Histological techniques form the basis of many areas of research, yet they can often be poorly understood. Aimed at postgraduate students and those at an early stage of their career, this title provides a detailed and comprehensive introduction to histological techniques. With detailed images and slides, this book provides a unique overview of the area while providing the reader with a guide to how to use and incorporate histological techniques within their own research. Written by experts working within the field, this book is an essential handbook for anyone wanting to learn more about histological methods and how to apply them successfully.

This chart shows posterior view of the pharynx and shows sagittal section, deep side view, and tonsils. Illustrations provide various views of the larynx: anterior, posterior, side, cut-away side, top, and sagittal section. The chart also shows laryngeal function, including phonation, inspiration, and deep inspiration.

This book uniquely presents conceptual understanding as well as advancements in the field of endocrinology. It emphasizes the harmonization between the function and the structure of different endocrine glands in the body. The book's initial chapters introduce hormones' biological synthesis, structure, function, and signaling pathways. The subsequent chapters examine the functional relationship between hypothalamus and pituitary gland and its leading and regulating roles on other endocrine and non- endocrine organs. A separate chapter discusses the synergistic functions of adrenal glands and pineal gland in the circadian rhythm and analyze the role of corticoids in carbohydrate and mineral metabolism. Furthermore, the book addresses the role of growth hormones, prolactin, gonads regulating hormones, adrenocorticotropin, thyroid hormones, parathormone, gluco- and mineral corticoids, insulin and glucagon, Physiology of bone remodeling is presented with the role of parathyroid glands, C cells and vitamin D explaining the bone as an endocrine organ. The regulation of male and female reproductive functions is represented well. Lastly, the book reviews the novel endocrine role and metabolic aspects of adipose tissue as an endocrine tissue and its relationship to inflammatory diseases, insulin resistance and many metabolic disorders. The book introduces key parts for endocrine's stem cell in each gland is discussed in term of its survival, proliferation, migration, homing, differentiation and its regeneration and remodeling roles.

Mechanisms of Taste Transduction introduces a number of topics essential to a complete understanding of taste. These topics range from the control of food intake to the biophysical mechanisms of transduction and the design of food flavors in the food industry. The responses and organization of special sensory pathways are described in regard to their development, morphology, composition, electrophysiological and biochemical responses. Details are presented at several levels to appeal to researchers in molecular biology, membrane biophysics, human psychophysics, neuroanatomy, and chemistry. Current research is described in the context of what preceding studies have revealed, and the chapter authors are among today's most active and highly respected researchers in the field of chemical senses.

Think you know your cranium from your clavicle? Tibia from your trachea? Think again... Test your brain, solve riddles and learn about how the body works with this unique puzzle book using illustrations from Gray's Anatomy. Divided into different sections of the body, the Gray's Anatomy Puzzle Book takes the medical reference classic as its starting point for puzzles, riddles and general knowledge questions that will test your wits and challenge your brain. Learn more about the body in an easy and fun way with questions that vary in difficulty, from easy to fiendish, and are suitable for those with little knowledge of the human body, or those in the know who are interested in testing themselves with a new challenge. Puzzle types include: Sudoku Anagrams Crosswords Encoded pairs Missing letters Secret codes Lettermorphosis Follow visual clues and apply logic to reveal fascinating facts from medical history and learn about how our amazing bodies function.

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research

A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases.

• Classic anatomical atlases • Detailed labeling of the earliest phases of prenatal neurological development • Intended for neuroanatomists, developmental biologists and clinical practitioners. • Persistent relevance - brain development is not going to change.

Completely revised and updated, The Human Body in Health & Disease, 8th Edition makes it easier to understand how the body works, both in typical conditions and when things change. Its easy-to-read writing style, more than 500 full-color illustrations, and unique Clear View of the Human Body transparencies keep you focused on the principles of anatomy, physiology, and pathology. Key features are Connect It! with bonus online content, concept maps with flow charts to simplify complex topics, and chapter objectives and active learning sections. From noted educator Kevin Patton, this book presents A&P in a way that lets you know and understand what is important. More than 500 full-color photographs and drawings illustrate the most current scientific knowledge and bring difficult concepts to life. The beautifully rendered illustrations are unified by a consistent color key and represent a diversity of human identity. A conversational writing style is paired with "chunked" content, making it easy to read and comprehend. UNIQUE! Creative page design uses color backgrounds to organize information in a more inviting, accessible, and motivating way to enhance learning. UNIQUE! The full-color, semi-transparent Clear View of the Human Body permits the on-demand virtual dissection of typical male and female human bodies along several body planes. This 22-page insert contains a series of transparencies that allows you to peel back the layers of the body anterior-to-posterior and posterior-to-anterior. Language of Science/Language of Medicine word lists at the beginning of chapters present key terms, pronunciations, and word-part translations to help you become familiar with new and complex terminology. Animation Direct feature throughout the text guides you to state-of-the-art animations on the companion Evolve website to provide dynamic visual explanations of key concepts. Active Concept Maps offer animated, narrated walk-throughs of concept maps to clarify the text narrative and provide you with clear examples of how to build your own concept maps.

This is the ninth of 15 short atlases reimagining the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition focuses on the second trimester of human brain development. Serial sections from specimens between 160mm and 170mm are illustrated and annotated in great detail, together with 3D reconstructions. An introduction and glossary summarize these earliest stages of human central nervous system development. Key Features • Classic anatomical atlases • Detailed labeling of the earliest phases of prenatal neurological development • Intended for neuroanatomists, developmental biologists and clinical practitioners. • Persistent relevance - brain development is not going to change.

Remarkable atlas provides exceptionally detailed, clinically relevant anatomic knowledge! Thieme Atlas of Anatomy: General Anatomy and Musculoskeletal System, Third Edition, Latin Nomenclature, by renowned educators Michael Schuenke, Erik Schulte, and Udo Schumacher, along with consulting editors Nathan Johnson and Hugo Zeberg, expands on the award-winning prior editions with updated spreads and added information on joints, muscle actions, and functional muscle groups. Organized by region, the book begins with an introduction on basic human embryology and development and an overview of the human body. Subsequent general anatomy chapters explore surface anatomy, the bones, joints, muscles, vessels, lymphatic system and glands, and general neuroanatomy. The next section delineates the trunk wall, functional musculature, and the neurovascular system, while the last two sections are dedicated to the upper limb and lower limb. Key Features Labels and anatomic terminology are in Latin nomenclature Nearly 2,100 images including extraordinarily realistic illustrations by Markus Voll and Karl Wesker, X-rays, MRIs, CT scans, diagrams, tables, and descriptive text provide an unparalleled wealth of information about muscle structure and bones Musculoskeletal, vascular, and nervous system structures are presented systematically first, then topographically, thereby supporting classroom learning and active laboratory dissection Emphasizes important relationships between anatomic structure and function in addition to introducing clinical applications, providing knowledge trainees can apply in practice Online images with "labels-on and labels-off" capability are ideal for review and self-testing This visually stunning atlas is a must have for medical, allied health, and physical therapy students, instructors, and practicing physical and massage therapists. It is also a wonderful anatomic reference for professional artists and illustrators. The THIEME Atlas of Anatomy series also includes two additional volumes, Internal Organs and Head, Neck, and Neuroanatomy. All volumes of the THIEME Atlas of Anatomy series are available in softcover English/International nomenclature and in hardcover with Latin nomenclature. This book includes complimentary access to a digital copy on https://medone.thieme.com.

This tenth of 15 short atlases reimagines the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition focuses on the second trimester of human brain development. Serial sections from specimens between 190mm and 210mm are illustrated and annotated in great detail, together with 3D reconstructions. An introduction and glossary summarize these earliest stages of human CNS development. Key Features • Classic anatomical atlases • Detailed labeling of the earliest phases of prenatal neurological development • Appeals to neuroanatomists, developmental biologists and clinical practitioners. • Persistent relevance - brain development is not going to change

• Classic anatomical atlases • Detailed labeling of the earliest phases of prenatal neurological development • Intended for neuroanatomists, developmental biologists and clinical practitioners. • Persistent relevance - brain development is not going to change.

This tenth of 15 short atlases reimagines the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition focuses on the second trimester of human brain development. Serial sections from specimens between 190mm and 210mm are illustrated and annotated in great detail, together with 3D reconstructions. An introduction and glossary summarize these earliest stages of human CNS development. Key Features • Classic anatomical atlases • Detailed labeling of the earliest phases of prenatal neurological development • Appeals to neuroanatomists, developmental biologists and clinical practitioners. • Persistent relevance - brain development is not going to change

Clinical Neuroanatomy offers an extensive review of higher cortical behavioral functions and their anatomical substrates. The book begins with a review of the basic internal and external morphology, major nerve and fiber tracts, behavioral correlates, and clinical syndromes associated with spinal cord, brain stem, and cerebellum, reacquainting readers with the functional anatomy of the subtentorial central nervous system. The central chapters offer more detailed, integrated, and, at times, theoretical models of cortical systems and their internal organization. Additional chapters highlight vascular anatomy and neurochemical systems. Nearly 300 illustrations help identify key structures and pathways, as well as providing clinical and pathological examples.

Guidelines and Gamuts in Musculoskeletal Ultrasound

edited by Rethy K. Chhem, M.D., Ph.D. and Etienne Cardinal, M.D.

This practical guidebook provides an overview of the capability of musculoskeletal ultrasonography to assess disorders of the shoulder, elbow, wrist, hands, hip, knee, ankle, and foot.

Each chapter provides a concise overview of anatomical structure, clinical indications, scanning techniques, and possible normal and abnormal findings. Guidelines and Gamuts in Musculoskeletal Ultrasound features a highly visual and easily accessible format that makes great use of tables, schematic diagrams, gamuts, and representative images.

Individual chapters address such topics as:

• Rotator and nonrotator cuff shoulder disorders
• Disorders of the elbow, wrist, adult hip, knee, and ankle
• Muscle and fascia
• Bone
• Soft tissue masses: an algorithmic approach
• Soft tissue masses in pediatrics.

Guidelines and Gamuts in Musculoskeletal Ultrasound is an indispensable reference for radiologists and orthopedists and will also be of interest to rheumatologists, physical therapists, and physicians in sports medicine.

Clinical psychologists and neuropsychologists are traditionally taught that cognition is mediated by the cortex and that subcortical brain regions mediate the coordination of movement. However, this argument can easily be challenged based upon the anatomic organization of the brain. The relationship between the prefrontal cortex/frontal lobes and basal ganglia is characterized by loops from these anterior brain regions to the striatum, the globus pallidus, and the thalamus, and then back to the frontal cortex. There is also a cerebrocerebellar system defined by projections from the cerebral cortex to the pontine nuclei, to the cerebellar cortex and deep cerebellar nuclei, to the red nucleus and then back to thalamus and cerebral cortex, including all regions of the frontal lobes. Therefore, both the cortical-striatal and cortical-cerebellar projections are anatomically defined as re-entrant systems that are obviously in a position to influence not only motor behavior, but also cognition and affect. This represents overwhelming evidence based upon neuroanatomy alone that subcortical regions play a role in cognition. The first half of this book defines the functional neuroanatomy of cortical-subcortical circuitries and establishes that since structure is related to function, what the basal ganglia and cerebellum do for movement they also do for cognition and emotion.

The second half of the book examines neuropsychological assessment. Patients with lesions restricted to the cerebellum and/or basal ganglia have been described as exhibiting a variety of cognitive deficits on neuropsychological tests. Numerous investigations have demonstrated that higher-level cognitive functions such as attention, executive functioning, language, visuospatial processing, and learning and memory are affected by subcortical pathologies. There is also considerable evidence that the basal ganglia and cerebellum play a critical role in the regulation of affect and emotion. These brain regions are an integral part of the brain s executive system. The ability to apply new methodologies clinically is essential in the evaluation of disorders with subcortical pathology, including various developmental disorders (broadly defined to include learning disorders and certain psychiatric conditions), for the purpose of gaining greater understanding of these conditions and developing appropriate methodologies for treatment.

The book is organized around three sources of evidence:

1. neuroanatomical connections;
2. patients with various disease processes;
3. experimental studies, including various imaging techniques.

These three sources of data present compelling evidence that the basal ganglia and cerebellum are involved in cognition, affect, and emotion. The question is no longer if these subcortical regions are involved in these processes, but instead, how they are involved. The book is also organized around two basic concepts: (1) the functional neuroanatomy of the basal ganglia and the cerebellum; and (2) how this relates to behavior and neuropsychological testing.

Cognitive neuroscience is entering a new era as we recognize the roles of subcortical structures in the modulation of cognition. The fields of neuropsychology, cognitive psychology, neuropsychiatry, and neurology are all developing in the direction of understanding the roles of subcortical structures in behavior. This book is informative while defining the need and direction for new paradigms and methodologies for neuropsychological assessment. "

This book focuses on human anatomy and medicine and specifically on both muscular and skeletal birth defects in humans with trisomy. Moreover, this book also deals with Down syndrome, which is one of the most studied human syndromes and, due to its high incidence and the fact that individuals with this syndrome often live until adulthood, is of special interest to the scientific and medical community. This new line of inquiry is addressed to a wide audience, including medical researchers, physicians, surgeons, medical and dental students, pathologists, and pediatricians, among others, while also being of interest to developmental and evolutionary biologists, anatomists, functional morphologists, and zoologists.

New biological techniques and a revival of interest in both acute and chronic wound healing have led to an enormously improved understanding of the cellular and chemical complexities of the healing process. Exciting developments in the evolution of epidermal biology are creating new opportunities for research and clinical applications in wound healing. Edited by an expert team of researchers and clinicians, The Epidermis in Wound Healing combines current information with the latest research results to provide a complete picture of the most recent advances in the field. The book focuses on biological advances that improve knowledge and stimulate development in wound therapy. The chapter authors address quantifying repair in the epidermis, biological and clinical elements of wound healing, state-of-the-art approaches to understanding and treating wounds, and gene therapy during wound repair. A discussion on the underlying chemistry of acute and chronic healing describes the special challenges presented by chronic wounds. Featuring the most up-to-date information available, the book chronicles the progress and practices in the field of wound therapy over the past 30 years. This reference will be an essential tool in the generation of innovations and applications in epidermal biology.

The importance of measurements for the proper assessment of human locomotion is increasingly being recognized. The fields of application encompass both healthy and pathological locomotion as encountered in rehabilitation medicine, orthopedics, kinesiology, sports medicine, and the like. Measurement of Human Locomotion provides an up-to-date description of the instrument systems used for measurement of: kinematics of human movement; kinetic quantities experienced by the human body in contact with the ground; and, myoelectric changes associated with locomotor activity. Physical principles behind the operation of various measurement systems are emphasized, as well as signal processing issues that must be addressed in order to obtain and use quantitative measurement variables in biomechanics. The book explains how measurement data are acquired, processed and presented to the user in the environment of a modern, computer-based laboratory. The ultimate aim is to contribute to the processes of the diagnosis and treatment of locomotion disorders. The purpose of Measurement of Human Locomotion is to provide a concise but comprehensive presentation of the systems used for the measurement of human locomotion, with a view to the assessment and diagnosis of the phenomenon.

Proteins of Iron Metabolism presents a clear picture of the structure and function of the main proteins involved in iron metabolism. The book gives you a detailed description of the structure and function of each protein, and discusses the structure and regulation of the corresponding genes in parallel. It supplies an analysis of the differential expression and regulation of these proteins. Numerous figures offer an integrated view of iron metabolism at the level of various tissues. The book delineates the mechanisms controlling cellular iron metabolism and shows how these mechanisms adapt to the differential and peculiar iron need of different cell types. Each chapter contains extensive bibliographical information providing a wide reference to the literature. The comprehensive coverage of the advances in understanding the mechanisms controlling cellular iron metabolism, especially at the molecular level, found in this book will give you insight into the regulation of iron metabolism. Proteins of Iron Metabolism fills the need for a clearly written, comprehensive review of the latest research, putting every thing you need in one easy-to-use resource.

Lippincott (R) Connect Featured Title Purchase of the new print edition of this Lippincott (R) Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments. The go-to tool for mastering histology, Gartner & Hiatt's Atlas and Text of Histology, 8th Edition, equips medical, dental, allied health, and biology students with a concise review of all of the major tissue classes and body systems in an engaging approach optimized for superior classroom and clinical success. A consistent presentation combines relevant text and detailed photomicrographs to facilitate understanding and provide valuable review for in-class and licensing examinations. Helpful explanatory text in each chapter details Histophysiology, Clinical Considerations, Summaries of Histologic Organization, and more, accompanied by more than 700 vivid, full-color, high-quality images. NEW! Streamlined organization aligns relevant text, figures, and Clinical Considerations in one place to help students study most effectively. NEW! Clinical vignette-style review questions provide valuable self-assessment and board exam preparation. More than 700 images - including colorful photomicrographs and illustration as well as clear electron micrographs - clarify relevant structures and anatomic relationships. Tissues That Resemble Each Other appendix hones students' ability to distinguish commonly confused tissues. Clinical Considerations demonstrate the link between histology and pathophysiology. Chapter Outlines and Summaries of Histologic Organization keep students focused on key concepts. Histologic Techniques chapter elucidates various stains and techniques. Abundant tables consolidate related topics for fast, efficient review. Lippincott (R) Connect features: Full access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience. Carefully curated resources, such as interactive diagrams, audio and video tutorials, and self-assessment, all designed to facilitate further comprehension. Lippincott (R) Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can: Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics. Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material. Annotate and highlight key content for easy access later. Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page.

The genome's been mapped.
But what does it mean?

Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.

"Genome" offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.