This invaluable book provides the first description of the diverse and fascinating functions of heme in life processes for a broad audience. It begins with an introduction to the intricate chemical properties of heme and the history of early observations of human diseases associated with heme. It then proceeds to describe the versatile roles of heme in controlling diverse molecular and cellular processes germane to human life and disease processes. Finally, an up-to-date review of human diseases associated with heme synthesis and application of heme synthesis in photodynamic therapy in cancer treatment is presented.Heme biology is unified and logical in presentation. It is well suited for students and professionals in life sciences who wish to comprehend the fascinating biology of heme and its usefulness in health and diseases. It may also be used as a reference book for advanced readers and researchers who are interested in heme biology. The explanations in the book are detailed enough to capture the interest of the curious reader, and complete enough to provide the necessary information for researchers to have an in-depth molecular understanding of heme biology and further their studies in this fascinating realm.

Hundreds of questions you'd only ask your doctor after your third martini! You know how it is... you're at a party, you've had a drink or two, and then someone introduces you to a friend. He's a doctor. And it seems like the perfect time to ask all those strange questions you've always wondered about, but never had the courage to ask: Can poppy seeds make you test positive for heroin? What are goosebumps? Why does asparagus make your wee smell? Why do old people get hairy ears? Is it possible to lose your contact lenses inside your head forever? Why do some people have an "outie" belly button and some people an "innie"? Does warm milk really help you sleep? Is it actually possible to get scared to death? This book gives the answer to these and many more questions - pretty much everything you've ever wanted to know - but never had enough Dutch courage to ask!

The adipokines (also called adipocytokines), are a group of peptides secreted by adipose tissue. They have diverse roles, from the cell to the whole body. The book is designed for health scientists, doctors, physiologists, immunologists, biochemists, college and university teachers and lecturers, undergraduates and graduates. The chapters are written either by experts or specialists in their field.

Thoroughly revised and updated to reflect key advances in behavioral neurology, "Neurobehavioral Anatomy, Third Edition" is a clinically based account of the neuroanatomy of human behavior centered on a consideration of behavioral dysfunction caused by disorders of the brain. A concise introduction to brain-behavior relationships that enhances patient care and assists medical students, the book also serves as a handy reference to researchers, neuroscientists, psychiatrists, and geriatricians.

The book outlines how cognitive and emotional functions are represented and organized in the brain to produce the behaviors regarded as uniquely human. It reviews the effects of focal and diffuse brain lesions, and from this analysis a conception of the normal operations of the healthy brain emerges. Christopher M. Filley integrates data and material from different disciplines to create a concise and accessible synthesis that informs the clinical understanding of brain-behavior relationships. Clinically practical and theoretically stimulating, the book is an invaluable resource for those involved in the clinical care and study of people with neurobehavioral disorders.

Including a useful glossary and extensive references guiding users to further research, the third edition will be of significance to medical students, residents, fellows, practicing physicians, and the general reader interested in neurology.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Written for the modern medical student and designed to accompany any current gross anatomy textbook, this brand-new pictorial handbook presented by Drs. Vilensky, Weber, Carmichael, and Sarosi lets you quickly identify pathologic correlates of gross anatomy. Abundant side-by-side high-quality radiography, MR, CT, and ultrasound images of normal and pathologic conditions help you quickly develop the skills you need to differentiate between what's normal and what's not. Discussions on the choice of imaging modality for various pathologies will help you select the right imaging procedure in many clinical situations, making this a handy resource in the clinical environment. But best of all, this visual approach to pathologic correlates will help you ace your courses, the USMLE and NBME final exams. . Features side-by-side radiography, MR, CT, and ultrasound images that illustrate normal and abnormal anatomy, helping you quickly identify conditions while improving your diagnostic skills. . Covers clinical conditions found in the main core of textbooks and radiologically depicts the clinical correlates that you're exposed to daily, making it the ideal companion resource for any medical gross anatomy course. . Uses concise, brief text that explains the condition, thus allowing the radiologic images to guide you to the differentiating factors. . Incorporates discussions of imaging modality choices for a range of pathologies to help you understand how to select imaging procedures for various clinical situations in the clinical environment. . Offers the visual guidance you need to study for and pass your exams.

Stem cells are central to the development and homeostasis of metazoan tissues and play roles at multiple times within a diversity of organs during the lifetime of an animal. A key goal of regenerative medicine is the in vivo repair of organs damaged by disease or injury. In order to facilitate this goal we need to understand how stem cells are generated, what factors maintain them in their respective tissues and how their differentiation is regulated. In this volume, leading researchers discuss the nature of stem cells and pluripotency and how this state can be experimentally induced. Stem cell maintenance, proliferation and differentiation is under tight regulation as excess stem cell proliferation could facilitate tumour formation and conversely loss of stem cells or failure of differentiation could disrupt tissue homeostasis or repair. Hence, stem cells are regulated by multiple layers of molecular control and this volume discusses transcriptional, translational, epigenetic, cell signalling and microRNA modalities that affect stem cell behaviour. Many of the underlying key principles of stem cell biology were discovered by genetic analysis of invertebrate systems and chapters in this volume describe regulation of the germline in C. elegans and in the digestive system, central nervous system and germline of Drosophila. The molecular processes that regulate regenerative organ systems from all three of the vertebrate germ layers are described with emphasis on the male germline, nervous system, epidermis, intestine, haematopoietic system and derivatives of the mesoderm. Several chapters also focus on molecular families that have been implicated in controlling a range of stem cell types including the JAK-STAT, Wnt and Notch signalling pathways; Myc, Myb and nuclear receptor transcriptional regulators; the Musashi family of RNA-binding proteins; microRNAs and epigenetic regulators. This volume will provide access to the current state of re

Anatomy and pathology are key areas in medical training, but the amount medical students have to learn within them can seem overwhelming. This book helps students gain a firm grasp of the facts they must know before they enter their clinical years. It encompasses the core basics of the major organ systems in the body and presents them in a memorable, easy-to-read form. The book covers the background and knowledge that are clinically relevant to, and commonly encountered in, end-of-semester exams and provides a solid preparation for clinical years. It is an excellent resource for all medical students wishing to gain and retain anatomy and pathology knowledge in a time-effective manner.

First published in 1990, this indispensable volume brings together authoritative, up-to-date, critical accounts of the present status of positron emission tomography (PET) in the study of movement disorders both in terms of the basic science relevant to PET and the clinical science related to the study of specific disease processes. For better understanding, it includes a review of the basic principles of PET and tracer kinetics. It also reviews clinical studies concerning Parkinson's and Huntington's disease, as well as some of the less common movement disorders such as progressive supranuclear palsy, olivopontocerebellar atrophy, and dystonia. Throughout the text, it emphasizes PET as a tool for the quantitative measurement of meaningful biochemical and physiological processes. This state-of-the-art work provides a perspective concerning the degree to which PET studies have advanced knowledge and the future role anticipated for PET. All clinical and basic researchers interested in functional imaging with PET and movement disorders will find this book an absolute must.

Since its inception two generations ago, oculoplastic surgery has constantly evolved. What was once dogma may now be passe. Procedures that were once passe may be resurrected and utilized again. Providing simplified solutions to complex problems, Atlas of Oculoplastic and Orbital Surgery is a practical, problem-orientated guide to the management of common oculoplastic and orbital disorders. Based on Dr. Spoor s thirty years of practice, the book emphasizes the more common oculoplastic conditions likely to present to a busy ophthalmologist.

The text covers upper and lower eyelid surgery and repair, orbital surgery, and the prevention and treatment of potential complications. The procedures are described with surgical photos and illustrations in a casual, didactic fashion, as a senior doctor would use instructing a resident or fellow. The book is essential reading for ophthalmologists, oculoplastic surgeons, neuro-ophthalmologists and plastic surgeons."

Lippincott (R) Connect Featured Title Purchase of the new print edition of this Lippincott (R) Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments. Photographic Atlas of Anatomy features outstanding full-color photographs of actual cadaver dissections, with accompanying schematic drawings and diagnostic images, to help students develop an unparalleled mastery of human anatomy with ease. Depicting anatomic structures more realistically than illustrations in traditional atlases, this proven resource shows students exactly what they will see in the dissection lab. Chapters are organized by region in the order of a typical dissection, with each chapter presenting regional anatomical structures in a systematic manner. This updated 9th edition includes revised content throughout and features additional cadaver dissection photos, medical imaging, and clinical illustrations, as well as a new appendix with learning resources that strengthen students' understanding of the vascular, lymphatic, muscular, and nervous systems. UPDATED! Chapters organized by region guide you through the order of a typical dissection. NEW! Appendix with learning resources reinforces your understanding of the vascular, lymphatic, muscular, and nervous systems. More than 1,200 full-color dissection photos, medical imaging, and clinical illustrations -all new or updated- depict key anatomical distinctions and functional connections as seen in the dissection lab. Authentic photographic reproduction of colors, structures, and spatial dimensions familiarize you with the human anatomy as seen in the dissection lab and on the operating table. Functional connections between single organs, the surrounding tissue, and organ systems are clarified to help you prepare for the dissection lab and practical exams. Dissections illustrate the regional anatomy in layers "from the outside in" to prepare you for the lab and operating room. Clinical comments strengthen your understanding and clinical readiness. Lippincott (R) Connect features: Full access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience. Carefully curated resources, such as interactive diagrams, audio and video tutorials, and self-assessment, all designed to facilitate further comprehension. Lippincott (R) Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can: Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics. Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material. Annotate and highlight key content for easy access later. Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page.

The way you perceive the world, plan, make decisions and communicate your thoughts and feelings depends on the function and hierarchical arrangement of cortical modules. The ability to both provide adaptive responses to our ever-changing environment and to pursue a useful role in society is the most important problem faced by present day neuroscientists. In essence, the workings of cortical modules define the nature of our soul, making each of us who we are. This book provides a breath-taking view of different perspectives by world renowned authorities as to the workings of these cortical modules both in the normal state and in mental disorders.

The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease.

Learn everything you need to know about the anatomy of the limbs and back and how to apply the material to everyday activities and movements with this updated edition of the classic text. This user-friendly book is packed with detailed quick-reference tables and newly revised illustrations. Take advantage of expanded study questions and exercises at the end of each chapter to actively engage yourself in the learning process and enhance your comprehension of the material. Understanding the functional and clinical relevance of musculoskeletal anatomy has never been easier! Well-rounded, detailed coverage of the musculoskeletal system includes information on the head, neck, thorax, abdomen, and pelvis. Easy-to-understand, flowing text is presented in paragraph form. Abundant tables on muscles and nerves condense the information in the text for easy reference. Detailed discussions of specific movements focus on individual joints and muscles. A glossary provides a quick reference for useful terms. Evolve online resources for students and instructors include an image bank, test bank, Archie animations, and anatomy labeling exercises. UPDATED!! Clear, concise, and informative color illustrations enable you to better interpret the text. MORE Functional/Clinical Notes highlight the applications and importance of the material. MORE Analyses of Activities and Associated Movements boxes help you apply the anatomical information on movements and muscles to everyday life. EXPANDED information on surface anatomy describes palpable structures and how to "visualize" anatomy through the skin. MORE Review Questions and Exercises are provided at the end of each chapter to enhance your level of comprehension.

By popular request - Frank H. Netter, MD's classic anatomy paintings on playing cards! Perfect for clinicians, medical and healthcare students, and all Netter fans! Favorite illustrations from Netter's Atlas of Human Anatomy on card faces - from the iconic Netter skull on the Jokers to the superficial vessels of the face on the Jacks . and on the Kings, a photo of the dapper Dr. Netter himself! Standard 52-card deck includes classic Netter paintings plus assorted pieces by Netter successor, Carlos Machado, MD; 14 different illustrations in all.

The eminent physician and anatomist Dr William Hunter (1718-1783) made an important and significant contribution to the history of collecting and the promotion of the fine arts in Britain in the eighteenth century. Born at the family home in East Calderwood, he matriculated at the University of Glasgow in 1731 and was greatly influenced by some of the most important philosophers of the Scottish Enlightenment, including Francis Hutcheson (1694-1746). He quickly abandoned his studies in theology for Medicine and, in 1740, left Scotland for London where he steadily acquired a reputation as an energetic and astute practitioner; he combined his working life as an anatomist successfully with a wide range of interests in natural history, including mineralogy, conchology, botany and ornithology; and in antiquities, books, medals and artefacts; in the fine arts, he worked with artists and dealers and came to own a number of beautiful oil paintings and volumes of extremely fine prints. He built an impressive school of anatomy and a museum which housed these substantial and important collections. William Hunter's life and work is the subject of this book, a cultural-anthropological account of his influence and legacy as an anatomist, physician, collector, teacher and demonstrator. Combining Hunter's lectures to students of anatomy with his teaching at the St Martin's Lane Academy, his patronage of artists, such as Robert Edge Pine, George Stubbs and Johan Zoffany, and his associations with artists at the Royal Academy of Arts, the book positions Hunter at the very centre of artistic, scientific and cultural life in London during the period, presenting a sustained and critical account of the relationship between anatomy and artists over the course of the long eighteenth century.

Key features: * Presents a concise, accessible guide to regional and clinically applied anatomy, that clearly demonstrates to students the level of knowledge that is required for medical and healthcare-related curricula. * Uses high-quality clinical and intra-operative images integrated into the text which emphasizes important topics through bullet points. * Features logically arranged seven sections, each devoted to a body region or system, which includes a self-test quiz, with the single best answer and spotter-style questions.

This Third Edition of Medical Cell Biology focuses on the scientific aspects of cell biology important to medical students, dental students, veterinary students, and prehealth undergraduates. Maintaining a primary focus on eukaryotic cell biology, the text explains general cell biology principles in the context of organ systems and human and animal disease.
* 60% New Material
* New Topics include:
Apoptosis and cell dealth from a neural perspective
Signal transduction as it relates to normal and abnormal heart function
Cell cycle and cell division related to cancer biology
* All new clinical cases
* Serves as a prep guide to the National Medical Board Exam with a CD-ROM of 200 sample board-style questions (using Exam Master(R) technology): www.exammaster.com
* Focuses on eukaryotic cell biology as it related to human disease, thus making the subject more accessible to pre-med and pre-health students

Human Anatomy: A Clinically-Orientated Approach, part of the Illustrated Colour Text series, provides a highly illustrated short account of human anatomy for medical and other health science students. The illustrations include a high proportion of cadavaric photographs prepared especially for this book. The organisation of the book follows the normal regional approach; the text concentrates on the clinical relevance of the anatomy. Succint and highly illlustrated account of the subject suitable for courses that have restricted anatomical teaching. Illustations include a larage number of cadavaric photographs from specially prepared dissections Text emphasises clinical relevance of subject Now in the easy to access Illustrated Colour Text format More clinical material highlighted in boxes New chapter on anatomy of the breast

For the two-semester A&P laboratory course. Help manage time and improve learning inside and outside of the lab The #1 best-selling Human Anatomy & Physiology Laboratory Manual helps students and instructors manage time inside and outside of the A&P lab classroom and works hand-in-hand with Mastering A&P, the leading online homework and learning program for A&P. The 13th Edition features dozens of new, full-color figures and photos in the review sheets, as well as revamped clinical application questions and critical thinking questions that reinforce the most important concepts from lab. Encourage students to prepare for lab by assigning recommended Mastering A&P activities for each lab exercise, including 18 pre-lab videos (8 are new to this edition), Building Vocabulary Coaching Activities, exercise review sheet assessment questions, art labeling activities, mobile-ready Practice Anatomy Lab (TM) 3.1 with customizable flashcards, and more. Thousands of assignment options in the Item Library are closely correlated with the print edition of the manual, making it easier than ever to create homework assignments that are aligned with your lab activities. Continuing to set the standard for the 2-semester A&P laboratory course, the lab manual complies with the illustration and presentation style of the best-selling Marieb/Hoehn Human Anatomy & Physiology text, but can accompany any A&P textbook. New customization options are available through Pearson Collections, as well as three conventional versions: Main (12th Edition), Cat (13th Edition), and Fetal Pig (13th Edition). Also available with Mastering A&P Mastering (TM) is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools developed to engage students and emulate the office-hour experience, Mastering personalizes learning and improves results for each student. Mastering A&P assignments support interactive features in the lab manual, including pre-lab video coaching activities, bone, muscle, and dissection videos, Dynamic Study Modules, Get Ready for A&P, plus a variety of Art Labeling Questions, Clinical Application Questions, and more. Note: You are purchasing a standalone product; Mastering A&P does not come packaged with this content. Students, if interested in purchasing this title with Mastering A&P, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and Mastering A&P, search for: 0134767349 / 9780134767345 Human Anatomy & Physiology Laboratory Manual, Cat version Plus MasteringA&P with Pearson eText -- Access Card Package, 13/e 0134763246 / 9780134763248 MasteringA&P with Pearson eText -- ValuePack Access Card -- for Human Anatomy & Physiology Laboratory Manuals 0134632338 / 9780134632339 Human Anatomy & Physiology Lab Manual, Cat Version

In 1768, Ahmad al-Damanhuri became the rector (shaykh) of al-Azhar, which was one of the most authoritative and respected positions in the Ottoman Empire. He occupied this position until his death. Despite being a prolific author, whose writings are largely extant, al-Damanhuri remains almost unknown, and much of his work awaits study and analysis. This book aims to shed light on al-Damanhuri's diverse intellectual background, and that of and his contemporaries, building on and continuing the scholarship on the academic thought of the late Ottoman Empire. The book specifically investigates the intersection of medical and religious knowledge in Eighteenth-Century Egypt. It takes as its focus a manuscript on anatomy by al-Damanhuri (d. 1778), entitled "The Clear Statement on the Science of Anatomy (al-qawl al-sarih fi 'ilm al-tashrih),". The book includes an edited translation of The Clear Statement, which is a well-known but unstudied and unpublished manuscript. It also provides a summary translation and analysis of al-Damanhuri's own intellectual autobiography. As such, the book provides an important window into a period that remains deeply understudied and a topic that continues to cause debates and controversies. This study, therefore, will be of keen interest to scholars working on the "post-Classical" Islamic world, as well as historians of religion, science, and medicine looking beyond Europe in the Early Modern period.

Applied Anatomy for the FRCA covers the anatomical knowledge that trainee anaesthetists who are revising for the Primary and Final FRCA exams will need. The topics covered are derived from the FRCA curriculum and include the most up-to-date version of past exam questions, in order to ensure targeted and successful exam revision. The content, illustrations and overall layout of this book ensure that common gaps in anatomical knowledge encountered by FRCA trainees are included. This reference is divided into sections pertaining to anatomical regions: head and neck, thorax, abdomen, spine, and the upper and lower limbs. The topics of importance to anaesthetists are presented under 'structures', 'circulation' and 'nervous system' (with relevance to regional anaesthesia). Each topic is extensively researched and presented in a simple format for maximum retention. This book makes learning and remembering applied anatomy as straightforward as possible. Applied Anatomy for the FRCA supplements the knowledge required by trainee anaesthetists appearing for the FRCA exams. Clinical educators will also find it useful in teaching. It serves as a practical reference for anatomical knowledge at any point in an anaesthetist's career. About the Editors Dr Bobby Krishnachetty has been a Consultant Anaesthetist at Southend University Hospital since 2010 and a college tutor for six years. She completed her diploma in medical education and is the author of The Final FRCA Structured Oral Examination: A Complete Guide. She is also the organiser of the regional teaching for Core trainees in the East of England school of anaesthesia, as well as Founder of the 'Southend Viva Club' Primary and Final FRCA SOE revision courses for more than nine years, and Cofounder of MRCS OSCE webinars. Mr Abdul Syed has been a Consultant Surgeon at Southend University Hospital since 2015. He is Lead for postgraduate teaching of surgical trainees, Cofounder of MRCS OSCE webinars and conducts Core surgical trainee interview skills courses. Mr Syed is also an Assessor for medical school interviews and an active participant in QI projects and research.

The fourth volume in the Atlas of Human Central Nervous System Development series, The Human Brain During the Late First Trimester provides new information about features of the perinatal brain. It deals with brain development during the late first trimester (GW11-GW7.5). The major theme of this volume is the identification of stretches and patches (mosaics) of the NEP matrix along the hypertrophied telencephalic, diencephalic, mesencephalic, and rhombencephalic superventricles. Many putative migratory paths of young nerons on their way to their settling sites are also identified. In the younger specimens, the brain sections are presented as they are embedded in the skull and developing facial structures. The older specimens show the onset of development of some of the large fiber tracts. Like the rest of the series, it contains photographs of the entire brain arranged in companion plates that include two parts: a large, high resolution black and white photograph and a "ghost image" of the photograph with unabbreviated labels. It is a user-friendly survey of the complex structural processes that occur during human CNS development. This volume can be purchased as part of the complete five volume set.

Anatomy and physiology presented in a clear and accessible manner for the midwifery student. Well illustrated with numerous line diagrams, Anatomy & Physiology in Maternity Care takes a system-approach to the physiological changes that occur throughout the childbearing year. Varied case studies reflecting the latest research findings ensure that theory is firmly rooted in midwifery practice. This is an excellent first textbook for those students needing to understand the anatomy and physiology of pregnancy and childbirth An introductory text covering anatomy and physiology relevant to midwifery students Simple, accessible language ensures complete understanding of complex theory Case studies relate anatomy and physiology to midwifery practice Covers physiological changes throughout the childbearing year Updated references New case studies reflecting latest research findings