This set includes Volumes 1-7 of 15 short atlases reimagining the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition completes the coverage of the first trimester of human brain development. Serial sections from specimens between 4mm and 60mm are illustrated and annotated in great detail, together with 3D reconstructions. An introduction and glossary summarize these earliest stages of human Central Nervous System development. Key Features 1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor cells to facilitate carcinogenesis. In addition, the book examines research topics including cellular and molecular biology approaches, in vivo genetic approaches, various "omics"-based strategies, therapeutic strategies to target the microenvironment, and, finally, advanced techniques in the fields of tissue engineering and nanotechnology. Written and validated in the laboratories of a number of trusted collaborating authors for the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, The Tumor Microenvironment: Methods and Protocols constitutes a compendium of techniques now available to a broad audience, including basic and clinician scientists, systems biologists, and biological engineers.

Designed for the one-semester anatomy and physiology course, Hole's Essentials of Human Anatomy and Physiology assumes no prior science knowledge and supports core topics with clinical applications, making difficult concepts relevant to students pursuing careers in the allied health field. The Learn, Practice, and Assess system is used throughout the text and digital content for immediate application. "Learning" outcomes begin the chapter and set the stage for what students will learn, "Practice" questions conclude each major section and help students recall the information they've consumed, and "Assess" end-of-chapter resources allow students to confirm their accurate recall of what they learned and practiced. The learn, practice, and assess system is highly effective in providing students with a solid understanding of the important concepts in anatomy and physiology.

The rapid expansion of the area of free radical biology in the last 25 years has occurred within a framework of assumptions and preconceived notions that has at times directed the course of this movement. The most dominant of these notions has been the view that free radical production is without exception a bad thing, and that the more efficient our elimination of these toxic substances, the better off we will be. The very important observation by Bernard Babior and colleagues in 1973 that activated phagocytes produce superoxide in order to kill micro organisms, served to illustrate that constructive roles are possible for free radicals. For many in the field, however, this merely underscored the deadly nature of oxygen-derived radicals, both from the microbe's point of view and from the host's as well. (Phagocyte-produced superoxide is responsible in part for the tissue injury manifested as inflammation. See Harris and Granger, Chapter 5, and Leff, Hybertson and Repine, Chapter 6.)
Mother Nature, however, has a penchant for being able to make a silk purse from a sow's ear. If one is dealt a bad hand, one must simply make the best of it. After two decades of focusing on the destructive side of free radicals, the last few years have begun to reveal a new and finer perspective on free radical metabolism - a role in regulation of cellular function (see Schulze-Osthoff and Baeuerle, Chapter 2). Evidence from a number of sources suggests that an increase in the oxidative status of cell encourages that cell to grow and divide. Increasing the expression of mangnese superoxide dismutase can suppress the malignant phenotype of melanon cells (see Oberley and Oberley, Chapter 3). Oxidative stress beyond a certain poitosis (from the Greek, literally "to fall apart"). Is this suicide response an evolutionary fail-safe device to curtail tumorogenesis? Does oxidative stress-induced apoptosis account for the loss of immune cells in AIDS (see Flores and McCor Chapter 4)?
This volume attempts to present the spectrum of roles, both good and bad played by active oxygen species as understood at this point in the evolution of this field of free radical biology.

The book presents an integrative review of paleoneurology, the study of endocranial morphology in fossil species. The main focus is on showing how computed methods can be used to support advances in evolutionary neuroanatomy, paleoanthropology and archaeology and how they have contributed to creating a completely new perspective in cognitive neuroscience. Moreover, thanks to its multidisciplinary approach, the book addresses students and researchers approaching human paleoneurology from different angles and for different purposes, such as biologists, physicians, anthropologists, archaeologists and computer scientists. The individual chapters, written by international experts, represent authoritative reviews of the most important topics in the field. All the concepts are presented in an easy-to-understand style, making them accessible to university students, newcomers and also to anyone interested in understanding how methods like biomedical imaging, digital anatomy and computed and multivariate morphometrics can be used for analyzing ontogenetic and phylogenetic changes according to the principles of functional morphology, morphological integration and modularity.

Complete, labeled illustrations of the viscera.
Chart is loaded with beautifully illustrated diagrams, clearly and concisely labeled for easy identification.
Illustrations by award-winning medical illustrator Vincent Perez.

Chart includes detailed diagrams of:
. heart & lung lymphatics
. respiratory system
. anterior heart
. posterior heart
. viscera
. digestive system
. posterior digestive system
. bronchial tree
. circulatory system
. posterior circulatory system
. stomach & pancreatic lymphatics
. stomach
. bile & pancreatic duct
. hepatic portal veins
. large intestine
. lymphatics & large intestine
. small intestine
. ileocecal sphincter & appendix
. rectum
. male urinary system, anterior view
. lymphatic system
. kidneys
. female urogenital system, lateral view
. male urogenital system, lateral view
"

This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

Andreas Vesalius 1514-1564 By Stephen N. Joffe, M.D. Vesalius was the foremost pioneer of modern anatomy. Born in Brussels, he came from a family of physicians. Educated in Louvain, he studied medicine in Montpelier and Paris, returning to Louvain to teach anatomy. In 1535 he went to France to be an army surgeon to King Charles V and two years later became a professor of anatomy in Padua, Italy. Subsequently he became a physician to the court of Philip II of Spain. On a pilgrimage to Jerusalem, he received a call to return to Padua to occupy chair of Fallopius. In a storm leading to a shipwreck and subsequent death on the Isle of Zante, Vesalius was buried there in an unmarked grave in 1564. This marked the end of the 'prince of anatomy.' Vesalius' book De Humani Corporus Fabrica published in Basel in 1543, contributes one of the greatest treasures of western civilization and culture. With its companion volume the Epitome, began the modern observational science and research.

This easy-to-use, chapter-by-chapter companion to Mosby's Pharmacy Technician: Principles and Practice, 6th Edition helps you solidify your understanding and mastery of key skills and concepts. Each chapter of this combination workbook and lab manual contains a wide variety of review questions, exercises, and experiential lab activities to help reinforce key concepts, encourage you to reflect critically, and relate to practice for success on the job. Combined with the core textbook, this learning package takes you from day one through graduation and certification! Comprehensive content aligns with ASHP competencies and certification exam coverage. Reinforce Key Concepts sections offer valuable review and practice. Reflect Critically sections with realistic scenarios encourage content assimilation and application. Relate to Practice sections with laboratory exercises provide hands-on practice to promote multi-dimensional skills mastery. Skills checklists correlated to textbook procedures enable you to track your progress on key competencies. NEW! Additional content ensures thorough coverage of all entry-level and many advanced ASHP accreditation competencies, including: Wellness, disease prevention, and immunizations Medication compliance and point-of-care testing Professional and regulatory standards Medication requiring special handling and documentation Nonsterile and sterile compounding Advanced Pharmacy Technician duties

Humans receive the vast majority of sensory perception through the eyes and ears. This non-technical book examines the everyday physics behind hearing and vision to help readers understand more about themselves and their physical environment. It begins wit

Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.

This second edition volume expands on the previous edition by presenting updated protocols for several of the techniques described in the first edition of Drosophila: Methods and Protocols and current methods that cover recent breakthroughs in Drosophila research. The book begins with a description of FlyBase--a database of genes and genomes--followed by the presentation of systems for versatile gene expression in the fly. The first few chapters in this book detail gene knockdown and editing, including CRISPR-Cas9 and protein knockdown. The next few chapters are devoted to methods describing live imaging of different tissues and organs, followed by chapters on how to quantify image data and how to probe tissue mechanics by laser ablation. The next two chapters provide methods for analyzing transcription followed by protocols to study growth, metabolism, ageing, and behavior in Drosophila. This volume concludes with chapters on electrophysiological recordings and methods to establish cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Drosophila: Methods and Protocols, Second Edition is a valuable source of hands-on protocols and reviews for molecular, cell, and developmental biologists using Drosophila as model systems in their work.

Considerable advances have taken place since the initial isolation and characterization of human embryonic stem (HES) cells; however, significant challenges remain before their potential for restoration and regeneration processes in patients can be realized. Understanding the diversity amongst HES cell lines and realizing the ability to isolate lines with robust differentiation potential remain difficult. In the Human Embryonic Stem Cells Handbook, experts in the field provide an assortment of protocols that have been used by various laboratories around the world so as to allow both novices and experienced investigators to compare and contrast different approaches to HES cell isolation and characterization with the hope that, from these protocols, researchers might standardize approaches for HES cell biology. Written in the Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and accessible, Human Embryonic Stem Cells Handbook serves as a valuable reference for scientists pursuing this vital field and its enormous potential.

Ribonucleic acid (RNA) binding proteins currently number in the thousands and defects in their function are at the heart of diseases such as cancer and neurodegeneration. RNA binding proteins have become implicated in the intricate control of surprisingly diverse biological settings, such as circadian rhythm, stem cell self-renewal, oncogenesis and germ cell development. This book surveys a range of genome-wide and systems approaches to studying RNA binding proteins, the importance of RNA binding proteins in development, cancer and circadian rhythm.

Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

This issue of Thoracic Surgery Clinics includes well-illustrated articles on surface anatomy, the pleura and pleural spaces (including the anatomy of the parietal and visceral pleura, the pleural reflections and recesses, and microscopic anatomy of the pleura), anatomy of the? mediastinum (including mediastinal divisions and compartments, the thymus, the superior vena cava and brachiocephalic veins, the heart and pericardium, the thoracic aorta and its branches, the thoracic duct, and the nerves of the thorax) and the anatomy of the diaphragm and the esophagus (including? vascular supply, lymphatic pathways, innvervation).

A major revision of the leading textbook of FNA cytology Both text and illustrations provide a systematic and logical approach to the acquisition, interpretation and diagnosis of Fine Needle Aspirate biopsy specimens. Orell's FNA Cytology will assist in establishing diagnostic criteria and results in the examination of benign and malignant condition in all body systems where the technique is currently applied. The information is always presented in a clinical context: it details the role of FNA and other ancillary techniques in the investigative sequence (the cytological findings are always set in the context of the patient's clinical history, physical exam and other laboratory tests). It gives practical, technical advice on how to obtain good smears and alerts the reader as to possible diagnostic pitfalls and complications. The contents are organized in a framework of anatomical regions (rather than histopathological classifications) in order to reflect the way problems present in clinical practice. Each chapter is divided into two parts: the first deals with indications, accuracy, techniques and complications; the second illustrates the cytological patterns and their implication. Both common and rare conditions are covered.Provides practical tips and advice on how to avoid pitfalls and ensure accurate diagnoses. Over 1,200 colour illustrations capture each entity's cellular, morphological and immunohistochemical appearance. Chapters have been up-dated and revised and a brand new one on cytological findings in infectious diseases added. Both MGG and Pap smears illustrated in parallel as well as the corresponding histology to help provide side-by-side analysis. Access the full text online and download images via Expert Consult. Brand new chapter on cytological findings in infectious diseases. Inclusion of immuno-profiles and other relevant ancillary tests. New illustrations. New contributing authors. Available online via Expert Consult.

Cytometry is one of the most rapidly growing methodologies available for basic cell and molecular biology, cytogenetics, immunology, oncology, environmental sciences and also various fields of clinical medicine. Thisnew edition, split into 2 Parts, is an almost completely new book, with nearly all of the chapters devoted to new topics. Like the previous volumes on cytometry published as part of the Methods in Cell Biology series, it provides a comprehensive description of particular cytometric methods and reviews their applications. Chapters present the theoretical foundations of the described methods, their applicability in experimental laboratory and clinical settings, and describes common traps and pitfalls such as problems with data interpretation, comparison with alternative assays, and choosing the optimal assay.
* Comprehensive presentation of cytometric methods covering theoretical applications, applicability, potential pitfalls, and comparisions to alternative assays
* Discusses many new assays developed since the previous edition
* Presents recent developments in cytometric intrumentation/technology"

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.