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Mathematical modelling of physiological systems promises to advance our understanding of complex biological phenomena and pathophysiology of diseases. In this book, the authors adopt a mathematical approach to characterize and explain the functioning of the gastrointestinal system. Using the mathematical foundations of thin shell theory, the authors patiently and comprehensively guide the reader through the fundamental theoretical concepts, via step-by-step derivations and mathematical exercises, from basic theory to complex physiological models. Applications to nonlinear problems related to the biomechanics of abdominal viscera and the theoretical limitations are discussed. Special attention is given to questions of complex geometry of organs, effects of boundary conditions on pellet propulsion, as well as to clinical conditions, e.g. functional dyspepsia, intestinal dysrhythmias and the effect of drugs to treat motility disorders. With end of chapter problems, this book is ideal for bioengineers and applied mathematicians.
Bernard Rosner's FUNDAMENTALS OF BIOSTATISTICS is a practical introduction to the methods, techniques, and computation of statistics with human subjects. It prepares students for their future courses and careers by introducing the statistical methods most often used in medical literature. Rosner minimizes the amount of mathematical formulation (algebra-based) while still giving complete explanations of all the important concepts. As in previous editions, a major strength of this book is that every new concept is developed systematically through completely worked out examples from current medical research problems. Most methods are illustrated with specific instructions as to implementation using software either from SAS, Stata, R, Excel or Minitab.
This book will be mainly focussed on the properties and uses of dendrimers and dendrons. The aim of this book is to be the reference book about dendrimers applications. It will not describe all details, but it will give the reader a unique overview of what has currently been done with dendrimers, with numerous references and illustrations. It will be divided in four main parts: Part 1) Generalities, syntheses, characterizations and properties; Part 2) Applications in catalysis; Part 3) Applications for the elaboration or modification of materials; and Part 4) Applications in biology/medicine. The role of the nanometric size and the multiple functions of dendrimers on the properties will be emphasized.
Comprehensively covers the key technologies for the development of tactile perception in minimally invasive surgery
Covering the timely topic of tactile sensing and display in minimally invasive and robotic surgery, this book comprehensively explores new techniques which could dramatically reduce the need for invasive procedures. The tools currently used in minimally invasive surgery (MIS) lack any sort of tactile sensing, significantly reducing the performance of these types of procedures. This book systematically explains the various technologies which the most prominent researchers have proposed to overcome the problem. Furthermore, the authors put forward their own findings, which have been published in recent patents and patent applications. These solutions offer original and creative means of surmounting the current drawbacks of MIS and robotic surgery.
Key features: -Comprehensively covers topics of this ground-breaking technology including tactile sensing, force sensing, tactile display, PVDF fundamentalsDescribes the mechanisms, methods and sensors that measure and display kinaesthetic and tactile data between a surgical tool and tissueWritten by authors at the cutting-edge of research into the area of tactile perception in minimally invasive surgeryProvides key topic for academic researchers, graduate students as well as professionals working in the area
This step-by-step guide to medical technology innovation, now in full color, has been rewritten to reflect recent trends of industry globalization and value-conscious healthcare. Written by a team of medical, engineering, and business experts, the authors provide a comprehensive resource that leads students, researchers, and entrepreneurs through a proven process for the identification, invention, and implementation of new solutions. Case studies on innovative products from around the world, successes and failures, practical advice, and end-of-chapter 'Getting Started' sections encourage readers to learn from real projects and apply important lessons to their own work. A wealth of additional material supports the book, including a collection of nearly one hundred videos created for the second edition, active links to external websites, supplementary appendices, and timely updates on the companion website at ebiodesign.org. Readers can access this material quickly, easily, and at the most relevant point in the text from within the ebook.
The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.
Biosensors are devices that detect the presence of microbials such as bacteria, viruses or a range biomolecules, including proteins, enzymes, DNA and RNA. For example, they are routinely applied for monitoring the glucose concentration in blood, quality analysis of fresh and waste water and for food control. Nanomaterials are ideal candidates for building sensor devces: where in just a few molecules can alter the properties so drastically that these changes may be easily detected by optical, electrical or chemical means. Recent advantages have radically increased the sensitivity of nanomaterial-based biosensors, making it possible to detect one particular molecule against a background of billions of others. Focusing on the materials suitable for biosensor applications, such as nanoparticles, quantum dots, meso- and nanoporous materials and nanotbues, this text enables the reader to prepare the respective nanomaterials for use in actual devices by appropriate functionalization, surface processing or directed self-assembly. The emphasis throughout is on electrochemical, optical and mechancial detection methods, leading to solutions for today's most challenging tasks. The result is a reference for researchers and developers, disseminating first-hand information on which nanomaterial is best suited to a particular application - and why.
Develop the critical thinking skills you need to choose and fit effective orthoses for patients with hand injuries and functional deficits. As a combination workbook/textbook, Introduction to Orthotics, 5th Edition uses reader friendly language to cover the theory, design, and fabrication of orthopedic devices. Ideal for use in the classroom or in the clinical setting, it emphasizes upper extremity versus hand orthoses, with additional coverage of lower extremity orthotics and upper extremity prosthetics, and offers case studies promoting clinical reasoning and problem solving as well as an occupation-based approach. This new edition also demonstrates the fine detail of orthotics and equips you with a repertoire of skills and knowledge related to orthoses. Updated content, references, grading forms and self-evaluation, and case studies provide students and practitioners with the most current and up-to-date information they need to prepare to serve their clients' needs. Combined textbook/workbook format makes it easier to develop fundamental skills in the theory, design, and fabrication of orthoses Numerous case studies in each chapter show how concepts relate to real-life clinical practice. How-To videos on the Evolve companion website let students watch the construction of orthotics again and again to increase their proficiency. Integration of patient safety addresses this important aspect of patient care. Spiral binding lets the book lay flat when opened for convenient use while on the job. Self-evaluation forms allow you to analyze personal strengths and weaknesses related to new orthotic intervention techniques. Review questions and self-quizzes reinforce your comprehension of the material. Laboratory exercises test your clinical reasoning and technical skills. NEW! chapter covering Casting techniques provides guidance regarding current advances. NEW! Chapter for Professional Issues Related to Orthotic Provision. NEW! Elbow, Forearm, and Shoulder Immobilization Orthoses expands the content that previously only addressed elbow and forearm orthoses to include shoulder immobilization orthoses. NEW! Photos and illustrations for pre-fabrication, fitting, and fabrication techniques appear throughout the text. NEW! Evidence-based practice charts
Cutting-edge coverage of stem cell biology and applications
Featuring contributions from leading global experts, this authoritative volume addresses all major areas of stem cell biology and their potential therapeutic applications. The first part of the book covers embryonic stem cells and contains details on the emerging field of embryonic stem cell-based drug screening platforms. The second part deals with multipotent adult stem cells from different tissue types, and covers unique concepts such as cancer stem cells and tissue engineering-based approaches for designing microenvironments for tissue regeneration. Eighty pages of inserts with 113 color figures are included in this pioneering work.
Coverage includes: Zebrafish, medaka, chicken embryonic, and mouse embryonic stem cells Derivation of human embryonic stem cells (hESCs) from blastocysts Treating diabetes with hESCs hESCs as a model system to study human genetics Application of hESCs in drug discovery Adult stem cells for regenerative medicine and cancer therapies Mesenchymal stem cells for neurodegenerative disease therapies Dental pulp, hematopoietic, and spermatogonial stem cells Epigenetic regulators of stem cell pluripotency Cancer stem cells
The introduction of femtosecond pulse lasers has provided numerous new methods for non-destructive diagnostic analysis of biological samples. This book is the first to provide a focused and systematic treatment of femtosecond biophotonic methods. Each chapter combines theory, practice and applications, walking the reader through imaging, manipulation and fabrication techniques. Beginning with an explanation of nonlinear and multiphoton microscopy, subsequent chapters address the techniques for optical trapping and the development of laser tweezers. In a conclusion that brings together the various topics of the book, the authors discuss the growing field of femtosecond micro-engineering. The wide range of applications for femtosecond biophotonics means this book will appeal to researchers and practitioners in the fields of biomedical engineering, biophysics, life sciences and medicine.
A comprehensive reference on biochemistry, bioimaging, bioanalysis, and therapeutic applications of carbon nanomaterials Carbon nanomaterials have been widely applied for biomedical applications in the past few decades, because of their unique physical properties, versatile functionalization chemistry, and biological compatibility. This book provides background knowledge at the entry level into the biomedical applications of carbon nanomaterials, focusing on three applications: bioimaging, bioanalysis, and therapy. Carbon Nanomaterials for Bioimaging, Bioanalysis and Therapy begins with a general introduction to carbon nanomaterials for biomedical applications, including a discussion about the pros and cons of various carbon nanomaterials for the respective therapeutic applications. It then goes on to cover fluorescence imaging; deep tissue imaging; photoacoustic imaging; pre-clinical/clinical bioimaging applications; carbon nanomaterial sensors for cancer and disease diagnosis; targeted cancer therapy; and photothermal/photodynamic therapy. Each chapter briefly introduces the biomedical application and emphasizes the most appropriate carbon nanomaterial(s) for the application. Provides an introduction to the biomedical applications of carbon nanomaterials for early-career scientists, as well as background and context for mid-career scientists and researchers Contains four sections covering biochemistry, bioimaging, bioanalysis, and therapeutic applications of carbon nanomaterials Presented by experts who have strong background in the field of nanotechnology for biomedical applications Covers a hot area of research which has very unique physical properties, versatile functionalization chemistry, and biological compatibility Carbon Nanomaterials for Bioimaging, Bioanalysis and Therapy is an excellent resource for academic researchers and industrial scientists working on preparation and bio-application of carbon nanomaterials, biomedical engineering, and nanotechnology.
A must-have compendium on biomedical telemetry for all biomedical professional engineers, researchers, and graduate students in the field Handbook of Biomedical Telemetry describes the main components of a typical biomedical telemetry system, as well as its technical challenges. Written by a diverse group of experts in the field, it is filled with overviews, highly-detailed scientific analyses, and example applications of biomedical telemetry. The book also addresses technologies for biomedical sensing and design of biomedical telemetry devices with special emphasis on powering/integration issues and materials for biomedical telemetry applications. Handbook of Biomedical Telemetry: * Describes the main components of a typical biomedical telemetry system, along with the technical challenges * Discusses issues of spectrum regulations, standards, and interoperability while major technical challenges related to advanced materials, miniaturization, and biocompatibility issues are also included * Covers body area electromagnetics, inductive coupling, antennas for biomedical telemetry, intra-body communications, non-RF communication links for biomedical telemetry (optical biotelemetry), as well as safety issues, human phantoms, and exposure assessment to high-frequency biotelemetry fields * Presents biosensor network topologies and standards; context-aware sensing and multi-sensor fusion; security and privacy issues in biomedical telemetry; and the connection between biomedical telemetry and telemedicine * Introduces clinical applications of Body Sensor Networks (BSNs) in addition to selected examples of wearable, implantable, ingestible devices, stimulator and integrated mobile healthcare system paradigms for monitoring and therapeutic intervention Covering biomedical telemetry devices, biosensor network topologies and standards, clinical applications, wearable and implantable devices, and the effects on the mobile healthcare system, this compendium is a must-have for professional engineers, researchers, and graduate students.
The new research field of Ambient/Active Assisted Living (AAL) is quickly evolving. Ambient Integrated Robotics provides an easy-to-understand medical perspective to architects, designers, and engineers, bridging the different disciplines and showing how they fuse together to create the future of AAL technology. Using robotics as an example, the book illustrates how embedding its subsystems results in unique ambient technology that can be used to help people, particularly in adapting to the needs of the unwell and elderly populations. You will be provided with the knowledge and tools to contribute to the future of AAL. The Cambridge Handbooks on Construction Robotics series gives professionals, researchers, lecturers, and students basic conceptual and technical skills and strategies to manage, research, or teach the implementation of advanced automation, and robot-technology-based processes and technologies in construction. Books discuss progress in robot systems theory and demonstrates their integration using real applications and projections.
This book provides an in-depth, numerical investigation of tensegrity systems from a structural point of view, using the laws of fundamental mechanics for general pin-jointed systems with self-stressed mechanisms. Tensegrity structures have been known for decades, mostly as an art of form for monuments in architectural design. In Computational Modeling of Tensegrity Structures Professor Buntara examines these formations, integrating perspectives from mechanics, robotics, and biology, emphasizing investigation of tensegrity structures for both inherent behaviors and their apparent ubiquity in nature. The author offers numerous examples and illustrative applications presented in detail and with relevant MATLAB codes. Combining a chapter on the analyses of tensegrity structures along with sections on computational modeling, design, and the latest applications of tensegrity structures, the book is idea for R&D engineers and students working in a broad range of disciplines interested in structural design.
Over the past decade, Big Data have become ubiquitous in all economic sectors, scientific disciplines, and human activities. They have led to striking technological advances, affecting all human experiences. Our ability to manage, understand, interrogate, and interpret such extremely large, multisource, heterogeneous, incomplete, multiscale, and incongruent data has not kept pace with the rapid increase of the volume, complexity and proliferation of the deluge of digital information. There are three reasons for this shortfall. First, the volume of data is increasing much faster than the corresponding rise of our computational processing power (Kryder's law > Moore's law). Second, traditional discipline-bounds inhibit expeditious progress. Third, our education and training activities have fallen behind the accelerated trend of scientific, information, and communication advances. There are very few rigorous instructional resources, interactive learning materials, and dynamic training environments that support active data science learning. The textbook balances the mathematical foundations with dexterous demonstrations and examples of data, tools, modules and workflows that serve as pillars for the urgently needed bridge to close that supply and demand predictive analytic skills gap. Exposing the enormous opportunities presented by the tsunami of Big data, this textbook aims to identify specific knowledge gaps, educational barriers, and workforce readiness deficiencies. Specifically, it focuses on the development of a transdisciplinary curriculum integrating modern computational methods, advanced data science techniques, innovative biomedical applications, and impactful health analytics. The content of this graduate-level textbook fills a substantial gap in integrating modern engineering concepts, computational algorithms, mathematical optimization, statistical computing and biomedical inference. Big data analytic techniques and predictive scientific methods demand broad transdisciplinary knowledge, appeal to an extremely wide spectrum of readers/learners, and provide incredible opportunities for engagement throughout the academy, industry, regulatory and funding agencies. The two examples below demonstrate the powerful need for scientific knowledge, computational abilities, interdisciplinary expertise, and modern technologies necessary to achieve desired outcomes (improving human health and optimizing future return on investment). This can only be achieved by appropriately trained teams of researchers who can develop robust decision support systems using modern techniques and effective end-to-end protocols, like the ones described in this textbook. * A geriatric neurologist is examining a patient complaining of gait imbalance and posture instability. To determine if the patient may suffer from Parkinson's disease, the physician acquires clinical, cognitive, phenotypic, imaging, and genetics data (Big Data). Most clinics and healthcare centers are not equipped with skilled data analytic teams that can wrangle, harmonize and interpret such complex datasets. A learner that completes a course of study using this textbook will have the competency and ability to manage the data, generate a protocol for deriving biomarkers, and provide an actionable decision support system. The results of this protocol will help the physician understand the entire patient dataset and assist in making a holistic evidence-based, data-driven, clinical diagnosis. * To improve the return on investment for their shareholders, a healthcare manufacturer needs to forecast the demand for their product subject to environmental, demographic, economic, and bio-social sentiment data (Big Data). The organization's data-analytics team is tasked with developing a protocol that identifies, aggregates, harmonizes, models and analyzes these heterogeneous data elements to generate a trend forecast. This system needs to provide an automated, adaptive, scalable, and reliable prediction of the optimal investment, e.g., R&D allocation, that maximizes the company's bottom line. A reader that complete a course of study using this textbook will be able to ingest the observed structured and unstructured data, mathematically represent the data as a computable object, apply appropriate model-based and model-free prediction techniques. The results of these techniques may be used to forecast the expected relation between the company's investment, product supply, general demand of healthcare (providers and patients), and estimate the return on initial investments.
This book portrays the commonality of tissue micro-structure that dictates physiological function in various organs (microstructure-function relation). Tissue and organ models are used to illustrate physiological functions based on microstructure. Fiber scale properties such as orientation and crimp are described in detail. Structurally-based constitutive models are given throughout the book, not only to avoid ambiguities in material characterization, but also to offer insights into the function, structure, and mechanics of tissue components. A statement of future directions of the field is also given, including how advancements, such as state-of-the-art computational modeling and optical measurements of tissue/cells structures, are taking structure-based modeling to the next level. This book also: Provides a comprehensive view of tissue modeling across multiple systems Broadens readers' understanding of state-of-the-art computational modeling and optical measurements of tissue/cells structures Describes in detail fiber scale properties such as orientation and crimp
This groundbreaking single-authored textbook equips students with everything they need to know to truly understand the hugely topical field of biomaterials science, including essential background on the clinical necessity of biomaterials, relevant concepts in biology and materials science, comprehensive and up-to-date coverage of all existing clinical and experimental biomaterials, and the fundamental principles of biocompatibility. It features extensive case studies interweaved with theory, from a wide range of clinical disciplines, equipping students with a practical understanding of the phenomena and mechanisms of biomaterials performance; a whole chapter dedicated to the biomaterials industry itself, including guidance on regulations, standards and guidelines, litigation, and ethical issues to prepare students for industry; informative glossaries of key terms, engaging end-of-chapter exercises and up-to-date lists of recommended reading. Drawing on the author's forty years' experience in biomaterials, this is an indispensable resource for students studying these lifesaving technological advances.
Written in a versatile, contemporary style that will benefit both novice and expert alike, Biological and Biomedical Coatings Handbook, Two-Volume Set covers the state of the art in the development and implementation of advanced thin films and coatings in the biological field. Consisting of two volumes -- Processing and Characterization and Applications -- this handbook details the latest understanding of advances in the design and performance of biological and biomedical coatings, covering a vast array of material types, including bio-ceramics, polymers, glass, chitosan, and nanomaterials. Contributors delve into a wide range of novel techniques used in the manufacture and testing of clinical applications for coatings in the medical field, particularly in the emerging area of regenerative medicine. Building on the theoretical and methodological fundamentals of coatings as presented in the first volume, Applications covers: * Biological/biomedical implants and other applications of carbon-based materials * Control of drug release from coatings * MIcrofluidic and biosensing/bioactive coatings and applications * Surfaces and coatings of orthopedic, dental, and other implants * Sol-gel-derived hydroxyapatite coatings on metallic implants * Impedance spectroscopy With chapters authored by world experts at the forefront of research in their respective areas, this timely set provides searing insights and practical information to explore a subject that is fundamental to the success of biotechnological pursuits.
Written in a versatile, contemporary style that will benefit both novice and expert alike, Biological and Biomedical Coatings Handbook, Two-Volume Set explores the state of the art in the development and implementation of advanced thin films and coatings in the biological field. The set covers advances in the latest understanding, design, and performance of biological and biomedical coatings for a vast array of material types, including sol-gel, bio-ceramics, polymers, glass, chitosan, and nanomaterials. Contributors delve into a wide range of novel techniques used in the manufacture and testing of clinical applications for coatings in the medical field, particularly in the field of regenerative medicine. Topics include: * Implants and implanted devices * Organically modified coatings * Orthopedic and dental implants * Control of drug release * Biosensing and bioactive coatings * Thermal and plasma spraying * Hydrothermal, physical, and chemical vapor deposition * Impedance spectroscopy * Hydroxyapatite nanocoatings With chapters authored by world experts at the forefront of research in their respective areas, this timely set consists of two volumes -- Processing and Characterization and Applications -- to cover a subject that is truly fundamental to the success of biotechnological pursuits.
Written in a versatile, contemporary style that will benefit both novice and expert alike, Biological and Biomedical Coatings Handbook, Two-Volume Set covers the state of the art in the development and implementation of advanced thin films and coatings in the biological field. Consisting of two volumes -- Processing and Characterization and Applications -- this handbook details the latest understanding of advances in the design and performance of biological and biomedical coatings, covering a vast array of material types, including bio-ceramics, polymers, glass, chitosan, and nanomaterials. Contributors delve into a wide range of novel techniques used in the manufacture and testing of clinical applications for coatings in the medical field, particularly in the emerging area of regenerative medicine. An exploration of the fundamentals elements of biological and biomedical coatings, the first volume, Processing and Characterization, addresses: * Synthesis, fabrication, and characterization of nanocoatings * The sol-gel method and electrophoretic deposition * Thermal and plasma spraying * Hydroxyapatite and organically modified coatings * Bioceramics and bioactive glass-based coatings * Hydrothermal crystallization and self-healing effects * Physical and chemical vapor deposition * Layered assembled polyelectrolyte films With chapters authored by world experts at the forefront of research in their respective areas, this timely set provides searing insights and practical information to explore a subject that is fundamental to the success of biotechnological pursuits.
Foreword from a Clinical Biomechanist, Applied Physiologist and Prosthetist teaching graduate students in Prosthetics & Orthotics. While there are many books on Biomechanics, arguably the quintessential science of limb prosthetics, none addresses the fundamental principles in sufficient detail and depth to be practically useful to the prosthetist, rehabilitation specialist or researcher. Dr. Pitkin's monograph is an exemplary collection of theoretical principles from his research and o- ers, presented in its clinical and applied biomechanics form. The textbook provides an excellent overview of the many facets of lower limb prosthetic design and engineering for the ardent clinician researcher and student. The book delves into many of the basic concepts that are required knowledge for the clinician and the scientist to have as the foundation for their work. Dr. Pitkin has an e- quent manner in which he reflects on the history and literature to tell the storied evolution of prosthetic design . He takes the reader on a journey to consider his theories, which have substantive foundations to contemplate. By the end of chapter one, we have the basic h- tory and an appreciation for the rationale behind the "rolling joint ankle" with evidence to support his theoretical views.
The present book volume presents a holistic view of the aspects of nanobiomaterials incl. their stellar merits and limitations, applications in diverse fields, their futuristic promise in the fields of biomedical science and drug delivery. The federal & regulatory issues on the usage of nanobiomaterials have been assigned due consideration.
With mathematical and computational models furthering our understanding of lung mechanics, function and disease, this book provides an all-inclusive introduction to the topic from a quantitative standpoint. Focusing on inverse modeling, the reader is guided through the theory in a logical progression, from the simplest models up to state-of-the-art models that are both dynamic and nonlinear. Key tools used in biomedical engineering research, such as regression theory, linear and nonlinear systems theory, and the Fourier transform, are explained. Derivations of important physical principles, such as the Poiseuille equation and the wave speed equation, from first principles are also provided. Example applications to experimental data throughout illustrate physiological relevance, whilst problem sets at the end of each chapter provide practice and test reader comprehension. This book is ideal for biomedical engineering and biophysics graduate students and researchers wishing to understand this emerging field.
Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior of cells, specifically tumor cells.
In the first part of the text, the book discusses the powerful tool of microrheology for investigating cell mechanical properties, multiphysics and multiscale approaches for studying intracellular mechanisms in cell motility, and the role of subcellular effects involving certain genes for inducing cell motility in cancer. Focusing on models based on physical, mathematical, and computational approaches, the second section develops tools for describing the complex interplay of cell adhesion molecules and the dynamic evolution of the cell cytoskeleton. The third part explores cell interactions with the environment, particularly the role of external mechanical forces and their effects on cell behavior. The final part presents innovative models of multicellular systems for developmental biology, cancer, and embryogenesis.
This book collects novel methods to apply to cells and tissues through a multiscale approach. It presents numerous existing tools while stimulating the discovery of new approaches that can lead to more effective and accurate predictions of pathologies.
Biopolymers found in marine animals and plants offer tremendous, largely untapped pharmaceutical potential. Research shows that these biopolymers can be used to combat various infectious as well as inflammatory, oxidative, and carcinogenic factors. Chitin, Chitosan, Oligosaccharides and Their Derivatives: Biological Activities and Applications covers the key aspects of these therapeutically valuable biopolymers and their derivatives, namely, their properties, sources, production, and applications in food science and technology as well as biological, biomedical, industrial, and agricultural fields.
Contains more than 100 Tables & Figures and more than 800
With their wide range of applications, the world is looking to biopolymers to serve as the basis for functional food- and drug development. This book is an important resource for those leading this effort.
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