This edited book explores the use of mobile technologies such as phones, drones, robots, apps, and wearable monitoring devices for improving access to healthcare for socially disadvantaged populations in remote, rural or developing regions. This book brings together examples of large scale, international projects from developing regions of China and Belt and Road countries from researchers in Australia, Bangladesh, Denmark, Norway, Japan, Spain, Thailand and China. The chapters discuss the challenges presented to those seeking to deploy emerging mobile technologies (e.g., smartphones, IoT, drones, robots etc.) for healthcare (mHealth) in developing countries and discuss the solutions undertaken in these case study projects. This book brings together joint work in mHealth projects across multiple disciplines (software, healthcare, mobile communications, entrepreneurship and business and social development). Bringing together research from different institutions and disciplines, the editors illustrate the technical and entrepreneurial aspects of using mobile technologies for healthcare development in remote regions. Chapters are grouped into five key themes: the global challenge, portable health clinics, sustainable and resilient mHealth services, mHealth for the elderly, and mHealth for chronic illnesses. The book will be of particular interest to engineers, entrepreneurs, NGOs and researchers working in healthcare in sustainable development settings.

Breaches and identity theft involving medical data are on the rise. Data security has become especially critical to the healthcare industry as patient privacy hinges on legal compliance and secure adoption of electronic health records. As cyber criminals see medical data as an easy way to illegally obtain medical goods and services or sell sensitive information, major security flaws can pose serious threats to the health and safety of patients. The Handbook of Research on Medical Data Security for Bioengineers seeks to provide a cross-disciplinary forum on research in privacy preserving healthcare systems and engineering applications in medical data security. The goal of the book is to instigate discussion on these critical issues since the success of electronic healthcare applications depends directly on patient security and privacy for ethical and legal reasons. While highlighting topics including data privacy, encryption strategies, and smart health, this book is ideally designed for IT experts, computer engineers, biomedical engineer practitioners, professionals, researchers, and post-doctoral and graduate students.

Methods for detecting protein-protein interactions (PPIs) have given researchers a global picture of protein interactions on a genomic scale. ""Biological Data Mining in Protein Interaction Networks"" explains bioinformatic methods for predicting PPIs, as well as data mining methods to mine or analyze various protein interaction networks. A defining body of research within the field, this book discovers underlying interaction mechanisms by studying intra-molecular features that form the common denominator of various PPIs.

Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies.

Over the past few decades, there has been unprecedented progress in the design of versatile biopolymer-based nanoplatforms for pharmaceutical and biomedical applications, particularly due to their attractive traits, including excellent biocompatibility, outstanding biodegradability, low immunogenicity, and facile chemical modifiability. Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications serves as a clear and detailed body of information on the synthesis and characterization of biopolymer-based materials in nanomedicine. This book describes various nanomaterials consisting of biopolymers including polysaccharides (i.e., derived from plants, animals, bacteria, algae, and fungi) and polypeptides in terms of their structures, synthetic protocols, and characterization and uses as therapeutic drugs and gene delivery carriers and in other biomedical fields. The chapters of this book, which are contributed by internationally renowned scholars working in the arena of biopolymer-based nanomaterials, would offer a wide vision on the potential future applications of these nanomaterials in the delivery and targeting of bioactive molecules of pharmaceutical interests and in tissue engineering, biosensing, bioimaging, and diagnostic purposes. The state-of-the-art information presented in the book would also encourage young investigators and researchers to further bring cutting-edge developments in the field of nanomedicine in the near future.

This contributed volume, "Multifaceted Protocols in Biotechnology, Volume 2", consists of multidisciplinary methods and techniques commonly used in biotechnology studies. There are two sections covered in this book - Ionic Liquid Related Techniques & Evergreen Biotechnology Techniques. A brief introduction supports each protocol to allow easy learning and implementation. The first section consists of three chapters covering studies in modern biotechnology focusing on the role of ionic liquid techniques in extracting secondary metabolites, enzyme stabilization and biomass processing. The second section covers evergreen methodologies. It comprises five chapters covering topics on microcarrier technology for cell culture; Polymerase Chain Reaction for non-halal sources detection in food; ELISA for biomarker identification; gamma ray-induced mutagenesis for enhancing microbial fuel cells; and the effect of temperature on antibacterial activity of Carica papaya seed extract. This book will be useful to graduate students, researchers, academics, and industry practitioners working in the area of biotechnology

Portable Biosensors and Point-of-Care Systems describes the principles, design and applications of a new generation of analytical and diagnostic biomedical devices, characterized by their very small size, ease of use, multi-analytical capabilities and speed to provide handheld and mobile point-of-care (POC) diagnostics. The book is divided in four Parts. Part I is an in-depth analysis of the various technologies upon which portable diagnostic devices and biosensors are built. In Part II, advances in the design and optimization of special components of biosensor systems and handheld devices are presented. In Part III, a wide scope of applications of portable biosensors and handheld POC devices is described, ranging from the support of primary healthcare to food and environmental safety screening. Diverse topics are covered, including counterterrorism, travel medicine and drug development. Finally, Part IV of the book is dedicated to the presentation of commercially available products including a review of the products of point-of-care in-vitro-diagnostics companies, a review of technologies which have achieved a high Technology Readiness Level, and a special market case study of POC infusion systems combined with intelligent patient monitoring. This book is essential reading for researchers and experts in the healthcare diagnostic and analytical sector, and for electronics and material engineers working on portable sensors.

This volume considers the most common materials used in medical devices. State-of-the-art reference information is given for implant materials including stainless steels, cobalt-base alloys, titanium, shape memory alloys, noble metals, ceramics, and polymers. Examples of materials- and mechanical-based failures of medical devices provide lessons learned in the failure analysis section. Biotribology and implant wear are covered extensively, including clinical wear and biological aspects of implant wear. A detailed look at corrosion includes its effects, corrosion products, mechanically assisted corrosion and corrosion fatigue. Biocompatibility is also discussed at length including biocompatibility of ceramics and polymers. Engineers with little exposure to medical and biomedical engineering will find this book particularly useful. Volume 23 is a replacement for the Handbook of Materials for Medical Devices edited by J.R. Davis (ASM, 2003). The new volume features brand-new content that greatly expands the scope and depth of coverage, including a more in-depth discussion of materials and focus on applications.

Control Applications for Biomedical Engineering Systems presents different control engineering and modeling applications in the biomedical field. It is intended for senior undergraduate or graduate students in both control engineering and biomedical engineering programs. For control engineering students, it presents the application of various techniques already learned in theoretical lectures in the biomedical arena. For biomedical engineering students, it presents solutions to various problems in the field using methods commonly used by control engineers.

Biomedical signal processing in the medical field has helped optimize patient care and diagnosis within medical facilities. As technology in this area continues to advance, it has become imperative to evaluate other ways these computation techniques could be implemented. Computational Tools and Techniques for Biomedical Signal Processing investigates high-performance computing techniques being utilized in hospital information systems. Featuring comprehensive coverage on various theoretical perspectives, best practices, and emergent research in the field, this book is ideally suited for computer scientists, information technologists, biomedical engineers, data-processing specialists, and medical physicists interested in signal processing within medical systems and facilities.

Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research.

This book integrates bioengineering for solving health issues. It shows how the use of applied mechanics and strength of materials using 3D printing models, digital correlation techniques and computed tomography images, provides solutions to biology, medicine and mechanical engineering. The book provides clear processes and illustrations, several worked examples, and many projects. It helps scientists to analyze different modes of applying mechanical and biomedical concepts, physical principles to develop devices, sensors, prosthesis, orthotic systems, new materials and techniques that may improve the health system. It can be used in courses such as biomechanics and orthopedics, rehabilitation and mechanical engineering, also in rehabilitation or sports medicine.

The book discusses the complex interactions between plants and their associated microbial communities. It also elucidates the ways in which these microbiomes are connected with the plant system, and how they affect plant health. The different chapters describe how microbiomes affect plants with regard to immunity, disease conditions, stress management and productivity. In addition, the book describes how an 'additional plant genome' functions as a whole organ system of the host, and how it presents both challenges and opportunities for the plant system. Moreover, the book includes a dedicated section on using omics tools to understand these interactions, and on exploiting them to their full potential.

This book highlights numerical models as powerful tools for the optimal design of Micro-Electro-Mechanical Systems (MEMS). Most MEMS experts have a background in electronics, where circuit models or behavioral models (i.e. lumped-parameter models) of devices are preferred to field models. This is certainly convenient in terms of preliminary design, e.g. in the prototyping stage. However, design optimization should also take into account fine-sizing effects on device behavior and therefore be based on distributed-parameter models, such as finite-element models. The book shows how the combination of automated optimal design and field-based models can produce powerful design toolboxes for MEMS. It especially focuses on illustrating theoretical concepts with practical examples, fostering comprehension through a problem-solving approach. By comparing the results obtained using different methods, readers will learn to identify their respective strengths and weaknesses. In addition, special emphasis is given to evolutionary computing and nature-inspired optimization strategies, the effectiveness of which has already been amply demonstrated. Given its scope, the book provides PhD students, researchers and professionals in the area of computer-aided analysis with a comprehensive, yet concise and practice-oriented guide to MEMS design and optimization. To benefit most from the book, readers should have a basic grasp of electromagnetism, vector analysis and numerical methods.

Before the integration of expert systems in biomedical science, complex problems required human expertise to solve them through conventional procedural methods. Advancements in expert systems allow for knowledge to be extracted when no human expertise is available and increases productivity through quick diagnosis. Expert System Techniques in Biomedical Science Practice is an essential scholarly resource that contains innovative research on the methods by which an expert system is designed to solve complex problems through the automation of decision making through the use of if-then-else rules rather than conventional procedural methods. Featuring coverage on a broad range of topics such as image processing, bio-signals, and cognitive AI, this book is a vital reference source for computer engineers, information technologists, biomedical engineers, data-processing specialists, medical professionals, and industrialists within the fields of biomedical engineering, pervasive computing, and natural language processing.

This thesis demonstrates a technology that enables pipetting-free high-throughput screening (HTS) on a miniaturized platform, eliminating the need for thousands of one-by-one pipetting and conventional liquid handling systems. This platform enhances accessibility to HTS and enables HTS to be used in small-to-medium scale laboratories. In addition, it allows large-scale combinatorial screening with a small number of valuable cells, such as patients' primary cancer cells. This technique will have a high impact for widespread use of HTS in the era of personalized medicine. In this thesis, the author firstly describes the need and concept of 'partipetting' for pipetting-free HTS platform. It is realized by the one-step pipetting and self-assembly of encoded drug-laden microparticles (DLPs) on the microwells. Next, the technical implementations required for the platform demonstration are described. It includes preparation of encoded DLPs, plastic chip fabrication, and realization of automated system. Lastly, screening of sequential drug combinations using this platform is demonstrated. This shows the potential of the proposed technology for various applications.

Clinical and Basic Neurogastroenterology and Motility is a state-of-the-art, lucidly written, generously illustrated, landmark publication that comprehensively addresses the underlying mechanisms and management of common adult and pediatric motility disorders. These problems affect 50% of the population and include conditions such as dysphagia, achalasia, gastroesophageal reflux disease, gastroparesis, irritable bowel syndrome (IBS), gas and bloating, SIBO, constipation and fecal incontinence. The book brings together international experts and clinician scientists, epitomizing their years of wisdom into a concise yet practical text that is delivered in two distinct sections, basic and clinical. It fulfills a large unmet need, and bridges a long-awaited knowledge gap among trainees, clinicians, scientists, nurses and technicians, earnestly engaged in this field.

This edited volume presents fundamentals as well as applications of oculomotor methods in industrial and clinical settings. The topical spectrum covers 1.) basics and background material, 2.) methods such as recording techniques, markov models, Levy flights, pupillometry and many more, as well as 3.) a broad range of applications in clinical and industrial settings. The target audience primarily comprises research experts and practitioners, but the book may also be beneficial for graduate students.

Technology has made it possible to bridge such distinct fields as engineering and medicine, creating systems with benefits that people could have never before imagined. Intelligent Medical Technologies and Biomedical Engineering: Tools and Applications helps young researchers and developers understand the basics of the field while highlighting the various developments over the last several years. Broad in scope and comprehensive in depth, this volume serves as a base text for any project or work into the domain of medical diagnosis or other areas of medical engineering.

This book focuses on the design, development, and characterization of a compact magnetic laser scanner for microsurgical applications. In addition, it proposes a laser incision depth controller to be used in soft tissue microsurgeries. The use of laser scanners in soft tissue microsurgery results in high quality ablations with minimal thermal damage to surrounding tissue. However, current scanner technologies for microsurgery are limited to free-beam lasers, which require direct line-of-sight to the surgical site, from outside the patient. Developing compact laser micromanipulation systems is crucial to introducing laser-scanning capabilities in hard-to-reach surgical sites, e.g., vocal cords. In this book, the design and fabrication of a magnetically actuated endoscopic laser scanner have been shown, one that introduces high-speed laser scanning for high quality, non-contact tissue ablations in narrow workspaces. Static and dynamic characterization of the system, its teleoperation through a tablet device, and its control modelling for automated trajectory executions have been shown using a fabricated and assembled prototype. Following this, the book discusses how the laser position and velocity control capabilities of the scanner can be used to design a laser incision depth controller to assist surgeons during operations.