The purpose of this book is to summarize key strategies and recent accomplishments in the area of developing cell/biomaterial constructs for regenerative medicine. The first section is a review of the state-of-the-art of biomaterial carriers and is divided into synthetic and natural materials. A subset of the latter are decellularized organs which retain the structure and some of the biological activities of the target organ. The bulk of the book is devoted to unique problems associated with key tissue and organ targets. Key selling features: Describes developing cell/biomaterial constructs for regenerative medicine Reviews state-of-the-art of biomaterial carriers Summarizes the unique problems associated with key tissue and organ targets Discusses issues associated with clinical translation including quality control, manufacturing practices, nondestructive imaging, and animal models

Presents a comprehensive description of the theory and practical implementation of Doppler radar-based physiological monitoring This book includes an overview of current physiological monitoring techniques and explains the fundamental technology used in remote non-contact monitoring methods. Basic radio wave propagation and radar principles are introduced along with the fundamentals of physiological motion and measurement. Specific design and implementation considerations for physiological monitoring radar systems are then discussed in detail. The authors address current research and commercial development of Doppler radar based physiological monitoring for healthcare and other applications. * Explains pros and cons of different Doppler radar architectures, including CW, FMCW, and pulsed Doppler radar * Discusses nonlinear demodulation methods, explaining dc offset, dc information, center tracking, and demodulation enabled by dc cancellation * Reviews advanced system architectures that address issues of dc offset, spectrum folding, motion interference, and range resolution * Covers Doppler radar physiological measurements demonstrated to date, from basic cardiopulmonary rate extractions to more involved volume assessments Doppler Radar Physiological Sensing serves as a fundamental reference for radar, biomedical, and microwave engineers as well as healthcare professionals interested in remote physiological monitoring methods. Olga Boric-Lubecke, PhD, is a Professor of Electrical Engineering at the University of Hawaii at Manoa, and an IEEE Fellow. She is widely recognized as a pioneer and leader in microwave radar technologies for non-contact cardiopulmonary monitoring, and in the design of integrated circuits for biomedical applications. Victor M. Lubecke, PhD, is a Professor of Electrical Engineering at the University of Hawaii at Manoa. He is an emeritus IEEE Distinguished Microwave Lecturer and has over 25 years of experience in research and development of devices and methods for radio-based remote sensing systems. Amy Droitcour, PhD, has spent ten years developing radar-based vital signs measurement technology through her dissertation research and leading product development as CTO of Kai Medical. She currently serves as Senior Vice President of R&D at Wave 80 Biosciences. Byung-Kwon-Park, PhD, is a senior research engineer at the Mechatronics R&D Center in Korea. Aditya Singh, PhD, is currently a postdoctoral researcher at the University of Hawaii Neuroscience and MRI research Program.

This book is written for undergraduate and graduate students in biomedical engineering wanting to learn how to pursue a career in building up their entrepreneur ventures. Practicing engineers wanting to apply their innovations for healthcare will also find this book usefulThe 21st century is the "Biotech Century" where many nations are investing heavily in biotechnology. As a result, tremendous business opportunities exist for biomedical engineering graduates who are interested in becoming successful entrepreneurs. However, many challenges await these entrepreneurs intending to invent safe and effective devices and drugs to prevent, diagnose, alleviate and cure diseases.In this publication, many examples of innovations in biomedical engineering are covered, from the conceptualization stage to successful implementation and commercialization. Part I teaches working and would-be biomedical engineers to assess how well their innovations and their team can succeed; Part II will guide budding entrepreneurs to launch their ventures to the point of pre-production models. Other important aspects like financing, negotiations, leading by example, manufacturing, marketing, venture and globalization are covered in Part III. Two concluding chapters, with excerpts from leaders in community, education and industries, touch on the growth and investment in biomedical engineering entrepreneurship.

This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal book for students, teachers, researchers, and clinicians interested in a deeper understanding of nanotechnological advances in therapeutic medicine. This book also: Broadens readers' understanding of viral vector gene delivery to the brain for treating neurogenetic diseases as well as targeted gene delivery into the brain using microbubble-facilitated focused ultrasound Covers in detail the latest developments in delivering therapeutic materials, such as siRNA delivery to the brain for treating neurological diseases, neuroprotective effects of gelatin nanoparticles in stroke, and nanowired drug delivery for brain diseases, heat stroke, and CNS injury Enriches understanding of new technologies for delivering therapeutic materials treating Alzheimer's Disease, including targeted nanodrug delivery through the blood-brain barrier and the superior neuroprotective effects of nanowired drug delivery in Alzheimer's Disease

Conjugation of synthetic materials with cell-responsive biologically-active molecules, in addition to providing structural support and release of biomolecules in the regenerating region, can provide the signaling factors required to initiate the cascade of cell migration, adhesion, differentiation, maturation, growth factor modulation, maintenance of matrix integrity, and tissue morphogenesis. Nanoparticles conjugated with ligands that preferentially interact with cell surface receptors in the tumor environment have the potential to drastically improve bioavailability, selectivity and residence time of the chemotherapeutic agent in the tumor microenvironment, while limiting their peripheral toxicity. Multivalent presentation of tumor-associated antigens on a targeted delivery system containing T and B cell epitopes can result in strong, long-lasting, self-adjuvant immunity against cancer and other diseases in vaccination. These examples demonstrate that cell-responsive conjugate biomaterials have profoundly impacted the medical field.This book is divided into three sections. In the first section, synthesis and characterization, conformation, structure-activity, self-assembly, and host response of conjugate hybrid biomaterials are covered. The second section is dedicated to the applications of conjugate biomaterials in drug delivery and vaccination while the last section is devoted to tissue engineering applications including cell adhesion, control of the stem cell niche, cartilage regeneration, neural and vascular tissue engineering, and dynamic cell culture systems for functionalized biomaterials.There is no doubt that biologically-responsive conjugate biomaterials play a key role in the design of biologics and medical devices, and this pioneering reference book provides a comprehensive review on synthesis, characterization, structure-activity, 3D assembly/fabrication, host response and the emerging applications of conjugate hybrid biomaterials.

This book is a tribute to Professor Yuan-Cheng Fung, the Father of Biomechanics and a pioneer in Bioengineering, in honor of his 90th Birthday. The book consists of articles contributed by his colleagues, students, friends and family. These articles illustrate Professor Fung's profound influence on outstanding leaders in bioengineering, especially biomechanics, and on the life and work of all people who have been in contact with him. The scientific topics covered range from fundamentals of science and engineering (e.g., residual stress, flow dynamics, and cellular signaling) to clinical disorders (e.g., atherosclerosis, diabetes, and hypertension). The articles cover the whole spectrum of biological hierarchy, from genes/molecules to cells/tissues, and organs/systems, with close correlations between engineering and biomedical sciences. This book provides an excellent view of the marvelous contributions of Professor Fung as a Renaissance Man.

This book prepares students and technologists for registry examinations in nuclear medicine technology by providing practice questions and answers with detailed explanations, as well as a mock registry exam. The questions are designed to test both the basic knowledge required of nuclear medicine technologists and the practical application of that knowledge. The topics covered closely follow the content specifications and the components of preparedness as published by the certification boards. This 5th edition includes expanded coverage of positron emission tomography, multimodality imaging, and other new procedures and practices in the field of nuclear medicine and molecular imaging.

White biotechnology, or industrial biotechnology as it is also known, refers to the use of living cells and/or their enzymes to create industrial products that are more easily degradable, require less energy, create less waste during production and sometimes perform better than products created using traditional chemical processes. Over the last decade considerable progress has been made in white biotechnology research, and further major scientific and technological breakthroughs are expected in the future. Fungi are ubiquitous in nature and have been sorted out from different habitats, including extreme environments (high temperature, low temperature, salinity and pH), and may be associated with plants (epiphytic, endophytic and rhizospheric). The fungal strains are beneficial as well as harmful for human beings. The beneficial fungal strains may play important roles in the agricultural, industrial, and medical sectors. The fungal strains and their products (enzymes, bioactive compounds, and secondary metabolites) are very useful for industry (e.g., the discovery of penicillin from Penicillium chrysogenum). This discovery was a milestone in the development of white biotechnology as the industrial production of penicillin and antibiotics using fungi moved industrial biotechnology into the modern era, transforming it into a global industrial technology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high value nutraceutical and pharmaceutical products. The fungal strains and bioactive compounds also play an important role in environmental cleaning. This volume covers the latest developments and research in white biotechnology with a focus on diversity and enzymes.

This monograph addresses an innovative autologous muscle-derived stem cell therapy for urinary incontinence in women. It provides a detailed overview of studies and research projects on the use of stem cells for the treatment of urinary incontinence. It provides updated information about this condition for the era of regenerative medicine, making it a valuable resource for both students and physicians.

Nanotechnology is a budding field and has a pivotal role in sensing. Nanomaterials exist in various forms such as nanoparticles, nanoclusters, nanobelts, and nanospheres. These nanomaterials act as sensing interfaces and immobilization surfaces for various biomolecules such as enzymes, DNA, and antigens. Therefore, the preparation and characterization of these nanoparticles play an important role in sensing devices. This handbook has evolved from the authors' teaching and research experience in the field of nanoparticle biosensing. It encompasses protocols for the synthesis of various forms of metal oxide nanoparticles; study of the various characterizing techniques that help deduce the shape, size, and morphology of these nanoparticles; and applications of these nanoparticles in the field of biosensors. It presents voltammetry techniques such as cyclic, linear wave, wave pulse, and differential pulse voltammetry, throws light on the interactions of nanomaterials and biomolecules, and discusses microfluidic devices, which due to their unique capability of miniaturization fascinate many researchers. It is a practical and user-friendly textbook that introduces the various basic principles and practical information that will help undergraduate and advanced-level students and researchers understand the science behind nanoscale sensing.

This book summarizes the recent advances in the science and engineering of polymer-gel-based materials in different fields. It also discusses the extensive research developments for the next generation of smart materials. It takes an in-depth look at the current perspectives and market opportunities while pointing to new possibilities and applications. The book addresses important topics such as stimuli responsive polymeric nanoparticles for cancer therapy; polymer gel containing metallic materials; chemotherapeutic applications in oncology; conducting polymer-based gels and their applications in biological sensors; imprinted polymeric gels for pharmaceutical and biomedical purposes; applications of biopolymeric gels in the agricultural sector; application of polymer gels and their nanocomposites in electrochemistry; smart polyelectrolyte gels as a platform for biomedical applications; agro-based polymer gels and their application in purification of industrial water wastes; polymer gel composites for bio-applications. It will be of interest to researchers working in both industry and academia.

The maturing of the baby boomers has heralded the age of the bionic man, who is literally composed of various replacement organs or biomechanical parts. This book provides a comprehensive and up-to-date scientific source of biomedical engineering principles of replacement parts and assist devices for the bionic man. It contains topics ranging from biomechanical, biochemical, rehabilitation, and tissue engineering principles, to applications in cardiovascular, visual, auditory, and neurological systems, as well as recent advances in transplant, gene therapy, and stem cell research.

The maturing of the baby boomers has heralded the age of the bionic man, who is literally composed of various replacement organs or biomechanical parts. This book provides a comprehensive and up-to-date scientific source of biomedical engineering principles of replacement parts and assist devices for the bionic man. It contains topics ranging from biomechanical, biochemical, rehabilitation, and tissue engineering principles, to applications in cardiovascular, visual, auditory, and neurological systems, as well as recent advances in transplant, gene therapy, and stem cell research.

Biosensors are devices that detect the presence of microbials such as bacteria, viruses or a range biomolecules, including proteins, enzymes, DNA and RNA. For example, they are routinely applied for monitoring the glucose concentration in blood, quality analysis of fresh and waste water and for food control. Nanomaterials are ideal candidates for building sensor devces: where in just a few molecules can alter the properties so drastically that these changes may be easily detected by optical, electrical or chemical means. Recent advantages have radically increased the sensitivity of nanomaterial-based biosensors, making it possible to detect one particular molecule against a background of billions of others. Focusing on the materials suitable for biosensor applications, such as nanoparticles, quantum dots, meso- and nanoporous materials and nanotbues, this text enables the reader to prepare the respective nanomaterials for use in actual devices by appropriate functionalization, surface processing or directed self-assembly. The emphasis throughout is on electrochemical, optical and mechancial detection methods, leading to solutions for today's most challenging tasks. The result is a reference for researchers and developers, disseminating first-hand information on which nanomaterial is best suited to a particular application - and why.

Plant endophytes are a potential source for the production of bioactive compounds that can fight against devastating diseases in both plants and humans. Among these endophytic microorganisms, endophytic fungi are one of the dominant group of microorganisms with a potential role in plant growth promotion and the discovery of noble bioactive natural products. Endophytic fungi possess several bioactivities like anticancer, antimicrobial, insecticidal, plant growth stimulants, crop protection, phytoremediation, etc. Presence of modular biosynthetic genes clusters like PKS and NRPS in several endophytic fungi underscores the need to understand and explore such organisms. This volume presents and demonstrates the applied aspects of endophytic fungi. Practical applications of such endophytes are discussed in detail, including studies in pharmaceutical development and agricultural management of important microbial diseases. The beneficial effects that endophytic fungi provide to host plants-enhancing growth, increasing fitness, strengthening tolerance to abiotic and biotic stresses through secondary metabolites-are also discussed. The reader is provided with a comprehensive and detailed understanding of such relationships between endophytic fungi and their host.

* Tom Kenny, one of the best-known and well-respected educators in EP brings his signature style to this new primer * Practical, accessible, highly illustrated approach makes learning easy * Provides an overview of the algorithms and devices offered by the world s five pacemaker manufacturers * Offers clinicians learning objectives, test questions and essential points in bulleted lists * Perfect introductory guide to the topic, assumes little baseline knowledge and appropriate for residents, fellows, EP nurses, general clinical cardiologists, EP fellows and industry professionals

This book explores the role of cancer stem cells in the diagnosis, treatment, and cure of cancers. This book also tackles novel methodology for cancer stem cell marker identification, cancer stem cell respiration and metabolism, genetic and epigenetic mechanisms including DNA methylation, and mi-RNA assemble. It also emphasizes the role of Bioinformatics techniques, which provide a novel methodology for modeling cancer outcomes. The authors investigate the difference between cancer stem cells and normal stem cells, along with the concept of targeted cancer stem cell therapy. Although the theoretical explanations of cancer stem cell involvement in leukemia and solid cancers are controversial, there is now little doubt that cancer stem cells exist within otherwise heterogeneous cancer cell population. The brief examines the two leading theories, hierarchical and the stochastic/cancer stem cell model. Researchers, professors and advanced-level students focused on bioengineering and computer science will find this book to be a valuable resource. It is a very good source of critical references for understanding of this problem, and a useful tool for professionals in related fields.

This book presents an approach to postmortem human identification using dental image processing based on dental features and characteristics, and provides information on various identification systems based on dental features using image processing operations. The book also provides information on a novel human identification approach that uses Infinite Symmetric Exponential Filter (ISEF) based edge detection and contouring algorithms. Provides complete details on dental imaging; Discusses the important features of a human identification approach and presents a brief review on DICOM standard for dental imaging; Presents human identification approach based on dental features.

This book highlights the latest, cutting-edge advances in implantable biomaterials. It brings together a class of advanced biomaterials in two highly active research areas, namely implants and tissue scaffolds, to underline their respective functional requirements for further development. It is unique in providing a full range of methodological procedures, including materials syntheses, characterisation, cellular tests and mathematical modelling. Covering metallic, ceramic, polymeric and composite materials commonly used in biological applications and clinical therapeutics, it is a valuable resource for anyone wanting to further their understanding of the latest developments in implantable biomaterials. Focusing on biomedical applications in implants and scaffolds, it provides methodological guides to this rapidly growing field. Qing Li and Yiu-Wing Mai are both professors at the University of Sydney, School of Aerospace, Mechanical and Mechatronic Engineering.

Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This book elucidates the underlying concepts and emerging applications of hydrogels and will provide key case studies and critical analysis of the existing research.

This book presents the main scientific results of the 10th International Symposium of Computer Science in Sport (IACSS/ISCSS 2015), sponsored by the International Association of Computer Science in Sport in collaboration with the International Society of Sport Psychology (ISSP), which took place between September 9-11, 2015 at Loughborough, UK. This proceedings aims to build a link between computer science and sport, and reports on results from applying computer science techniques to address a wide number of problems in sport and exercise sciences. It provides a good platform and opportunity for researchers in both computer science and sport to understand and discuss ideas and promote cross-disciplinary research. The strictly reviewed and carefully revised papers cover the following topics:Modelling and Analysis, Artificial Intelligence in Sport, Virtual Reality in Sport, Neural Cognitive Training, IT Systems for Sport, Sensing Technologies and Image Processing.

This book documents the state of the art in the field of ambient assisted living (AAL), highlighting the impressive potential of novel methodologies and technologies to enhance well-being and promote active ageing. The coverage is wide ranging, with sections on care models and algorithms, enabling technologies and assistive solutions, elderly people monitoring, home rehabilitation, ICT solutions for AAL, living with chronic conditions, robotic assistance for the elderly, sensing technologies for AAL, and smart housing. The book comprises a selection of the best papers presented at the 9th Italian Forum on Ambient Assisted Living (ForitAAL 2018), which was held in Lecce, Italy, in July 2018 and brought together end users, technology teams, and policy makers to develop a consensus on how to improve provision for elderly and impaired people. Readers will find that the expert contributions offer clear insights into the ways in which the most recent exciting advances may be expected to assist in addressing the needs of the elderly and those with chronic conditions.

This new work is dedicated to glasses and their variants which can be used as biomaterials to repair diseased and damaged tissues. Bio-glasses are superior to other biomaterials in many applications, such as healing bone by signaling stem cells to become bone cells.

Key features: First book on biomaterials to focus on bio-glassesEdited by a leading authority on bio-glasses trained by one of its inventors, Dr Larry HenchSupported by the International Commission on Glass (ICG)Authored by members of the ICG Biomedical Glass Committee, with the goal of creating a seamless textbookWritten in an accessible style to facilitate rapid absorption of informationCovers all types of glasses, their properties and applications, and demonstrates how glass is an attractive improvement to current proceduresOf interest to the biomedical as well as the materials science community.

The book covers all types of glasses: traditional glasses, bioactive glasses, sol-gel glasses, phosphate glasses, glass-ceramics, composites and hybrids. Alongside discussion on how bio-glasses are made, their properties, and the reasons for their use, the authors also cover their applications in dentistry, bone regeneration and tissue engineering and cancer treatment. Its solid guidance describes the steps needed to take a new material from concept to clinic, covering the essentials of patenting, scale-up, quality assurance and FDA approval.

Optical microscopy is used in a vast range of applications ranging from materials engineering to in vivo observations and clinical diagnosis, and thanks to the latest advances in technology, there has been a rapid growth in the number of methods available. This book is aimed at providing users with a practical guide to help them select, and then use, the most suitable method for their application. It explores the principles behind the different forms of optical microscopy, without the use of complex maths, to provide an understanding to help the reader utilise a specific method and then interpret the results. Detailed physics is provided in boxed sections, which can be bypassed by the non-specialist. It is an invaluable tool for use within research groups and laboratories in the life and physical sciences, acting as a first source for practical information to guide less experienced users (or those new to a particular methodology) on the range of techniques available. Features: The first book to cover all current optical microscopy methods for practical applications Written to be understood by a non-optical expert with inserts to provide the physical science background Brings together conventional widefield and confocal microscopy, with advanced non-linear and super resolution methods, in one book To learn more about the author please visit here.

Building on the success of the first edition of this book, the winner of the 2004 British Medical Association Radiology Medical Book Competition, Quantitative MRI of the Brain: Principles of Physical Measurement gives a unique view on how to use an MRI machine in a new way. Used as a scientific instrument it can make measurements of a myriad of physical and biological quantities in the human brain and body. For each small tissue voxel, non-invasive information monitors how tissue changes with disease and responds to treatment. The book opens with a detailed exposition of the principles of good practice in quantification, including fundamental concepts, quality assurance, MR data collection and analysis and improved study statistical power through minimised instrumental variation. There follow chapters on 14 specific groups of quantities: proton density, T1, T2, T2*, diffusion, advanced diffusion, magnetisation transfer, CEST, 1H and multi-nuclear spectroscopy, DCE-MRI, quantitative fMRI, arterial spin-labelling and image analysis, and finally a chapter on the future of quantification. The physical principles behind each quantity are stated, followed by its biological significance. Practical techniques for measurement are given, along with pitfalls and examples of clinical applications. This second edition of this indispensable 'how to' manual of quantitative MR shows the MRI physicist and research clinician how to implement these techniques on an MRI scanner to understand more about the biological processes in the patient and physiological changes in healthy controls. Although focussed on the brain, most techniques are applicable to characterising tissue in the whole body. This book is essential reading for anyone who wants to use the gamut of modern quantitative MRI methods to measure the effects of disease, its progression, and its response to treatment. Features: The first edition was awarded the book prize for Radiology by the British Medical Association in 2004 Written by an authority in the field: Professor Tofts has an international reputation for quantification in MRI Gives specific 'how to' information for implementation of MRI measurement sequence techniques