Ando establishes a theory of subjective preference of the sound field in a concert hall, based on preference theory with a model of human auditory- brain system. The model uses the autocorrelation function and the interaural crosscorrelation function for signals arriving at two ear entrances and considers the specialization of human cerebral hemispheres. The theory may be applied to describe primary sensations such as pitch or missing fundamental, loudness, timbre, and duration. The theory may also be applied to visual sensations as well as subjective preference of visual environments. Remarkable findings in activities in both auditory-brain and visual-brain systems in relation to subjective preference as a primitive response are described.

The auditory system has a remarkable ability to adjust to an ever-changing environment. The six review chapters that comprise Plasticity of the Central Auditory System cover a spectrum of issues concerning this ability to adapt, defined by the widely applicable term "plasticity." With chapters focusing on the development of the cochlear nucleus, the mammalian superior olivary complex, plasticity in binaural hearing, plasticity in the auditory cortex, neural plasticity in bird songs, and plasticity in the insect auditory system, this volume represents much of the most current research in this field. The volume is thorough enough to stand alone, but is closely related a previous SHAR volume, Development of the Auditory System (Volume 9) by Rubel, Popper, and Fay. The book fully addresses the difficulties, challenges, and complexities of this topic as it applies to the auditory development of a wide variety of species.

The cochlear implant is a device that bypasses a nonfunctional inner ear and stimulates the auditory nerve directly with patterns of electrical currents derived from incoming sounds. The culmination of investigations in many disciplines, it is the first major advance in helping profoundly deaf children communicate since the Sign Language for the Deaf was developed at the Institution des Jeunes Sourds in Paris some 200 years ago. Written by the "father" of the multi-electrode implant, this comprehensive text and reference gives an account of the fundamental principles underlying cochlear implants and their clinical application. It thus discusses research in all relevant disciplines, including: - Surgical anatomy, concentrating on essentials relevant to engineering - Pathology, focusing on the inner ear's response to the implant and to electrical stimulation - Biophysics and electrochemistry, addressing the interface between electrode and tissue - Neurobiology, with particular emphasis on the issue of safety - Physiology, summarizing current theories of frequency and amplitude coding - Psychophysics, focusing on pitch and loudness perception - Speech science, including phonetics, perception, and language - Electronic principles of signal processing needed for speech perception - Clinical factors of importance to the engineering - Surgical procedures to help scientists and engineers understand the realities for implant development - Communication skills achieved for different speech processing strategies - Socioeconomic and ethical issues For the clinician, the book will provide guidance in the treatment of patients; for the engineer and researcher it will provide the background for further research; and for the student, it will provide a through understanding of the subject.

The sensory hair cells in the inner ear and vestibular system convert mechanical stimuli, sound and motion into neural activity that is responsible for the sensations of hearing, motion and head position. In mammals, the loss of hair cells from acoustic overstimulation, ototoxic drugs and aging is irreversible, leading to a permanent loss of function. However, it is now clear that hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. Moreover, partially damaged hair cells can undergo self-repair or be protected from traumatic insults by external compounds.This volume provides a comprehensive survey of what is currently known about the regeneration, repair and protection of sensory hair cells and subsequent recovery of function in the auditory and vestibular system. The aim is to provide graduate students, postdoctoral fellows, clinicians and scientists in related disciplines with the biological bases of hair cells and with an understanding of the factors that contribute to their regeneration and repair.

Hearing and communication present a variety of challenges to the nervous system. To be heard and understood, a communication signal must be transformed from a time-varying acoustic waveform to a perceptual representation to an even more abstract representation that integrates memory stores with semantic/referential information. Finally, this complex, abstract representation must be interpreted to form categorical decisions that guide behavior. Did I hear the stimulus? From where and whom did it come? What does it tell me? How can I use this information to plan an action? All of these issues and questions underlie auditory cognition. Since the early 1990s, there has been a re-birth of studies that test the neural correlates of auditory cognition with a unique emphasis on the use of awake, behaving animals as model. Continuing today, how and where in the brain neural correlates of auditory cognition are formed is an intensive and active area of research. Importantly, our understanding of the role that the cortex plays in hearing has the potential to impact the next generation of cochlear- and brainstem-auditory implants and consequently help those with hearing impairments. Thus, it is timely to produce a volume that brings together this exciting literature on the neural correlates of auditory cognition. This volume compliments and extends many recent SHAR volumes such as Sound Source Localization (2005) Auditory Perception of Sound Sources (2007), and Human Auditory Cortex (2010). For example, in many of these volumes, similar issues are discussed such as auditory-object identification and perception with different emphases: in Auditory Perception of Sound Sources, authors discuss the underlying psychophysics/behavior, whereas in the Human Auditory Cortex, fMRI data are presented. The unique contribution of the proposed volume is that the authors will integrate both of these factors to highlight the neural correlates of cognition/behavior. Moreover, unlike other these other volumes, the neurophysiological data will emphasize the exquisite spatial and temporal resolution of single-neuron as opposed to more coarse fMRI or MEG data] responses in order to reveal the elegant representations and computations used by the nervous system.

This volume will serve as the first Handbook of its kind in the area of hearing aid research, often the least-defined, least-understood, part of the multi-disciplinary research process. Most scientific training is very advanced within the particular disciplines but provides little opportunity for systematic introduction to the issues and obstacles that prevent effective hearing-aid related research. This area has emerged as one of critical importance, as signified by a single specialized meeting (the International Hearing Aid Conference, IHCON) that brings together specialists from the disparate disciplines involved, including both university and industry researchers. Identification of the key steps that enable high-impact basic science to ultimately result in significant clinical advances that improve patient outcome is critical. This volume will provide an overview of current key issues in hearing aid research from the perspective of many different disciplines, not only from the perspective of the key funding agencies, but also from the scientists and clinicians who are currently involved in hearing aid research. It will offer insight into the experience, current technology and future technology that can help improve hearing aids, as scientists and clinicians typically have little or no formal training over the whole range of the individual disciplines that are relevant. The selection and coverage of topics insures that it will have lasting impact, well beyond immediate, short-term, or parochial concerns.

The past decade has brought great advances in our understanding of the mechanisms underlying auditory pathologies. Molecular biology and genetics have primarily contributed to this enhanced understanding, which in turn has driven the design of novel rational therapeutic interventions. Auditory Trauma, Protection and Repair presents recent developments in auditory research and their potential translation to the clinical setting. In particular the authors address the major entities of peripheral auditory trauma, discuss the underlying mechanisms, the central nervous system consequences, protective interventions and finally explore the possibilities to restore cochlear morphology and function.

Two themes run through the chapters in this book: cellular homeostasis and cell death. In the broadest sense, all auditory pathologies are disorders of cellular homeostasis.

Contents:

• Auditory Pathology: When Hearing Is Out of Balance Jochen Schacht
• Genetics of Hearing Loss Ella Shalit and Karen B. Avraham
• Cochlear Homeostasis and Homeostatic Disorders Philine Wangemann
• Tinnitus: Theories, Mechanisms and Treatments Carol A. Bauer and Thomas J. Brozoski
• Autoimmune Inner Ear Disease Quinton Gopen, and Jeffrey P. Harris
• Age-Related Hearing loss and Its Cellular and Molecular Bases Kevin K. Ohlemiller and Robert D. Frisina
• The Patterns and Mechanisms of Noise-Induced Cochlear Pathology Donald Henderson, Bohua Hu, and Eric Bielefeld
• Drug-Induced Hearing Loss Leonard P. Rybak, Andrea E. Talaska, and Jochen Schacht
• Central Consequences ofCochlear Trauma D. Kent Morest and Steven J. Potashner
• Cell Death and Cochlear Protection Steven Green, Richard A. Altschuler, and Josef M. Miller
• Emerging Strategies for Restoring the Cochlea Stefan Heller and Yehoash Raphael

About the editors:

Jochen Schacht is Professor and Director of the Kresge Hearing Research Institute, University of Michigan, Ann Arbor. Arthur N. Popper is Professor in the Department of Biology and Co-Director of the Center for Comparative and Evolutionary Biology of Hearing at the University of Maryland, College Park. Richard R. Fay is Director of the Parmly Hearing Institute and Professor of Psychology at Loyola University of Chicago.

About the series:

The Springer Handbook of Auditory Research presents a series of synthetic reviews of fundamental topics dealing with auditory systems. Each volume is independent and authoritative; taken as a set, this series is the definitive resource in the field.

Brain imaging and neurophysiological methods have been rapidly developed. The purpose of this book is to describe hearing problems which are caused by various kinds of brain diseases in central auditory pathway. Each topic is explained to use a lot of figures such as brain imaging and neurophysiological data comparing with neuropsychological tests. Readers will understand what happens in patients, when bilateral auditory nerve and auditory cortex are damaged in patients. Some patients can hear but cannot discriminate meanings of speech, music and environmental sounds. The author tries to explain why such a difference occurs.

This book considers deafness as a medical condition, exploring the neuronal consequences on the peripheral and the central nervous system as well as on cognition and learning, viewed from the standpoint of genetics, neuroanatomy and neurophysiology, molecular biology, systems neuroscience, and cognitive neuroscience.

For courses in Introductory Audiology A comprehensive introduction to hearing and balance disorders. This comprehensive, well-organized introduction to hearing and balance disorders gives students a number of vital tools to help them better understand, retain, and analyze the material. The book continues to update the material to keep content current with recent research, while retaining and improving a user-friendly approach to the topics and an abundance of how-to information, which shows the rewarding, fascinating aspects of a career in audiology. This text is designed to provide the ultimate teaching and learning experience. * Organized to ensure maximum teaching and learning effectiveness and success through a highly useful, unique chapter arrangement, flexible depth of coverage, and helpful chapter organization. * Includes features designed to facilitate learning, including illustrative visual tools, clinical commentaries, evolving case studies, footnoted material, review tables, a comprehensive glossary, and 20 new video clips interspersed throughout.

The Oxford Handbook of Deaf Studies in Literacy brings together state-of-the-art research on literacy learning among deaf and hard of hearing learners (DHH). With contributions from experts in the field, this volume covers topics such as the importance of language and cognition, phonological or orthographic awareness, morphosyntactic and vocabulary understanding, reading comprehension and classroom engagement, written language, and learning among challenged populations. Avoiding sweeping generalizations about DHH readers that overlook varied experiences, this volume takes a nuanced approach, providing readers with the research to help DHH students gain competence in reading comprehension.

Language development, and the challenges it can present for individuals who are deaf or hard-of-hearing, have long been a focus of research, theory, and practice in D/deaf studies and deaf education. Over the past 150 years, but most especially near the end of the 20th and beginning of the 21st century, advances in the acquisition and development of language competencies and skills have been increasing rapidly. This volume addresses many of those accomplishments as well as remaining challenges and new questions that have arisen from multiple perspectives: theoretical, linguistic, social-emotional, neuro-biological, and socio-cultural. The contributors comprise an international group of prominent scholars and practitioners from a variety of academic and clinical backgrounds. The result is a volume that addresses, in detail, current knowledge, emerging questions, and innovative educational practice in a variety of contexts. The volume takes on topics such as discussion of the transformation of efforts to identify a "best" language approach (the "sign" versus "speech" debate) to a stronger focus on individual strengths, potentials, and choices for selecting and even combining approaches; the effects of language on other areas of development as well as effects from other domains on language itself; and how neurological, socio-cognitive, and linguistic bases of learning are leading to more specialized approaches to instruction that address the challenges that remain for deaf and hard-of-hearing individuals. This volume both complements and extends The Oxford Handbook of Deaf Studies and Deaf Education, Volumes 1 and 2, going further into the unique challenges and demands for deaf or hard-of-hearing individuals than any other text and providing not only compilations of what is known but setting the course for investigating what is still to be learned.

Cochlear implants are currently the standard treatment for profound sensorineural hearing loss. In the last decade, advances in auditory science and technology have not only greatly expanded the utility of electric stimulation to other parts of the auditory nervous system in addition to the cochlea, but have also demonstrated drastic changes in the brain in responses to electric stimulation, including changes in language development and music perception. Volume 20 of SHAR focused on basic science and technology underlying the cochlear implant. However, due to the newness of the ideas and technology, the volume did not cover any emerging applications such as bilateral cochlear implants, combined acoustic-electric stimulation, and other types of auditory prostheses, nor did it review brain plasticity in responses to electric stimulation and its perceptual and language consequences. This proposed volume takes off from Volume 20, and expands the examination of implants into new and highly exciting areas. This edited book starts with an overview and introduction by Dr. Fan-Gang Zeng. Chapters 2-9 cover technological development and the advances in treating the full spectrum of ear disorders in the last ten years. Chapters 10-15 discuss brain responses to electric stimulation and their perceptual impact. This volume is particularly exciting because there have been quantum leap from the traditional technology discussed in Volume 20. Thus, this volume is timely and will be of real importance to the SHAR audience.

Cochlear implants have instigated a popular but controversial revolution in the treatment of deafness. This book discusses the physiological bases of using artificial devices to electrically stimulate the brain to interpret sounds. As the first successful device to restore neural function, the cochlear implant serves as a model for research in neuroscience and biomedical engineering. These and other auditory prostheses are discussed in the context of historical treatments, engineering, psychophysics and clinical issues as well as implications for speech, behavior, cognition and long-term effects on people.

Early hearing detection and intervention (EHDI) is the gold standard for any practising audiologist, and for families of infants and children with hearing impairment. EHDI programmes aim to identify, diagnose and provide intervention to children with hearing impairment from as early as six months old (as well as those at risk for hearing impairment) to ensure they develop and achieve to their potential. Yet EHDI remains a significant challenge for Africa, and various initiatives are in place to address this gap in transferring policy into practice within the southern African context. The diversity of factors in the southern African context presents unique challenges to teaching and research in this field, which has prompted this book project. The South African government's heightened focus on increasing access to health care which includes ongoing Early Childhood Development (ECD) programmes, make this an opportune time for establishing and documenting evidence-based research for current undergraduate and postgraduate students. Early Detection and Intervention in Audiology: An African Perspective aims to address this opportunity. Grounded in an African context with detailed case studies, this book provides rich content that pays careful attention to contextual relevance and contextual responsiveness to both identification and intervention in hearing impairment. With diverse contributions from experts in local and international contexts, but always with an African perspective, this is textbook will be an invaluable resource for students, researchers and practitioners.

Tinnitus is a prevalent hearing disease, affecting 15% of the population, particularly hearing impaired, veterans and even young people who grow up with mp3 players and iPods. The mechanisms underlying tinnitus remain controversial. At present there is no cure for tinnitus, and treatment options are limited. Different from previous tinnitus books, including A. R. Moller's book [in press at Springer], which typically have a strong clinical flavor, the present volume focuses on neural mechanisms of tinnitus and its behavioral consequences. The proposed book starts with a general summary of the field and a short introduction on the selection and content of the remaining chapters. Chapter 2 overviews tinnitus prevalence and etiologies to set the tone for significance and complexity of this neurological disorder spectrum. Chapters 3-8 cover neuroscience of tinnitus in animal models from molecular mechanisms to cortical manifestation. Chapters 9-12 cover human brain responses to tinnitus and it clinical management.

This book is the final result of the NATO Advanced Research Workshop 'Interactive Learning Technology for the Deaf' , which was held between June 4 -7, 1991, in Sint-Michielsgestel, the Netherlands. The scientific organizing committee consisted of Frans Coninx (director), Ben Elsendoorn, Richard Foulds and Christopher Jones. The idea for this workshop originated from the observation that interactive learning technology seemed to be very promising in that it might help improve education of deaf children, but also from the given fact that general achievements in helping deaf children to acquire language could still be improved. Before this workshop, results on research in the areas of (sign) language acquistion and education of deaf children, improvement of speech produc tion and listening skills, as well as the use of interactive learning technol ogy, could be gathered in journals and at congresses. However, no meeting was ever organised where experts from these different fields were present at the same time. The aim of the workshop was to bring together experts in the fields of deaf education as well as interactive learning technology, to construct a multi disciplinary platform where ideas and research results could be discussed from various angles and which would serve as a jumping-board for future collaboration. We thought it essential that specialists from various direc tions in deaf education -i.e. bilingual, oral, and Total Communication (TC) approaches -were present, to contribute to the multi-displinary character of the workshop.

The Springer Handbook of Auditory Research presents a series of com prehensive and synthetic reviews of the fundamental topics in modem auditory research. It is aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes will introduce new investigators to important aspects of hearing science and will help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume is intended to present a particular topic comprehensively, and each chapter will serve as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The series focuses on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature. Each volume in the series consists of five to eight substantial chapters on a particular topic. In some cases, the topics will be ones of traditional interest for which there is a solid body of data and theory, such as auditory neuroanatomy (Vol. 1) and neurophysiology (Vol. 2). Other volumes in the series will deal with topics which have begun to mature more recently, such as development, plasticity, and computational models of neural processing."

The human species is largely defined by its use of spoken language, so integral is speech communication to behavior and social interaction. Despite its importance in everyday life, comparatively little is known about the auditory mechanisms that underlie the ability to understand language. The current volume examines the perception and processing of speech from the perspective of the hearing system. The chapters in this book describe a comprehensive set of approaches to the scientific study of speech and hearing, ranging from anatomy and physiology, to psychophysics and perception, and computational modeling. The auditory basis of speech is examined within a biological and an evolutionary context, and its relevance to applied domains such as communication disorders and speech technology discussed in detail. This volume will be of interest to scientists, engineers, and clinicians whose professional work pertains to any aspect of spoken language or hearing science.

Understanding human hearing is not only a scientific challenge but also a problem of growing social and political importance, given the steadily increasing numbers of people with hearing deficits or even deafness. This book is about the highest level of hearing in humans and other mammals. It brings together studies of both humans and animals thereby giving a more profound understanding of the concepts, approaches, techniques, and knowledge of the auditory cortex. All of the most up-to-date procedures of non-invasive imaging are employed in the research that is described.

This volume will provide an important contemporary reference on hearing development and will lead to new ways of thinking about hearing in children and about remediation for children with hearing loss. Much of the material in this volume will document that a different model of hearing is needed to understand hearing during development. The book is expected to spur research in auditory development and in its application to pediatric audiology.

- Coverage of deaf people and cognition, neuroscience, bimodal/bilingualism, and education technology - Strong multicultural focus - Case studies from authors' clinical and educational practices - Three deaf and one hearing author-a deaf/hearing bilingual team

The major aim of this book is to introduce the ways in which scientists approach and think about a phenomenon -- hearing -- that intersects three quite different disciplines: the physics of sound sources and the propagation of sound through air and other materials, the anatomy and physiology of the transformation of the physical sound into neural activity in the brain, and the psychology of the perception we call hearing. Physics, biology, and psychology each play a role in understanding how and what we hear.
The text evolved over the past decade in an attempt to convey something about scientific thinking, as evidenced in the domain of sounds and their perception, to students whose primary focus is not science. It does so using a minimum of mathematics (high school functions such as linear, logarithmic, sine, and power) without compromising scientific integrity. A significant enrichment is the availability of a compact disc (CD) containing over 20 examples of acoustic demonstrations referred to in the book. These demonstrations, which range from echo effects and filtered noise to categorical speech perception and total more than 45 minutes, are invaluable resources for making the text come alive.

Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these findings was the implementation of antioxidants in preclinical studies for the treatment of hearing loss. These antioxidants have provided different levels of protection in animal and human studies, but none of these have been approved by the US Food and Drug Administration for the treatment of hearing loss. More recently, it was shown that noise-induced hearing loss was associated with recruitment of inflammatory cells and mediators in the cochlea. This finding would suggest that noise could produce injury to the cochlea which stimulates local and/or circulating inflammatory cells. A similar finding was observed in the cochlea following administration of the anticancer drug, cisplatin. In addition, our laboratory and others have provided a plausible mechanism by which noise or chemotherapeutic agents could stimulate the inflammatory response. Surprisingly, this mechanism involves ROS activation of transcription factors linked to inflammatory processes in the cochlea. These studies have led to the use of anti-inflammatory agents for the treatment of hearing loss. Preliminary studies targeting inflammatory cytokines appear especially promising in preclinical studies. A primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this relates to cochlear inflammation. Several different aspects of the cochlear inflammatory process will be discussed in detail, ranging from the sources of inflammatory cells, chemokines, inflammatory cytokines, and cochlea resident immune cells. Molecular pathways leading to activation of the local inflammatory process will be highlighted and treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-typmanic steroids will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss.