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The book uses an integrated approach to predict the behavior of various biological interactions. It further discusses how synthetic biology gathers the information about various systems, in order to either devise an entirely new system, or, to modulate existing systems. The book also tackles the concept of modularity, where biological systems are visualized in terms of their parts. The chapters discuss how the principles of engineering are being used in biomedical sciences, to design biological circuits that can harbor multiple inputs and generate multiple outputs; to create genetic networks and control gene activity, in order to generate a desired response. The book aims to help the readers develop an array of biological parts, and to use these parts to develop synthetic circuits that can be assembled like electronic circuits. The ultimate aim of the book will be to serve as an amalgamation of key ideas of how judiciously synthetic biology could be exploited in therapeutic device and delivery mechanism.
This book describes for readers technology used for effective sensing of our physical world and intelligent processing techniques for sensed information, which are essential to the success of the Internet of Things (IoTs). The authors provide a multidisciplinary view of sensor technology from MEMS, biological, chemical, and electrical domains and showcase smart sensor systems in real applications including smart home, transportation, medical, environmental, agricultural, etc. Unlike earlier books on sensors, this book provides a "global" view on smart sensors covering abstraction levels from device, circuit, systems, and algorithms.
This book is intended as a reference guide for graduate students, postgraduate students and researchers with a basic knowledge of protein chemistry who would like to know more about the biomedical applications of natural proteins to promote healthier lives. The book is divided into ten chapters, each of which explains different natural proteins and their established biomedical applications. The first chapter extensively deals with protein based natural fibers and provides an overview of all protein based fibers currently available. In turn, chapter two mainly focuses on the biomedical applications of a special class of proteins called Heat Shock Proteins; the biomedical applications of silkworm pupae proteins are dealt in chapter three. Chapter four examines an interesting use of Eri silk fibroin as a biomaterial for Tissue Engineering, while chapter five discusses the key experimental details involved in converting Tasar silk sericin into self-assembled nanoparticles. Chapter six offers brief descriptions of bioactive proteins with respect to their sources, synthesis and applications. Chapter seven is dedicated to Interleukine-8 and its role in human life, while chapter eight addresses the importance of natural proteins in infectious diseases. Chapter nine explores the issue of excess intake of dietary proteins and its adverse effects, and finally, chapter ten discusses the efficiency of drug delivery systems made up of gelatin nanocomposites. The book is above all intended as a valuable resource for students and researchers alike, sparking their curiosity with regard to the applications of natural proteins and motivating them to focus their own energies on the discovery or identification of additional natural proteins for diverse biomedical uses.
Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer--while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician's performance criteria, and maintaining the safety of the patients. Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more. Introduces readers to the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project Presents in detail the theoretical background, computational tools, and methods that are used in all the different biomedical systems Teaches the theory for multi-parametric mixed-integer programming and explicit optimal control of volatile anaesthesia Provides an overview of the framework for modelling, optimization, and control of biomedical systems This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.
FUNDAMENTALS OF BIOSTATISTICS leads you through the methods, techniques, and computations of statistics necessary for success in the medical field. Every new concept is developed systematically through completely worked out examples from current medical research problems.
The first of its kind, this comprehensive resource integrates cellular mechanobiology with micro-nano techniques to provide unrivalled in-depth coverage of the field, including state-of-the-art methods, recent advances, and biological discoveries. Structured in two parts, the first part offers detailed analysis of innovative micro-nano techniques including FRET imaging, electron cryo-microscopy, micropost arrays, nanotopography devices, laser ablation, and computational image analysis. The second part of the book provides valuable insights into the most recent technological advances and discoveries in areas such as stem cell, heart, bone, brain, tumor, and fibroblast mechanobiology. Written by a team of leading experts and well-recognised researchers, this is an essential resource for students and researchers in biomedical engineering.
This book offers a systematic introduction to the engineering principles and techniques of cavitation in biomedicine on the basis of its physics and mechanism. Adopting an interdisciplinary approach, it covers areas of interest ranging from physics and engineering to the biological and medical sciences. Individual chapters introduce the fundamentals of cavitation, describe its characterization, control and imaging techniques, and present cavitation-enhanced thermal and mechanical effects and their applications. Intended as both a reference work for graduate students, and as a guide for scientists and engineers who work with cavitation in biomedicine, it provides a broad and solid foundation of knowledge. The aim is to bridge the different disciplines involved, and to promote cross-discipline research, thus encouraging innovations in the scientific research and engineering applications alike. Dr. Mingxi Wan is a professor at Department of Biomedical Engineering, Xi'an Jiao Tong University, Xi'an, Shaanxi, China; Dr. Yi Feng works at Department of Biomedical Engineering, Xi'an Jiao Tong University, Xi'an, Shaanxi, China; Dr. Gail ter Haar is a professor at The Institute of Cancer Research, Sutton, Surry, UK.
This book offers an impressive collection of contributions on the epistemology of international biolaw and its applications, both in the legal and ethical fields. Bringing together works by some of the world's most prominent experts on biolaw and bioethics, it constitutes a paradigmatic text in its field. In addition to exploring various ideologies and philosophies, including European, American and Mediterranean biolaw traditions, it addresses controversial topics straight from today's headlines, such as genetic editing, the dual-use dilemma, and neurocognitive enhancement. The book encourages readers to think objectively and impartially in order to resolve the ethical and juridical dilemmas that stem from biotechnological empowerment and biomedical techniques. Accordingly, it offers a valuable resource for courses on biolaw, law, bioethics, and biomedical research, as well as courses that discuss law and the biosciences at different professional levels, e.g. in the courts, biomedical industry, pharmacological companies and the public space in general.
Written to help companies comply with GMP, GLP, and validation requirements imposed by the FDA and regulatory bodies worldwide, Quality Control Training Manual: Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories presents cost-effective training courses that cover how to apply advances in the life sciences to produce commercially viable biotech products and services in terms of quality, safety, and efficacy. This book and its accompanying CD-ROM comprise detailed text, summaries, test papers, and answers to test papers, providing an administrative solution for management. Provides the FDA, Health Canada, WHO, and EMEA guidelines directly applicable to pharmaceutical laboratory-related issues Offers generic formats and styles that can be customized to any organization and help management build quality into routine operations to comply with regulatory requirements Contains ready-to-use training courses that supply a good source of training material for experienced and inexperienced practitioners in the biotechnology/biopharmaceutical industries Includes a CD with downloadable training courses that can be adopted and directly customized to a particular organization Supplies ready-to-use test papers that allow end users to record all raw data up to the issuance of the attached certificate The biotechnology/bioscience industries are regulated worldwide to be in compliance with cGMP and GLP principles, with particular focus on safety issues. Each company must create a definite training matrix of its employees. The training procedures in this book enable end users to understand the principles and elements of manufacturing techniques and provide documentation language ranging from the generic to the specific. The training courses on the CD supply valuable tools for developing training matrices to achieve FDA, Health Canada, EMEA, MHRA UK, WHO, and GLP compliance.
Today China is a major player in advancing the frontiers of biomedicine, yet previous accounts have examined only whether medical ideas and institutions created in the West were successfully transferred to China. This is the first book to demonstrate the role China played in creating a globalized biomedicine between 1850 and 1950. This was China's "Century of Humiliation" when imperialist powers dominated China's foreign policy and economy, forcing it to join global trends that included limited public health measures in the nineteenth century and government-sponsored healthcare in the twentieth. These external pressures, combined with a vast population immiserated by imperialism and the decline of the Chinese traditional economy, created extraordinary problems for biomedicine that were both unique to China and potentially applicable to other developing nations. In this book, scholars based in China, the United States, and the United Kingdom make the case that developments in biomedicine in China such as the discovery of new diseases, the opening of the medical profession to women, the mass production of vaccines, and the delivery of healthcare to poor rural areas should be at the center of our understanding of biomedicine, not at the periphery. CONTRIBUTORS: Daniel Asen, Nicole Barnes, Mary Augusta Brazelton, Gao Xi , He Xiaolian, Li Shenglan, David Luesink, William H. Schneider, Shi Yan, Yu Xinzhong, DAVID LUESINK is Assistant Professor of History at Sacred Heart University. WILLIAM H. SCHNEIDER is Professor Emeritus of History and Medical Humanities at Indiana University Purdue University Indianapolis. ZHANG DAQING is Professor and Director, Institute of Medical Humanities at Peking University in Beijing.
A comprehensive guide to understanding and interpreting digital images in medical and functional applications Biomedical Image Understanding focuses on image understanding and semantic interpretation, with clear introductions to related concepts, in-depth theoretical analysis, and detailed descriptions of important biomedical applications. It covers image processing, image filtering, enhancement, de-noising, restoration, and reconstruction; image segmentation and feature extraction; registration; clustering, pattern classification, and data fusion. With contributions from experts in China, France, Italy, Japan, Singapore, the United Kingdom, and the United States, Biomedical Image Understanding: * Addresses motion tracking and knowledge-based systems, two areas which are not covered extensively elsewhere in a biomedical context * Describes important clinical applications, such as virtual colonoscopy, ocular disease diagnosis, and liver tumor detection * Contains twelve self-contained chapters, each with an introduction to basic concepts, principles, and methods, and a case study or application With over 150 diagrams and illustrations, this bookis an essential resource for the reader interested in rapidly advancing research and applications in biomedical image understanding.
This book comprehensively discusses the latest research in the area of metabolic engineering. Metabolic engineering solutions for bioactive compounds are now being derived by means of heterologous gene expression, in a wide range of organisms. The book provides an overview of the model systems being employed for metabolic manipulation to yield bioactive molecules, such as single-cell proteins, antibody generation, metabolites, proteases, chaperones, therapeutic proteins, nanomaterials, polymeric conjugates, dendrimers and nanoassemblies, Escherichia coli, Agrobacterium, Saccharomyces cerevisiae and cell lines, etc. In addition, it shares insights into the scope of these methods in the areas of prevention, diagnosis and treatment of diseases, e.g. immunotherapy for curing various diseases like cancer, allergies, autoimmune diseases, etc.
Presents the proceedings of the World Congress on Medical Physics and Biomedical Engineering in Beijing: Promoting Health through Technology The congress's unique structure represents the two dimensions of technology and medicine: 13 themes on science and medical technologies intersect with five challenging main topics of medicine to create a maximum of synergy and integration of aspects on research, development and application. Each of the congress themes was chaired by two leading experts. The themes address specific topics of medicine and technology that provide multiple and excellent opportunities for exchanges.
This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.
This book presents the proceedings of the International Conference on Emerging Research in Electronics, Computer Science and Technology (ICERECT) organized by PES College of Engineering in Mandya. Featuring cutting-edge, peer-reviewed articles from the field of electronics, computer science and technology, it is a valuable resource for members of the scientific research community.
This book explores the aggregation-induced emission (AIE) effect, which has opened new avenues for the development of advanced luminogenic materials in the aggregate or solid state. By enabling light emission in the practically useful solid state, AIE has the potential to significantly expand the technological applications of luminescent materials. This book addresses principles, methods, and applications of AIEs, offering a new platform for the investigation of light-emitting processes from luminogen aggregates. Applications of AIE include biomedical diagnostics, sensor materials, and optoelectronic devices, among others, and are described in detail within the book. The development of a new generation of AIEgens, a deep understanding of the AIE mechanism(s), and the exploration of advanced technological applications will enable this exciting field to develop further. Headed by the pioneering researcher who started the field, Professor Ben Zhong Tang, this book combines both principles and applications and brings together global researchers in the field to report the progress, current challenges, and potential breakthroughs that may be accomplished in the near future. Provides an authoritative account of the fundamentals, properties, and potential of AIE by the pioneer of this active, highly-researched field; Highlights technological applications of AIE spanning biomedicine, sensor materials, and optoelectronics, among others; Presents a comprehensive view on challenges in the further development of AIE and derived technologies.
The book focuses on novel particulate technologies for the purpose of drug delivery to humans. Nowadays, macro and nano-scale particles are being investigated for targeted delivery of small and large biological macromolecules. The targeting of drugs can minimize the dosage regimen and reduces dose related potential toxicity of drug molecules, which in turn lead to increased potential compliance. Various types of organic, inorganic and polymer particles are currently being investigated. These are attracting the attention of the research workers in the field of drug delivery science and technology. This book covers polymersomes, inorganic- organic composites, gold nanoparticles biopolymer and synthetic polymer particles etc.All aspects of drug delivery in relation to each technology have been described including these advances, Easy to read and understand the content of each chapter Rich in up-to-date information regarding their application.
The thesis focuses on the control of blood glucose devices and design of implantable devices, and offers valuable insights on diabetes mellitus and related physiology and treatments. Diabetes mellitus is a widespread chronic disease in the modern world that affects millions of people around the globe. In Singapore, one in ten of the population has diabetes, and the severity of the problem has prompted the country's prime minister to talk about the disease at the National Day Rally in 2017. Designing an artificial pancreas that can provide effective blood glucose control for individuals with diabetes is one of the most challenging engineering problems. The author reports on research into the development of an implantable artificial pancreas that can regulate blood glucose levels by delivering appropriate dosages of insulin when necessary. By sensing blood glucose and injecting insulin directly into the vein, the implantable device aims to remove delays that occur with subcutaneous blood glucose sensing and insulin delivery. Preliminary in-vitro and in-vivo experimental results suggest that the implantable device for blood glucose control could be a clinically viable alternative to pancreas transplant.
This brief highlights the association of different performance variables that influences archery performance and the employment of different machine learning algorithms in the identification of potential archers. The sport of archery is often associated with a myriad of performance indicators namely bio-physiological, psychological, anthropometric as well as physical fitness. Traditionally, the determination of potential archers is carried out by means of conventional statistical techniques. Nonetheless, such methods often fall short in associating non-linear relationships between the variables. This book explores the notion of machine learning that is capable of mitigating the aforesaid issue. This book is valuable for coaches and managers in identifying potential archers during talent identification programs.
Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Biomedical Engineering Fundamentals, the first volume of the handbook, presents material from respected scientists with diverse backgrounds in physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardiac biomechanics, the mechanics of blood vessels, cochlear mechanics, biodegradable biomaterials, soft tissue replacements, cellular biomechanics, neural engineering, electrical stimulation for paraplegia, and visual prostheses. The material is presented in a systematic manner and has been updated to reflect the latest applications and research findings.
Written by an authority involved in the field since its nascent stages, Diffuse Optical Tomography: Principles and Applications is a long-awaited profile of a revolutionary imaging method. Diffuse Optical Tomography (DOT) provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through model-based reconstruction algorithms using NIR measurements along or near the boundary of tissue. Despite the practical value of DOT, many engineers from electrical or applied mathematics backgrounds do not have a sufficient understanding of its vast clinical applications and portability value, or its uncommon advantages as a tool for obtaining functional, cellular, and molecular parameters. A collection of the author's research and experience, this book fuses historical perspective and experiential anecdotes with fundamental principles and vital technical information needed to successfully apply this technology-particularly in medical imaging. This reference finally outlines how to use DOT to create experimental image systems and adapt the results of laboratory studies for use in clinical applications including: Early-stage detection of breast tumors and prostate cancer "Real-time" functional brain imaging Joint imaging to treat progressive diseases such as arthritis Monitoring of tumor response New contrast mechanisms and multimodality methods This book covers almost every aspect of DOT-including reconstruction algorithms based on nonlinear iterative Newton methods, instrumentation and calibration methods in both continuous-wave and frequency domains, and important issues of imaging contrast and spatial resolution. It also addresses phantom experiments and the development of various image-enhancing schemes, and it describes reconstruction methods based on contrast agents and fluorescence DOT. Offering a concise description of the particular problems involved in optical tomography, this reference illustrates DOT's fundamental foundations and the principle of image reconstruction. It thoroughly explores computational methods, forward mathematical models, and inverse strategies, clearly illustrating solutions to key equations.
A practical handbook rather than merely a chemistry reference, Szycher's Handbook of Polyurethanes, Second Edition offers an easy-to-follow compilation of crucial new information on polyurethane technology, which is irreplaceable in a wide range of applications. This new edition of a bestseller is an invaluable reference for technologists, marketers, suppliers, and academicians who require cutting-edge, commercially valuable data on the most advanced uses for polyurethane, one of the most important and complex specialty polymers. internationally recognized expert Dr. Michael Szycher updates his bestselling industry "bible" With seven entirely new chapters and five that are revised and updated, this book summarizes vital contents from U.S. patent literature-one of the most comprehensive sources of up-to-date technical information. These patents illustrate the most useful technology discovered by corporations, universities, and independent inventors. Because of the wealth of information they contain, this handbook features many full-text patents, which are carefully selected to best illustrate the complex principles involved in polyurethane chemistry and technology. Features of this landmark reference include: Hundreds of practical formulations Discussion of the polyurethane history, key terms, and commercial importance An in-depth survey of patent literature Useful stoichiometric calculations The latest "green" chemistry applications A complete assessment of medical-grade polyurethane technology Not biased toward any one supplier's expertise, this special reference uses a simplified language and layout and provides extensive study questions after each chapter. It presents rich technical and historical descriptions of all major polyurethanes and updated sections on medical and biological applications. These features help readers better understand developmental, chemical, application, and commercial aspects of the subject.
Nanophotonics has emerged rapidly into technological mainstream with the advent and maturity of nanotechnology available in photonics and enabled many new exciting applications in the area of biomedical science and engineering that were unimagined even a few years ago with conventional photonic engineering techniques. Handbook of Nanophotonics in Biomedical Engineering is intended to be a reliable resource to a wealth of information on nanophotonics that can inspire readers by detailing emerging and established possibilities of nanophotonics in biomedical science and engineering applications. This comprehensive reference presents not only the basics of nanophotonics but also explores recent experimental and clinical methods used in biomedical and bioengineering research. Each peer-reviewed chapter of this book discusses fundamental aspects and materials/fabrication issues of nanophotonics, as well as applications in interfaces, cell, tissue, animal studies, and clinical engineering. The organization provides quick access to current issues and trends of nanophotonic applications in biomedical engineering. All students and professionals in applied sciences, materials, biomedical engineering, and medical and healthcare industry will find this essential reference book highly useful.
This book is a practical guidebook in biochemistry, for medical as well as life sciences' students. The book covers reference values, sample collection procedure and detailed protocol to perform experiments. Each experiment starts with a brief introduction of the protocol, followed by specimen requirements and procedure. The procedures are presented in a very lucid manner and discuss details of calculations and clinical interpretations,The book is divided into 29 chapters, It offers references, general guidelines and abbreviations and provides principles and procedures of clinical biochemistry tests, along with their diagnostic importance.
This book summarizes the recent advances in the science and engineering of polymer-gel-based materials in different fields. It also discusses the extensive research developments for the next generation of smart materials. It takes an in-depth look at the current perspectives and market opportunities while pointing to new possibilities and applications. The book addresses important topics such as stimuli responsive polymeric nanoparticles for cancer therapy; polymer gel containing metallic materials; chemotherapeutic applications in oncology; conducting polymer-based gels and their applications in biological sensors; imprinted polymeric gels for pharmaceutical and biomedical purposes; applications of biopolymeric gels in the agricultural sector; application of polymer gels and their nanocomposites in electrochemistry; smart polyelectrolyte gels as a platform for biomedical applications; agro-based polymer gels and their application in purification of industrial water wastes; polymer gel composites for bio-applications. It will be of interest to researchers working in both industry and academia.
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