Key features: * Presents a concise, accessible guide to regional and clinically applied anatomy, that clearly demonstrates to students the level of knowledge that is required for medical and healthcare-related curricula. * Uses high-quality clinical and intra-operative images integrated into the text which emphasizes important topics through bullet points. * Features logically arranged seven sections, each devoted to a body region or system, which includes a self-test quiz, with the single best answer and spotter-style questions.

Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment. With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development.

Hutton looks at Manchester and Oxford to provide a comparative history of anatomical study. Using the Anatomy Act as a focal point, she examines how these two cities dealt with the need for bodies over two centuries.

Pattern Formation in the Vertebrate CNS: Hox Gene Function and the Development of the Head; M. Mark, et al. Genetic Mechanisms Responsible for Pattern Formation in the Vertebrate Hindbrain: Regulation of Hoxb1; M. Studer, et al. Pax Genes as Pleiotropic Regulators of Embryonic Development; P. Tremblay, et al. Introduction and the Generation of Regional and Cellular Diversity in the Developing Mammalian Brain; A.S. LaMantia. Genetic Determinants of Neural Cell Fate: Potential Role of Homeobox Genes in Neural Cell Differentiation; M. Gulisano, et al. Multiple Roles for Proneural Genes in Drosophila Neurogenesis; A.P. Jarman, Y.N. Jan. Genetic Analysis of Neuronal Migration in The Nematode Caenorhabditis elegans; G. Garriga. Induction and Differentiation of Motor Neurons; S.L. Pfaff, et al. Neural Cell Differentiation: Neuronal Development in the Rat Sympathoadrenal Lineage; S.J. Birren, et al. Specification of Cell Fate in the Vertebrate Retina; C.P. Austin. Neurotrophins and Trk Receptors in Hippocampal Development; D. Collazo, R. McKay. 8 additional articles. Index.

This third of 15 short atlases reimagines the classic 5-volume Atlas of Human Central Nervous System Development. This volume presents serial sections from specimens between 15 mm and 18 mm with detailed annotations, together with 3D reconstructions. An introduction summarizes human CNS development by using high-resolution photos of methacrylate-embedded rat embryos at a similar stage of development as the human specimens in this volume. The accompanying Glossary gives definitions for all the terms used in this volume and all the others in the Atlas. Features Classic anatomical atlas Detailed labeling of structures in the developing brain offers updated terminology and the identification of unique developmental features, such as germinal matrices of specific neuronal populations and migratory streams of young neurons Appeals to neuroanatomists, developmental biologists, and clinical practitioners A valuable reference work on brain development that will be relevant for decades

1) Classic anatomical atlases 2) Detailed labelling of the earliest phases of prenatal neurological development without abbreviations 3) Appeals to neuroanatomists, developmental biologists and clinical practioners 4) Persistent relevance - brain development is not going to change, but this Atlas offers updated terminology for primordial neural structures.

Almost every medical faculty possesses anatomical and/or pathological collections: human and animal preparations, wax- and other models, as well as drawings, photographs, documents and archives relating to them. In many institutions these collections are well-preserved, but in others they are poorly maintained and rendered inaccessible to medical and other audiences. This volume explores the changing status of anatomical collections from the early modern period to date. It is argued that anatomical and pathological collections are medically relevant not only for future generations of medical faculty and future research, but they are also important in the history of medicine, the history of the institutions to which they belong, and to the wider understanding of the cultural history of the body. Moreover, anatomical collections are crucial to new scholarly inter-disciplinary studies that investigate the interaction between arts and sciences, especially medicine, and offer a venue for the study of interactions between anatomists, scientists, anatomical artists and other groups, as well as the display and presentation of natural history and medical cabinets. In considering the fate of anatomical collections - and the importance of the keeper's decisions with respect to collections - this volume will make an important methodological contribution to the study of collections and to discussions on how to preserve universities' academic heritage.

For the two-semester A&P laboratory course. Help manage time and improve learning inside and outside of the lab The #1 best-selling Human Anatomy & Physiology Laboratory Manual helps students and instructors manage time inside and outside of the A&P lab classroom and works hand-in-hand with Mastering A&P, the leading online homework and learning program for A&P. The 13th Edition features dozens of new, full-color figures and photos in the review sheets, as well as revamped clinical application questions and critical thinking questions that reinforce the most important concepts from lab. Encourage students to prepare for lab by assigning recommended Mastering A&P activities for each lab exercise, including 18 pre-lab videos (8 are new to this edition), Building Vocabulary Coaching Activities, exercise review sheet assessment questions, art labeling activities, mobile-ready Practice Anatomy Lab (TM) 3.1 with customizable flashcards, and more. Thousands of assignment options in the Item Library are closely correlated with the print edition of the manual, making it easier than ever to create homework assignments that are aligned with your lab activities. Continuing to set the standard for the 2-semester A&P laboratory course, the lab manual complies with the illustration and presentation style of the best-selling Marieb/Hoehn Human Anatomy & Physiology text, but can accompany any A&P textbook. New customization options are available through Pearson Collections, as well as three conventional versions: Main (12th Edition), Cat (13th Edition), and Fetal Pig (13th Edition). Also available with Mastering A&P Mastering (TM) is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools developed to engage students and emulate the office-hour experience, Mastering personalizes learning and improves results for each student. Mastering A&P assignments support interactive features in the lab manual, including pre-lab video coaching activities, bone, muscle, and dissection videos, Dynamic Study Modules, Get Ready for A&P, plus a variety of Art Labeling Questions, Clinical Application Questions, and more. Note: You are purchasing a standalone product; Mastering A&P does not come packaged with this content. Students, if interested in purchasing this title with Mastering A&P, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and Mastering A&P, search for: 0134767322 / 9780134767321 Human Anatomy & Physiology Laboratory Manual, Fetal Pig Version Plus MasteringA&P with Pearson eText -- Access Card Package, 13/e 0134763246 / 9780134763248 MasteringA&P with Pearson eText -- ValuePack Access Card -- for Human Anatomy & Physiology Laboratory Manuals 0134806360 / 9780134806365 Human Anatomy & Physiology Lab Manual, Fetal Pig Version

Taking the Vesalian anatomical revolution as its point of departure, this volume charts the apparent rise and fall of anatomy studies within universities in sixteenth-century Spain, focussing particularly on primary sources from 1550 to 1600. In doing so, it both clarifies the Spanish contribution to the field of anatomy and disentangles the distorted political and historiographical viewpoints emerging from previous research. Studies of early modern Iberian science have only been carried out coherently and collaboratively in the last few decades, even though fierce debates on the subject have dominated Spanish historiography for more than two centuries. In the field of anatomy studies, many uninformed and biased readings of archival sources have resulted in a very confused picture of the practice of dissection and the teaching of anatomy in the Iberian Peninsula, in which the highly complex conditions of anatomical research within Spain's national context are often oversimplified. The new empirical evidence that this book brings to light suggests a far more multifaceted narrative of Iberian Renaissance anatomy than has been presented to date.

Clinical Exercise Physiology, Fifth Edition With HKPropel Access, is a comprehensive guide to the clinical aspects of exercise physiology, investigating 24 chronic diseases and conditions and addressing a variety of populations. The text has been a mainstay in the field since its inception in 2003 and is an ideal resource for students preparing for clinical exercise certifications, including those offered by the American College of Sports Medicine (ACSM-CEP), American Council on Exercise (Medical Exercise Specialist), Canadian Society for Exercise Physiology (CSEP-CEP), and Exercise & Sports Science Australia (ESSA-AEP). Clinical Exercise Physiology, Fifth Edition, employs a logical progression of content to provide greater coverage and depth of diseases than is typically found in most clinical exercise physiology textbooks. It examines the effects of exercise on 24 chronic conditions, with each chapter covering the epidemiology, pathophysiology, clinical considerations, drug and surgical therapies, and exercise testing and prescription issues for the chronic condition. Other chapters are devoted to examining exercise-related issues for four special populations. Each chapter in this fifth edition is revised and updated to include the latest research, clinical guidelines, and position statements from professional organizations. In addition, it incorporates the following new elements: An upgrade to a full-color layout, for a more engaging learning experience and enhanced presentation of data New Clinical Exercise Bottom Line sidebars that highlight key information a clinical exercise physiologist needs when working with clinical populations A new chapter on clinical exercise programming that offers detailed recommendations for clinical populations A completely rewritten chapter on spinal cord injury and updates throughout each chapter to reflect the most up-to-date guidelines and position statements Expanded coverage of clinical exercise physiology certification options In addition to practical application sidebars throughout the text, the fifth edition also has related online tools to support student learning. Delivered through HKPropel, more than 60 case studies are presented in a SOAP note format so students can explore clinical evaluations, looking closely at subjective and objective data, assessments, and plans. Discussion questions and interactive key term flash cards foster better understanding and retention, while chapter quizzes can be assigned by instructors through the platform to assess student comprehension. Endorsed by the Clinical Exercise Physiology Association (CEPA), the Canadian Society for Exercise Physiology (CSEP), the British Association of Sport and Exercise Sciences (BASES), and Exercise & Sports Science Australia (ESSA), Clinical Exercise Physiology, Fifth Edition, offers a contemporary review of the variety of diseases and conditions that students and professionals may encounter in the field. New and veteran clinical exercise physiologists, as well as those preparing for clinical exercise certification exams, will appreciate the in-depth coverage of the clinical populations that benefit from physical activity. Note: A code for accessing HKPropel is included with this ebook.

In 1967, after a twin baby boy suffered a botched circumcision, his family agreed to a radical treatment that would alter his gender. The case would become one of the most famous in modern medicine and a total failure. "As Nature Made Him" tells the extraordinary story of David Reimer, who, when finally informed of his medical history, made the decision to live as a male. A macabre tale of medical arrogance, it is first and foremost a human drama of one man's and one family's amazing survival in the face of terrible odds.

Completely revised and updated, The Human Body in Health & Disease, 8th Edition makes it easier to understand how the body works, both in typical conditions and when things change. Its easy-to-read writing style, more than 500 full-color illustrations, and unique Clear View of the Human Body transparencies keep you focused on the principles of anatomy, physiology, and pathology. Key features are Connect It! with bonus online content, concept maps with flow charts to simplify complex topics, and chapter objectives and active learning sections. From noted educator Kevin Patton, this book presents A&P in a way that lets you know and understand what is important. More than 500 full-color photographs and drawings illustrate the most current scientific knowledge and bring difficult concepts to life. The beautifully rendered illustrations are unified by a consistent color key and represent a diversity of human identity. A conversational writing style is paired with "chunked" content, making it easy to read and comprehend. UNIQUE! Creative page design uses color backgrounds to organize information in a more inviting, accessible, and motivating way to enhance learning. UNIQUE! The full-color, semi-transparent Clear View of the Human Body permits the on-demand virtual dissection of typical male and female human bodies along several body planes. This 22-page insert contains a series of transparencies that allows you to peel back the layers of the body anterior-to-posterior and posterior-to-anterior. Language of Science/Language of Medicine word lists at the beginning of chapters present key terms, pronunciations, and word-part translations to help you become familiar with new and complex terminology. Animation Direct feature throughout the text guides you to state-of-the-art animations on the companion Evolve website to provide dynamic visual explanations of key concepts. Active Concept Maps offer animated, narrated walk-throughs of concept maps to clarify the text narrative and provide you with clear examples of how to build your own concept maps.

The transplantation of organs such as the heart, kidney, and lungs is an important means of replacing seriously damaged or diseased body parts. However, a transplanted organ may fail if the recipient's immune system mounts a response to it. Transplant patients are usually prescribed a life-long course of immunosuppressive medication, but these drugs can have adverse effects, including increased risk of infection and cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a current and comprehensive review of the molecular mechanisms behind graft rejection and how they may be overcome. Contributors discuss immunosuppressive drug therapies and tolerance induction strategies, including the use of regulatory T cells, mesenchymal stromal cells, and lymphodepletion. They describe how mouse and non-human primate models have been used to gain insight into the immunobiology of transplantation and to test therapeutic approaches. Clinical considerations, such as donor selection, organ preservation, surgery, and post-operative care, are also covered. This volume includes discussion of the emerging field of regenerative medicine and the bioethical issues surrounding organ transplantation, and provides historical background to the field. It is an essential reference for immunologists, pharmacologists, clinicians, and all who are working to improve this remarkable medical procedure.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neorological development 3) Appeals to neuroanatomists, developmental biologists and clinical practioners. 4) Persistent relevance - brain development is not going to change.

Main image shows the bones, muscles, ligaments, veins and arteries of the shoulder. Illustrates posterior, lateral, anterior and superior views of the shoulder anatomy, as well as the socket of a normal shoulder joint. Shows impingement syndrome, rotator cuff tear, trauma (such as proximal humeral fracture and acromioclavicular separation), and bicipital tendon problems. Also illustrates instability such as anterior dislocation of the humerus, Bankart lesion, and Hill Sachs formationbr>Size is 20" W by 26" H. For more information about our chart mounting styles, click here.

Hutton looks at Manchester and Oxford to provide a comparative history of anatomical study. Using the Anatomy Act as a focal point, she examines how these two cities dealt with the need for bodies over two centuries.

First published in 1990, this indispensable volume brings together authoritative, up-to-date, critical accounts of the present status of positron emission tomography (PET) in the study of movement disorders both in terms of the basic science relevant to PET and the clinical science related to the study of specific disease processes. For better understanding, it includes a review of the basic principles of PET and tracer kinetics. It also reviews clinical studies concerning Parkinson's and Huntington's disease, as well as some of the less common movement disorders such as progressive supranuclear palsy, olivopontocerebellar atrophy, and dystonia. Throughout the text, it emphasizes PET as a tool for the quantitative measurement of meaningful biochemical and physiological processes. This state-of-the-art work provides a perspective concerning the degree to which PET studies have advanced knowledge and the future role anticipated for PET. All clinical and basic researchers interested in functional imaging with PET and movement disorders will find this book an absolute must.

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.

With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:

• Electron transport and energy production
• Mitochondrial biogenesis and dynamics
• Mitochondrial signaling
• Apoptosis and autophagy
• Pharmacology signaling
• Epigenetic signaling: mitochondrial methylation and acetylation reactions

An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Key Features 1) Detailed summary of every recorded variation and anomaly for each muscle in the human body 2) Information on comparative anatomy of each muscle (e.g., how each human muscle may appear in our closest living relatives, the apes). 3) Schematic illustrations of the variations and anomalies for easy visualization 4) Comprehensive literature review resulting in the most accurate prevalence information for each variation and anomaly 5) Diverse group of co-authors from various academic and cultural backgrounds

The Patella provides a comprehensive, practical approach to the management of disorders of the patella and extensor mechanism of the knee. Discussions of the basic sciences, physical exam and imaging of the patellofemoral joint are followed by treatment options, including arthroscopy, osteotomy, surgical management of patellar malalignment, patellofemoral arthritis, conservative care, and complications of surgery. Additional chapters include problems in the young patient and rehabilitation. With over 300 illustrations, this book is a must for all orthopaedic surgeons and residents.

The regenerative capacity of the liver has been recognized for centuries, but when it is overwhelmed by insulting stimuli or is chronically damaged, its regenerative capability is substantially reduced or lost. Researchers have been working to find solutions to cure failing human liver function. Given the ability of stem cells to self- renew and differentiate into specialized cell liver types, they represent an attractive strategy to replace lost liver function. This book begins by outlining the complex nature of human liver disease and proceeds to examine the potential that stem cell-based approaches have to offer.

Science is a force for good in the world-at least usually. But sometimes, when obsession gets the better of scientists, they twist a noble pursuit into something sinister. Under this spell, knowledge isn't everything, it's the only thing-no matter the cost. Bestselling author Sam Kean tells the true story of what happens when unfettered ambition pushes otherwise rational men and women to cross the line in the name of science, trampling ethical boundaries and often committing crimes in the process. The Icepick Surgeon masterfully guides the reader across two thousand years of history, beginning with Cleopatra's dark deeds in ancient Egypt. The book reveals the origins of much of modern science in the transatlantic slave trade of the 1700s, as well as Thomas Edison's mercenary support of the electric chair and the warped logic of the spies who infiltrated the Manhattan Project. But the sins of science aren't all safely buried in the past. Many of them, Kean reminds us, still affect us today. We can draw direct lines from the medical abuses of Tuskegee and Nazi Germany to current vaccine hesitancy, and connect icepick lobotomies from the 1950s to the contemporary failings of mental-health care. Kean even takes us into the future, when advanced computers and genetic engineering could unleash whole new ways to do one another wrong. Unflinching, and exhilarating to the last page, The Icepick Surgeon fuses the drama of scientific discovery with the illicit thrill of a true-crime tale. With his trademark wit and precision, Kean shows that, while science has done more good than harm in the world, rogue scientists do exist, and when we sacrifice morals for progress, we often end up with neither.

This volume provides a comprehensive and multidisciplinary overview of fibrocytes, written by the main researchers in the field. It is aimed at a broad audience of scientists and clinicians with an interest in the role of circulating fibrocytes in the etiopathogenesis of different fibrosing disorders, atherosclerosis, autoimmunity, and cancer.