For students and clinical professionals who are learning anatomy, participating in a dissection lab, sharing anatomy knowledge with patients, or refreshing their anatomy knowledge, the Netter Atlas of Human Anatomy illustrates the body, system by system, in clear, brilliant detail from a clinician's perspective. Unique among anatomy atlases, it contains illustrations that emphasize anatomic relationships that are most important to the clinician in training and practice. Illustrated by clinicians, for clinicians, it contains more than 550 exquisite plates plus dozens of carefully selected radiologic images for common views. Presents world-renowned, superbly clear views of the human body from a clinical perspective, with paintings by Dr. Frank Netter as well as Dr. Carlos A. G. Machado, one of today's foremost medical illustrators. Content guided by expert anatomists and educators: R. Shane Tubbs, Paul E. Neumann, Jennifer K. Brueckner-Collins, Martha Johnson Gdowski, Virginia T. Lyons, Peter J. Ward, Todd M. Hoagland, Brion Benninger, and an international Advisory Board. Offers system-by-system coverage, including quick reference notes on structures with high clinical significance in common clinical scenarios and a muscle table appendix. Contains new illustrations by Dr. Machado including clinically important areas such as the pelvic cavity, temporal and infratemporal fossae, nasal turbinates, and more. Features new nerve tables devoted to the cranial nerves and the nerves of the cervical, brachial, and lumbosacral plexuses. Uses updated terminology based on the second edition of the international anatomic standard, Terminologia Anatomica, and includes common clinically used eponyms. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Provides access to extensive digital content: every plate in the Atlas?and over 100 bonus plates including illustrations from previous editions?is enhanced with an interactive label quiz option and supplemented with "Plate Pearls" that provide quick key points of the major themes of each plate. Digital content also includes over 300 multiple choice questions and other learning tools. Also available: . Netter Atlas of Human Anatomy: Classic Regional Approach-Same content as the systems approach, but organized traditionally, body region by body region. Both options contain the same table information and same 550+ illustrated plates painted by clinician artists, Frank H. Netter, MD, and Carlos Machado, MD.

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research

This detailed volume for the first time explores techniques and protocols involving quantitative imaging flow cytometry (IFC), which has revolutionized our ability to analyze cells, cellular clusters, and populations in a remarkable fashion. Beginning with an introduction to technology, the book continues with sections addressing protocols for studies on the cell nucleus, nucleic acids, and FISH techniques using an IFC instrument, immune response analysis and drug screening, IFC protocols for apoptosis and cell death analysis, as well as morphological analysis and the identification of rare cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Imaging Flow Cytometry: Methods and Protocols will be a critical source for all laboratories seeking to implement IFC in their research studies.

This is by far the most exhaustive biography on Niels Stensen, anatomist, geologist and bishop, better known as "Nicolaus Steno". We learn about the scientist's family and background in Lutheran Denmark, of his teachers at home and abroad, of his studies and travels in the Netherlands, Belgium, France, Italy, Austria, Hungary, Bohemia and Germany, of his many pioneering achievements in anatomy and geology, of his encounters with Swammerdam, Malpighi and with members of the newly established Royal Society of London and the Accademia del Cimento in Florence, and with the philosopher Spinoza. It further treats Stensen's religious conversion. The book includes the full set of Steno's anatomical and geological scientific papers in original language. The editors thoroughly translated the original Latin text to English, and included numerous footnotes on the background of this bibliographic and scientific treasure from the 17th century.

Offering a targeted, concise approach to clinical anatomy, Netter's Clinical Anatomy, 5th Edition, is a portable, easy-to-read text that bridges normal anatomy to common clinical conditions. It features nearly 600 superb illustrations by Drs. Frank H. Netter and Carlos Machado that provide essential descriptions of anatomy, embryology, and pathology to help you understand their clinical relevance. Authored by John Hansen, PhD, an Honored Member of the American Association of Clinical Anatomists, this visually stunning text covers and reviews the sizable area of human anatomy and pathology in a quick, easy-to-grasp format. Nearly 600 Netter and Machado illustrations provide essential depictions of anatomy, embryology, and pathology to help you quickly learn and understand through visuals. Every clinical correlation is illustrated-more than 200 in all. Clinical Focus boxes present hundreds of illustrated clinical correlations that bridge anatomy to pathophysiology, and Features and Characteristics boxes explain the relation between structure and function. Muscle/Ligament/Joint tables summarize attachment points, actions, and other key information related to each structure. Uses updated terminology based on the second edition of the international anatomic standard, Terminologia Anatomica, and content is aligned with Netter Atlas of Human Anatomy, 8th Edition. Both USMLE-style review questions and short answer questions online help you gauge your mastery of the material and assess areas in need of further study. Other study tools include bonus clinical focus boxes, and 3D models. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Evolve Instructor site with an image bank of clinical correlates is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.

Anatomy and Physiology is a complex subject spanning many health science disciplines. Principles of Anatomy and Physiology has always been recognized for its pioneering homeostatic approach to learning the subject.

This International Adaptation of the 16th edition combines exceptional content and outstanding visuals for a rich and comprehensive classroom experience and continues to set the standard for the discipline. It has been paired with a comprehensive Study Guide, offering a thoughtfully designed course in Anatomy and Physiology.

Highly regarded authors, Jerry Tortora and Bryan Derrickson motivate and support learners at every level, from novice to expert, and equip them with the skills they need to succeed in this class and beyond.

What’s new?:

• Packaged as a set, comprising the textbook and single-colour study guide
• The study guide is designed to reinforce the learning from the textbook and build relevance to the concepts studied. It comprises:Chapter Review and features such as Clinical Connection, Disorders, and Medical Terminology; Self-Quiz questions (with solutions); Solutions to Figure Questions

Roiger and Bullock's unique pedagogical and visual approach helps students make the important connections between systems and learn how the body functions normally in homeostasis, and how disruption of homeostasis leads to disease and disorder. With a straightforward, engaging writing style, the authors explain difficult concepts in the context of routine activities, making concepts easier to grasp. Measurable learning outcomes throughout the textbook, workbook, and digital learning and assessment program help direct students through the content so there are no surprises. Anatomy, Physiology, Disease requires no prior knowledge of chemistry or cell biology, and is designed for an anatomy and physiology course or an anatomy, physiology, and pathology course. It is neither too high nor too low and can be customized to accommodate the organization of individual courses.

"Autophagy in Health and Disease" offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, "Autophagy in Health and Disease" presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information.
Discusses current understanding of the roles of autophagy in health and diseaseCovers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

The intimate relationship between form and function inherent in the design of animals is perhaps nowhere more evident than in the musculoskeletal system. This book, about how function determines form, addresses the role of mechanical factors in the development, adaptation, maintenance, aging, and repair of skeletal tissues. The authors refer to this process as mechanobiology and develop their theme within an evolutionary framework. They show how degenerative disorders such as arthritis and osteoporosis are regulated by the same mechanical processes that influence normal development and growth. Skeletal Function and Form bridges important gaps among disciplines, providing a common ground for a multidisciplinary understanding.

Aimed at postgraduate students in a variety of biology-related disciplines, this volume presents a collection of mathematical and computational single-cell-based models and their application. The main sections cover four general model groupings: hybrid cellular automata, cellular potts, lattice-free cells, and viscoelastic cells. Each section is introduced by a discussion of the applicability of the particular modelling approach and its advantages and disadvantages, which will make the book suitable for students starting research in mathematical biology as well as scientists modelling multicellular processes.

This atlas provides all the basic and advanced information required by surgeons in order to understand fully the skull base anatomy. It is organized according to anatomo-surgical pathways to the hidden areas of the skull base. These pathways are described in step-by-step fashion with the aid of a wealth of color images and illustrations. The emphasis is on endoscopic anatomy, but in order to provide a holistic perspective, informative three-dimensional reconstructions are presented alongside the endoscopic images and radiologic images are included when appropriate. In effect, windows are opened on the anatomy so that the reader is guided on a journey throughout the skull base region. This anatomically oriented atlas will serve as an ideal learning tool for novice surgeons and will also prove an invaluable reference for the more experienced surgeon

First published in 1992, AY's Neuroanatomy of C. elegans for Computation provides the neural circuitry database of the nematode Caenorhabditis elegans, both in printed form and in ASCII files on 5.25-inch diskettes (for use on IBM (R) and compatible personal computers, Macintosh (R) computers, and higher level machines). Tables of connections among neuron classes, synapses among individual neurons, gap junctions among neurons, worm cells and their embryonic origin, and synthetically derived neuromuscular connections are presented together with the references from which the data were compiled and edited. Sample data files and source codes of FORTRAN and BASIC programs are provided to illustrate the use of mathematical tools for any researcher or student interested in examining a natural neural network and discovering what makes it tick.

The aim of Mechano-Electric Correlations in the Human Physiological System is to present the mechanical and electrical properties of human soft tissues and the mathematical models related to the evaluation of these properties in time, as well as their biomedical applications. This book also provides an overview of the bioelectric signals of soft tissues from various parts of the human body. In addition, this book presents the basic dielectric and viscoelastic characteristics of soft tissues, an introduction to the measurement and characteristics of bioelectric signals and their relationship with the mechanical activity, electromyography and the correlation of electromyograms with the muscle activity in normal and certain clinical conditions. The authors also present a case study on the effect of lymphatic filariasis on the mechanical and electrical activity of the muscle. Features: Explains the basics of electrical and mechanical properties of soft tissues in time and frequency domain along with the mathematical models of soft tissue mechanics Explores the correlation of electrical properties with the mechanical properties of biological soft tissues using computational techniques Provides a detailed introduction to electrophysiological signals along with the types, applications, properties, problems and associated mathematical models Explains the electromechanics of muscles using electromyography recordings from various muscles of the human physiological system Presents a case study on the effect of lymphatic filariasis on the mechanical and electrical activity of the muscle Mechano-Electric Correlations in the Human Physiological System is intended for biomedical engineers, researchers and medical scientists as well graduate and undergraduate students working on the mechanical properties of soft tissues.

Now in its seventh edition, Wheater's Functional Histology is designed to give students a working knowledge of histology, including the basic histological structures, tissue types and organ systems. You will learn to recognise the microscopic structure of normal human tissues and understand how this relates to function. The book shows you how to apply histology in a clinical context through coverage of common clinical conditions in each chapter. This must-have book is written clearly and concisely, designed for those studying histology for the first time. Packed with a wealth of illustrations and learning aids, it is a must-have for every medical and health science student. Concise and easy to digest text - easy to follow for those new to histology More than 900 high quality histology images and illustrations, plus detailed explanations to support understanding End of chapter review tables summarising important points Self-assessment questions and rationales to support exam preparation Appendix outlining the basics of microscopy and histological staining techniques Basic glossary An enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud More clinical correlation boxes More clinical images More questions added

The Physiological Measurement Handbook presents an extensive range of topics that encompass the subject of measurement in all departments of medicine. The handbook describes the use of instruments and techniques for practical measurements required in medicine. It covers sensors, techniques, hardware, and software as well as information on processing systems, automatic data acquisition, reduction and analysis, and their incorporation for diagnosis. Suitable for both instrumentation designers and users, the handbook enables biomedical engineers, scientists, researchers, students, health care personnel, and those in the medical device industry to explore the different methods available for measuring a particular physiological variable. It helps readers select the most suitable method by comparing alternative methods and their advantages and disadvantages. In addition, the book provides equations for readers focused on discovering applications and solving diagnostic problems arising in medical fields not necessarily in their specialty. It also includes specialized information needed by readers who want to learn advanced applications of the subject, evaluative opinions, and possible areas for future study.

Completely revised and updated, The Human Body in Health & Disease, 8th Edition makes it easier to understand how the body works, both in typical conditions and when things change. Its easy-to-read writing style, more than 500 full-color illustrations, and unique Clear View of the Human Body transparencies keep you focused on the principles of anatomy, physiology, and pathology. Key features are Connect It! with bonus online content, concept maps with flow charts to simplify complex topics, and chapter objectives and active learning sections. From noted educator Kevin Patton, this book presents A&P in a way that lets you know and understand what is important. More than 500 full-color photographs and drawings illustrate the most current scientific knowledge and bring difficult concepts to life. The beautifully rendered illustrations are unified by a consistent color key and represent a diversity of human identity. A conversational writing style is paired with "chunked" content, making it easy to read and comprehend. UNIQUE! Creative page design uses color backgrounds to organize information in a more inviting, accessible, and motivating way to enhance learning. UNIQUE! The full-color, semi-transparent Clear View of the Human Body permits the on-demand virtual dissection of typical male and female human bodies along several body planes. This 22-page insert contains a series of transparencies that allows you to peel back the layers of the body anterior-to-posterior and posterior-to-anterior. Language of Science/Language of Medicine word lists at the beginning of chapters present key terms, pronunciations, and word-part translations to help you become familiar with new and complex terminology. Animation Direct feature throughout the text guides you to state-of-the-art animations on the companion Evolve website to provide dynamic visual explanations of key concepts. Active Concept Maps offer animated, narrated walk-throughs of concept maps to clarify the text narrative and provide you with clear examples of how to build your own concept maps.

The Geometric Induction of Bone Formation describes new biomimetic biomaterials that offer mechanistic osteogenic surfaces for the autonomous and spontaneous induction of bone formation without the addition of osteogenic soluble molecular signals of the transforming growth factor- supergene family. The chapters frame our understanding of regenerative medicine in primate species, including humans. The goal is to unravel the fundamental biological mechanisms of bone formation unique to non-human and human primates. The broad target audience dovetails with several disciplines both in the academic and private biotech sectors primarily involved in molecular biology, tissue biology, tissue engineering, biomaterial science, and reconstructive, orthopedic, plastic, and dental surgery. Key Features Includes outstanding images of undecalcified whole mounted sections Summarizes non-human primate research - ideal for clinical translation Reviews methods for creating devices capable of making bone autonomously, i.e. an intrinsically osteo-inductive bioreactor and/or biomaterial Describes the spontaneous induction of bone formation including a whole spectrum of tissue biology, from basic molecular biology to clear-cut morphology and pre-clinical application in non-human primate species Intended for audiences in both academic research and the biotech industry

Applied Anatomy for the FRCA covers the anatomical knowledge that trainee anaesthetists who are revising for the Primary and Final FRCA exams will need. The topics covered are derived from the FRCA curriculum and include the most up-to-date version of past exam questions, in order to ensure targeted and successful exam revision. The content, illustrations and overall layout of this book ensure that common gaps in anatomical knowledge encountered by FRCA trainees are included. This reference is divided into sections pertaining to anatomical regions: head and neck, thorax, abdomen, spine, and the upper and lower limbs. The topics of importance to anaesthetists are presented under 'structures', 'circulation' and 'nervous system' (with relevance to regional anaesthesia). Each topic is extensively researched and presented in a simple format for maximum retention. This book makes learning and remembering applied anatomy as straightforward as possible. Applied Anatomy for the FRCA supplements the knowledge required by trainee anaesthetists appearing for the FRCA exams. Clinical educators will also find it useful in teaching. It serves as a practical reference for anatomical knowledge at any point in an anaesthetist's career. About the Editors Dr Bobby Krishnachetty has been a Consultant Anaesthetist at Southend University Hospital since 2010 and a college tutor for six years. She completed her diploma in medical education and is the author of The Final FRCA Structured Oral Examination: A Complete Guide. She is also the organiser of the regional teaching for Core trainees in the East of England school of anaesthesia, as well as Founder of the 'Southend Viva Club' Primary and Final FRCA SOE revision courses for more than nine years, and Cofounder of MRCS OSCE webinars. Mr Abdul Syed has been a Consultant Surgeon at Southend University Hospital since 2015. He is Lead for postgraduate teaching of surgical trainees, Cofounder of MRCS OSCE webinars and conducts Core surgical trainee interview skills courses. Mr Syed is also an Assessor for medical school interviews and an active participant in QI projects and research.

Goodman's Medical Cell Biology, Fourth Edition, has been student tested and approved for decades. This updated edition of this essential textbook provides a concise focus on eukaryotic cell biology (with a discussion of the microbiome) as it relates to human and animal disease. This is accomplished by explaining general cell biology principles in the context of organ systems and disease. This new edition is richly illustrated in full color with both descriptive schematic diagrams and laboratory findings obtained in clinical studies. This is a classic reference for moving forward into advanced study.

Thoroughly researched using experimentation and re-examination of all previously published evidence, Molecular and Physiological Mechanisms of Muscle Contraction is a carefully crafted treatise and revision of previous conceptions of muscle contraction. It presents detailed descriptions of new, previously unpublished data and hybrids recent findings with the standard Huxley model. This book demonstrates that traditional concepts cannot fully explain contraction and builds upon previous work. It identifies flaws in the reasoning initially used to explain some results as well as alternative interpretations accounting for inconsistencies. In response to previous bodies of inconsistent or conflicting theories and data, the book synthesizes research based on the Huxley model with more recent experimental and laboratory findings to define a new model. The new model this book proposes is not a replacement for the standard Huxley model of muscle contraction, but a modification based on recent research and synthesized with pre-existing data and conceptions. It reconciles new data with prior information that is contradictory or not entirely explicable in proposing a new integrated and more complete model of muscle contraction.

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.