Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

The previous two editions of the "Human Nervous System "have been the standard reference for the anatomy of the central and peripheral nervous system of the human. The work has attracted nearly 2,000 citations, demonstrating that it has a major influence in the field of neuroscience. The 3e is a complete and updated revision, with newchapters covering genes and anatomy, gene expression studies, and glia cells. The book continues to be an excellent companion to the "Atlas of the Human Brain," and a common nomenclature throughout the book is enforced. Physiological data, functional concepts, and correlates to the neuroanatomy of the major model systems (rat and mouse) as well as brain function round out the new edition.
Adopts standard nomenclature following the new scheme by Paxinos, Watson, and Puelles and aligned with the Mai et al. "Atlas of the Human Brain" (new edition in 2007)Full color throughout with many new and significantly enhanced illustrationsProvides essential reference information for users in conjunction with brain atlases for the identification of brain structures, the connectivity between different areas, and to evaluate data collected in anatomical, physiological, pharmacological, behavioral, and imaging studies"

Tamoxifen Tales: Suggestions for Scientific Survival presents a case study describing the academic journey of teams behind major advances in medical sciences, highlighting lessons learned that are applicable to the next generation of scientists. This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry. The book documents Professor V. Craig Jordan's 50-year career in medical sciences that led to the discovery and development of Selective Estrogen Receptor Modulators (SERMs), which became the standard of women's healthcare around the world. Additionally, it illustrates the versatility of a scientist with a commitment to serving societies. This important resource will be a useful and interesting book for established medical scientists, research mentors and advanced students wanting to chart a successful and impactful research career.

Cytometry is one of the most rapidly growing methodologies available for basic cell and molecular biology, cytogenetics, immunology, oncology, environmental sciences and also various fields of clinical medicine. Thisnew edition, split into 2 Parts, is an almost completely new book, with nearly all of the chapters devoted to new topics. Like the previous volumes on cytometry published as part of the Methods in Cell Biology series, it provides a comprehensive description of particular cytometric methods and reviews their applications. Chapters present the theoretical foundations of the described methods, their applicability in experimental laboratory and clinical settings, and describes common traps and pitfalls such as problems with data interpretation, comparison with alternative assays, and choosing the optimal assay.
* Comprehensive presentation of cytometric methods covering theoretical applications, applicability, potential pitfalls, and comparisions to alternative assays
* Discusses many new assays developed since the previous edition
* Presents recent developments in cytometric intrumentation/technology"

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

A good knowledge of descriptive, surgical and functional anatomy and biomechanics of the extensor tendons of the hand is fundamental for adequate surgical and rehabilitation management of their lesions. Extensor tendons are immediately localised under skin which makes them vulnerable to trauma. They are divided into extrinsic and intrinsic systems with complicated anatomy and biomechanics. This book examines different effective rehabilitation strategies to treat and repair tendons as well as discussing the anatomy and biomechanics of extensor tendons.

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

- Coming Soon - The long-awaited update of The Netter Collection of Medical Illustrations is now becoming a reality! Master artist-physician, Carlos Machado, and other top medical illustrators have teamed-up with medical experts to make the classic Netter "green books" a reliable effective current-day reference. The first three volumes to be released will be: The Reproductive System The Endocrine System The Respiratory System See www.NetterReference.com/greenbooks for more information. Pre-order your copies today! Access rare illustrations in one convenient source from the only Netter work devoted specifically to the respiratory system. Get a complete overview of the respiratory system through multidisciplinary coverage from physiology and biochemistry to adult and pediatric medicine and surgery. Gain a quick understanding of complex topics from a concise text-atlas format that provides a context bridge between primary and specialized medicine. Grasp the nuances of the pathophysiology of today's major respiratory conditions-including pulmonary hypertension, COPD, asthma, environmental lung disease, sleep disorders, infections of the immunocompromised, neonatal breathing disorders, and drug-resistant TB, and modern endoscopic and surgical techniques-through advances in molecular biology and radiologic imaging. Benefit from the expertise of the new editor, David Kaminsky, MD, who contributes significant experience in asthma and general pulmonary and critical care medicine, and his team of world class contributors. Clearly see the connection between basic and clinical sciences with an integrated overview of normal structure and function as it relates to pathologic conditions. Apply a visual approach-with the classic Netter art, updated illustrations, and modern imaging-to normal and abnormal body function and the clinical presentation of the patient. Tap into the perspectives of an international advisory board for content that reflects the current global consensus. A reliable and effective reference on the respiratory system with the visual support of Netter

Since its first publication in 1989, Anatomy and Human Movement has grown to become a best-selling seminal textbook, helping students to understand and remember the mechanisms which allow movement to take place. Written specifically for physiotherapists and occupational therapists, this textbook is the ideal resource for students learning how to perform a musculoskeletal examination and for practising clinicians who need to refresh their functional anatomy. The approach used is the same as in the previous edition, which shows the physiotherapist's perspective during patient examinations through an intact skin: bones are presented first, followed by accurate descriptions of muscles, joints, nervous system and blood supply. New to this edition, the introduction of an e-learning course as a helpful study aid and an ideal complement to the text. Fully revised and updated text and introduction of online resources Excellent new full-colour images and photographs provide the highest level of clarity Summary boxes for quick reference and overview Detailed and focused account of anatomy for physiotherapists and other allied health professionals Part of the Elsevier Physiotherapy Essentials series, which are key textbooks for students and lecturers

As one of the first cortical areas to be explored experimentally, the motor cortex continues to be the focus of intense research. Motor Cortex in Voluntary Movements: A Distributed System for Distributed Functions presents developments in motor cortex research, making it possible to understand and interpret neural activity and use it to reconstruct movements. Featuring viewpoints based on monkey and human studies, the book focuses on how neuronal activity changes during learning, discusses what the motor cortex encodes for, and covers the neuronal representations of voluntary movements and the mechanism of their generation during learning. Section 1 uses functional neuroanatomy and imaging studies to describe motor cortical function, and Section 2 provides an overview of studies about neural representations in the motor cortex. The third section concentrates on motor learning, and the final section highlights the reconstruction of movements using brain activity. Revealing many exciting applications of this rapidly expanding science, this book enhances our understanding of the generation of motor commands. It is an essential resource for neuroscientists interested in motor function, rehabilitation medicine practitioners, and biomedical engineers.

For more than 30 years, "Current Topics in Developmental Biology" has provided a forum for dissemination and discussion of new ideas and thought in developmental biology. Bringing together a series of articles on the structural, functional, and developmental characteristics of epithelials, this thematic volume represents a timely and valuable contribution to an exciting and multidisciplinary field of study. Because defects in epithelial function and growth control play a major role in human disease-cancerous tumors, spina bifida, cardiac malformations, for example-this volume will be of particular interest to researchers working in cancer drug design and development and those working in therapeutic areas to treat developmental abnormalities.

Coverage of current research findings and thought on cell-cell and cell-extracellular matrix interactions gives researchers a better understanding of the processes of remodeling and morphogenesis, which are critical to the development of drugs aimed at disrupting the early formation and proliferation of cancerous tumors.

Inclusion of chapters that discuss the most contemporary thought on cell polarity and tissue morphogenesis, providing researchers with a better understanding of the control of cellular organization and polarity (particularly important to researchers who are developing treatments for developmental abnormalities and those working in cancer drug development).

Use of a variety of animal models, allowingresearchers to compare and contrast the molecular mechanisms that underlie cell-cell and cell-extracelluar matrix interactions in a variety of research models."

Full multiplanar coverage of the spine, extremities, and joints! Renowned for its superb illustrations and highly practical information, the third volume of this classic reference reflects the very latest in state-of-the-art imaging technology. Together with Volumes 1 and 2, this compact and portable book provides a highly specialized navigational tool for clinicians seeking to master the ability to recognize anatomical structures and accurately interpret CT and MR images. Highlights of Volume 3: New CT and MR images of the highest quality Didactic organization using two-page units, with radiographs on one page and full-color illustrations on the next Concise, easy-to-read labeling on all figures Color-coded, schematic diagrams that indicate the level of each section Sectional enlargements for detailed classification of the anatomical structure Comprehensive, compact, and portable, this popular book is ideal for use in both the classroom and clinical setting.

History of Anatomy: An International Perspective is unique in its global approach to studying the development of human anatomy. Though it references widely known anatomists, such as Aristotle, Galen, and Bell, the book also pay homage to less famous contributors to the field and explains their findings. This comprehensive history of the morphology of humans serves as a useful guide to anatomists, anthropologists, physicians, surgeons, and anyone interested in the early history of medicine and surgery.

The better you understand anatomy, the better you understand yourself. This book clearly identifies all the major muscles of the human body and shows how they work. For each muscle there is straightforward information, including common problems, signs of weakness, and self-massage for first aid. Provides anatomical terminology and clearly outlined reference pages.

Rather than focusing on dance injuries, this book takes a positive approach showing what a dancer can do to dance better, which, in turn, will decrease injury rates. It presents human anatomy and motion in a functional, dance-specific way that teaches the readers to appreciate and take ownership of their bodies through a tour of the musculoskeletal system and movement analysis. The book is divided into three parts. Part one, Anatomy, describes the specific characteristics that affect motion at each individual joint, demonstrated by a variety of hands-on activities for readers to perform. Part two, Movement Analysis, discusses muscles that produce movement and introduces readers to a system of movement analysis. Part three, Conditioning, provides a practical, integrative approach to exercise for enhanced performance. The written material is accompanied by anatomical line drawings commissioned for the book, photographs, and an assortment of experiential activities specifically designed for dancers.

Interest in the therapeutic value of embryonic, fetal and adult stem cell types is rapidly expanding throughout the scientific community. The first half of this century should see an explosion of therapeutic applications of stem cells which will grow from the cells and techniques described in this book. Stem Cell Culture provides a comprehensive resource for researchers in the fields of embryonic, fetal and adult stem cell biology to find methods for the purification, culture, and differentiation of these cell types, with the main emphasis on the maintenance of the stem cell phenotype in vitro. This volume will be the first to broadly cover multiple types of stem cell culture from different ages, organs and species. Chapters focus on the practical do's and don'ts of isolating and culturing these cell types, and use illustrative data or diagrams that allow the reader to confidently apply techniques and make this a standard reference.
*Compares and contrasts a broad range of species and stem cell types.
*Describes techniques in stem cell research, and goes beyond just protocols by presenting methods within perspective of recent literature reviews.
*Delineates critical steps and potential pitfalls for each method, provided by at-the-bench authors for expert information.
*Covers specific procedures in dealing with Human Embryonic Stem Cells, but also emphasizes other sources of potentially therapeutic stem cells such as amniotic fluid, adult muscle and adipose tissue, and umbilical cord.

BMA Book Awards - Winner of Basic and Clinical Sciences category! The perfect up-to-date imaging guide for a complete and 3-dimensional understanding of applied human anatomy Imaging is ever more integral to anatomy education and throughout modern medicine. Building on the success of previous editions, this fully revised sixth edition provides a superb foundation for understanding applied human anatomy, offering a complete view of the structures and relationships within the whole body, using the very latest imaging techniques. All relevant imaging modalities are included, from plain radiographs to more advanced imaging of ultrasound, CT, MRI, functional imaging and angiography. Coverage is further enhanced by a carefully selected range of BONUS electronic content, including clinical photos and cases, ultrasound videos, labelled radiograph 'slidelines', cross-sectional imaging stacks and test-yourself materials. Uniquely, key syllabus image sets are now highlighted throughout to aid efficient study, as well as the most common, clinically important anatomical variants that you should be aware of. This superb package is ideally suited to the needs of medical students, as well as radiologists, radiographers and surgeons in training. It will also prove invaluable to the range of other students and professionals who require a clear, accurate, view of anatomy in current practice. Fully revised legends and labels and new high-quality images-featuring the latest imaging techniques and modalities as seen in clinical practice Covers the full variety of relevant modern imaging-including cross-sectional views in CT and MRI, angiography, ultrasound, fetal anatomy, plain film anatomy, nuclear medicine imaging and more - with better resolution to ensure the clearest anatomical views Core syllabus image sets now highlighted throughout-to help you focus on the most essential areas to excel on your course and in examinations Unique summaries of the most common, clinically important anatomical variants for each body region-reflects the fact that around 20% of human bodies have at least one clinically significant variant New orientation drawings-to help you understand the different views and the 3D anatomy of 2D images, as well as the conventions between cross-sectional modalities Ideal as a stand-alone resource or in conjunction with Abrahams' and McMinn's Clinical Atlas of Human Anatomy-where new links help put imaging in the context of the dissection room Now a more complete learning package than ever before, with superb BONUS electronic enhancements embedded within the accompanying eBook, including: Labelled image 'stacks'-that allow you to review cross-sectional imaging as if using an imaging workstation Labelled image 'slidelines'-showing features in a full range of body radiographs to enhance understanding of anatomy in this essential modality Self-test image 'slideshows' with multi-tier labelling-to aid learning and cater for beginner to more advanced experience levels Labelled ultrasound videos-bring images to life, reflecting this increasingly clinically practiced technique Questions and answers accompany each chapter-to test your understanding and aid exam preparation 34 pathology tutorials-based around nine key concepts and illustrated with hundreds of additional pathology images, to further develop your memory of anatomical structures and lead you through the essential relationships between normal and abnormal anatomy High-yield USMLE topics-clinical photos and cases for key topics, linked and highlighted in chapters

International Review of Cytology presents current advances and comprehensive reviews in cell biology - both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

This book presents the anatomical systems that take part in the scientific and clinical study of emotional functions and neuropsychiatric disorders. It discusses the limbic system-the cortical and subcortical structures in the human brain involved in emotion, motivation, and emotional association with memory-at length and how this is no longer a useful guide to the study of psychiatric disorders. The book provides an understanding of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century. The goal is to help the reader develop an understanding of the gross anatomical organization of the human forebrain.
The book also includes an enlightening DVD describing the basic surface anatomy of the cerebral hemispheres, coronal and horizontal sections, and blunt dissection of the forebrain with special attention to clinical-anatomical correlations of interest to psychiatrists.
* A re-evaluation of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century
* A compellingly expanded conceptualization of Broca's famous limbic lobe
* Clinical and basic science boxes highlighting specific concepts, structures, or neuronal circuits from a clinical perspective
* DVD illustrating dissection of the human brain by one of the world's masters

International Review of Cytology presents current advances and comprehensive reviews in cell biology both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include Function and Evolution of the Vacuolar Compartment in Green Algae and Land Plants
(Viridiplantae); Cell biology and pathophysiology of diacylglycerol kinase family: morphological aspects in tissues and organs; Structure and function of desmosomes; Subepithelial Fibroblasts in Intestinal Villi: Roles in Intercellular Communication; and Syndrome of Aluminum Toxicity and Diversity of Aluminum Resistance in Higher Plants.

International Review of Cytology presents current advances and comprehensive reviews in cell biology both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include Mechanisms of Gradient Detection: A Comparison of Axon Pathfinding with Eukaryotic Cell Migration; Leptin and the Regulation of Hypothalamic-Pituitary-Adrenal Axis; Focal Adhesion and p53 Signaling in Cancer Cells; Cell and Molecular Biology of the Spindle Matrix; Mitochondrial Biology and Disease in Dictyostelium; Oxytocin and the Human Prostate in Health and Disease.

"International Review of Cytology" presents current advances and comprehensive reviews in cell biology both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include LEM-domain Proteins: New Insights into lamin-interacting Proteins; New Insights into Membrane Trafficking and Protein Sorting; Structure and Function of the Atypical Orphan Nuclear Receptor; Zebrafish Gastrulation: Cell Movements, Signals and Mechanisms; Calcium Dynamics: Spatio-tempral Organization from the Subcellular to the Organ Level; New Technologies Used in the Study of Human Melanoma.