as the T-celllymphomas histogenetic interrelationships are still far from clear. We are aware, therefore, that in writing this book we have been aiming at a moving target; nevertheless, we feel that the need for such a book, particularly amongst diagnostic histopathologists, outweighs the advan tage of waiting until all the t's are crossed and all the i's dotted."

Anthropocentricity and pragmatism seem to be the main reasons why pigeons have served as the "black boxes" of so many psychologists and neurobehaviorists during the past decade. Anthropocentricity, because at first glance pigeons show several strik ing features which bear a beautiful similarity to human systems in respects such as drinking, bipedality, territoriality, and apparently easy pursual of individual interests. Pragmatism, because of the suspected lesser complexity of the pigeon's system, which enables them to serve as good paradigms for human systems. For example, the visually guided grasping system of the beak could be used as a model for the visually guided grasping system of the tips of the thumb and forefinger in humans (personal communi cation, Zeigler). Other pragmatic reasons are the low cost of breeding these birds, their easy adaptation to experimental conditions, and their obvious capacity for learning and remembering. Although a closer and more critical examination largely undermines the anthropomorphic arguments, this has not diminished interest in the pigeon. In many studies on sensorimotor and motivational processes of hunger, thirst, and learning, pecking and drinking behavior serve as the systems on which the outcome of different black box systems is measured. Clear examples of this application are found in McFarland (1964, 1965), Dawkins (1966), Dawkins and Dawkins (1973), Goodman and Schein (1974), Machliss (1977), and Zeigler, Levitt, and Levine (1980)."

In the past decennia nonhuman primates have been increasingly used for research purposes in various scientific fields. Much interest has been focused on this group of animals in general and on the rhesus monkey in particular because of its close phylo genetic relationship with man. In some fields of research, however, such as embryology and microscopic anatomy, much less attention has been paid to nonhuman primates, probably because of the expense involved in the collection of the extensive material needed. On the other hand, teratological and experimental embryologic studies must be based upon a thorough knowledge of the normal ontogenesis since only in that way can a reliable distinction be made between normal and abnormal or induced develop ment. Each ontogenetic study essentially consists of a comparison of different deve lopmental stages. In most reports dealing with the development of individual organs or their subunits the material used is classified according to the estimated age or the length of the embryos. These criteria, however, are not valid, since considerable varia tion in developmental stage occurs between animals of the same age even between littermates and between animals of the same length. Therefore a method is needed for assigning embryos to successive developmental stages that are defmed on the basis of extemal and internal characteristics. This type of classification was elaborated by Stree ter (1942, 1945, 1948,1951), who arranged human embryos into developmental hori zons numbered XI through XXIII."

This highly regarded text is one of the most comprehensive reference works available on the topographical, functional and radiographic anatomy of the lumbosacral spine. Fully updated in this sixth edition, Clinical and Radiological Anatomy of the Lumbar Spine walks the reader through the structure, function and common disorders of the lumbar spine. It covers the basic anatomy of lumbar components, how the spine changes with age, clinical problems, and imaging. Internationally renowned author Nikolai Bogduk's thorough referencing and clear text bridge the gap between science and clinical presentation to provide practical, validated and clinically relevant information that will be invaluable for students and clinicians alike. Clearly written and accessible - brings the science to life Thoroughly and comprehensively referenced - can be used as a starting point for research High quality illustrations to support understanding Highly relevant to undergraduate and postgraduate courses in physiotherapy, pain medicine, chiropractic, and rehabilitation medicine New understanding of the causes and pathology of back pain Additional references reflect current literature New, colour illustrations of nerves Expanded radiographic anatomy chapter

In recent years the inferior olive and its projection to the cerebellum have attracted considerable interest. Numerous experimental anatomic and electrophysiologic studies have been undertaken, and much new information has been brought forward. Many apparently discordant observations have been reported however, and on many points the data obtained by the use of different methbds and approaches appear to be diffi cult to reconcile. Much of the interest in the olivocerebellar projection concerns the topographical localization within the projection. Particularly as a result of research in recent years the pattern of localization has turned out to be far more complex than previously be lieved. It was found useful, therefore, to attempt a review of the subject in the hope that a critical analysis of available observations might make it possible to obtain an integrated picture of the olivocerebellar projection and perhaps fmd some basic principles in the organization of this fiber system. As will be seen, our attempt has been only partly successful. There are still riddles that remain to be solved. In the present review attention will be focused on problems related to the locali zation within the olivocerebellar projection, particularly its anatomic aspects. An extensive review of the physiology of the inferior olive has been published recently by Armstrong (1974), who considers some anatomicophysiologic correlations as well. Physiologic fmdings will be referred to here mainly in relation to our main theme."

The afferent connections of the cerebellar cortex of the cat have been extensively in- vestigated by Alf Brodal and his collaborators using retrograde degeneration methods. These experiments (reviewed in Larsell and Jansen 1972) established that cerebellar corti- cal afferents arise from widespread areas of the brain stem and spinal cord. Brain stem nuclei shown to provide input to the cerebellar cortex included the pontine nuclei, the medial and descending vestibular nuclei, vestibular cell group x, the lateral reticular nucleus, the perihypoglossal nuclei, the paramedian reticular nucleus, the inferior olive, and the external cuneate nucleus. In addition, the red nucleus and certain of the raphe nuclei were thought to send fibers to the intracerebellar nuclei, but not to the cortex. With the advent of the horseradish peroxidase (HRP) technique, new information on the distribution and organization of cerebellar cortical afferents has recently be- come available. Thus Gould and Graybiel (1976) demonstrated that afferents to the cat cerebellar cortex arise from a previously undescribed lateral tegmental cell group at the level of the isthmus and from the intracerebellar nuclei, as well as from the classic precerebellar nuclei. Moreover, these studies showed that fibers from the vestibular nuclei, previously thought to be distributed only to the flocculonodular lobe and uvula, reach widespread areas of the cerebellar cortex. Experiments by other investi- gators have established that the cerebellar cortex of the cat receives afferents from cer- tain of the raphe nuclei (Shinnar et al. 1975; Taber Pierce et al.

The previous two editions of the "Human Nervous System "have been the standard reference for the anatomy of the central and peripheral nervous system of the human. The work has attracted nearly 2,000 citations, demonstrating that it has a major influence in the field of neuroscience. The 3e is a complete and updated revision, with newchapters covering genes and anatomy, gene expression studies, and glia cells. The book continues to be an excellent companion to the "Atlas of the Human Brain," and a common nomenclature throughout the book is enforced. Physiological data, functional concepts, and correlates to the neuroanatomy of the major model systems (rat and mouse) as well as brain function round out the new edition.
Adopts standard nomenclature following the new scheme by Paxinos, Watson, and Puelles and aligned with the Mai et al. "Atlas of the Human Brain" (new edition in 2007)Full color throughout with many new and significantly enhanced illustrationsProvides essential reference information for users in conjunction with brain atlases for the identification of brain structures, the connectivity between different areas, and to evaluate data collected in anatomical, physiological, pharmacological, behavioral, and imaging studies"

Studies on cell kinetics in untreated animals have for the most part been done on or gans in which many proliferating cells can be found. In general the proliferating cells have been identified either in histologic sections as mitoses or by autoradiography as labeled interphase cells following the injection of a labeled precursor of DNA, such as 3H_ or 14C-thymidine (TdR). A great many proliferating cells can be observed in the rat and mouse brain during the embryonic period and for a short time after birth, and many studies on cell kinetics have been performed for this phase of life. By contrast, very few proliferating cells are found in the brain of adult rodents (except for the subependymallayer, see below). As a result, only isolated studies have been done on cell kinetics during this period. Al though there is an increase in proliferating cells in adult animals which had been pre treated (e g. , by wounding, X-irradiation, viral infection, withdrawal of water), this proliferation too has not been investigated in detail. A number of studies have been done since 1959 on the proliferation of cells in the sub ependymal layer of the lateral ventricles of the forebrain. This cell type is well suited for such investigations because mitoses can be found there even in animals which are quite old. Since the studies ofLe blond and co-workers (Walker and Leblond 1958 ;Messier et al.

References ............................... 76 Subject Index ............................. 93 VIII Acknowledgments This study was funded by the Deutsche Forschungsgemeinschaft. I am indebted to Prof. Dr. W. Schlote for helpful advice and numerous discussions. I am also grateful to Dr. G. Kurz-Isler for her generous help in problems dealing with electron microscopy and to Mrs. B. Sabrowski for her careful preparation of the manuscript. The careful translation of T.C. Telger is gratefully acknowledged. The translation was financially supported by the Erwin Riesch Foundation. IX 1 Introduction One of the basic principles underlying the efficiency and adaptability of cellular meta bolism is the structural compartmentalization of the cell. Only through compartmenta lization can reaction components be kept apart prior to their reaction, isolated from other "reaction spaces" during the course of their reaction, and the reaction products incorporated into designated structures or transported to remote parts of the cell. Thus, the partitioning of the cellular substance into countless membranous spaces corresponds to the spatial segregation of reaction components, and the dynamics of intracellular membrane systems is an expression of ever-changing equilibrium condi tions and the continuous formation of new reaction spaces. It has been shown with some certainty that many of the processes in membrane dynamics can take place only with the aid of contractile proteins such as actin, myosin, and tubulin."