Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.

This volume of Progress in Molecular Biology and Translational Science focuses on the growth hormone in health and disease.

Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not - as we once believed - unique to a few receptor subfamilies.

The Pharmacological Potential of Cyanobacteria explores the bioactive compounds isolated from cyanobacteria and their relationship to human health and biotechnological applications. The book presents an overview of the chemistry and ecology of cyanobacteria, focusing on culture needs and techniques of biomass production. It is organized according to the different biological activities and biotechnological applications of compounds discovered in recent years. Besides biological activity, the mechanism of action of compounds is explained, along with molecular structure. Finally, compounds already used in therapeutics and biotechnology, as well as those in phases of approval or clinical trials are explored. Each chapter is written by a different research group with expertise in the field and publications in peer reviewed journals. Researchers and students in pharmaceutical academic research, pharmaceutical industrial sector personnel, health professionals, and nutritionists will find this book to be very useful.

"Integrative Anatomy and Pathophysiology in Traditional Chinese Medicine Cardiology" covers the structure, function, and pathology of the cardiovascular system from the TCM and western medical perspectives. It focuses specifically on western medicine anatomy and pathophysiology, along with TCM aspects of essence, qi, blood and body fluid concepts, production, and function to explain cardiovascular system dysfunction, its independent role and dependent interactions with the functions of other organ systems.

This book is designed for US-based licensed TCM practitioners as well as cardiology researchers.
Compares and contrasts the TCM basic theories and western medicine basic sciencesGives a specific connection between the heart dysfunction and the disease mechanisms of other organ systems using TCM and western medicine terms and diagnosesPrepares the practitioner to sit for the Niambi Wellness Integrative Anatomy and pathophysiology in cardiology final online exam

Herbal Biomolecules in Healthcare Applications presents extensive detailed information on all the vital principles, basics and fundamental aspects of multiple herbal biomolecules in the healthcare industry. This book examines important herbal biomolecules including alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, terpenes, fats and waxes, proteins and peptides, and vitamins. These herbal biomacromolecules are responsible for different bioactivities as well as pharmacological potentials. A systematic understanding of the extraction, purification, characterization, applications of these herbal biomolecules and their derivatives in healthcare fields is developed in this comprehensive book. Chapters explore the key topics along with an emphasis on recent research and developments in healthcare fields by leading experts. They include updated literature review of the relevant key topics, good quality illustrations, chemical structures, flow charts, well-organized tables and case studies. Herbal Biomolecules in Healthcare Applications will be useful for researchers working on natural products and biomolecules with bioactivity and nutraceutical properties. Professionals specializing in scientific areas such as biochemistry, pharmacology, analytical chemistry, organic chemistry, clinics, or engineering focused on bioactive natural products will find this book useful.

Human Growth and Development, Third Edition provides a comprehensive volume covering the biology of human growth and the genetic, endocrine, environmental, nutritional, and socio-economic factors that contribute towards its full expression. Human Growth and Development continues to be a valuable resource for researchers, professors and graduate students across the interdisciplinary area of human development. For the new edition, updates are made to all fourteen of the "core chapters" of the book which form the essential reading for a comprehensive understanding of human growth and development. Additionally, new special topics are covered including the interpretation of recently found sub-adult fossils that expand our understanding of the evolution of human growth and a discussion of the early pattern of growth and development as the developmental origins of risk for non-communicable diseases of adulthood. Human Growth and Development, Third Edition includes contributions from the well-known experts in the field and is the most reputable, comprehensive resource available.

Food and water are necessary for survival, but can only be obtained via ingestive behavior (feeding, drinking, and moving). Survival thus depends on the ability of the brain to coordinate the need for water and energy with appropriate behaviors to modify their intake as necessary for homeostasis. However, the balance of these behaviors also inherently determines body weight, and imbalances contribute to the development of weight disorders, such as obesity and anorexia nervosa. The lateral hypothalamic area (LHA) of the brain is anatomically positioned to coordinate the sensation of osmotic and energy status with goal-directed ingestive behaviors necessary to maintain homeostasis and body weight, and, hence, may hold insight into the potential treatment for energy balance disorders. This volume reviews the essential role of the LHA for the control of body weight, from its historical description as a ""feeding center"" to the current view of this LHA as a cellularly heterogeneous hub that regulates multiple aspects of physiology to influence body weight. Furthermore, we evaluate how specific LHA populations coordinate certain metabolic cues and behaviors, which may guide the development of pathway-specific interventions to improve the treatment of energy balance disorders.

In Elegant Anatomy Marieke Hendriksen offers an account of the material culture of the eighteenth-century Leiden anatomical collections, which have not been studied in detail before. The author introduces the novel analytical concept of aesthesis, as these historical medical collections may seem strange, and undeniably have a morbid aesthetic, yet are neither curiosities nor art. As this book deals with issues related to the keeping and displaying of historical human remains, it is highly relevant for material culture and museum studies, cultural history, the history of scientific collections and the history of medicine alike. Unlike existing literature on historical anatomical collections, this book takes the objects in the collections as its starting point, instead of the people that created them.

Theory of Endobiogeny, Volume 3: Advanced Concepts for Treatment of Complex Clinical Conditions explains complex and multi-factorial disorders and diseases using the theory of endobiogeny. It provides detailed applications of biological modeling, in-depth assessment into common disorders, an endobiogenic analysis, guidance on using biological modeling tools, and suggestions for treatment using standard of care treatments that also take into account diet, lifestyle and medicinal plants. This approach is an evolution in thinking from reductionism to holism, offering advice for symptomatic treatments that can be used in conjunction with a new way of thinking about diseases and disease management.

This book provides therapists with the background knowledge they require before they can safely and accurately treat patients with musculoskeletal disorders of the spine. Thoroughly referenced and extensively illustrated with over 200 specially prepared and original diagrams of the highest quality, Functional Anatomy of the Spine will be invaluable to the student and practitioner physiotherapists, chiropractors and osteopaths, and indeed to all those who regularly treat spinal dysfunction. Accessory and physiological spinal movements are thoroughly described. Palpation is covered in detail. Numerous guidelines for safe practice are provided. A valuable, comprehensive chapter covers posture, lifting, and the prevention of injury. Coverage of applied anatomy and biomechanics is written by therapists for therapists. New theories on thoracic biomechanics are presented, rarely covered by other anatomy books. All topics have been updated to reflect recent scientific evidence, enabling the reader to more effectively formulate and manage treatment plans. New illustrations to complement the text and improve readers' understanding of the material. A one-of-a-kind chapter covering the sacroiliac joint has been comprehensively revised. Expanded material is provided on the autonomic nervous system, thoracic spine biomechanics, and the biomechanics of the lower limb as it relates to the spine. New sections address adverse neural tension, cervical discs, proprioception and muscle imbalance, and mechanics of the jaw and upper cervical spine. An update on vertebral artery and blood supply presents the latest knowledge on the subject.

In Functional Anatomy of the Pelvis and the Sacroiliac Joint author and respected bodywork specialist John Gibbons looks at one of the most important areas of the body: the pelvis and the sacroiliac joint. He takes readers on a fascinating journey of enlightenment, teaching us to recognize pain and dysfunctional patterns that arise from the pelvic girdle. Gibbons addresses key issues such as: * The walking/gait cycle and its relationship to the pelvis * Leg length discrepancy and its relationship to the kinetic chain and the pelvis * The laws of spinal mechanics * The relationship of the hip joint, gluteal muscles, lumbar spine to the pelvis * Sacroiliac joint screening In addition, he provides step-by-step techniques to identify and correct a number of impaired patterns as well as functional exercises for the pelvis that promote recovery.

The Theory of Endobiogeny Volume 1: Global Systems Thinking and Biological Modeling for Clinical Medicine offers researchers and clinicians a detailed introduction to the theory of Endobiogeny. The book presents a new approach to medicine that is at once scientific and humanistic, quantitative, and qualitative. The philosophical and experimental basis of a global complex systems approach to physiology is presented along with a mathematical approach to modeling the dynamism of the terrain. The importance of the history and physical examination are renewed as a source of "big data" readily available to clinicians for greater insight into the patient's state. Expansion of the therapeutic compendium is proposed based on a rational, clinical approach correlated to mathematical indicators of the physiologic state. What is proposed in this work is a fundamental shift in scientific thinking with a resulting expansion of the boundaries of clinical medicine for the 21st century and beyond.

An avalanche of recent newspapers, weekly newsmagazines, scholarly journals, and academic books has helped to spark a heated debate by publishing warnings of a "boy crisis" in which male students at all academic levels have begun falling behind their female peers. In Learning the Hard Way, Edward W. Morris explores and analyzes detailed ethnographic data on this purported gender gap between boys and girls in educational achievement at two low-income high schools-one rural and predominantly white, the other urban and mostly African American. Crucial questions arose from his study of gender at these two schools. Why did boys tend to show less interest in and more defiance toward school? Why did girls significantly outperform boys at both schools? Why did people at the schools still describe boys as especially "smart"? Morris examines these questions and, in the process, illuminates connections of gender to race, class, and place. This book is not simply about the educational troubles of boys, but the troubled and complex experience of gender in school. It reveals how particular race, class, and geographical experiences shape masculinity and femininity in ways that affect academic performance. His findings add a new perspective to the "gender gap" in achievement.

Met lewensgetroue hoedefinisie-illustrasies bied hierdie publikasie ’n uitsonderlike blik op al die belangrikste liggaamsdele en -stelsels, van kroontjie tot kleintoontjie. Akkurate terminologie in Afrikaans en Engels, asook definisies en verhelderende teks stel lesers verder in staat om grondige kennis van die spesiale eienskappe en werking van die verskillende liggaamstelsels op te doen.

Designed for the one-semester anatomy and physiology course, Hole's Essentials of Human Anatomy and Physiology assumes no prior science knowledge and supports core topics with clinical applications, making difficult concepts relevant to students pursuing careers in the allied health field. The Learn, Practice, and Assess system is used throughout the text and digital content for immediate application. "Learning" outcomes begin the chapter and set the stage for what students will learn, "Practice" questions conclude each major section and help students recall the information they've consumed, and "Assess" end-of-chapter resources allow students to confirm their accurate recall of what they learned and practiced. The learn, practice, and assess system is highly effective in providing students with a solid understanding of the important concepts in anatomy and physiology.