The realization that epithelial tissues are not simply passive barriers to the adsorption of materials into internal environments has brought about an enormous growth of investigation of mucosal functions and their active and passive protective roles. Epithelia are highly organized but complex structures, subserving numerous functions, including immunological defence. The use of pharmacological tools in these systems is increasing, which is improving our understanding of epithelial immunobiology.;This volume adopts a step-by-step approach whereby each chapter builds upon the previous one, progressively adding important foundation information, culminating in a series of chapters concerning particular epithelia, including respiratory, gastrointestinal, renal and ocular. The result is a comprehensive, but integrated, treatise of piethelial function and its immunopharmacology, which aims to scrve as an appropriate starting point at which the clinical pulmonologist and the research scientist can obtain an appreciation of some aspects of epithelial immununopharmacology as they are currently understood.

The Human Brain Circulation offers an original, up-to-date synthesis and summary of our current knowledge of the cerebrovascular circulatory system, with special emphasis on the study of isolated vessels. The contributors describe the normal vasculature and the many complex changes that occur with age and disease. Fetal and newborn circulation is also addressed. In areas where knowledge of human vessels is deficient, research on animal tissues is included.
The book is significant because it challenges some of the traditional assumptions based on animal studies of the mechanisms that control human brain vasculature and presents a contemporary view that includes the role of shear stress and intravascular pressure on the arterial circulation.
Among the topics discussed are the receptors for vasoactive substances; the molecular aspects of endothelial function in hemostasis; inflammation and thrombosis; the effect of hypertension; the pathophysiology of vasospasm, ischemia, and reperfusion; and the actions of free radicals. Techniques for the in vivo study of cerebrovascular dysfunction are also described.
The Human Brain Circulation presents a definitive understanding of this centrally important vascular bed and clearly defines the future direction for research into human cerebrovascular disease and its treatment.

By popular request - Frank H. Netter, MD's classic anatomy paintings on playing cards! Perfect for clinicians, medical and healthcare students, and all Netter fans! Favorite illustrations from Netter's Atlas of Human Anatomy on card faces - from the iconic Netter skull on the Jokers to the superficial vessels of the face on the Jacks . and on the Kings, a photo of the dapper Dr. Netter himself! Standard 52-card deck includes classic Netter paintings plus assorted pieces by Netter successor, Carlos Machado, MD; 14 different illustrations in all.

Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment. With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

Spiral Bound explores the potential for yoga as a healing modality by examining the body's anatomical structure as it has evolved embryonically. With a light touch approach, Karen weaves together threads of development to see how our morphological constraints arise in the earliest moments of life and how this rotation lays the spiral groundwork for rotational kinematics that encompass all tissue. This book sets out to link theory with practice, all at a conversational level richly illustrated with full-color photographs and drawings that bring the biomotion to life for practitioners and teachers of yoga. This book for anyone seeking to simplify the parts-list pedagogy of classical anatomy with contemporary research in fascia literature for an integrated approach especially suitable to postural yoga.

Clinical Exercise Physiology, Fifth Edition With HKPropel Access, is a comprehensive guide to the clinical aspects of exercise physiology, investigating 24 chronic diseases and conditions and addressing a variety of populations. The text has been a mainstay in the field since its inception in 2003 and is an ideal resource for students preparing for clinical exercise certifications, including those offered by the American College of Sports Medicine (ACSM-CEP), American Council on Exercise (Medical Exercise Specialist), Canadian Society for Exercise Physiology (CSEP-CEP), and Exercise & Sports Science Australia (ESSA-AEP). Clinical Exercise Physiology, Fifth Edition, employs a logical progression of content to provide greater coverage and depth of diseases than is typically found in most clinical exercise physiology textbooks. It examines the effects of exercise on 24 chronic conditions, with each chapter covering the epidemiology, pathophysiology, clinical considerations, drug and surgical therapies, and exercise testing and prescription issues for the chronic condition. Other chapters are devoted to examining exercise-related issues for four special populations. Each chapter in this fifth edition is revised and updated to include the latest research, clinical guidelines, and position statements from professional organizations. In addition, it incorporates the following new elements: An upgrade to a full-color layout, for a more engaging learning experience and enhanced presentation of data New Clinical Exercise Bottom Line sidebars that highlight key information a clinical exercise physiologist needs when working with clinical populations A new chapter on clinical exercise programming that offers detailed recommendations for clinical populations A completely rewritten chapter on spinal cord injury and updates throughout each chapter to reflect the most up-to-date guidelines and position statements Expanded coverage of clinical exercise physiology certification options In addition to practical application sidebars throughout the text, the fifth edition also has related online tools to support student learning. Delivered through HKPropel, more than 60 case studies are presented in a SOAP note format so students can explore clinical evaluations, looking closely at subjective and objective data, assessments, and plans. Discussion questions and interactive key term flash cards foster better understanding and retention, while chapter quizzes can be assigned by instructors through the platform to assess student comprehension. Endorsed by the Clinical Exercise Physiology Association (CEPA), the Canadian Society for Exercise Physiology (CSEP), the British Association of Sport and Exercise Sciences (BASES), and Exercise & Sports Science Australia (ESSA), Clinical Exercise Physiology, Fifth Edition, offers a contemporary review of the variety of diseases and conditions that students and professionals may encounter in the field. New and veteran clinical exercise physiologists, as well as those preparing for clinical exercise certification exams, will appreciate the in-depth coverage of the clinical populations that benefit from physical activity. Note: A code for accessing HKPropel is included with this ebook.

Hutton looks at Manchester and Oxford to provide a comparative history of anatomical study. Using the Anatomy Act as a focal point, she examines how these two cities dealt with the need for bodies over two centuries.

Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neorological development 3) Appeals to neuroanatomists, developmental biologists and clinical practioners. 4) Persistent relevance - brain development is not going to change.

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.

Almost every medical faculty possesses anatomical and/or pathological collections: human and animal preparations, wax- and other models, as well as drawings, photographs, documents and archives relating to them. In many institutions these collections are well-preserved, but in others they are poorly maintained and rendered inaccessible to medical and other audiences. This volume explores the changing status of anatomical collections from the early modern period to date. It is argued that anatomical and pathological collections are medically relevant not only for future generations of medical faculty and future research, but they are also important in the history of medicine, the history of the institutions to which they belong, and to the wider understanding of the cultural history of the body. Moreover, anatomical collections are crucial to new scholarly inter-disciplinary studies that investigate the interaction between arts and sciences, especially medicine, and offer a venue for the study of interactions between anatomists, scientists, anatomical artists and other groups, as well as the display and presentation of natural history and medical cabinets. In considering the fate of anatomical collections - and the importance of the keeper's decisions with respect to collections - this volume will make an important methodological contribution to the study of collections and to discussions on how to preserve universities' academic heritage.

Taking the Vesalian anatomical revolution as its point of departure, this volume charts the apparent rise and fall of anatomy studies within universities in sixteenth-century Spain, focussing particularly on primary sources from 1550 to 1600. In doing so, it both clarifies the Spanish contribution to the field of anatomy and disentangles the distorted political and historiographical viewpoints emerging from previous research. Studies of early modern Iberian science have only been carried out coherently and collaboratively in the last few decades, even though fierce debates on the subject have dominated Spanish historiography for more than two centuries. In the field of anatomy studies, many uninformed and biased readings of archival sources have resulted in a very confused picture of the practice of dissection and the teaching of anatomy in the Iberian Peninsula, in which the highly complex conditions of anatomical research within Spain's national context are often oversimplified. The new empirical evidence that this book brings to light suggests a far more multifaceted narrative of Iberian Renaissance anatomy than has been presented to date.

1. Einleitung 2. 2.1. Der Stand der anatomischen Wissenschaft an der Schwelle zum 16. Jahrhundert 2.2.1 Biographie 2.2.2. Leonardos urologisch-anatomische Zeichnungen 3. Das 16. Jahrhundert 3.1 Andreas Vesal 3.1.1. Biographie 3.1.2. Vesals Abb. zum Urogenitalsystem 3.1.3. Vesals Konsil uber die Behandlung einer Nierensteinerkrankung 3.2 Charles Estienne 3.2.1. Charles Estienne - Biographie 3.2.2. Die Darstellung des Urogenitaltraktes bei Charles Estienne und Estienne la Riviere 3.3 Bartholomaeus Eustachi 3.3.1 Biographie 3.3.2 Eustachis urologisch-anatomische Graphik 4. Das 17. Jahrhundert 4.1 Regnier de Graaf 4.1.1 Biographie 4.1.2 De Graafs urologisch-anatomische Abbildungen 4.2 Godefridus Bidloo 4.2.1 Biographie 4.2.2 Bidloos urologisch-anatomische Abbildungen von 1685 5. Das 18. Jahrhundert 5.1. Giovanni Domenico Santorini 5.1.1. Biographie 5.1.2. Santorinis Darstellungen zum Plexus venosus vesicoprostaticus 5.2. William Cheselden 5.2.1. Biographie 5.2.2. Cheseldens Darstellungen zum Urogenitaltrakt 5.3. Weitere urologisch-anatomische Abbildungen aus dem 18. Jahrhundert 5.3.1. Urologisch-anatomische Buntkupferdrucke 6. Das 19. Jahrhundert 6.1. Justus Christian Loder 6.1.1. Biographie 6.1.2. Loders Darstellungen zum Urogenitaltrakt 6.2. Antonio Scarpa 6.2.1. Biographie 6.2.2. Scarpas Darstellungen zum mannlichen Urogenitaltrakt 6.3. Martin Munz 6.3.1 Biographie 6.3.2. Die Lithographischen Darstellungen von Martin Munz zumUrogenitaltrakt 6.4. Marc Jean Bourgery 6.4.1. Biographie 6.4.2. Farblithographische Darstellungen des Urogenitaltraktes im Atlas von Marc Jean Bourgery 7. Die Urologie an der Schwelle zum 20. Jahrhundert 7.1. Gustav Simon 7.1.1. Biographie 7.1.2. Die erste wissenschaftlich geplante Exstirpation einer Niere durch Gustav Simon 7.2. Henry Morris 7.2.1. Biographie 7.2.2. Die erste operative Entfernung einer Nebenniere aufgrund eines Tumorleidens durch Henry Morris 1885 7.3. Bernhard Bardenheuer 7.3.1. Biographie 7.3.2. Die erste totale Blasenexstirpation aufgrund eines Tumorleidens ohne Harnleiterneuimplantation durch Bernhard Bardenheuer 1887 7.4. Karl Pawlik 7.4.1 Biographie 7.4.2. Die erste totale Blasenexstirpation mit Harnleiterneueinpflanzung bei einer Frau durch Karl Pawlik 1889 7.5. Hugh Hampton Young 7.5.1 Biographie 7.5.2. Die erste perineale radikale Prostatavesikulektomie aufgrund eines Proststakarzinoms durch H. H.Young 1904 7.6. Friedrich Voelcker 7.6.1 Biographie 7.6.2. Die Erstbeschreibung der totalen Samenblasenexstirpation auf ischiorektalem Weg durch Friedrich Voelcker 1912 8. Schlussbetrachtung

Cytopathologic, Physiologic, Diagnostic and Clinical Aspects of Retinal Degeneration: Histochemical Comparison of Ocular Drusen in Bruch's Membrane and Drusen in Eyes from Normal and Age-Related Macular Degeneration Donors; M. Kamei, et al. Animal Models of Retinal Degeneration: Development of a Model for Macular Degeneration; P.E. Rakoczy, et al. Subretinal Iodoacetate: A Model of Retinal Degeneration in Cats; J.C. Huang, et al. Mechanisms of Retinal Degeneration and Cell Death: Nitric Oxide-Induced Increases in Retinal cGMP: A Role in Photoreceptor Degenerations; I. Morgan, J.W. Wellard. Candidate Genes, Cloning Mapping and Other Molecular Genetics of Retinal Degeneration: Isolation of Candidate Genes for Retinal Degenerations; G. Inana, et al. Transplantation, Gene Therapy and Cell Rescue: bFGF Transfected Iris Pigment Epithelial Cells Rescue Photoreceptor Cell Degeneration in RCS Rats; M. Tamai, et al. Structural, Physiologic and Ageing Correlates of Retinal Degeneration. Further Studies on the Phagocytosis of Photoreceptor Outer Segments by Rat Retinal Pigment Epithelial Cells; M.O. Hall. 36 Additional Articles. Index.

Key Features 1) Detailed summary of every recorded variation and anomaly for each muscle in the human body 2) Information on comparative anatomy of each muscle (e.g., how each human muscle may appear in our closest living relatives, the apes). 3) Schematic illustrations of the variations and anomalies for easy visualization 4) Comprehensive literature review resulting in the most accurate prevalence information for each variation and anomaly 5) Diverse group of co-authors from various academic and cultural backgrounds

The transplantation of organs such as the heart, kidney, and lungs is an important means of replacing seriously damaged or diseased body parts. However, a transplanted organ may fail if the recipient's immune system mounts a response to it. Transplant patients are usually prescribed a life-long course of immunosuppressive medication, but these drugs can have adverse effects, including increased risk of infection and cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a current and comprehensive review of the molecular mechanisms behind graft rejection and how they may be overcome. Contributors discuss immunosuppressive drug therapies and tolerance induction strategies, including the use of regulatory T cells, mesenchymal stromal cells, and lymphodepletion. They describe how mouse and non-human primate models have been used to gain insight into the immunobiology of transplantation and to test therapeutic approaches. Clinical considerations, such as donor selection, organ preservation, surgery, and post-operative care, are also covered. This volume includes discussion of the emerging field of regenerative medicine and the bioethical issues surrounding organ transplantation, and provides historical background to the field. It is an essential reference for immunologists, pharmacologists, clinicians, and all who are working to improve this remarkable medical procedure.

Because of the huge potential of human embryonic stem (hES) cells, especially the newly developed human induced pluripotent stem (hiPS) cells, in disease treatment and life quality improvement, enormous efforts have been made to develop new methodologies to translate lab discoveries in stem cell research into bed-side clinical technologies. In Human Embryonic and Induced Pluripotent Stem Cells: Lineage-Specific Differentiation Protocols, experts in the field present a comprehensive collection of protocols designed for labs around the world. The topics covered in this detailed volume include techniques used for maintenance of hES and iPS cells in either small or large scale, techniques for directing hES and iPS cell lineage specification, techniques for enhancing the maturity of differentiated hES and iPS cells within three-dimensional scaffolds, techniques for reprogramming adult cells into iPS cells, techniques for generating patient-specific iPS cells, and techniques for translating hES and iPS cell research into new therapies. Chapters include lab ready protocols with tips on troubleshooting and avoiding known pitfalls. Wide-ranging and authoritative, Human Embryonic and Induced Pluripotent Stem Cells: Lineage-Specific Differentiation Protocols will be a tremendous aid for researchers and students who wish to explore these areas and transform their discoveries into the next generation of regenerative medicine and tissue engineering technologies.

Fundamentals of Anatomy & Physiology is designed to help you succeed in the challenging A&P course with an easy-to-understand narrative, precise visuals, and steadfast accuracy. The authors incorporate research that explores how learners use and process visual information, guiding you through complex figures as you deconstruct and better understand complicated processes. The 12th Edition features thoroughly updated content and enhanced art and figures to provide the most recent research and to support learning. An extensive review and revision ensures the content aligns better with current standards related to diversity, equity, and inclusion and reflects all learners’ lived experiences. Updates include improved language-sensitivity and discussions of gender and reproduction in the genetics and human development chapters.

Developed in response to student and faculty feedback worldwide, Gray's Basic Anatomy is a concise, easy-to-read text known for its utility and clarity, relevant and accurate content, strong clinical focus, and interactive online features. Perfect for readers who need an efficient, high-yield anatomy text, the fully updated 3rd Edition covers the key anatomical concepts that students need to know, all superbly illustrated with full-color artwork. Using a progressive and accessible approach, it provides a practical foundation of anatomical knowledge in a time-saving, highly understandable manner. Offers readable, concise and complete anatomy coverage with true-to-life illustrations and useful clinical examples Features fully revised and updated content throughout, including new non-binary information, equal coverage of male and female anatomy, and surface anatomy illustrations that reflect people of color. Integrates anatomy with current modes of imaging, clinical material, and surface anatomy. Includes a Conceptual Overview in each chapter that introduces readers to basic concepts of that region-now supplemented by additional simplified schematic diagrams for key structures. Incorporates superb artwork that includes select views from the wider Gray's family of texts. Contains updated classification of cranial nerves and new references to lymphatics associated with the central nervous system. Features outstanding electronic ancillaries, including a new bonus e-chapter on neuroanatomy essentials, an interactive surface anatomy tool, self-assessment questions, additional clinical and PT cases, and more. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Hutton looks at Manchester and Oxford to provide a comparative history of anatomical study. Using the Anatomy Act as a focal point, she examines how these two cities dealt with the need for bodies over two centuries.

PCR Quantification and Technical Aspects: Multiple Competitors for Single-Tube Quantification of HIV1 DNA; T. Vener, et al. Quantitation of p53 Tumor Suppressor Gene Copy Number in Tumor DNA Samples by Competitive PCR in an ELISA-Format; M. Hahn, et al. Standardisation of Messenger RNA Quantification Using an RTPCR Method Involving Coamplification with a Multi-Specific Internal Control; D. Shire, et al. Quantitative Analysis of Human DNA Sequences by Solid-Phase Minisequencing; A.C. Syvanen. Bioimage Analysers: Application for Ribozyme Kinetics; C.S. Voertler, K. Birikh. First Approaches to Quantitate MDR1Messenger RNA by in cell PCR; D. Lassner, et al. Application of in situ-PCR for Detection of Intracellular mRNAs; V. Uhlmann, et al. Psoralen Biotin: A Novel Reagent for Non-Enzymatic and Specific Labeling of Nucleic Acid Probes and Oligonucleotides; R.L. Burghoff, et al. The Effect of Quantitative Ratio between Primer Pairs on PCR Products in Multi-Target Amplification; D. Bercovich, et al. PCR Quantification of Infectious Agents: Quantitation of Rubella Virus Genome by QPCR and Its Application to Resolution for Mechanism of Congenital Rubella Syndrome; S. Katow, S. Arai. Significance of the Detection of Rubella Virus RNA by Nested PCR in Prenatal Diagnostics of Viral Infections; B. Pustowoit. Quantitative Detection of Human Cytomegalovirus DNA in Cerebrospinal Fluid by Polymerase Chain Reaction; J.U. Vogel, B. Weber. Quality Control and External Quality Assessment Schemes for the Diagnostic Use of PCR in Microbiological Laboratories-European Trials on Hepatitis B Virus and Cytomegalovirus; J. Schirm. Suppliers of Specialist Items. Index.

First published in 1990, this indispensable volume brings together authoritative, up-to-date, critical accounts of the present status of positron emission tomography (PET) in the study of movement disorders both in terms of the basic science relevant to PET and the clinical science related to the study of specific disease processes. For better understanding, it includes a review of the basic principles of PET and tracer kinetics. It also reviews clinical studies concerning Parkinson's and Huntington's disease, as well as some of the less common movement disorders such as progressive supranuclear palsy, olivopontocerebellar atrophy, and dystonia. Throughout the text, it emphasizes PET as a tool for the quantitative measurement of meaningful biochemical and physiological processes. This state-of-the-art work provides a perspective concerning the degree to which PET studies have advanced knowledge and the future role anticipated for PET. All clinical and basic researchers interested in functional imaging with PET and movement disorders will find this book an absolute must.

"Autophagy in Health and Disease" offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, "Autophagy in Health and Disease" presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information.
Discusses current understanding of the roles of autophagy in health and diseaseCovers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables