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This tutorial book offers an in-depth overview of the fundamental principles of micro/nano technologies and devices related to sensing, actuation and diagnosis in fluidics and biosystems. Research in the MEMS/NEMS and lab-on-chip fields has seen rapid growth in both academic and industrial domains, as these biodevices and systems are increasingly replacing traditional large size diagnostic tools. This book is unique in describing not only the devices and technologies but also the basic principles of their operation. The comprehensive description of the fabrication, packaging and principles of micro/nano biosystems presented in this book offers guidance for researchers designing and implementing these biosystems across diverse fields including medical, pharmaceutical and biological sciences. The book provides a detailed overview of the fundamental mechanical, optical, electrical and magnetic principles involved, together with the technologies required for the design, fabrication and characterization of micro/nano fluidic systems and bio-devices. Written by a collaborative team from France and Korea, the book is suitable for academics, researchers, advanced level students and industrial manufacturers.
This book introduces readers to the latest exciting advances in human motion sensing and recognition, from the theoretical development of fuzzy approaches to their applications. The topics covered include human motion recognition in 2D and 3D, hand motion analysis with contact sensors, and vision-based view-invariant motion recognition, especially from the perspective of Fuzzy Qualitative techniques. With the rapid development of technologies in microelectronics, computers, networks, and robotics over the last decade, increasing attention has been focused on human motion sensing and recognition in many emerging and active disciplines where human motions need to be automatically tracked, analyzed or understood, such as smart surveillance, intelligent human-computer interaction, robot motion learning, and interactive gaming. Current challenges mainly stem from the dynamic environment, data multi-modality, uncertain sensory information, and real-time issues. These techniques are shown to effectively address the above challenges by bridging the gap between symbolic cognitive functions and numerical sensing & control tasks in intelligent systems. The book not only serves as a valuable reference source for researchers and professionals in the fields of computer vision and robotics, but will also benefit practitioners and graduates/postgraduates seeking advanced information on fuzzy techniques and their applications in motion analysis.
Handbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-science students or researchers can learn fundamental concepts and the application of new techniques in addressing biomedical challenges. Chapters will develop the conceptual framework of the physics formalism and illustrate the biomedical applications. With the addition of problem sets, guides to further study, and references, the interested reader can continue to independently explore the ideas presented.Volume 5: Modern Tools of BiophysicsEditor: Thomas Jue, PhDIn Modern Tools of Biophysics, a group of prominent professors have provided insights into the tools used in biophysics with respect to the following topics: Wave Theory of Image Formation in a Microscope: Basic Theory and Experiments Computer Simulations and Nonlinear Dynamics of Cardiac Action Potentials Myoglobin and Hemoglobin Contribution to the NIRS Signal in Muscle Anomalous Low Angle X-Ray Scattering of Membrane with Lanthanides Recording of Ionic Currents under Physiological Conditions-Action Potential-Clamping and "Onion-Peeling" Techniques Patch Clamp Technique and Applications About the EditorThomas Jue is a Professor in the Department of Biochemistry and Molecular Medicine at the University of California, Davis. He is an internationally recognized expert in developing and applying magnetic resonance techniques to study animal as well as human physiology in vivo and has published extensively in the field of magnetic resonance spectroscopy and imaging, near-infrared spectroscopy, bioenergetics, cardiovascular regulation, exercise, and marine biology. He served as a Chair of the Biophysics Graduate Group Program at UC Davis, where he started to develop scholarly approaches to educate graduate students with a balance of physical-science/mathematics formalism and biomedical perspective in order to promote interest at the interface of physical science, engineering, mathematics, biology, and medicine. He continues to develop the biophysics curriculum, and the Handbook of Modern Biophysics represents an aspect of that effort.
This book describes for readers technology used for effective sensing of our physical world and intelligent processing techniques for sensed information, which are essential to the success of the Internet of Things (IoTs). The authors provide a multidisciplinary view of sensor technology from MEMS, biological, chemical, and electrical domains and showcase smart sensor systems in real applications including smart home, transportation, medical, environmental, agricultural, etc. Unlike earlier books on sensors, this book provides a "global" view on smart sensors covering abstraction levels from device, circuit, systems, and algorithms.
This volume contains14 contributed papers from the following 2012 Materials Science and Technology (MS&T 12) symposia: * Next Generation Biomaterials * Surface Properties of Biomaterials
In this book, leading authors in the field discuss the habitats of tomorrow. These habitats will be connected through autonomous and assistive systems, turning habitats into health resorts. This book discusses how assistance technologies enable a smooth transition from comfortable health support to medical or nursing care. The contributions have been chosen and invited at the 9th AAL congress, Frankfurt.
Presents the proceedings of the World Congress on Medical Physics and Biomedical Engineering in Beijing: Promoting Health through Technology The congress's unique structure represents the two dimensions of technology and medicine: 13 themes on science and medical technologies intersect with five challenging main topics of medicine to create a maximum of synergy and integration of aspects on research, development and application. Each of the congress themes was chaired by two leading experts. The themes address specific topics of medicine and technology that provide multiple and excellent opportunities for exchanges.
Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Biomedical Engineering Fundamentals, the first volume of the handbook, presents material from respected scientists with diverse backgrounds in physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardiac biomechanics, the mechanics of blood vessels, cochlear mechanics, biodegradable biomaterials, soft tissue replacements, cellular biomechanics, neural engineering, electrical stimulation for paraplegia, and visual prostheses. The material is presented in a systematic manner and has been updated to reflect the latest applications and research findings.
Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Medical Devices and Human Engineering, the second volume of the handbook, presents material from respected scientists with diverse backgrounds in biomedical sensors, medical instrumentation and devices, human performance engineering, rehabilitation engineering, and clinical engineering. More than three dozen specific topics are examined, including optical sensors, implantable cardiac pacemakers, electrosurgical devices, blood glucose monitoring, human-computer interaction design, orthopedic prosthetics, clinical engineering program indicators, and virtual instruments in health care. The material is presented in a systematic manner and has been updated to reflect the latest applications and research findings.
In this book, the authors present in detail several recent methodologies and algorithms that they developed during the last fifteen years. The deterministic methods account for uncertainties through empirical safety factors, which implies that the actual uncertainties in materials, geometry and loading are not truly considered. This problem becomes much more complicated when considering biomechanical applications where a number of uncertainties are encountered in the design of prosthesis systems. This book implements improved numerical strategies and algorithms that can be applied to biomechanical studies.
Carbon nanomaterials have gained relevance in chem/bio sensing applications owing to their unique chemical, mechanical, electrical, and thermal characteristics. Written by leading experts in the field, this book discusses selected, state-of-the art carbon-based nanomaterials, including nanodiamonds, graphene nanodots, carbon nanopores, and nanocellulose. It presents examples of chem/bio sensing applications ranging from biomedical studies, such as DNA sequencing and neurotransmitter sensing, to heavy-metal detection in environmental monitoring scenarios, and reviews the unique properties of carbon-based nanomaterials with respect to targeted sensing applications. Further, it highlights exciting future applications. Providing comprehensive information for practitioners and scientists working in the field of carbon nanomaterial technologies and their application, it is also a valuable resource for advanced students of analytical chemistry, biochemistry, electrochemistry, materials science, and micro-/nanotechnology and -sensing.
As the third volume in the author's series on "Biomedical Signals and Sensors," this book explains in a highly instructive way how electric, magnetic and electromagnetic fields propagate and interact with biological tissues. The series provides a bridge between physiological mechanisms and theranostic human engineering. The first volume focuses on the interface between physiological mechanisms and the resultant biosignals that are commonplace in clinical practice. The physiologic mechanisms determining biosignals are described from the cellular level up to the mutual coordination at the organ level. In turn, the second volume considers the genesis of acoustic and optic biosignals and the associated sensing technology from a strategic point of view. This third volume addresses the interface between electric biosignals and biomedical sensors. Electric biosignals are considered, starting with the biosignal formation path to biosignal propagation in the body and finally to the biosignal sensing path and the recording of the signal. The series also emphasizes the common features of acoustic, optic and electric biosignals, which are ostensibly entirely different in terms of their physical nature. Readers will learn how these electric, magnetic and electromagnetic fields propagate and interact with biological tissues, are influenced by inhomogeneity effects, cause neuromuscular stimulation and thermal effects, and finally pass the electrode/tissue boundary to be recorded. As such, the book helps them manage the challenges posed by the highly interdisciplinary nature of biosignals and biomedical sensors by presenting the basics of electrical engineering, physics, biology and physiology that are needed to understand the relevant phenomena.
The integration of enzymes in food processing is well known, and dedicated research is continually being pursued to address the global food crisis. This book provides a broad, up-to-date overview of the enzymes used in food technology. It discusses microbial, plant and animal enzymes in the context of their applications in the food sector; process of immobilization; thermal and operational stability; increased product specificity and specific activity; enzyme engineering; implementation of high-throughput techniques; screening of relatively unexplored environments; and development of more efficient enzymes. Offering a comprehensive reference resource on the most progressive field of food technology, this book is of interest to professionals, scientists and academics in the food and biotech industries.
This book addresses electron spin-qubit based quantum computing and quantum information processing with a strong focus on the background and applications to EPR/ESR technique and spectroscopy. It explores a broad spectrum of topics including quantum computing, information processing, quantum effects in electron-nuclear coupled molecular spin systems, adiabatic quantum computing, heat bath algorithmic cooling with spins, and gateway schemes of quantum control for spin networks to NMR quantum information. The organization of the book places emphasis on relevant molecular qubit spectroscopy. These revolutionary concepts have never before been included in a comprehensive volume that covers theory, physical basis, technological basis, applications, and new advances in this emerging field. Electron Spin Resonance (ESR) Based Quantum Computing, co-edited by leading and renowned researchers Takeji Takui, Graeme Hanson and Lawrence J Berliner, is an ideal resource for students and researchers in the fields of EPR/ESR, NMR and quantum computing. This book also * Explores methods of harnessing quantum effects in electron-nuclear coupled molecular spin systems * Expertly discusses applications of optimal control theory in quantum computing * Broadens the readers' understanding of NMR quantum information processing
Introduction to Biomedical Engineering is a comprehensive survey text for biomedical engineering courses. It is the most widely adopted text across the BME course spectrum, valued by instructors and students alike for its authority, clarity and encyclopedic coverage in a single volume. Biomedical engineers need to understand the wide range of topics that are covered in this text, including basic mathematical modeling; anatomy and physiology; electrical engineering, signal processing and instrumentation; biomechanics; biomaterials science and tissue engineering; and medical and engineering ethics. Enderle and Bronzino tackle these core topics at a level appropriate for senior undergraduate students and graduate students who are majoring in BME, or studying it as a combined course with a related engineering, biology or life science, or medical/pre-medical course. * NEW: Each chapter in the 3rd Edition is revised and updated, with new chapters and materials on compartmental analysis, biochemical engineering, transport phenomena, physiological modeling and tissue engineering. Chapters on peripheral topics have been removed and made avaialblw online, including optics and computational cell biology. * NEW: many new worked examples within chapters * NEW: more end of chapter exercises, homework problems
* NEW: Image files from the text available in PowerPoint format
for adopting instructors * Readers benefit from the experience and
expertise of two of the most internationally renowned BME educators
* Instructors benefit from a comprehensive teaching package
including a fully worked solutions manual
* A complete introduction and survey of BME * NEW: new chapters on compartmental analysis, biochemical engineering, and biomedical transport phenomena
* NEW: revised and updated chapters throughout the book feature current research and developments in, for example biomaterials, tissue engineering, biosensors, physiological modeling, and biosignal processing. * NEW: more worked examples and end of chapter exercises
* NEW: Image files from the text available in PowerPoint format for adopting instructors * As with prior editions, this third edition provides a historical look at the major developments across biomedical domains and covers the fundamental principles underlying biomedical engineering analysis, modeling, and design
*bonus chapters on the web include: Rehabilitation Engineering and Assistive Technology, Genomics and Bioinformatics, and Computational Cell Biology and Complexity."
This book explains how diffusion weighted imaging has been incorporated in routine MRI examinations of the abdomen and pelvis: though its clinical role is still evolving, it is already considered an important tool for the assessment of rectal cancer treatment response, as was confirmed in recent ESGAR consensus statements. The standardization and clinical validation of quantitative DWI related biomarkers are still in progress, although certain efforts have been undertaken to establish imaging guidelines for different clinical indications/body parts. The book reviews the technical aspects and clinical applications of DWI in imaging of the GI tract, and provides specific technical details (imaging protocols, artefacts, optimization techniques) for each GI tract division. This volume is mainly intended for radiologists who are interested in abdominal radiology, as well as radiology residents. Given that magnetic resonance physics is complex and can be cumbersome to learn, the authors have made it as simple and practical as possible.
This book offers readers an introduction to the current status of nanoparticles and other nanomaterials that have potential applications in theranostics. Above all, it highlights the diagnostic and therapeutic applications of metallic (e.g. Au, Ag), semiconducting quantum dots (e.g. CdSe, CdTe), magnetic (e.g. Fe3O4, FePt, Co), and multifunctional (combination of two or three) nanoparticles.
Annette Barchanski deals with the question how to design nanoparticles for biomedical research. She considers properties such as size, charge, biocompatibility, and functionalization of nanoparticles from a biologist's point of view in order to achieve specific cellular responses. The author discusses the structure-function relationship of nanoparticle conjugates derived from a laser-based fabrication method. Both the limits and perspectives of tunable conjugate functions are presented, providing a general outline for researchers to configure functionalized nanoparticles with a specifically optimized design for biomedical requests, e.g. in biomedical engineering regenerative science and reproductive biology.
Mechanics of Biological Systems and Materials, Volume 4: Proceedings of the 2013 Annual Conference on Experimental and Applied Mechanics, the fourth volume of eight from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of areas, including: Structure-Function & Design of Soft Biological Tissues Soft Tissue Biomechanics: Nanoscale to Physiological Control Bone Mechanics Biomimetic Materials Residual Stresses in Biological Materials Cells Cellulose Materials
This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal book for students, teachers, researchers, and clinicians interested in a deeper understanding of nanotechnological advances in therapeutic medicine. This book also: Broadens readers' understanding of viral vector gene delivery to the brain for treating neurogenetic diseases as well as targeted gene delivery into the brain using microbubble-facilitated focused ultrasound Covers in detail the latest developments in delivering therapeutic materials, such as siRNA delivery to the brain for treating neurological diseases, neuroprotective effects of gelatin nanoparticles in stroke, and nanowired drug delivery for brain diseases, heat stroke, and CNS injury Enriches understanding of new technologies for delivering therapeutic materials treating Alzheimer's Disease, including targeted nanodrug delivery through the blood-brain barrier and the superior neuroprotective effects of nanowired drug delivery in Alzheimer's Disease
This book covers the latest information on the anatomic features, underlying physiologic mechanisms, and treatments for diseases of the heart. Key chapters address animal models for cardiac research, cardiac mapping systems, heart-valve disease and genomics-based tools and technology. Once again, a companion of supplementary videos offer unique insights into the working heart that enhance the understanding of key points within the text. Comprehensive and state-of-the art, the Handbook of Cardiac Anatomy, Physiology and Devices, Third Edition provides clinicians and biomedical engineers alike with the authoritative information and background they need to work on and implement tomorrow's generation of life-saving cardiac devices.
In this book, leading authors in the field discuss developments of Ambient Assisted Living. The contributions have been chosen and invited at the 8th AAL Congress, Frankfurt/M. The meeting presents new technological developments which support the autonomy and independence of individuals with special needs. The 8th AAL Congress focusses its attention on technical assistance systems and their applications in homecare, health and care.
This book addresses biometrics from a biomedical engineering point of view. Divided into five sections, it discusses topics including the influence of pathologies on various biometric modalities (e.g. face, iris, fingerprint), medical and security biometrics, behavioural biometrics, instrumentation, wearable technologies and imaging. The final chapters also present a number of case studies. The book is suitable for advanced graduate and postgraduate students, engineers and researchers, especially those in signal and image processing, biometrics, and biomedical engineering.
This book explores the role of cancer stem cells in the diagnosis, treatment, and cure of cancers. This book also tackles novel methodology for cancer stem cell marker identification, cancer stem cell respiration and metabolism, genetic and epigenetic mechanisms including DNA methylation, and mi-RNA assemble. It also emphasizes the role of Bioinformatics techniques, which provide a novel methodology for modeling cancer outcomes. The authors investigate the difference between cancer stem cells and normal stem cells, along with the concept of targeted cancer stem cell therapy. Although the theoretical explanations of cancer stem cell involvement in leukemia and solid cancers are controversial, there is now little doubt that cancer stem cells exist within otherwise heterogeneous cancer cell population. The brief examines the two leading theories, hierarchical and the stochastic/cancer stem cell model. Researchers, professors and advanced-level students focused on bioengineering and computer science will find this book to be a valuable resource. It is a very good source of critical references for understanding of this problem, and a useful tool for professionals in related fields.
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