The book provides an insight into the advantages and limitations of the use of fractals in biomedical data. It begins with a brief introduction to the concept of fractals and other associated measures and describes applications for biomedical signals and images. Properties of biological data in relations to fractals and entropy, and the association with health and ageing are also covered. The book provides a detailed description of new techniques on physiological signals and images based on the fractal and chaos theory. The aim of this book is to serve as a comprehensive guide for researchers and readers interested in biomedical signal and image processing and feature extraction for disease risk analyses and rehabilitation applications. While it provides the mathematical rigor for those readers interested in such details, it also describes the topic intuitively such that it is suitable for audience who are interested in applying the methods to healthcare and clinical applications. The book is the outcome of years of research by the authors and is comprehensive and includes other reported outcomes.

Improve the Accurate Detection and Diagnosis of Cancer and Other Diseases Despite the expansion of the CAD field in recent decades, there is currently no single book dedicated to the development and use of CAD systems. Filling this need, Computer-Aided Detection and Diagnosis in Medical Imaging covers the major technical advances and methodologies shaping the development and clinical utility of CAD systems in breast imaging, chest imaging, abdominal imaging, and other emerging applications. After a historical overview of CAD, the book is divided into four sections. The first section presents CAD technologies in breast imaging, which is the most advanced area of CAD application. The second section discusses CAD technologies in chest and abdominal imaging. The third section explores emerging CAD technologies in a wide range of imaging modalities designed to address a variety of diseases. The final section describes the current use of CAD systems in clinical practice as well as how CAD will play an important role in quantitative image biomarkers and imaging genomics research. This book brings together existing and emerging CAD approaches at a level understandable to students, CAD system developers, basic scientists, and physician scientists. Newcomers to CAD research will learn about fundamental aspects in the process of CAD system development. Developers of CAD systems will gain insight on designing new or improved CAD systems. Experienced researchers will get up-to-date information on the latest CAD technologies.

Healthcare Technology Management: A Systematic Approach offers a comprehensive description of a method for providing safe and cost effective healthcare technology management (HTM). The approach is directed to enhancing the value (benefit in relation to cost) of the medical equipment assets of healthcare organizations to best support patients, clinicians and other care providers, as well as financial stakeholders. The authors propose a management model based on interlinked strategic and operational quality cycles which, when fully realized, delivers a comprehensive and transparent methodology for implementing a HTM programme throughout a healthcare organization. The approach proposes that HTM extends beyond managing the technology in isolation to include advancing patient care through supporting the application of the technology. The book shows how to cost effectively manage medical equipment through its full life cycle, from acquisition through operational use to disposal, and to advance care, adding value to the medical equipment assets for the benefit of patients and stakeholders. This book will be of interest to practicing clinical engineers and to students and lecturers, and includes self-directed learning questions and case studies. Clinicians, Chief Executive Officers, Directors of Finance and other hospital managers with responsibility for the governance of medical equipment will also find this book of interest and value. For more information about the book, please visit the website.

The first reference on this emerging interdisciplinary research area at the interface between materials science and biomedicine is written by pioneers in the field, who address the requirements, current status and future challenges. Focusing on inherently conducting polymers, carbon nanotubes and graphene, they adopt a systematic approach, covering all relevant aspects and concepts: synthesis and fabrication, properties, introduction of biological function, components of bionic devices and materials requirements. Established bionic devices, such as the bionic ear are examined, as are emerging areas of application, including use of organic bionic materials as conduits for bone re-growth, spinal cord injury repair and muscle regeneration. The whole is rounded off with a look at future prospects in sustainable energy generation and storage.
Invaluable reading for materials scientists, polymer chemists, electrotechnicians, chemists, biologists, and bioengineers.

The book helps readers develop fundamental skills in the field of biomedical illustrations with a training approach based on step-by-step tutorials with a practical approach. Medical/scientific illustration mainly belongs to professionals in the art field or scientists trying to create artistic visualization. There is not a merging between the two, even if the demand is high. This leads to accurate scientific images with no appeal (or trivial mistakes), or appealing CSI-like images with huge scientific mistakes. This gives the fundamentals to the scientist so they can apply CG techniques that give a more scientific approach creating mistake-free images. Key Features This book provides a reference where none exist. Without overwhelming the reader with software details it teaches basic principles to give readers to fundamentals to create. Demonstrates professional artistic tools used by scientists to create better images for their work. Coverage of lighting and rendering geared specifically for scientific work that is toturoal based with a practical approach. Included are chapter tutorials, key terms and end of chapter references for Art and Scientific References for each chapter.

Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This book elucidates the underlying concepts and emerging applications of hydrogels and will provide key case studies and critical analysis of the existing research.

Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.

This immensely valuable book provides a comprehensive, easy-to-understand, and up-to-date glossary of technical and scientific terms used in the fields of bioengineering and biotechnology, including terms used in agricultural sciences. The volume also includes terms for plants, animals, and humans, making it a unique, complete, and easily accessible reference. Scientific and Technical Terms in Bioengineering and Biological Engineering opens with an introduction to bioengineering and biotechnology and presents an informative timeline covering the important developments and events in the fields, dating from 7000 AD to the present, and it even makes predictions for developments up the year 2050. From ab initio gene prediction to zymogen and from agrobacterium to zoonosis, this volume provides concise definitions for over 5400 specialized terms peculiar to the fields of bioengineering and biotechnology, including agricultural sciences. The use of consistent terminology is critical in presenting clear and meaningful information, and this helpful reference manual will be essential for graduate and undergraduate students of biomedical engineering, biotechnology, nanotechnology, nursing, and medicine and health sciences as well as for professionals who work with medicine and health sciences.

Gallstone and other diseases of the biliary tract affect more than around 20% of the adult population. The complications of gallstones, acute pancreatitis and obstructive jaundice, can be lethal. This is the first book to systematically treat biliary tract and gallbladder modelling with physiological and clinical information in a biomechanical context. The book provides readers with detailed biomechanical modelling procedures for the biliary tract and gallbladder based on physiological information, clinical observations and experimental data and with the results properly interpreted in terms of clinical diagnosis and with biomechanical mechanisms for biliary diseases. The text can be used as a reference book for university undergraduates, postgraduates and professional researchers in applied mathematics, biomechanics, biomechanical engineering and biomedical engineering, as well as related surgeons.

The book provides an introduction to deterministic (and some stochastic) modeling of spatiotemporal phenomena in ecology, epidemiology, and neural systems. A survey of the classical models in the fields with up to date applications is given. The book begins with detailed description of how spatial dynamics/diffusive processes influence the dynamics of biological populations. These processes play a key role in understanding the outbreak and spread of pandemics which help us in designing the control strategies from the public health perspective. A brief discussion on the functional mechanism of the brain (single neuron models and network level) with classical models of neuronal dynamics in space and time is given. Relevant phenomena and existing modeling approaches in ecology, epidemiology and neuroscience are introduced, which provide examples of pattern formation in these models. The analysis of patterns enables us to study the dynamics of macroscopic and microscopic behaviour of underlying systems and travelling wave type patterns observed in dispersive systems. Moving on to virus dynamics, authors present a detailed analysis of different types models of infectious diseases including two models for influenza, five models for Ebola virus and seven models for Zika virus with diffusion and time delay. A Chapter is devoted for the study of Brain Dynamics (Neural systems in space and time). Significant advances made in modeling the reaction-diffusion systems are presented and spatiotemporal patterning in the systems is reviewed. Development of appropriate mathematical models and detailed analysis (such as linear stability, weakly nonlinear analysis, bifurcation analysis, control theory, numerical simulation) are presented. Key Features Covers the fundamental concepts and mathematical skills required to analyse reaction-diffusion models for biological populations. Concepts are introduced in such a way that readers with a basic knowledge of differential equations and numerical methods can understand the analysis. The results are also illustrated with figures. Focuses on mathematical modeling and numerical simulations using basic conceptual and classic models of population dynamics, Virus and Brain dynamics. Covers wide range of models using spatial and non-spatial approaches. Covers single, two and multispecies reaction-diffusion models from ecology and models from bio-chemistry. Models are analysed for stability of equilibrium points, Turing instability, Hopf bifurcation and pattern formations. Uses Mathematica for problem solving and MATLAB for pattern formations. Contains solved Examples and Problems in Exercises. The Book is suitable for advanced undergraduate, graduate and research students. For those who are working in the above areas, it provides information from most of the recent works. The text presents all the fundamental concepts and mathematical skills needed to build models and perform analyses.

Targets both students or professionals, both novice and experienced, in medical radiotherapy physics. Combines overviews of development, methods and references to facilitate Monte Carlo studies. Focuses on applications in radiotherapy.

Targets both students or professionals, both novice and experienced, in medical radiotherapy physics. Combines overviews of development, methods and references to facilitate Monte Carlo studies. Focuses on applications in radiotherapy.

As the requirements for low power consumption and very small physical dimensions in portable, wearable and implantable medical devices are calling for integrated circuit design techniques using MOSFETs operating in the subthreshold regime, this book first revisits some well-known circuit techniques that use CMOS devices biased in subthreshold in order to establish nanopower integrated circuit designs. Based on the these findings, this book shows the development of a class-AB current-mode sample-and-hold circuit with an order of magnitude improvement in its figure of merit compared to other state-of-the-art designs. Also, the concepts and design procedures of 1) single-branch filters 2) follower-integrator-based lowpass filters and 3) modular transconductance reduction techniques for very low frequency filters are presented. Finally, to serve the requirement of a very large signal swing in an energy-based action potential detector, a nanopower class-AB current-mode analog multiplier is designed to handle input current amplitudes of more than 10 times the bias current of the multiplier circuit. The invented filter circuits have been fabricated in a standard 0.18 CMOS process in order to verify our circuit concepts and design procedures. Their experimental results are reported.

First Published in 1997. Routledge is an imprint of Taylor & Francis, an informa company.

Broadly tunable lasers continue to have a tremendous impact in many and diverse fields of science and technology. From a renaissance in laser spectroscopy to Bose-Einstein condensation, the one nexus is the tunable laser. Tunable Laser Applications describes the physics and architectures of widely applied tunable laser sources. Fully updated and expanded to address important advances in the science and technology, this Third Edition: Contains new chapters on tunable laser microscopy and tunable laser atomic vapor laser isotope separation Offers extended coverage of optical parametric oscillators and their application to atmospheric sensing, biomedicine, defense counter measures, microscopy, and spectroscopy Discusses exciting new applications in astronomy, defense R&D, medicine, and more Featuring fresh contributions from internationally recognized experts-including 100+ new pages and extensive reference listings-Tunable Laser Applications, Third Edition provides a timely account of the most promising tunable laser applications to date.

How Does the Body's Motor Control System Deal with Repetition? While the presence of nonlinear dynamics can be explained and understood, it is difficult to be measured. A study of human movement variability with a focus on nonlinear dynamics, Nonlinear Analysis for Human Movement Variability, examines the characteristics of human movement within this framework, explores human movement in repetition, and explains how and why we analyze human movement data. It takes an in-depth look into the nonlinear dynamics of systems within and around us, investigates the temporal structure of variability, and discusses the properties of chaos and fractals as they relate to human movement. Providing a foundation for the use of nonlinear analysis and the study of movement variability in practice, the book describes the nonlinear dynamical features found in complex biological and physical systems, and introduces key concepts that help determine and identify patterns within the fluctuations of data that are repeated over time. It presents commonly used methods and novel approaches to movement analysis that reveal intriguing properties of the motor control system and introduce new ways of thinking about variability, adaptability, health, and motor learning. In addition, this text: Demonstrates how nonlinear measures can be used in a variety of different tasks and populations Presents a wide variety of nonlinear tools such as the Lyapunov exponent, surrogation, entropy, and fractal analysis Includes examples from research on how nonlinear analysis can be used to understand real-world applications Provides numerous case studies in postural control, gait, motor control, and motor development Nonlinear Analysis for Human Movement Variability advances the field of human movement variability research by dissecting human movement and studying the role of movement variability. The book proposes new ways to use nonlinear analysis and investigate the temporal structure of variability, and enables engineers, movement scientists, clinicians, and those in related disciplines to effectively apply nonlinear analysis in practice.

This Atlas presents both normal and pathological conditions of the Brain and Spine pictorially. Targeted towards non-radiologists, it is a unique book with well labeled and self-explanatory images. All routine conditions involving neuroradiology have been included. Images from different radiological modalities such as X-ray, Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and Digital Subtraction Angiography (DSA) have also been included. This book aims to serve as a ready reckoner for clinicians, trainees, residents as well as professional radiologists. Key Features Discusses topics related to allied branches of neurology, neuroanesthesia, neurointensive care and neurosurgery Presents both common and uncommon neurological conditions Contains actual real-life scans and images Works as a unique, quick reference guide of neuroradiological images for non-radiologists

This book presents an experimental and computational account of the applications of biopolymers in the field of medicine. Biopolymers are macromolecules produced by living systems, such as proteins, polypeptides, nucleic acids, and polysaccharides. Their advantages over polymers produced using synthetic chemistry include: diversity, abundance, relatively low cost, and sustainability. This book explains techniques for the production of different biodevices, such as scaffolds, hydrogels, functional nanoparticles, microcapsules, and nanocapsules. Furthermore, developments in nanodrug delivery, gene therapy, and tissue engineering are described.

The field of medical imaging seen rapid development over the last two decades and has consequently revolutionized the way in which modern medicine is practiced. Diseases and their symptoms are constantly changing therefore continuous updating is necessary for the data to be relevant. Diseases fall into different categories, even a small difference in symptoms may result in categorising it in a different group altogether. Thus analysing data accurately is of critical importance. This book concentrates on diagnosing diseases like cancer or tumor from different modalities of images. This book is divided into the following domains: Importance of big data in medical imaging, pre-processing, image registration, feature extraction, classification and retrieval. It is further supplemented by the medical analyst for a continuous treatment process. The book provides an automated system that could retrieve images based on user's interest to a point of providing decision support. It will help medical analysts to take informed decisions before planning treatment and surgery. It will also be useful to researchers who are working in problems involved in medical imaging.

Biomaterials, Medical Devices, and Combination Products is a single-volume guide for those responsible for-or concerned with-developing and ensuring patient safety in the use and manufacture of medical devices. The book provides a clear presentation of the global regulatory requirements and challenges in evaluating the biocompatibility and clinical safety of the materials used in producing medical devices as well as the devices themselves. Starting with material characterization and selection, considerations of concerns arising from packaging and contact with production machinery, and extensive coverage of combination products, the book also provides the latest approaches to isolating, quantitating, identifying and assessing the risk arising from chemical entities released from market-ready devices. Also incorporated are new case examples and citations with the means of access to Internet-based regulatory and scientific sites, reflecting the universal adoption of this technology into our world. The book takes into consideration the fact that device markets are global, the continual advancement of technology, and the increasing global harmonization of safety regulations. Each aspect of device safety evaluation is reviewed in terms of the International Organization for Standardization (ISO), US Food and Drug Administration (FDA), European Union (EU), and Japanese Ministry of Health, Labour, and Welfare (MHLW) perspectives.

Cinematic Virtual Reality brings a combination of documentary, narrative and game design principles to the medical profession and, in the healthcare arena, collaboration is a key component for creating intellectually- and emotionally- rich immersive experiences. "The Power of Virtual Reality Cinema for Healthcare Training" gathers more than a dozen experts from both the production and healthcare fields to break down best practices for creating successful cine-VR projects. Designed for multi-disciplinary teams interested in integrating cine-VR production into their healthcare training and educational programs, this book has been written for two audiences: the healthcare professional interested in what production experts consider when approaching a project, and the media expert curious about how this new technology can be used in the medical field. Highlights include: Cutting edge medical education techniques developed by Ohio University's GRID Lab, including: PREality (creating a forced sense of deja-vu to increase acclimation time), a unique approach to eye-tracking to enhance team performance, and the low-CRIS technique (a low-cost rapid implementation strategy to capture patient care for rapid graduate student training). Insightful production techniques that will enhance your cine-VR projects including advanced plating methods to hide lighting set-ups, immersive audio considerations, and new ways to consider 360 storytelling including the Lovrick montage and the Christmas Carol continuum for story development. Detailed explanations of the production considerations and results of specific cine-VR productions (from funding approaches to distribution) including access to more than five hours of cine-VR examples of the actual productions available for download. Details on a wide variety of medical cine-VR projects, including 100 images that illustrate best practices for topics such as recording in active medical facilities, building successful multi-disciplinary teams, working within HIPAA regulations, conceptualizing cine-VR libraries for graduate education, and implementing innovative distribution models.

How do development and use of new technology relate? How can users contribute to innovation? This volume is the first to study these questions by following particular technologies over several product launches in detail. It examines the emergence of inventive ideas about future technology and uses, how these are developed into products and embedded in health care practices, and how the form and impact of these technologies then evolves through several rounds of design and deployment across different types of organizations. Examining these processes through three case studies of health care innovations, these studies reveal a blind spot in extant research on development-use relations. The majority of studies have examined shorter 'episodes': moments within particular design projects, implementation processes, usability evaluations, and human-machine interactions. Studies with longer time-frames have resorted to a relatively coarse 'grain-size' of analysis and hence lost sight of how the interchange is actually done. As a result there are no social science, information systems, or management texts which comprehensively or adequately address: * how different moments, sites and modes of shaping new technology determine the evolution of new technology; * the detailed mechanisms of learning, interaction, and domination between different actors and technology during these drawn out processes; and * the relationship of technology projects and the professional practices and social imaginations that are associated in technology development, evaluation, and usage. The "biographies of technologies and practices" approach to new technology advanced in this volume offers us urgent new insight to core empirical and theoretical questions about how and where development projects gain their representations of future use and users, how usage is actually designed, how users' requests and modifications affect designs, and what kind of learning takes place between developers and users in different phases of innovation-all crucial to our understanding and ability to advance new health technology, and innovation more generally.

The book presents the field of neuromorphic engineering from the perspectives of the scientist, the algorithm designer, and the computer architect. It covers the fundamentals of neuronal modeling, neuromorphic circuits, neuronal architectures, the neural engineering framework, and neuromorphic machine learning. It zooms in and out of the different disciplines, allowing readers with diverse backgrounds to understand and appreciate the field. The book walks the thin line of being descriptive enough to give the reader a clear understanding while not being too technical and tedious. It was designed for graduate students in the fields of computer science, electrical engineering, neuroscience, and computational biology.

"Everything worth winning in life boils down to teamwork and leadership. In my positions as a businessman, athlete, community leader, and University trustee; there are tremendous parallels between all of these endeavors that mirror an extreme team sport such as medical technology. Understanding the game, defining the game, playing your position at your highest performance, and helping others play their best game. Advanced Health Technology represents an incredible opportunity to level up the game of healthcare and highlights the multiple disciplines, or positions to be mastered while laying out winning plays to make that next level happen." Ronnie Lott, Managing Member, Lott Investments; Member, Pro Football Hall of Fame, and Trustee, Santa Clara University "Over the years we've known each other and worked together, Sherri and I have shared a passion for harm reduction. Whether that is due to failure of effective uses and deployment of technology or harm by one of today's biggest threats, drug overdose. We both recognize the need to strategically address the root causes of threats to health and wellbeing. Given that Mobile Medicine and related works are changing the way a whole generation of CTO's and CIO's are thinking about healthcare technology; this new book Advanced Health Technology takes the reader deeper into their leadership journey of transforming medicine with technology by understanding and addressing diverse risks rather than ignoring them." Dean Shold, Co-Founder FentCheck, Former Partner at Accenture, Former CTO Stanford Healthcare and Alameda Health System, former CTO at Medigram and current advisor. Healthcare stakeholders are paralyzed from making progress as risks explode in volume and complexity. This book helps readers understand how to manage and transcend risks to drive the Quadruple Aim of improved patient experiences, better patient and business outcomes, improved clinician experience, and lower healthcare costs. Learn from working successful examples across projects, programs, and careers to get ahead of these multidisciplinary healthcare risks.

This book brings together a collection of empirical case studies featuring a wide spectrum of medical innovation. While there is no unique pathway to successful medical innovation, recurring and distinctive features can be observed across different areas of clinical practice. This book examines why medical practice develops so unevenly across and within areas of disease, and how this relates to the underlying conditions of innovation across areas of practice. The contributions contained in this volume adopt a dynamic perspective on medical innovation based on the notion that scientific understanding, technology and clinical practice co-evolve along the co-ordinated search for solutions to medical problems. The chapters follow an historical approach to emphasise that the advancement of medical know-how is a contested, nuanced process, and that it involves a variety of knowledge bases whose evolutionary paths are rooted in the contexts in which they emerge. This book will be of interest to researchers and practitioners concerned with medical innovation, management studies and the economics of innovation. Chapter 5 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781138860346_oachapter5.pdf