Although hip, knee and other orthopaedic implants are well-established prostheses, much remains to be understood about how these implants wear in use. This important book summarises the wealth of recent research in this area and its implications for implant and joint design.
After an introductory overview, the book reviews the causes and prevention of implant wear. Part one discusses fundamental issues such as tissue response to wear, the anatomy and biomechanics of hips and knees as well as the materials and design issues they raise for hip, knee and other types of orthopaedic implant. Part two considers wear phenomena in a range of materials, including ultra-high molecular weight (UHMWPE), metal and ceramic joints. It also covers surgical and other factors influencing wear as well as ways of detecting, analysing and predicting implant wear and failure.
With its distinguished editor and international team of contributors, Wear of orthopaedic implants and artificial joints is a standard reference for implant manufacturers, surgeons and those researching this important area.
Summarises the wealth of recent research into the wear of orthopaedic implants and artificial joints and discusses the implications for implant and joint designReviews the causes and prevention of implant wear, tissue response to wear, the anatomy and biomechanics of hips and knees and the materials and design issues they raise for orthopaedic implantsConsiders wear phenomena in a range of materials, including ultra-high molecular weight (UHMWPE), metal and ceramic joints

The biomaterials sector is rapidly expanding and significant advances have been made in the technology of biomedical coatings and materials, which provide a means to improve the wear of joints, change the biological interaction between implant and host and combine the properties of various materials to improve device performance. Coatings for biomedical applications provides an extensive review of coating types and surface modifications for biomedical applications.
The first part of the book explores a range of coating types and their biomedical applications. Chapters look at hydrophilic, mineral and pyrolytic carbon coatings in and ex vivo orthopaedic applications and finally at surface modification and preparation techniques. Part two presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices.
With its clear structure and comprehensive review of research, Coatings for biomedical applications is a valuable resource to researchers, scientists and engineers in the biomedical industry. It will also benefit anyone studying or working within the biomedical sector, particularly those specialising in biomedical coatings.
Provides an extensive review of coating types and surface modifications for biomedical applicationsChapters look at hydrophilic coatings for biomedical applications in and ex vivo, mineral coatings for orthopaedic applications, pyrolytic carbon coating and other commonly-used biomedical coatingsPresents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices

Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.
Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.
With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.
Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic woundsChapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healingCovers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair

Bioactive materials play an increasingly important role in the biomaterials industry, and are used for a range of applications, including artificial organs, drug delivery systems, nanomedicine, and biosensors. Bioactive materials in medicine reviews the current status and ongoing development of bioactive materials for medical applications.
Following an introduction to bioactive materials in medicine, part one covers the process of designing bioactive materials, including chapters on molecular design, nanotechnology, and tissue engineering. Part two focuses on the different applications of bioactive materials in medicine, with chapters discussing applications in orthopaedics, in the circulatory system, and as antibacterials. The final chapters focus on the uses of these materials in gene therapy, plastic surgery and body reconstruction, and in drug delivery systems.
With its distinguished editors and international team of contributors, Bioactive materials in medicine is an essential reference for researchers and designers in industry, as well as those with an academic interest in the subject.
Discusses the current status and ongoing development of bioactive materials for medical applicationsExplores the process of designing bioactive materials, including molecular design, nanotechnology, and tissue engineeringAssesses different applications of bioactive materials in medicine featuring applications in orthopaedics, in the circulatory system, and as antibacterials

Among the most interesting fields in research are the emerging possibilities to interface the human brain directly with machines, e.g. with computers and robotic interfaces. The European Space Agency's Advanced Concept team as a multidisciplinary team from engineering, artificial intelligence, and neural engineering has been working on the cutting edge of exploring brain machine interfaces for application in space as solutions to limitations astronauts face in space, and this book for the first time presents the state-of-the-art-cohesively.
* A pioneering book for a pioneering field
* Presents the application of cutting-edge brain machine interface technologies and concepts to support astronauts in space
* Of great interest to space scientists, neuroscientists, and biomedical engineers alike

This book provides a foundation for understanding the fundamentals of biomedical informatics, which deals with the storage, retrieval, and use of biomedical data for biological problem solving and medical decision making. It covers the application of these principles to the three main biomedical domains of basic biology, clinical medicine, and public health. The author offers a coherent summary, focusing on the three core concept areas of biomedical data and knowledge representation, biomedical information access, biomedical decision making, and information and technology use in biomedical contexts.
* Develops principles and methods for representing biomedical data, using information in context and in decision making, and accessing information to assist the medical community in using data to its full potential
* Provides a series of principles for expressing biomedical data and ideas in a computable form to integrate biological, clinical, and public health applications
* Includes a discussion of user interfaces, interactive graphics, and knowledge resources and reference material on programming languages to provide medical informatics programmers with the technical tools to develop systems

Modelling and Control in Biomedical Systems (including Biological Systems) was held in Reims, France, 20-22 August 2006. This Symposium was organised by the University of Reims Champagne Ardenne and the Societe de l Electricite, de l Electronique et des TIC (SEE).
The Symposium attracted practitioners in engineering, information technology, mathematics, medicine and biology, and other related disciplines, with authors from 24 countries. Besides the abstracts of the four plenary lectures, this volume contains the 92 papers that were presented by their authors at the Symposium
The papers included two invited keynote presentations given by internationally prominent and well-recognised research leaders: Claudio Cobelli, whose talk is titled "Dynamic modelling in diabetes: from whole body to genes"; and Irving J. Bigio, whose talk is titled "Elastic scattering spectroscopy for non-invasive detection of cancer." Two prestigious industrial speakers were also invited to give keynote presentations: Terry O'Brien from LIDCO, whose talk is titled "LIDCO: From the laboratory to protocolized goal directed therapy"; and Lorenzo Quinzio of Philips, whose talk is titled "Clinical decision support in monitoring and information systems."
* A valuable source of information on the state-of- the-art in Modelling and Control in Biomedical Systems
* Including abstracts of four plenary lectures, and 92 papers presented by their authors"

Maintaining quality of life in an ageing population is one of the great challenges of the 21st Century. This book and collection of illustrated CD lectures summarises how this challenge is being met by multi-disciplinary developments of specialty biomaterials, devices, artificial organs and in-vitro growth of human cells as tissue engineered constructs.
Biomaterials, Artificial Organs and Tissue Engineering is intended for use as a textbook in a one semester course for upper level BS, MS and Meng students. The 25 chapters are organized in five parts: Part one provides an introduction to living and man-made materials for the non-specialist; Part two is an overview of clinical applications of various biomaterials and devices; Part three summarises the bioengineering principles, materials and designs used in artificial organs; Part four presents the concepts, cell techniques, scaffold materials and applications of tissue engineering; Part five provides an overview of the complex socio-economic factors involved in technology based healthcare, including regulatory controls, technology transfer processes and ethical issues. Each chapter is supplemented with illustrated Power Point lectures and study questions in an easy to use CD to aid the reader in self-paced instruction.
Comprehensive introduction to living and man-made materialsLooks at clinical applications of various biomaterials and devicesBioengineering principles, materials and designs used in artificial organs are summarised

This book covers emerging trends in signal processing research and biomedical engineering, exploring the ways in which signal processing plays a vital role in applications ranging from medical electronics to data mining of electronic medical records. Topics covered include statistical modeling of electroencephalograph data for predicting or detecting seizure, stroke, or Parkinson's; machine learning methods and their application to biomedical problems, which is often poorly understood, even within the scientific community; signal analysis; medical imaging; and machine learning, data mining, and classification. The book features tutorials and examples of successful applications that will appeal to a wide range of professionals and researchers interested in applications of signal processing, medicine, and biology.

Energy, water, affordable healthcare and global warming are four major concerns resulting from resource depletion, record high oil prices, clean water shortages, high costs of pharmaceuticals, and changing climate conditions. Among many potential solutions, advance in membrane technology is one of the most direct, effective and feasible approaches to solve these sophisticated issues. This membrane book presents cutting-edge membrane research and development for water reuse and desalination, energy development including biofuels, CO2 capture, pharmaceutical purification and separation, and biomedical applications.

Polysaccharide-Based Hydrogels: Synthesis, Characterization and Applications looks at the synthesis, characterization and application of polysaccharide-based materials in a broad array of fields. The book discusses the role of polysaccharides in the preparation of hydrogels, the use of hydrogel-based green materials, and their applications in biomedical applications, drug delivery, water purification techniques, food industries, agricultural fields, and pharmaceuticals applications. Written by leading experts in this field, this book will be a valuable reference for scientists, academicians, researchers, technologists, consultants and policymakers.

Nanostructured Materials for Tissue Engineering introduces the key properties and approaches involved in using nanostructured materials in tissue engineering, including functionalization, nanotechnology-based regenerative techniques, toxicological and biocompatible aspects. A broad range of nanomaterial types are covered, from polymer scaffolds and nanocomposites to gold nanoparticles and quantum dots. This book aids the reader in materials selection, as well as matching to the best applications, including bone, skin, pulmonary or neurological tissue engineering. Users will find this book to be an up-to-date review on this fast-changing field that is ideal for materials scientists, tissue engineers, biomedical engineers, and pharmaceutical scientists.

Bioengineered Nanomaterials for Wound Healing and Infection Control is a key reference for those working in the fields of materials science, pharmacy, nanotechnology, biomedical engineering and microbiology. Bioengineered nanomaterials have unique physicochemical properties which promote accelerated wound healing and treatment of infections. The biosynthesis of these nanomaterials also offers a clean, safe and renewable alternative to traditional nanomaterials, helping reduce environmental impact alongside antibacterial resistance.

Distributed Computing to Blockchain: Architecture, Technology, and Applications provides researchers, computer scientists and data scientists with a comprehensive and applied reference covering the evolution of distributed systems computing into blockchain and associated systems such as consensus algorithms, distributed ledgers, DApps, byzantine fault tolerance, distributed databases and operating systems. Sections cover key concepts and technologies such as distributed systems and their architecture, distributed ledger and decentralized web, application and properties of crypto economics, blockchain crypto-analysis for distributed systems followed by DApps architecture. Other sections cover blockchain architecture and security, including smart contracts, tokens, and more. The authors then review byzantine fault tolerance (BFT), distributed ledgers vs. blockchains, and blockchain protocols. The security issues of blockchain and how it aims to resolve trust problems is also covered, along with consensus algorithms used in blockchain. Throughout the book, the presentation of key concepts is supported by real-world tools, algorithms, programming languages and technology to support the implementation of distributed ledger and blockchain in a variety of fields, including healthcare, finance, legal and business applications.

Principles of Biomaterials Encapsulation: Volume Two provides an expansive and in-depth resource covering the key principles, biomaterials, techniques and applications of encapsulation in translational medicine. The book details the various biomaterials available for encapsulation, including polymers, natural and synthetic biomaterials, porous materials, and more. The advantages and disadvantages of conventional and contemporary biomaterials for encapsulations are reviewed, along with advice on the most effective materials for both shell and core. The final part of the book describes a broad range of applications in regenerative medicine, uniquely bringing encapsulation into the worlds of translational medicine and tissue engineering. This book enables readers to learn about the pros and cons of different biomaterials for encapsulation, as well as how they can be utilized in many bodily systems and tissues, such as the respiratory, digestive, endocrine and cardiovascular systems. Written and edited by well-versed materials scientists with extensive clinical, biomedical and regenerative medicine experience, this book offers a deeply interdisciplinary look at encapsulation in translational medicine.

Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery is a comprehensive guide to PLGA nanoparticles for targeting various diseases, covering principles, formation, characterization, applications, regulations and the latest advances. Sections introduce the fundamental aspects of PLGA nanoparticles for drug delivery, including properties, preparation methods, characterization, drug loading methods, and drug release mechanisms, along with a focus on applications. Application of PLGA nanoparticles for the treatment of cancer, inflammatory, cerebral, cardiovascular, and infectious diseases, as well as in regenerative medicine, photodynamic and photothermal therapy, and gene therapy, are all explained in detail. The final chapters explore recent advances and regulatory aspects. This book is a valuable resource for researchers and advanced students across nanomedicine, polymer science, bio-based materials, chemistry, biomedicine, biotechnology, and materials engineering, as well as for industrial scientists and R&D professionals with an interest in nanoparticles for drug delivery, pharmaceutical formulations and regulations, and development of innovative biodegradable materials.

Security and Privacy Issues in Internet of Medical Things addresses the security challenges faced by healthcare providers and patients. As IoMT devices are vulnerable to cyberattacks, and a security breach through IoMT devices may act as a pathway for hackers to enter hospital networks, the book covers a very timely topic. The incorporation of blockchain in the healthcare environment has given birth to the Internet of Medical Things (IoMT), which consists of a collection of healthcare systems that espouse groundbreaking technologies. Systems consist of inter-linked sensors, wearable technology devices and clinical frameworks that perform explicit, secure machine-to-machine and cloud platform communications. The significance of IoMT in the field of healthcare is undoubtedly a win-win situation for patients through technology enhancements and a collection of analytics that helps in better diagnosis and treatment. Due to higher accuracy levels, IoMT devices are more reliable in reporting and data tracking and help avoid human errors and incorrect reporting.

Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies. This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more. Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques.

Foot and Ankle Biomechanics is a one source, comprehensive and modern reference regarding foot and ankle biomechanics. This text serves as both a master reference for foot biomechanics, presenting a clear state of the research and capabilities in the field. The customers for this book will be those looking for information on foot and ankle biomechanics for a range of applications; for example, designers of orthotics.

Plant Polysaccharides as Pharmaceutical Excipients explores innovative techniques and applications of plant-derived polysaccharides as pharmaceutical excipients. Plant polysaccharides are sustainable, renewable and abundantly available, offering attractive properties in terms of water solubility, swelling ability, non-toxicity and biodegradability. These qualities have resulted in extensive exploration into their applications as excipients in a variety of pharmaceutical dosage forms. This book takes a comprehensive, application-oriented approach, drawing on the very latest research that includes sources, classification and extraction methods of plant polysaccharides. Subsequent chapters focus on plant polysaccharides for individual pharmaceutical applications, enabling the reader to understand their preparation for specific targeted uses. Throughout the book, information is supported by illustrations, chemical structures, flow charts and data tables, providing a clear understanding. Finally, future perspectives and challenges are reviewed and discussed.

Principles of Biomaterials Encapsulation: Volume One, provides an expansive and in-depth resource covering the key principles, biomaterials, strategies and techniques for encapsulation. Volume One begins with an introduction to encapsulation, with subsequent chapters dedicated to a broad range of encapsulation principles and techniques, including spray chilling and cooling, microemulsion, polymerization, extrusion, cell microencapsulation and much more. This book methodically details each technique, assessing the advantages and disadvantages of each, allowing the reader to make an informed decision when using encapsulation in their research. Principles of Biomaterials Encapsulation: Volume One enables readers to learn about the various strategies and techniques available for encapsulation of a wide selection of biomedical substrates, such as drugs, cells, hormones, growth factors and so on. Written and edited by well-versed materials scientists with extensive clinical, biomedical and regenerative medicine experience, this book offers a deeply interdisciplinary look at encapsulation in translational medicine. As such, this book will provide a useful resource to a broad readership, including those working in the fields of materials science, biomedical engineering, regenerative and translational medicine, pharmacology, chemical engineering and nutritional science.

3D Printing in Medicine, Second Edition examines the rapidly growing market of 3D-printed biomaterials and their clinical applications. With a particular focus on both commercial and premarket tools, the book looks at their applications within medicine and the future outlook for the field. The chapters are written by field experts actively engaged in educational and research activities at the top universities in the world. The earlier chapters cover the fundamentals of 3D printing, including topics such as materials and hardware. The later chapters go on to cover innovative applications within medicine such as computational analysis of 3D printed constructs, personalized 3D printing - including 3D cell and organ printing and the role of AI - with a subsequent look at the applications of high-resolution printing, 3D printing in diagnostics, drug development, 4D printing, and much more. This updated new edition features completely revised content, with additional new chapters covering organs-on-chips, bioprinting regulations and standards, intellectual properties, and socio-ethical implications of organs-on-demand.

AI Assurance: Towards Trustworthy, Explainable, Safe, and Ethical AI provides readers with solutions and a foundational understanding of the methods that can be applied to test AI systems and provide assurance. Anyone developing software systems with intelligence, building learning algorithms, or deploying AI to a domain-specific problem (such as allocating cyber breaches, analyzing causation at a smart farm, reducing readmissions at a hospital, ensuring soldiers' safety in the battlefield, or predicting exports of one country to another) will benefit from the methods presented in this book. As AI assurance is now a major piece in AI and engineering research, this book will serve as a guide for researchers, scientists and students in their studies and experimentation. Moreover, as AI is being increasingly discussed and utilized at government and policymaking venues, the assurance of AI systems-as presented in this book-is at the nexus of such debates.

Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers - such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available. This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy.

Protein-Based Biopolymers: From Source to Biomedical Applications provides an overview on the development and application of protein biopolymers in biomedicine. Protein polymers have garnered increasing focus in the development of biomedical materials, devices and therapeutics due to their intrinsic bioactivity, biocompatibility and biodegradability. This book comprehensively reviews the latest advances on the synthesis, characterization, properties and applications of protein-based biopolymers. Each chapter is dedicated to a single protein class, covering a broad range of proteins including silk, collagen, keratin, fibrin, and more. In addition, the book explores the biomedical potential of these polymers, from tissue engineering, to drug delivery and wound healing. This book offers a valuable resource for academics and researchers in the fields of materials science, biomedical engineering and R&D groups working in pharmaceutical and biomedical industries.