The third edition of this volume is aimed at providing both beginners and more experienced researchers a choice of methods to isolate and analyze dendritic cells(DC). An introductory review provides an overview of recent advances in the characterization of DC subsets in mouse and human. While additional chapters provide methods to culture human and mouse dendritic cells, protocols for the isolation of dendritic cells, the isolation of dendritic cell progenitors from mouse, and the purification of dendritic cells from human blood. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Dendritic Cell Protocols, Third Edition aims to ensure successful results in the further study of this vital field.

Bundle includes: 9781119576488 Fundamentals of Anatomy and Physiology: For Nursing and Healthcare Students, 3rd Edition A concise yet comprehensive introduction to the structure and function of the human body. Written with the needs of nursing and healthcare students in mind, this best-selling textbook incorporates clinical examples and scenarios throughout to illustrate how the topics covered are applied in practice. Hundreds of full-colour illustrations complement numerous case studies encompassing all fields of nursing practice, alongside learning outcomes, self-assessment tests and other effective learning tools. 9781119699491 Fundamentals of Applied Pathophysiology: An Essential Guide for Nursing and Healthcare Students, 4th Edition A highly visual and accessible introduction to pathophysiology for nursing and healthcare students, including brand-new content on homeostasis, a systematic approach to assessment, and key terminology. The book features links to clinical observations, vital signs to observe, investigation boxes, clinical red flags, medication alerts, and the latest, contemporary evidence for care management, including National Early Warning Score 2 (NEWS2).

The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism.

This book offers a critical review of the pelvic sciences past, present and future from an anatomical and physiological perspective and is intended for researchers, medical practitioners and paramedical therapists in the fields of urology, gynecology and obstetrics, proctology, physiotherapy, as well as for patients.

The book starts with a construction plan of the pelvis and shows its structural consequences. The historical background of pelvic studies proceeds from medieval and early Italian models to the definitive understanding of the pelvic anatomy in the Seventeenth century. During these eras of pelvic research, concepts and approaches developed that are illustrated with examples from comparative anatomy and from mutations, also with regard to the biomechanics of pelvic structures. Perceptions of the pelvis as an important element in sexual arousal and mating conduct are discussed, as well as attitudes to circumcision, castration and other mutilations, in its anthropological, social context.

The anatomy and physiology of the pelvic wall and its organs as well as the development of these pelvic organs are covered as a prerequisite to understanding, for example, the spread of pelvic carcinoma and male and female bladder muscle function. Connective pelvic tissue is examined in its reinforcing capacity for pelvic structures, but also as a hiding place for infections. Innervations and reflexes relayed through the pelvic nerves are discussed in order to explain incontinence, sphincter function and the control of smooth and striated muscles in the pelvis.

Catheters and drugs acting on pelvic function are described, and a critical review of alternative clinical methods for treating pelvic dysfunctions is provided."

Beautiful illustrations explain complex techniques and methods. Covers key themes relevant to the VTCT and ITEC qualifications. Extra web resources, including a full range of colour diagrams to label, can be used to revise for assessments. Expert authors ensure the highest quality advice and support.

This 3-book set provides a concise and highly visual approach to the basic sciences and clinical pathology of the digestive system. These books in The Netter Collection of Medical Illustrations (the CIBA "Green Books") have been expanded and revised to capture current perspectives in gastroenterology, hepatology, and pancreatology - from normal anatomy and physiology through pathophysiology, diagnostics and treatment. Endoscopic, radiographic and pathologic images supplement the classic Netter illustrations, as well as new illustrations. These updated classics are ideal for students and health professionals seeking an easily accessible guide to the complete digestive tract. Books included in this 3-Part Set include: Part 1 - Upper Digestive Tract, Part II - Lower Digestive Tract, and Part III - Liver, Biliary Tract and Pancreas. Put concepts into practice. An exquisite art program focuses on clarity of presentation with an emphasis on anatomy, pathology, patient presentation, and clinical context. Gain a rich, comprehensive overview of the digestive system by seeing classic Netter illustrations side by side with cutting-edge radiologic and laparoscopic images. See modern issues in digestive health and disease captured in the visually rich Netter artistic tradition via contributions from artists working in the Netter style. Get complete, integrated visual guidance in a single source, from basic sciences and normal anatomy and function through pathologic conditions. Benefit from the knowledge of a team of renowned clinicians and scientists.

This edited book explores the use of technology to enable us to visualize the life sciences in a more meaningful and engaging way. It will enable those interested in visualization techniques to gain a better understanding of the applications that can be used in visualization, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualization techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilization of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. We have something for a diverse and inclusive audience ranging from healthcare, patient education, animal health and disease and pedagogies around the use of technologies in these related fields. The first four chapters cover healthcare and detail how technology can be used to illustrate emergency surgical access to the airway, pressure sores, robotic surgery in partial nephrectomy, and respiratory viruses. The last six chapters in the education section cover augmented reality and learning neuroanatomy, historical artefacts, virtual reality in canine anatomy, holograms to educate children in cardiothoracic anatomy, 3D models of cetaceans, and the impact of the pandemic on digital anatomical educational resources.

This book is the first photographic and descriptive musculoskeletal atlas of Hylobates, and adopts the same format as the photographic atlas of Gorilla published by the same authors in 2010. These two books are part of a series of monographs that will set out the comparative and phylogenetic context of the gross anatomy and evolutionary history of the soft tissue morphology of modern humans and their closest relatives. This atlas, which includes detailed high-quality photographs of musculoskeletal structures from most anatomical regions of the body as well as textual information about the attachments, innervation and weight of the respective muscles, is based on dissections and on an extensive review of the literature. It provides an updated review of the anatomical variations within hylobatids as well as an extensive list of the synonyms used in the literature to designate the structures we discuss. The atlas will be of interest to students, teachers and researchers studying primatology, comparative anatomy, functional morphology, zoology, and physical anthropology and to medical students, doctors and researchers who are curious about the origin, evolution, homology and variations of the musculoskeletal structures of modern humans.

The heart-wrenchingly honest and fascinating new book from forensic pathologist and bestselling author of UNNATURAL CAUSES, Dr Richard Shepherd A TIMES AND SUNDAY TIMES BOOK OF THE YEAR 'Each chapter is like a finely-crafted detective story . . . Shepherd writes beautifully, and despite its subject, the book is very funny in parts' DAILY TELEGRAPH 'Enlightening, strangely uplifting . . . Shepherd's final chapter on death itself is a meditation of great beauty and light which puts all the darkness of the previous pages into perspective' DAILY MAIL 'Deeply insightful. Unflinching' THE TIMES 'Fascinating' DAILY EXPRESS 'This book is about death, but in it I will take readers on a journey through life . . .' _________ Dr Richard Shepherd, Britain's top forensic pathologist, has spent a lifetime close to the dead. As a medical detective, each autopsy he carries out is its own unique investigation, uncovering the secrets not only of how a person died, but also of how they lived. Through twenty-four of his most intriguing, enlightening and never-before-told cases, Dr Shepherd shares autopsies that span the seven ages of human existence, and have taught him as much about the marvels of life as the inevitability of death. From old to young, from murder to misadventure, and from illness to accidental death, each of these bodies has something to reveal: about human development, about mortality, about its owner's life story, about justice and even about Shepherd himself. From the bestselling author of Unnatural Causes comes a powerful, moving and above all reassuring book about death as it touches our own lives - how to understand it, and, when our time comes (as it must), how to embrace it as the last great adventure. _________ 'He has the ability to examine himself and other people with the same forensic eye that he applies to corpses - one of the reasons why his books feel so life-enhancing' Daily Telegraph Praise for Dr Richard Shepherd 'Gripping, grimly fascinating, and I suspect I'll read it at least twice' Evening Standard 'A deeply mesmerising memoir of forensic pathology. Human and fascinating' Nigella Lawson 'An absolutely brilliant book. I really recommend it, I don't often say that but it's fascinating' Jeremy Vine, BBC Radio 2 'Puts the reader at his elbow as he wields the scalpel' Guardian 'Fascinating, gruesome yet engrossing' Richard and Judy, Daily Express 'Fascinating, insightful, candid, compassionate' Observer

Formulation of Monoclonal Antibody Therapies: From Lab to Market covers a wide range of topics about therapeutic monoclonal antibodies (mAbs) with a focus on formulation aspects. Therapeutic monoclonal antibodies are used for treatment of chronic diseases. It brings together a comprehensive knowledge in one accessible volume. Starting with foundational information on monoclonal antibodies, the book then discusses the importance of biopharmaceutical products, monoclonal antibodies and biosimilars in treatment of chronic diseases, pharmaceutical aspects of mAbs, and how it can be administered. It also covers the industrial point of view and the clinical application of mAbs including in oncology, general medicine, rheumatology, hematology, dermatology, gastrointestinal tract, metabolic diseases, and dentistry. Formulation of Monoclonal Antibody Therapies: From Lab to Market is essential reading for researchers in biotechnology and biopharmaceutical fields, academics and pharmaceutical industrial scientists, and university students in pharmaceutical and biopharmaceutical sciences.

Offering a targeted, concise approach to clinical anatomy, Netter's Clinical Anatomy, 5th Edition, is a portable, easy-to-read text that bridges normal anatomy to common clinical conditions. It features nearly 600 superb illustrations by Drs. Frank H. Netter and Carlos Machado that provide essential descriptions of anatomy, embryology, and pathology to help you understand their clinical relevance. Authored by John Hansen, PhD, an Honored Member of the American Association of Clinical Anatomists, this visually stunning text covers and reviews the sizable area of human anatomy and pathology in a quick, easy-to-grasp format. Nearly 600 Netter and Machado illustrations provide essential depictions of anatomy, embryology, and pathology to help you quickly learn and understand through visuals. Every clinical correlation is illustrated-more than 200 in all. Clinical Focus boxes present hundreds of illustrated clinical correlations that bridge anatomy to pathophysiology, and Features and Characteristics boxes explain the relation between structure and function. Muscle/Ligament/Joint tables summarize attachment points, actions, and other key information related to each structure. Uses updated terminology based on the second edition of the international anatomic standard, Terminologia Anatomica, and content is aligned with Netter Atlas of Human Anatomy, 8th Edition. Both USMLE-style review questions and short answer questions online help you gauge your mastery of the material and assess areas in need of further study. Other study tools include bonus clinical focus boxes, and 3D models. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Evolve Instructor site with an image bank of clinical correlates is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.

Functional Awareness: Anatomy in Action for Dancers is where anatomy meets artistry. Each chapter provides explorations in embodied anatomy in an engaging manner with the use of images, storytelling, and experiential exercises. It is an accessible introduction to the relationship between daily movement habits, dance training and anatomy. The information is founded on over 30,000 hours of experience teaching and training dancers to generate efficient exertion and appropriate recuperation. Functional Awareness: Anatomy in Action for Dancers employs somatic practices along with explorations in experiential anatomy to awaken the body-mind connection and improve movement function. The book applies the Functional Awareness (R) approach to improve dance technique and provide skills to enable the dancer to move with balance and grace in the classroom, on stage, and in daily life.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research.

From powerful blows to explosive kicks, "Delavier's Mixed Martial Arts Anatomy" takes you inside the action and impact of one of the world's most popular, grueling, and challenging sports.

Over 230 full-color photos and 120 anatomical illustrations allow you to go inside more than 120 exercises specifically selected for the neuromuscular demands of the sport. You'll see how muscles interact with surrounding joints and skeletal structures and how variations and sequencing can isolate specific muscles to enhance the full arsenal of combat skills.

"Delavier's Mixed Martial Arts Anatomy" features an anatomomorphological approach to allow you to choose the most effective exercises for your body type, physical conditioning, and fighting style. From boxing to ground fighting, you'll enhance your strengths and minimize your weaknesses with more than 20 proven programs.

Featuring the latest exercises for injury prevention and foam roller techniques for muscle regeneration, it's all here and all in the stunning detail that only Frederic Delavier can provide.

First published in 1967, Human Guinea Pigs is a report by a consultant physician on the implications of medical research on both the medical profession and on the men, women and children who are the subjects of medical experiments. It suggests that there are limits to the permissibility of experiments on humans. It points out how it has become a common occurrence for medical investigators to take risks with patients of which the patients themselves are frequently unaware, and to submit them to mental and physical distress and possible hazards which in no way are necessitated by or have connection with the treatment of the disease from which are suffering. The author describes a number of experiments which, in his opinion, raise important problems. In his view, medical research must go on, but there must be acknowledged and observed safeguards for patients. This book will be of interest to students of medicine, ethics, law, politics and social work.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change

Resistance arteries have been recognized for some time as key factors in the regulation of vascular flow resistance, where they determine the regional and local distribution of blood and arterial pressure. Chapters provide an overview of the physiological, biochemical, and electrophysiological characteristics of these vessels, as well as a critical evaluation of the methodologies for studying small arteries and an examination of the membrane and neural mechanisms involved in the control of vascular tone.

Reproducibility in Biomedical Research: Epistemological and Statistical Problems explores the ideas and conundrums inherent in scientific research. It explores factors of reproducibility, including logic, distinguishing productive from unproductive irreproducibility, the scientific method, and the use of statistics. In multiple examples and six detailed case studies, the book demonstrates the misuse of logic resulting in unproductive irreproducibility, allowing researchers to develop their own logic and planning abilities. Biomedical researchers, clinicians, administrators of scientific institutions and funding agencies, journal editors, philosophers of science and medicine will find the arguments and explorations a valuable addition to their libraries.

For students and clinical professionals who are learning anatomy, participating in a dissection lab, sharing anatomy knowledge with patients, or refreshing their anatomy knowledge, the Netter Atlas of Human Anatomy illustrates the body, region by region, in clear, brilliant detail from a clinician's perspective. Unique among anatomy atlases, it contains illustrations that emphasize anatomic relationships that are most important to the clinician in training and practice. Illustrated by clinicians, for clinicians, it contains more than 550 exquisite plates plus dozens of carefully selected radiologic images for common views. Presents world-renowned, superbly clear views of the human body from a clinical perspective, with paintings by Dr. Frank Netter as well as Dr. Carlos A. G. Machado, one of today's foremost medical illustrators. Content guided by expert anatomists and educators: R. Shane Tubbs, Paul E. Neumann, Jennifer K. Brueckner-Collins, Martha Johnson Gdowski, Virginia T. Lyons, Peter J. Ward, Todd M. Hoagland, Brion Benninger, and an international Advisory Board. Offers region-by-region coverage, including muscle table appendices at the end of each section and quick reference notes on structures with high clinical significance in common clinical scenarios. Contains new illustrations by Dr. Machado including clinically important areas such as the pelvic cavity, temporal and infratemporal fossae, nasal turbinates, and more. Features new nerve tables devoted to the cranial nerves and the nerves of the cervical, brachial, and lumbosacral plexuses. Uses updated terminology based on the second edition of the international anatomic standard, Terminologia Anatomica, and includes common clinically used eponyms. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Provides access to extensive digital content: every plate in the Atlas?and over 100 bonus plates including illustrations from previous editions?is enhanced with an interactive label quiz option and supplemented with "Plate Pearls" that provide quick key points of the major themes of each plate. Digital content also includes over 300 multiple choice questions and other learning tools. Also available, alternative versions of the 8th Edition: . Netter Atlas of Human Anatomy: A Systems Approach-Same content as the classic regional approach, but organized by organ systems. . Netter Atlas of Human Anatomy: Classic Regional Approach-hardback Professional Edition with downloadable image bank for personal use. . Netter Atlas of Human Anatomy: Classic Regional Approach with Latin terminology

This is the only in-depth, single author survey of heart development. It will provide a more systematic, up-to-date synthesis of the subject than any other volume, spanning the range from classical anatomical studies to recent findings in molecular biology. It also covers topics that are often omitted from discussions of heart development, such as myocardial function, cardiac innervation, and conduction development and clinical correlates will be discussed throughout. The book is beautifully illustrated by Karen Waldo, an artist who has collaborated with Dr. Kirby for many years.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

This volume presents a series of protocols and methods, some of which are not widely used by researchers/practitioners, and will aid in the execution of different laboratory techniques. Forensic DNA Typing Protocols, Second Edition is arranged into a series of related chapters. Chapter 1-3 examines two different aspects of RNA analysis for body fluid identification. Chapters 4-7 focuses on the storage of biological materials and the extraction of DNA from hard tissues. Chapters 8-10 present methods for monitoring the quality of DNA extracts, and steps to aid in the purification of DNA. Chapters 11-16 talk about methods on non-standard markers, such as INDELs, Y chromosome STRs, and mitochondrial DNA. Detailed procedures and data analysis for phenotypes and ancestry are explored in Chapter 17-19. The last chapter (20) looks at the application of DNA typing to the identification of non-human material to species level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Forensic DNA Typing Protocols, Second Edition, is a valuable resource for forensic specialists, researchers, and anyone interested in the field of forensic science.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neorological development 3) Appeals to neuroanatomists, developmental biologists and clinical practioners. 4) Persistent relevantce - brain development is not going to change.