This collection of recent activities provides researchers and scientists with the latest trends in characterization and developments of biosystems and biomaterials. Well known experts present their research in materials for drug delivery, dental implants and filling materials, biocompatible membranes, bioactive surface coatings and bio-compatible and eco-sustainable building materials. In The book covers also topics like microorganisms, the human eye, the musculoskeletal system and human body parts.

Providing the most comprehensive, up-to-date coverage of this exciting biomedical field, Handbook of Photomedicine gathers together a large team of international experts to give you a complete account of the application of light in healthcare and medical science. The book progresses logically from the history and fundamentals of photomedicine to diverse therapeutic applications of light, known collectively as phototherapies. It facilitates your understanding of human diseases caused by light, the rationale for photoprotection, and major applications of phototherapy in clinical practice. The handbook begins with a series of historical vignettes of pioneers from the last two centuries. It also presents the fundamentals of physics and biology as applied to photomedicine. It next examines conditions and diseases caused by light, including skin cancer, dermatoses, and immunosuppression. The remainder of the book focuses on the most important clinical therapeutic applications of different kinds of light that vary in both wavelength and intensity. The book discusses ultraviolet phototherapy for skin diseases and infections and presents the basic science of photodynamic therapy and its use in cancer therapy and other medical specialties. It then covers mechanistic studies and clinical applications of low-level laser (light) therapy as well as the use of high power or surgical laser therapy in specialties, such as dentistry and dermatology. The book concludes with a collection of miscellaneous types of phototherapy.

This book provides an expert view into the current technologies that are revolutionizing the field of solid organ transplantation. This unique book provides insight into progress made in areas spanning robotic surgery to tissue engineering and also gives a glimpse into what may lie ahead for this innovative specialty. Topics covered include nanotherapy, machine perfusion, artificial organ development, robotics in transplant surgery, mobile health technology, stem cell therapy, and ex vivo repair of organs. This is an ideal book for biomedical engineers, physicians and surgeons, general and transplant surgeons, medical students, medical and surgical trainees, and transplant procurement technicians.

One of the greatest challenges for mechanical engineers is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, biomedical sciences, and medicine.This book is an opportunity for computational biomechanics specialists to present and exchange opinions on the opportunities of applying their techniques to computer-integrated medicine.

"Computational Biomechanics for Medicine: Deformation and Flow" collects the papers from the Medical Image Computing and Computer Assisted Intervention conference (MICCAI 2011) dedicated to research in the field of medical image computing and computer assisted medical interventions. The topics covered include: medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, injury mechanism analysis, implant and prostheses design, andmedical robotics."

This book introduces readers to the concept of 'frugal innovation' and describes novel low-cost technologies that aid in diagnosing infectious diseases. Rapidly deployable, portable, and affordable diagnostic tools have the potential to tremendously benefit populations in resource-limited settings and improve global health outcomes. Specifically, the book includes the following features: Cutting-Edge Research: Thorough coverage of scientific advances related to frugal bioengineering that have been developed within the last few years. A few examples of technologies covered in detail include low-cost paper-based and CD-based microfluidic diagnostic systems. Industry and Non-Profit Voices: Chapters written by scientists currently working in industry and philanthropic sectors.

Drawing on such process thinkers as Whitehead, Deleuze and Stengers, Innovation and Biomedicine develops a powerful framework for the analysis of Biomedical Innovation. With its sustained focus on the Pre-Exposure Prophylactic pill (PrEP) for the prevention of HIV infection, the volume explores the ethical, medical and political elements entailed in the pill's testing through offshore randomized control trials (RCTs). To this end, the key concept of 'eventuation' is elaborated and deployed in the scrutiny of the 'gold standard' status of RCTs, the role of ethics in RCTs, and the enactment of the PrEP pill as a singular entity. Further, the authors engage with affective, topological and virtual dimensions to show how PrEP's eventuation also allows for new scientific and ethical questions to be crafted. Innovation and Biomedicine is a major contribution to science and technology studies, medical sociology, and the multi-disciplinary study of HIV.

Sleep medicine has been developing for more than 40 years. The current concepts in sleep technology are mainly centered on polysomnography (PSG) and issues related to sleep technicians. However, the editorsbelieve that the true value of technology is revealed only when benefits to humanity are manifest. To this end, they endeavor to create a new era in sleep technology, one that will improve the quality of people's sleep and daily lives.

This edited book, Introduction to Modern Sleep Technology, provides a comprehensive reference volume to the latest advancements in the area of Sleep Technology. It offers an excellent range of insights and opinions from leading researchers and experts in multiple disciplines spanning academia, clinical practice and industry. Up-to-date insights into the current research topics in this field are featured in addition to the latest technological advances with reference to appropriate working examples.

Thecurrentbookcombines the five dimensions of knowledge, i.e., sleep medicine, clinical psychology engineering, industrial design and technology management to ensure the content is applicable to people's daily lives.

This edited book, Introduction to Modern Sleep Technology, provides a comprehensive reference volume to the latest advancements in the area of Sleep Technology. It offers an excellent range of insights and opinions from leading researchers and experts in multiple disciplines spanning academia, clinical practice and industry. Up-to-date insights into the current research topics in this field are featured in addition to the latest technological advances with reference to appropriate working examples.

Thecurrentbookcombines the five dimensions of knowledge, i.e., sleep medicine, clinical psychology engineering, industrial design and technology management to ensure the content is applicable to people's daily lives.

Thecurrentbookcombines the five dimensions of knowledge, i.e., sleep medicine, clinical psychology engineering, industrial design and technology management to ensure the content is applicable to people's daily lives.

Nanorobots represent a nanoscale device where proteins such as DNA, carbon nanotubes could act as motors, mechanical joints, transmission elements, or sensors. When these different components were assembled together they can form nanorobots with multi-degree-of-freedom, able to apply forces and manipulate objects in the nanoscale world. Design, Modeling and Characterization of Bio-Nanorobotic Systems investigates the design, assembly, simulation, and prototyping of biological and artificial molecular structures with the goal of implementing their internal nanoscale movements within nanorobotic systems in an optimized manner.

This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.

This book is a collection of articles presented by researchers and practitioners, including engineers, biologists, health professionals and informatics/computer scientists, interested in both theoretical advances and applications of information systems, artificial intelligence, signal processing, electronics and other engineering tools in areas related to biology and medicine in the All India Seminar on Biomedical Engineering 2012 (AISOBE 2012), organized by The Institution of Engineers (India), Jabalpur Local Centre, Jabalpur, India during November 3-4, 2012. The content of the book is useful to doctors, engineers, researchers and academicians as well as industry professionals.

This contributed volume presents computational models of diabetes that quantify the dynamic interrelationships among key physiological variables implicated in the underlying physiology under a variety of metabolic and behavioral conditions. These variables comprise for example blood glucose concentration and various hormones such as insulin, glucagon, epinephrine, norepinephrine as well as cortisol. The presented models provide a powerful diagnostic tool but may also enable treatment via long-term glucose regulation in diabetics through closed-look model-reference control using frequent insulin infusions, which are administered by implanted programmable micro-pumps. This research volume aims at presenting state-of-the-art research on this subject and demonstrating the potential applications of modeling to the diagnosis and treatment of diabetes. The target audience primarily comprises research and experts in the field but the book may also be beneficial for graduate students.

This book presents the Proceedings of ICON-2019, an international meeting exclusively dedicated to nanostructured materials in medicinal applications. The conference emphasized the recent advances in multidisciplinary research on processing, morphology, structure and properties of nanostructured materials and their applications in various medicinal fields. The papers encompass basic studies and applications and address topics of novel issues, difficulties, and breakthroughs in the field of nanomedicine in cancer, tuberculosis, tissue engineering, regenerative medicine etc.

This book collects the state-of-art and new trends in image analysis and biomechanics. It covers a wide field of scientific and cultural topics, ranging from remodeling of bone tissue under the mechanical stimulus up to optimizing the performance of sports equipment, through the patient-specific modeling in orthopedics, microtomography and its application in oral and implant research, computational modeling in the field of hip prostheses, image based model development and analysis of the human knee joint, kinematics of the hip joint, micro-scale analysis of compositional and mechanical properties of dentin, automated techniques for cervical cell image analysis, and biomedical imaging and computational modeling in cardiovascular disease.

The book will be of interest to researchers, Ph.D students, and graduate students with multidisciplinary interests related to image analysis and understanding, medical imaging, biomechanics, simulation and modeling, experimental analysis

This book presents the most important aspects of analysis of dynamical processes taking place on the human body surface. It provides an overview of the major devices that act as a prevention measure to boost a person's motivation for physical activity. A short overview of the most popular MEMS sensors for biomedical applications is given. The development and validation of a multi-level computational model that combines mathematical models of an accelerometer and reduced human body surface tissue is presented. Subsequently, results of finite element analysis are used together with experimental data to evaluate rheological properties of not only human skin but skeletal joints as well. Methodology of development of MOEMS displacement-pressure sensor and adaptation for real-time biological information monitoring, namely "ex vivo" and "in vitro" blood pulse type analysis, is described. Fundamental and conciliatory investigations, achieved knowledge and scientific experience about biologically adaptive multifunctional nanocomposite materials, their properties and synthesis compatibility, periodical microstructures, which may be used in various optical components for modern, productive sensors' formation technologies and their application in medicine, pharmacy industries and environmental monitoring, are presented and analyzed. This book also is aimed at research and development of vibrational energy harvester, which would convert ambient kinetic energy into electrical energy by means of the impact-type piezoelectric transducer. The book proposes possible prototypes of devices for non-invasive real-time artery pulse measurements and micro energy harvesting.

This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.

Nanomaterials and Nanosystems for Biomedical Applications brings together under a single cover various aspects of functional bioengineered materials and nanostructured biomaterials including commonly used implants and sustained release nanodevices. The book includes expert reviews on the advances and current problems associated with the implants and nanodevices along with their applications in medicine, pharmaceutics, cancer therapy, gene transfer and drug delivery. The editor, M. R. Mozafari (PhD), has been working in the field of nanobiotechnology for the past 14 years and has produced more than 60 publications. The book also describes the key research parameters pertaining to major technologies employed in the field.

Tissue engineering is an emerging interdisciplinary field, occupying a major position in the regenerative medicine that aims at restoring lost or damaged tissues and organs with use of cells. Regenerative medicine includes cellular therapy and tissue engineering. In general, the former treats patients by cell infusion alone, while tissue engineering needs biomaterials and growth factors in addition to cells. Biomaterials function in tissue engineering as the scaffold or template for cells to proliferate, differentiate, and produce matrices. This book focuses on the fundamentals (biomaterials, scaffolds, cell cultures, bioreactors, animal models etc.), recent animal and human trials, and future prospects regarding tissue engineering.

Almost twenty years have passed since the advent of the tissue engineering, whicht uses cells, scaffolds, and growth factors for regeneration of neotissues. The number of investigations on tissue engineering is still increasing tremendously. Nevertheless, it seems likely that the number of reports describing clinical trials of tissue engineering will remain very limited. Even the studies that apply tissue engineering research to large animals have not been performed yet on a large scale. The major objective of this book is to address this question from a science and technology point of view, and to describe the principles of basic technologies that have currently been developed by numerous research groups.
* Helps reader understand the key issues required for promotion of clinical trials in tissue engineering
* Covers in full the issues related to tissue engineering
* Looking at current technologies in the field

This book presents novel and advanced technologies for medical sciences in order to solidify knowledge in the related fields and define their key stakeholders. The fifteen papers included in this book were written by invited experts of international stature and address important technologies for medical sciences, including: computational modeling and simulation, image processing and analysis, medical imaging, human motion and posture, tissue engineering, design and development medical devices, and mechanic biology. Different applications are treated in such diverse fields as biomechanical studies, prosthesis and orthosis, medical diagnosis, sport, and virtual reality. This book is of interest to researchers, students and manufacturers from a wide range of disciplines related to bioengineering, biomechanics, computational mechanics, computational vision, human motion, mathematics, medical devices, medical image, medicine and physics.

The development and application of bioactive nano-structured constructs for tissue regeneration is the focus of the research summarised in this thesis. Moreover, a particular focus is the rational use of supercritical carbon dioxide foaming and electrospinning technologies which can lead to innovative polymeric bioresorbable scaffolds made of hydrolysable (both commercial and 'ad-hoc' synthesized) polyesters. Mainly, the author discusses the manipulation of polymer chemical structure and composition to tune scaffold physical properties, and optimization of scaffold 3D architecture by a smart use of both fabrication techniques. The multidisciplinary nature of this research is imperative in pursuing the challenge of tissue regeneration successfully. One of the strengths of this thesis is the integration of knowledge from chemistry, physics, engineering, materials science and biomedical science which has contributed to setting up new national and international collaborations, while strengthening existing ones.

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.

Recent technological breakthrough in the field of Terahertz radiation has triggered new applications in biology and biomedicine. Particularly, biological applications are based on the specific spectroscopic fingerprints of biological matter in this spectral region. Historically with the discovery of new electromagnetic wave spectrum, we have always discovered new medical diagnostic imaging systems. The use of terahertz wave was not realized due to the absence of useful terahertz sources. Now after successful generation of THz waves, it is reported that a great potential for THz wave exists for its resonance with bio-molecules.

There are many challenging issues such as development of THz passive and active instrumentations, understanding of THz-Bio interaction for THz spectroscopy, THz-Bio nonlinear phenomena and safety guideline, and THz imaging systems. Eventually the deeper understanding of THz-Bio interaction and novel THz systems enable us to develop powerful THz biomedical imaging systems which can contribute to biomedical industry.

This is a truly interdisciplinary field and convergence technology where the communication between different disciplines is the most challenging issue for the success of the great works. One of the first steps to promote the communications in this convergence technology would be teaching the basics of these different fields to the researchers in a plain language with the help of "Convergence of Terahertz Science in Biomedical Systems" which is considered to be 3-4th year college students or beginning level of graduate students. Therefore, this type of book can be used by many people who want to enter or understand this field. Even more it can be used for teaching in universities or research institutions.

In this book the authors describe their original research on the potential of both standard and high-resolution electroencephalography (EEG) for analyzing brain activity in response to TV advertising. When engineering techniques, neuroscience concepts and marketing stimuli converge in one research field, known as neuromarketing, various theoretical and practical aspects need to be considered. The book introduces and discusses those aspects in detail, while showing several experiments performed by the authors during their attempts to measure both the cognitive activity and emotional involvement of the test subjects. In these experiments, the authors apply simultaneous EEG, galvanic skin response and heart rate monitoring, and show how significant variations of these variables can be associated with attention to, memorization or enjoyment of the presented stimuli. In particular, this book shows the central role of statistical analysis in recovering significant information on the scalp and cortical areas involved, along with variations of activity in the autonomous nervous system. From an economic and marketing perspective, the aim of this work is to promote a better understanding of how mass consumer advertising of (established) brands affects brain systems. From a neuroscience perspective, the broader goal is to provide a better understanding of both the neural mechanisms underlying the impact of affect and cognition on memory, and the neural correlates of choice and decision-making.

=> Please download the extra material for this book http: //extras.springer.com

This book aims to give readers a basic understanding of commonly used additive manufacturing techniques as well as the tools to fully utilise the strengths of additive manufacturing through the modelling and design phase all the way through to post processing. Guidelines for 3D-printed biomedical implants are also provided. Current biomedical applications of 3D printing are discussed, including indirect applications in the rapid manufacture of prototype tooling and direct applications in the orthopaedics, cardiovascular, drug delivery, ear-nose-throat, and tissue engineering fields. Polymer-Based Additive Manufacturing: Biomedical Applications is an ideal resource for students, researchers, and those working in industry seeking to better understand the medical applications of additive manufacturing.

"Numerical Modeling in Biomedical Engineering" brings together the integrative set of computational problem solving tools important to biomedical engineers. Through the use of comprehensive homework exercises, relevant examples and extensive case studies, this book integrates principles and techniques of numerical analysis. Covering biomechanical phenomena and physiologic, cell and molecular systems, this is an essential tool for students and all those studying biomedical transport, biomedical thermodynamics & kinetics and biomechanics.
. Supported by Whitaker Foundation Teaching Materials Program; ABET-oriented pedagogical layout
. MATLAB problem sets and examples available electronically; UNIX, Windows, Mac OS compatible
. Extensive hands-on homework exercises