Over the last years, numerous studies have provided new insights into the structural and functional organization of the human cortical motor system. The data reviewed in this book indicate that striking similarities have been found between humans and non-human primates.   

Now in its seventh edition, Wheater's Functional Histology is designed to give students a working knowledge of histology, including the basic histological structures, tissue types and organ systems. You will learn to recognise the microscopic structure of normal human tissues and understand how this relates to function. The book shows you how to apply histology in a clinical context through coverage of common clinical conditions in each chapter. This must-have book is written clearly and concisely, designed for those studying histology for the first time. Packed with a wealth of illustrations and learning aids, it is a must-have for every medical and health science student. Concise and easy to digest text - easy to follow for those new to histology More than 900 high quality histology images and illustrations, plus detailed explanations to support understanding End of chapter review tables summarising important points Self-assessment questions and rationales to support exam preparation Appendix outlining the basics of microscopy and histological staining techniques Basic glossary An enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud More clinical correlation boxes More clinical images More questions added

The refereed proceedings of the Second International Workshop on Functional Imaging and Modeling of the Heart, FIMH 2003, held in Lyon, France in June 2003. The 29 revised full papers presented together with 2 invited papers were carefully reviewed and selected for presentation. The papers are organized in topical sections on anatomy extraction and description, modeling of the cardiac mechanics and functions, electro-physiology and electro- and magnetography, motion estimation, image registration and image analysis, and data acquisition and experimental and modeling issues.

The numerous and meticulously exposed findings are the very latest and of practical use for the cardiologist who is interested in new, morphologically-based diagnostics and the establishment of an exact anatomical basis for modern non-invasive therapy; for the radiologist who strives to obtain precise anatomical data, accurate and angiographical evaluations and diagnoses; for the cardiac surgeon, who strives, through precise and safe approaches in operations on the heart, to diminish surgical risks and increase the benefit of surgery to the patient. The review includes an great variety of new findings which relate to the greater (major) and smaller (minor) cardiac venous system and narrow a gap in the rather incomplete knowledge of the venous drainage of the human myocardium. A number of the results may help to achieve the success of the rather new technique of coronary sinus catheterization and reperfusion of the cardiac veins.

Visually engaging and easy to use, Human Histology: A Text and Atlas for Physicians and Scientists covers the normal histology of every organ in the human body. This book presents full-page high-definition photomicrographs for organs and tissues, followed by a compact and simple-to-read description of the structures identified on the micrographs, offering a clear, visual understanding of this complex subject. With over 300 outstanding images, this reference is an invaluable resource for every clinical researcher and pathologist in need of easily accessible, relatively simple but detailed enough information on normal histology of different organs systems. Due to its compact, but detailed layout, the volume is an excellent tool for medical board review and can be recommended for medical students and histology course directors.

This work is not an anatomical atlas nor textbook (like that of McAlpine and Anderson) nor an angiographical atlas (like that of Vlodaver et al.); it is a short and comprehensive survey of the many variations of the intrinsic cardiac vessels. The reader's attention is focused on the numerous structural details and peculiarities of the human coronary arteries. The many unique features have been revealed by meticulous dissection and present an excellent documentation. All in all, this study represents an up-to-date review of morphology of the coronary arteries.

Medical texts provide a powerful means of accessing contemporary perceptions of illness and through them assumptions about the nature of the body and identity. By mapping these perceptions, from their nineteenth-century focus on illness located in a biological body through to their 'discovery' of the psycho-social patient of the late twentieth century, a history of identity, both physical and psychological, is revealed.

This book is a concise summary of the present knowledge about skeletal muscle fibres. The fibre types aare characterized from different points of view. The difficulties and possibilities of classifying muscle fibres in distinct non-overlapping types are shown. A main emphasis is put on metabolic fibre typing by cytophotometry as well as the adaptability of a given fibre type to altered physiological and pathological conditions. Extensive analyses of several rat hindlimb muscles revealed regional differences of fibre properties within the muscles and showed the influence of ageing, myopathy, hypoxia, diabetes and Ginkgo biloba-treatment on the different fibre tyypes.

The studies presented in this monograph concentrate on the glycoconjugate characterisation of the mouse and human GALT and on the overlying follicle-associated epithelium (FAE), in order to identify their cell-specific carbohydrate residues.

Just because A&P is complicated, doesn't mean learning it has to be. Anthony's Textbook of Anatomy & Physiology, 21st Edition uses reader-friendly writing, visually engaging content, and a wide range of teaching and learning support to ensure classroom success. Focusing on the unifying themes of structure and function and homeostasis, author Kevin Patton uses a very conversational and easy-to-follow narrative to guide you through difficult A&P material. The new edition of this two-semester text has been updated to ensure you have a better understanding of how the entire body works together. In addition, you can connect with the textbook through a number of free electronic resources, including , an electronic coloring book, 3D animations, and more! Conversational writing style at a 11.7 reading level (the lowest available for 2-semester A&P books) makes text engaging and easy to understand. Updated Genetics chapter includes important advancements in that field. Updated content on osmosis revised to make it more simple and accurate. More than 1,400 full-color photographs and drawings illustrate the most current scientific knowledge and bring difficult concepts to life. Includes a unique color key to show color scheme that is used consistently throughout the book (for example, bones are off white, enzymes are lime green, nucleus is purple). UNIQUE! Consistent unifying themes, such as the Big Picture and Cycle of Life sections in each chapter, help you comprehend the interrelation of body systems and how the structure and function of these change in relation to age and development. Numerous feature boxes including: Language of Science and Language of Medicine, Mechanisms of Disease, Health Matters, Diagnostic Study, FYI, Sport and Fitness, and Career Choices provide interesting and important sidebars to the main content. Quick Check Questions reinforce learning by prompting you to review what you've just read. Chapter outlines, chapter objectives and study tips begin each chapter. NEW! Integrative Unit Closers ties together content with integrative critical thinking questions. NEW! Additional and updated Connect It! boxes (renamed from A&P Connect) provide relevant "bonus" information for you to explore. NEW! All-new animations in the text and on Evolve companion site help you understand the reasoning and knowledge behind each answer and assist with recalling correct answers.

The alternation between urine retention and discharge several times daily from a nappy to the cessation ofall vital functions only becomes the subject baby's first wet of greater attention if the harmony of the structure and function of the bladder is disturbed. Functional disturbances of the lower urinary tract are not only of great socio-economic importance, but are also a considerable personal burden for the patient. Hence urinary incontinence is rightly classified as a severelydisabling illness (Hauri 1985). Opinions still differ regarding the morphological basis ofurinary continence.The Terminologia Anatomica (1998) defines a musculus sphincter urethrae internus (in- ternal urethral sphincter) and a musculus sphincter urethrae externus (external ure- thral sphincter),which in the older nomenclature were known as musculus sphincter vesicae and musculussphincterurethrae,respectively.The internal urethral sphincter isascribed apurelyinvoluntaryandthe externalurethralsphincterapurelyvoluntary innervation. The significance of the musculature of the pelvic floor for maintaining urinarycontinence has notyetbeen ascertained. Duringnumerous urologicaloperations (forinstancetransurethralresectionofthe prostate and bladder neck incisions), the only involuntarily innervated sphincter at the collum vesicae,the internalurethralsphincter,is partiallyorcompletelydestroyed (Fig. 27C,D).All the patients remain continent as long as the externalurethral sphinc- ter remains intact.Howcan apurelyvoluntarilyinnervated sphincterlikethe external urethral sphincter ensureconstant continence in such cases? Improving the continence rate after radical surgery is a key topic of urological research. The incontinence rate after radical prostatectomy is still between 8.1% (third-degree incontinence) and41.4% (first- to second-degree incontinence; Rudyet al. 1984; Igel et a1.1987; Schroderand Ouden 1992).

The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. It covers both basic and up-to-date material on normal and defective chromosomes. This new edition is particularly strengthened by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects. The mapping and molecular analysis of chromosomes is one of the most exciting and active areas of modern biomedical research, and this book will be invaluable to scientists, students, technicians and physicians with an interest in the function and dysfunction of chromosomes.

From the reviews of the third edition
"Each word "tells" in this concise gem of a human cytogenetics text...Superb organization makes this an excellent text...for any cytogenetics course."
- American Journal of Human Genetics"

...the leading textbook in English on human cytogenetics."
- Cell

For courses in anatomy & physiology for health professions. An engaging journey through the human form Anatomy & Physiology for Health Professions: An Interactive Journey is a hands-?on, visually rich study companion guiding allied health and nursing students through human body systems and clinical applications. With a conversational tone, relatable analogies, and light humor, the authors provide an enjoyable read reinforcing lasting connections. The 4th edition presents the latest research and clinical applications in abnormal human A&P, plus new visual aids and practice opportunities. A student workbook, available separately, offers interactive exam prep resources, including concept maps and crossword puzzles. Also available with MyLab Health Professions MyLab (TM) is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools and a flexible platform, MyLab personalizes the learning experience and improves results for each student. Developed for allied health students and instructors, MyLab Health Professions supports students' mastery and application of the skills they'll need for a successful career in health care. Note: You are purchasing a standalone product; MyLab does not come packaged with this content. Students, if interested in purchasing this title with MyLab, ask your instructor to confirm the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and MyLab, search for: 0135188865 / 9780135188866 Anatomy & Physiology for Health Professions: An Interactive Journey Plus MyLab Health Professions with Pearson eText -- Access Card Package, 4/e Package consists of: 0134876814 / 9780134876818 Anatomy & Physiology for Health Professions: An Interactive Journey, 4/e 0134880226 / 9780134880228 MyLab Health Professions with Pearson eText -- Access Card -- for Anatomy & Physiology for Health Professions, 4/e

Preparatory work for this monograph started in 1988 and 1989. The motive was provided by certain incongruities in the illustra- tion of descensus testis for the chapter "Entwicklung der Genital- organe" in the book Humanembryologie. The evoked discussion was reason enough for our own re- search on the phenomenon and uncertainties of testicular des- cent in human. The basis ofthese investigations was the collection of human embryos founded by Prof. Hinrichsen in 1970 at the Department of Anatomy and Embryology, Ruhr-University Bo- chum. The preparation of the material used in this paper has been done with the help of many staff members of our department to whom we feel obliged. We are especially indebted to Prof. Hin- richsen who prepared the foetuses and took the first steps of this project. We wish also to acknowledge Dr. Heinz Jiirgen Jacob for careful fixation and microdissection of specimens intended for scanning electron microscopy. Weare also grateful to Mrs. Vera Mannheim for her involvement and her sensitivity in making scanning electron micrographs, and Mrs. Antje Jaeger for provid- ing an expert and skilful photographic technique especially in the setting up of micrographs. Our thanks are also due to Mrs. Marion Kohn for skilful technical assistance and to all those technical assistants who worked in our department during the past 25 years and who were engaged in providing the serial sec- tions. The English text has been thoroughly revised by Prof. Dr.

Spotting a face in a crowd is so easy, you take it for granted. But how you do it is one of science's great mysteries. Vision is involved in nearly a third of everything a brain does and explaining how it works reveals more than just how we see. It also tells us how the brain processes information - how it perceives, learns and remembers. In We Know It When We See It, pioneering neuroscientist Richard Masland covers everything from what happens when light hits your retina, to the increasingly sophisticated nerve nets that turn that light into knowledge, to what a computer algorithm must be able to do before it can truly be called 'intelligent'. It is a profound yet accessible investigation into how our bodies make sense of the world.

The objective of the present work is to review the existing literature on joint incongruity, cellular mechano-transduction, and computer simulations of mechano-adaptive bone remodelling, and to quantitatively assess the effect of incongruity on load transmission and subchondral mineralisation. Idealised computer models of incongruous joints and a specific anatomically based model of the humero-ulnar joint articulation were analysed with the finite element method, and the results directly compared with experimental and morphological data.

What is the function of the mammillary body? Which information is passed through the cuneate fasciculus or the internal arcuate fibers? Which hormones are produced by the paraventricular hypothalamic nucleus? Which nerves and vessels run through the jugular foramen? Which parts of the body are innervated by the accessory nerve? Which cortical regions are affected by a dysfunction of the central sulcus artery?These are frequently asked questions to which a short and precise answer is seldom found in textbooks or other scientific works. These questions - and more - are now answered in the long-awaited Dictionary of Human Neuroanatomy. It will be a useful companion for everyone looking for precise and functional definitions of terms in the field of neuroanatomy, and is absolutely essential for those studying neuroanatomy, and for quick reference.

5 Function of Splenic Compartments . . . . . . . . . . . . . . . 45 5. 1 Splenic White Pulp Compartments during Primary T Cell-Dependent Antibody Responses against Protein Antigens . . . . . . . . . . . . . . . . . . . . . . . . . 46 5. 1. 1 Priming of CD4+ Helper T Cells by Dendritic Cells in the PALS . . . . . . . . . . . . . . . . . . . . 46 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 5. 1. 1. 1 5. 1. 2 Interaction of Primed CD4+ T Cells with Antigen-Specific B Cells in the PALS and Formation of Extrafollicular Foci . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 5. 1. 2. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 5. 1. 3 Formation of Germinal Centres . . . . . . . . . . . . . . . . . . . 50 5. 1. 3. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5. 1. 4 Localisation of Memory B Cells in the Marginal Zone . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5. 1. 4. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 5. 2 Function of the Marginal Zone during Primary Antibody Responses against T Cell-Independent Type 2 Antigens . . . . . . . . 57 5. 2. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Function of the Red Pulp . . . . . . . . . . . . . . . . . . . . . . . . . 59 5. 3 5. 3. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 5. 4 Role of the Spleen in CD8+ Cytotoxic T Cell Responses . . . . . . . . . . . . . . . 61 5. 4. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 The Spleen, Natural Killer Cells 5. 5 and Gamma/Delta T Cells . . . . . . . . . . . . . . . . . . . . . . . . 62 5. 5. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 6 Recirculation of Lymphocytes Through the Spleen . . 65 6. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 7 The Role of Cytokines and Chemokines in the Development of Splenic Compartments . . . . . . 69 7. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 8 Unsolved Problems of Human Splenic Structure and Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 VI 8. 1 Arterial Blood Supply to the Splenic Follicles and to the Perifollicular Zone. . . . . . . . . . . . . . . . . 73 . . . . 8. 1. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 8.

This classification represents a project aimed at bringing together the variety of ways thymic epithelial neoplasms have been classified. It focuses on their growth characteristics, and cytoarchitectural features . The classification, though restricted to the thymic region rather than the mediastinum in general, also covers neuroendocrine, germ cell, lymphoid, and stromal tumours, as well as tumour-like lesions and the neck tumours of thymic or related branchial pouch derivation.

The 1973 WHO classification of bladder tumours anticipated a probable need for eventual revision of the criteria for diagnosing papillary and flat bladder neoplasia. A workshop sponsored by the WHO consisting of pathologists, urologists, cytologists, oncologists and basic scientists interested in bladder tumours addressed this subject, and after a follow- -up meeting sponsored by the International Society of Urological Pathology, the classification and terminology used in this text were agreed upon. A major change is in the introduction of a new category: papillary urothelial neoplasm of low malignant potential. Many of the tumours previously designated as papillary transitional cell carcinoma, grade I now fall into that category. Another major change is in the designation of flat lesions, and this includes a definition of carcinoma in situ. Furthermore, a number of variant forms of urothelials carcinomas are included as well as new entities not recognized when the 1st edition was issued.

This book reflects practical approaches to answering a variety of biological and medical questions using DNA fingerprinting and genetic profiling in a broad sense that also includes statistical evaluation of the data. It has been written for biology, biochemistry and medical students, graduates, postdoctoral fellows, academic teachers and for all researchers in the theoretical and applied sciences wherever genetic identification and relationship analysis are required.

Since the 1980s, ankle arthroplasty has been considered a dubious treatment for painful and degenerated joints. Many of the concerns that existed previously have been solved today. Prosthetic replacement of other joints also took a long time before reaching their present successful status. This is the first book to deal with ankle arthroplasty. International experts have given their opinion on (i) the kinematics of the ankle; (ii) the basics of replacing the ankle joint; and (iii) the current status of several modern ankle-prosthesis designs. A better understanding of the ankle kinematics, alignment techniques and biological stabilisation and the results of newer designs have changed the former attitude worldwide. The content of this book bears evidence for this change in opinion.

}This eloquent book takes us on a spell-binding journey into the workings of our bodies in health and disease. Dr. Charles A. Pasternak captivates us with his vivid and even poetic explanations of what keeps us healthy and vital, and what tears away at our health. He possesses the gift for rendering complex topics clear and lyrical, as in the ways our molecules interact with one another to decide the fate of our heart, brain, and lungs---whether we live or die.Why does disease rear its ugly head? Why does cancer take hold in some of us and pass by others? What roles do nutrition and stress play in determining our chances for a long, fulfilling life? Can we hold our eventual demise at bay by trying novel drugs and therapies? Dr. Pasternak also explores to what extent the illnesses we sufferand even our level of intelligenceare dependent on the genes we inherit from our parents, or the food we eat, or even the environment we inhabit. The story of our bodies is a true saga that has never before been so engrossingly told. }