Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set. This volume, Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, contains 28 authoritative chapters written by experts from around the world. Contributors cover the following topics: Processing polymeric biomaterials into specific forms that ensure biocompatibility and biodegradability for use in various applications in the medical and pharmaceutical arenas Use of biomaterials to address medical issues such as pulmonary disease, cancer, heart disease, tissue damage, and bone disease Applications including a variety of drug delivery systems, medical devices, anticancer therapies, biological uses for hydrogels, nanotechnology, bioartificial organs, and tissue engineering Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials and the most up-to-date applications of biomaterials in medicine.

Prostheses, assistive systems, and rehabilitation systems are essential to increasing the quality of life for people with disabilities. Research and development over the last decade has resulted in enormous advances toward that goal-none more so than the development of intelligent systems and technologies.

In the first truly comprehensive book addressing intelligent technologies for the disabled, top experts from around the world provide an overview of this dynamic, rapidly evolving field. They present state-of-the-art information on the latest, innovative technologies and their applications in various systems designed to better the lives of the disabled.

From the underlying principles to the design, practical applications, and assessment of results, Intelligent Systems and Technologies in Rehabilitation Engineering offers broad, pragmatic coverage of the field. It incorporates the most recent advances in sensory and limb prostheses, myoelectric control systems, circulatory systems, assistive technologies, and applications of virtual reality.

Rapid progress demands a concerted effort to keep up with the latest developments so they can begin to serve their purpose and improve the lives of the disabled. By incorporating details of the latest and most important advances into one volume, Intelligent Systems and Technologies in Rehabilitation Engineering makes that undertaking essentially effortless.

This book provides readers with basic principles of the electrochemistry of the electrodes used in modern, implantable neural prostheses. The authors discuss the boundaries and conditions in which the electrodes continue to function properly for long time spans, which are required when designing neural stimulator devices for long-term in vivo applications. Two kinds of electrode materials, titanium nitride and iridium are discussed extensively, both qualitatively and quantitatively. The influence of the counter electrode on the safety margins and electrode lifetime in a two electrode system is explained. Electrode modeling is handled in a final chapter.

Design and Use of Assistive Technology assesses major hurdles in the design and use of assistive technologies, while also providing guidelines and recommendations to improve these technologies. This volume takes an interdisciplinary approach to solving the major issues surrounding designing and using assistive technologies for the physically impaired by blending engineering, computer science and medicine. The most difficult problems in assistive technologies, such as privacy concerns in data gathering and analysis, inherent heterogeneity of the user population, knowledge transfer of novel technologies and incorporation of the user perspective into the design process are all addressed. The book also: -Presents theories on assistive technology through the lens of fields ranging from engineering and computer science to occupational therapy and neurology -Discusses assistive technologies in a broad scope that presents designs and theories that are universally applicable Design and Use of Assistive Technology features contributions from experts in their subject areas who discuss specific methods and mechanisms to integrate the user's experience into design and clinical evaluation in order to both create academic outreach through practical service models and improve knowledge transfer.

While there are many excellent texts focused on clinical medical imaging, there are few books that approach in vivo imaging technologies from the perspective of a scientist or physician-scientist using, or interested in using, these techniques in research. It is for these individuals that Essentials of In Vivo Biomedical Imaging is written. Featuring contributions from leading experts in the field, this authoritative reference text helps answer the following often-asked questions: Can imaging address my question? Which technique should I use? How does it work? What information does it provide? What are its strengths and limitations? What applications is it best suited for? How can I analyze the data? By explaining what each imaging technology can measure, describing major methods and approaches, and giving examples demonstrating the rich repertoire of modern biomedical imaging to address a wide range of morphological, functional, metabolic, and molecular parameters in a safe and noninvasive manner, Essentials of In Vivo Biomedical Imaging helps scientists and physician-scientists choose and utilize the appropriate in vivo imaging technologies and methods for their research.

This book summarizes the properties and applications of conventional and commercially available fiber-forming, bioresorbable polymers, as well as those currently under study, for use as biotextiles. Factors affecting the performance of these biomaterials are presented, and precautionary measures to reduce premature, hydrolytic degradation during manufacturing and processing are discussed. Because of the structural requirements of medical devices and the technological advancements in synthetic fibers and textile technology, the new field of "Biotextiles" has evolved to exploit the potential of various woven, knitted, braided and non-woven textile structures for biomedical applications. Textile substrates provide certain unique mechanical properties to the medical device and because of an inherently high level of porosity, they can encourage cell growth and promote migration and proliferation. Bioresorbable devices that assist in the repair and regeneration of damaged tissues have in recent years replaced many of the permanent prosthetic devices. Thus, the topic of "Bioresorbable Biomaterials" generates much interest and research activity in the field of biomaterials science today. For this reason, the use of bioresorbable polymers as fibers is currently dominating the field of resorbable biomaterials for applications from sutures to tissue engineering scaffolds.

The book is the proceedings of the 2nd International Conference on NeuroRehabilitation (ICNR 2014), held 24th-26th June 2014 in Aalborg, Denmark. The conference featured the latest highlights in the emerging and interdisciplinary field of neural rehabilitation engineering and identified important healthcare challenges the scientific community will be faced with in the coming years. Edited and written by leading experts in the field, the book includes keynote papers, regular conference papers, and contributions to special and innovation sessions, covering the following main topics: neuro-rehabilitation applications and solutions for restoring impaired neurological functions; cutting-edge technologies and methods in neuro-rehabilitation; and translational challenges in neuro-rehabilitation. Thanks to its highly interdisciplinary approach, the book will not only be a highly relevant reference guide for academic researchers, engineers, neurophysiologists, neuroscientists, physicians and physiotherapists working at the forefront of their field, but will also help to act as bridge between the scientific, engineering and medical communities.

From a biomedical engineering perspective, this book takes an analytic, quantitative approach to describing the basic components of physiological regulators and control systems (PRCs). In Endogenous and Exogenous Regulation and Control of Physiological Systems, the author provides grounding in the classical methods of designing linear and nonlinear systems. He also offers state-of-the-art material on the potential of PRCs to treat immune system ailments, most notably AIDS and cancer.

The book focuses on certain "wet" physiological regulators, such as those using endocrine hormones as parametric control substances. Endogenous and Exogenous Regulation and Control of Physiological Systems includes simulations that illustrate model validations and the putative control of cancer and HIV proliferation. It explores novel, untried immunotherapies on the cutting-edge of PRC treatment and explores the latest technologies.

Novel Optical Nanoprobes for Chemical and Biological Analysis starts with a brief introduction to several kinds of versatile nanomaterials with novel optical properties, such as gold/silver nanoparticles, quantum dots, upconversion nanoparticles and graphene. It mainly focuses on the latest sensor design strategies, which apply the optical properties of nanomaterials to various detection techniques including colorimetry, fluorescence, and surface-enhanced Raman scattering (SERS). These sensors are attractive owing to their high sensitivity, high specificity, and potential for easy quantification of targets in many applications, such as conventional chemical and biological analysis, clinical diagnosis, and intracellular system sensing as well as single-molecule detection. The challenges and future perspectives for optical nanoprobes are also presented, such as the increase in sensitivity for real environmental and clinical samples, the design and application of multifunctional nanoplatforms, and biocompatibility of nanomaterials.

Yulia Levakhina gives an introduction to the major challenges of image reconstruction in Digital Tomosynthesis (DT), particularly to the connection of the reconstruction problem with the incompleteness of the DT dataset. The author discusses the factors which cause the formation of limited angle artifacts and proposes how to account for them in order to improve image quality and axial resolution of modern DT. The addressed methods include a weighted non-linear back projection scheme for algebraic reconstruction andnovel dual-axis acquisition geometry. All discussed algorithms and methods are supplemented by detailed illustrations, hints for practical implementation, pseudo-code, simulation results and real patient case examples."

Marlitt Erbe provides a detailed introduction into the young research field of Magnetic Particle Imaging (MPI) and field free line (FFL) imaging in particular. She derives a mathematical description of magnetic field generation for FFL imaging in MPI. To substantiate the simulation studies on magnetic FFL generation with a proof-of-concept, the author introduces the FFL field demonstrator, which provides the world s first experimentally generated rotated and translated magnetic FFL field complying with the requirements for FFL reconstruction. Furthermore, she proposes a scanner design of considerably enhanced magnetic field quality and efficiency. The author discusses the influence of magnetic field quality optimization on the image quality achieved using efficient Radon-based reconstruction methods, which arise for a line detection scheme and based on this optimized design, presents a dynamic FFL scanner assembly."

"The Application of Biofluid Mechanics: Boundary Effects on Phoretic Motions of Colloidal Spheres" focuses on the phoretic motion behavior of various micron- to nanometer-size particles. The content of this book is divided into two parts: one on the concentration gradient-driven diffusiophoresis and osmophoresis, and one on thermocapillary motion and thermophoretic motion driven by temperature gradient. Diffusiophoresis and osmophoresis are mainly used in biomedical engineering applications, such as drug delivery, purification, and the description of the behavior of the immune system; thermocapillary motion and thermophoretic motion are applied in the field of semiconductors as well as in suspended impurities removal. The book also provides a variety of computer programming source codes compiled using Fortran for researchers' future applications.

This book is intended for chemical engineers, biomedical engineers and scientists, biophysicists and fundamental chemotaxis researchers. Dr. Po-Yuan Chen is an Assistant Professor at the Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

Features a solid foundation of mathematical and computational tools to formulate and solve real-world PDE problems across various fields With a step-by-step approach to solving partial differential equations (PDEs), Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R successfully applies computational techniques for solving real-world PDE problems that are found in a variety of fields, including chemistry, physics, biology, and physiology. The book provides readers with the necessary knowledge to reproduce and extend the computed numerical solutions and is a valuable resource for dealing with a broad class of linear and nonlinear partial differential equations. The author s primary focus is on models expressed as systems of PDEs, which generally result from including spatial effects so that the PDE dependent variables are functions of both space and time, unlike ordinary differential equation (ODE) systems that pertain to time only. As such, the book emphasizes details of the numerical algorithms and how the solutions were computed. Featuring computer-based mathematical models for solving real-world problems in the biological and biomedical sciences and engineering, the book also includes: * R routines to facilitate the immediate use of computation for solving differential equation problems without having to first learn the basic concepts of numerical analysis and programming for PDEs * Models as systems of PDEs and associated initial and boundary conditions with explanations of the associated chemistry, physics, biology, and physiology * Numerical solutions of the presented model equations with a discussion of the important features of the solutions * Aspects of general PDE computation through various biomedical science and engineering applications Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R is an excellent reference for researchers, scientists, clinicians, medical researchers, engineers, statisticians, epidemiologists, and pharmacokineticists who are interested in both clinical applications and interpretation of experimental data with mathematical models in order to efficiently solve the associated differential equations. The book is also useful as a textbook for graduate-level courses in mathematics, biomedical science and engineering, biology, biophysics, biochemistry, medicine, and engineering.

This is the first book devoted exclusively to the subject of immunogold-silver staining. This volume is authored by 47 distinguished scientist representing 12 countries. The primary objective of this book is to discuss principles, methods, and applications of IGSS.

This study deals with an underexplored area of the emerging technologies debate: robotics in the healthcare setting. The author explores the role of care and develops a value-sensitive ethical framework for the eventual employment of care robots. Highlighting the range of positive and negative aspects associated with the initiative to design and use care robots, it draws out essential content as a guide to future design both reinforcing this study's contemporary relevance, and giving weight to its prescriptions. The book speaks to, and is meant to be read by, a range of disciplines from science and engineering to philosophers and ethicists.

This comprehensive guide, by pioneers in the field, brings together, for the first time, everything a new researcher, graduate student or industry practitioner needs to get started in molecular communication. Written with accessibility in mind, it requires little background knowledge, and provides a detailed introduction to the relevant aspects of biology and information theory, as well as coverage of practical systems. The authors start by describing biological nanomachines, the basics of biological molecular communication and the microorganisms that use it. They then proceed to engineered molecular communication and the molecular communication paradigm, with mathematical models of various types of molecular communication and a description of the information and communication theory of molecular communication. Finally, the practical aspects of designing molecular communication systems are presented, including a review of the key applications. Ideal for engineers and biologists looking to get up to speed on the current practice in this growing field.

Lab-on-a-chip technology now permits us to make many important discoveries that can only be observed at the microscale or the nanoscale. The newest advances employed in biological and biochemical analysis translate into greater sensitivity, more accurate results, and more valuable findings. Authored by one of the field 's pioneering researchers, Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery focuses on all key aspects of microfluidic lab-on-a-chip technologies to offer an exceptionally cohesive overview of the science, its limitations, breakthroughs made over the years, and currently emerging advances.

The book emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays, and enzymatic assays.

The book includes more than 300 figures that depict novel chip functions and breakthroughs and 16 tables summarize materials and refer readers to additional resources. An appendix compiles extensive analytical applications from emerging and established research groups.

Beginners in the field will find the book useful for navigating the vast literature related to the technology, while experienced researchers will rely on the compiled information for easy comparison and references for further study.

Derived from the highly popular Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery (2006), this volume is also readily adaptable for classroom use. Problem sets in each chapter help students test their assimilation of the material and clarify challenging concepts. The book contains a comprehensive glossary, a complete index, and extensive references. A solutions manual is available with qualifying course adoption.

This introduction to medical imaging introduces all of the major medical imaging techniques in wide use in both medical practice and medical research, including Computed Tomography, Ultrasound, Positron Emission Tomography, Single Photon Emission Tomography and Magnetic Resonance Imaging. Principles of Medical Imaging for Engineers introduces fundamental concepts related to why we image and what we are seeking to achieve to get good images, such as the meaning of 'contrast' in the context of medical imaging. This introductory text separates the principles by which 'signals' are generated and the subsequent 'reconstruction' processes, to help illustrate that these are separate concepts and also highlight areas in which apparently different medical imaging methods share common theoretical principles. Exercises are provided in every chapter, so the student reader can test their knowledge and check against worked solutions and examples. The text considers firstly the underlying physical principles by which information about tissues within the body can be extracted in the form of signals, considering the major principles used: transmission, reflection, emission and resonance. Then, it goes on to explain how these signals can be converted into images, i.e., full 3D volumes, where appropriate showing how common methods of 'reconstruction' are shared by some imaging methods despite relying on different physics to generate the 'signals'. Finally, it examines how medical imaging can be used to generate more than just pictures, but genuine quantitative measurements, and increasingly measurements of physiological processes, at every point within the 3D volume by methods such as the use of tracers and advanced dynamic acquisitions. Principles of Medical Imaging for Engineers will be of use to engineering and physical science students and graduate students with an interest in biomedical engineering, and to their lecturers.

This book focuses on cell- and molecule-based biosensors using micro/nano devices as transducers. After providing basic information on micro/nano cell- and molecule-based biosensors, it introduces readers to the basic structures and properties of micro/nano materials and their applications. The topics covered provide a comprehensive review of the current state of the art in micro/nano cell- and molecule-based biosensors as well as their future development trends, ensuring the book will be of great interest to the interdisciplinary community active in this area: researchers, engineers, biologists, medical scientists, and all those whose work involves related interdisciplinary research and applications. Dr. Ping Wang is a Professor in Department of Biomedical Engineering at Zhejiang University, Hangzhou, China. Dr. Chunsheng Wu is a Professor in Medical School at Xi'an Jiaotong University, Xi'an, China. Dr. Ning Hu is an Assistant researcher in Department of Biomedical Engineering at Zhejiang University and a Postdoctoral researcher in Medical School at Harvard University, Boston, USA. Dr. K. Jimmy Hsia is a Professor in Department of Biomedical Engineering at Carnegie Mellon University, Pittsburgh, USA.

A comprehensive reference on biochemistry, bioimaging, bioanalysis, and therapeutic applications of carbon nanomaterials Carbon nanomaterials have been widely applied for biomedical applications in the past few decades, because of their unique physical properties, versatile functionalization chemistry, and biological compatibility. This book provides background knowledge at the entry level into the biomedical applications of carbon nanomaterials, focusing on three applications: bioimaging, bioanalysis, and therapy. Carbon Nanomaterials for Bioimaging, Bioanalysis and Therapy begins with a general introduction to carbon nanomaterials for biomedical applications, including a discussion about the pros and cons of various carbon nanomaterials for the respective therapeutic applications. It then goes on to cover fluorescence imaging; deep tissue imaging; photoacoustic imaging; pre-clinical/clinical bioimaging applications; carbon nanomaterial sensors for cancer and disease diagnosis; targeted cancer therapy; and photothermal/photodynamic therapy. Each chapter briefly introduces the biomedical application and emphasizes the most appropriate carbon nanomaterial(s) for the application. Provides an introduction to the biomedical applications of carbon nanomaterials for early-career scientists, as well as background and context for mid-career scientists and researchers Contains four sections covering biochemistry, bioimaging, bioanalysis, and therapeutic applications of carbon nanomaterials Presented by experts who have strong background in the field of nanotechnology for biomedical applications Covers a hot area of research which has very unique physical properties, versatile functionalization chemistry, and biological compatibility Carbon Nanomaterials for Bioimaging, Bioanalysis and Therapy is an excellent resource for academic researchers and industrial scientists working on preparation and bio-application of carbon nanomaterials, biomedical engineering, and nanotechnology.

The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.

This textbook integrates the classic fields of mechanics-statics, dynamics, and strength of materials-using examples from biology and medicine. The book is excellent for teaching either undergraduates in biomedical engineering programs or health care professionals studying biomechanics at the graduate level. Extensively revised from a successful third edition, Fundamentals of Biomechanics features a wealth of clear illustrations, numerous worked examples, and many problem sets. The book provides the quantitative perspective missing from more descriptive texts, without requiring an advanced background in mathematics. It will be welcomed for use in courses such as biomechanics and orthopedics, rehabilitation and industrial engineering, and occupational or sports medicine. This book: Introduces the fundamental concepts, principles, and methods that must be understood to begin the study of biomechanics Reinforces basic principles of biomechanics with repetitive exercises in class and homework assignments given throughout the textbook Includes over 100 new problem sets with solutions and illustrations

This book is the first comprehensive overview of the emerging field of cuffless blood pressure monitoring. Increasing clinical evidence proves that longitudinal measurements of blood pressure allow for earlier detection and better management of multiple medical conditions and for superior prediction of cardiovascular events. Unfortunately, today's clinical and industry standards for blood pressure monitoring still require the inflation of a pneumatic cuff around a limb each time a measurement is taken. Over the last decades clinicians, scientists and device manufacturers have explored the feasibility of technologies that reduce or even completely eliminate the need of cuffs, initiating the era of cuffless blood pressure monitoring. Among the existing literature, this book is intended to be a practical guide to navigate across this emerging field. The chapters of the handbook have been elaborated by experts and key opinion leaders in the domain, and will guide the reader along the clinical, scientific, technical, and regulatory aspects of cuffless blood pressure monitoring.

The research areas as well as the knowledge gained for the practical use of robots are growing and expanding beyond manufacturing and industrial automation, making inroads in sectors such as health care and terrain sensing, as well as general assistive systems working in close interaction with humans. In a situation like this, it is necessary for future robot systems to become less stiff and more specialized by taking inspiration from the mechanical compliance and versatility found in natural materials and organisms. At present, a new discipline is emerging in this area, called "Soft Robotics". It particularly challenges the traditional thinking of engineers, as the confluence of technologies, ranging from new materials, sensors, actuators and production techniques to new design tools, will make it possible to create new systems whose structures are almost completely made of soft materials, which bring about entirely new functions and behaviors, similar in many ways to natural systems. These Proceedings focus on four main topics: * Soft Actuators and Control * Soft Interactions * Soft Robot Assistants: Potential and Challenges * Human-centered "Soft Robotics".

Master simple to advanced biomaterials and structures with this essential text. Featuring topics ranging from bionanoengineered materials to bio-inspired structures for spacecraft and bio-inspired robots, and covering issues such as motility, sensing, control and morphology, this highly illustrated text walks the reader through key scientific and practical engineering principles, discussing properties, applications and design. Presenting case studies for the design of materials and structures at the nano, micro, meso and macro-scales, and written by some of the leading experts on the subject, this is the ideal introduction to this emerging field for students in engineering and science as well as researchers.